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Q9CZT5

- VASN_MOUSE

UniProt

Q9CZT5 - VASN_MOUSE

Protein

Vasorin

Gene

Vasn

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    May act as an inhibitor of TGF-beta signaling.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cellular response to hypoxia Source: MGI
    2. cellular response to redox state Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Vasorin
    Alternative name(s):
    Protein slit-like 2
    Gene namesi
    Name:Vasn
    Synonyms:Slitl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2177651. Vasn.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. lysosomal membrane Source: Ensembl
    3. mitochondrion Source: MGI
    4. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 673649VasorinPRO_0000232631Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi118 – 1181N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi410 ↔ 421PROSITE-ProRule annotation
    Disulfide bondi415 ↔ 431PROSITE-ProRule annotation
    Disulfide bondi433 ↔ 442PROSITE-ProRule annotation
    Glycosylationi501 – 5011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi529 – 5291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi555 – 5551N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9CZT5.
    PRIDEiQ9CZT5.

    PTM databases

    PhosphoSiteiQ9CZT5.

    Expressioni

    Developmental stagei

    Expression begins at E10.5 and increases as development progresses to E17.5. Expression rises in parallel with the differentiation of vascular smooth muscle cells (VSMCs) of the aorta.1 Publication

    Inductioni

    Upon retinoic acid-induced differentiation of smooth muscle cells in vitro.1 Publication

    Gene expression databases

    BgeeiQ9CZT5.
    GenevestigatoriQ9CZT5.

    Interactioni

    Subunit structurei

    Interacts with TGFB1, TGFB2 and TGFB3.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZT5.
    SMRiQ9CZT5. Positions 24-386, 464-543.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 576552ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini598 – 67376CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei577 – 59721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 5329LRRNTAdd
    BLAST
    Repeati54 – 7522LRR 1Add
    BLAST
    Repeati78 – 9922LRR 2Add
    BLAST
    Repeati102 – 12322LRR 3Add
    BLAST
    Repeati126 – 14722LRR 4Add
    BLAST
    Repeati150 – 17021LRR 5Add
    BLAST
    Repeati171 – 19222LRR 6Add
    BLAST
    Repeati194 – 21522LRR 7Add
    BLAST
    Repeati218 – 23922LRR 8Add
    BLAST
    Repeati241 – 26525LRR 9Add
    BLAST
    Repeati266 – 28823LRR 10Add
    BLAST
    Domaini299 – 35254LRRCTAdd
    BLAST
    Domaini406 – 44338EGF-likePROSITE-ProRule annotationAdd
    BLAST
    Domaini463 – 55997Fibronectin type-IIIPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation
    Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation
    Contains 10 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    EGF-like domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG273568.
    GeneTreeiENSGT00730000111167.
    HOGENOMiHOG000261606.
    HOVERGENiHBG084318.
    InParanoidiQ9CZT5.
    OMAiVTQLRPN.
    OrthoDBiEOG71ZP1F.
    PhylomeDBiQ9CZT5.
    TreeFamiTF351825.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF00008. EGF. 1 hit.
    PF00041. fn3. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    SM00060. FN3. 1 hit.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50853. FN3. 1 hit.
    PS51450. LRR. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CZT5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHSRSCLPPL LLLLLVLLGS GVQGCPSGCQ CNQPQTVFCT ARQGTTVPRD    50
    VPPDTVGLYI FENGITTLDV GCFAGLPGLQ LLDLSQNQIT SLPGGIFQPL 100
    VNLSNLDLTA NKLHEISNET FRGLRRLERL YLGKNRIRHI QPGAFDALDR 150
    LLELKLPDNE LRVLPPLHLP RLLLLDLSHN SIPALEAGIL DTANVEALRL 200
    AGLGLRQLDE GLFGRLLNLH DLDVSDNQLE HMPSVIQGLR GLTRLRLAGN 250
    TRIAQIRPED LAGLTALQEL DVSNLSLQAL PSDLSSLFPR LRLLAAARNP 300
    FNCLCPLSWF GPWVRENHVV LASPEETRCH FPPKNAGRLL LDLDYADFGC 350
    PVTTTTATVP TIRSTIREPT LSTSSQAPTW PSLTEPTTQA STVLSTAPPT 400
    MRPAPQPQDC PASICLNGGS CRLGARHHWE CLCPEGFIGL YCESPVEQGM 450
    KPSSIPDTPR PPPLLPLSIE PVSPTSLRVK LQRYLQGNTV QLRSLRLTYR 500
    NLSGPDKRLV TLRLPASLAE YTVTQLRPNA TYSICVTPLG AGRTPEGEEA 550
    CGEANTSQAV RSNHAPVTQA REGNLPLLIA PALAAVLLAV LAAAGAAYCV 600
    RRARATSTAQ DKGQVGPGTG PLELEGVKAP LEPGSKATEG GGEALSGGPE 650
    CEVPLMGYPG PSLQGVLPAK HYI 673
    Length:673
    Mass (Da):72,261
    Last modified:April 18, 2006 - v2
    Checksum:iAAB8DA82DA8E9D32
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti225 – 2251S → Y in BAB28075. (PubMed:16141072)Curated
    Sequence conflicti383 – 3831L → H in BAC38992. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ458938 mRNA. Translation: CAD30331.1.
    AK012169 mRNA. Translation: BAB28075.1.
    AK083684 mRNA. Translation: BAC38992.1.
    AK132325 mRNA. Translation: BAE21105.1.
    BC050274 mRNA. Translation: AAH50274.1.
    CCDSiCCDS27921.1.
    RefSeqiNP_647468.2. NM_139307.3.
    UniGeneiMm.482140.

    Genome annotation databases

    EnsembliENSMUST00000038770; ENSMUSP00000045162; ENSMUSG00000039646.
    GeneIDi246154.
    KEGGimmu:246154.
    UCSCiuc007xzz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ458938 mRNA. Translation: CAD30331.1 .
    AK012169 mRNA. Translation: BAB28075.1 .
    AK083684 mRNA. Translation: BAC38992.1 .
    AK132325 mRNA. Translation: BAE21105.1 .
    BC050274 mRNA. Translation: AAH50274.1 .
    CCDSi CCDS27921.1.
    RefSeqi NP_647468.2. NM_139307.3.
    UniGenei Mm.482140.

    3D structure databases

    ProteinModelPortali Q9CZT5.
    SMRi Q9CZT5. Positions 24-386, 464-543.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CZT5.

    Proteomic databases

    PaxDbi Q9CZT5.
    PRIDEi Q9CZT5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038770 ; ENSMUSP00000045162 ; ENSMUSG00000039646 .
    GeneIDi 246154.
    KEGGi mmu:246154.
    UCSCi uc007xzz.2. mouse.

    Organism-specific databases

    CTDi 114990.
    MGIi MGI:2177651. Vasn.

    Phylogenomic databases

    eggNOGi NOG273568.
    GeneTreei ENSGT00730000111167.
    HOGENOMi HOG000261606.
    HOVERGENi HBG084318.
    InParanoidi Q9CZT5.
    OMAi VTQLRPN.
    OrthoDBi EOG71ZP1F.
    PhylomeDBi Q9CZT5.
    TreeFami TF351825.

    Miscellaneous databases

    NextBioi 387103.
    PROi Q9CZT5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CZT5.
    Genevestigatori Q9CZT5.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF00008. EGF. 1 hit.
    PF00041. fn3. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    SM00060. FN3. 1 hit.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    PS50026. EGF_3. 1 hit.
    PS50853. FN3. 1 hit.
    PS51450. LRR. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and expression analysis of the mouse Slit-like 2 (Slitl2) gene."
      Schrewe H., Kutejova E.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.
    4. "Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo."
      Ikeda Y., Imai Y., Kumagai H., Nosaka T., Morikawa Y., Hisaoka T., Manabe I., Maemura K., Nakaoka T., Imamura T., Miyazono K., Komuro I., Nagai R., Kitamura T.
      Proc. Natl. Acad. Sci. U.S.A. 101:10732-10737(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE, INDUCTION.

    Entry informationi

    Entry nameiVASN_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZT5
    Secondary accession number(s): Q8BJJ0, Q8R2G5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3