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Q9CZT5

- VASN_MOUSE

UniProt

Q9CZT5 - VASN_MOUSE

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Protein
Vasorin
Gene
Vasn, Slitl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

May act as an inhibitor of TGF-beta signaling By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI

GO - Biological processi

  1. cellular response to hypoxia Source: MGI
  2. cellular response to redox state Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Vasorin
Alternative name(s):
Protein slit-like 2
Gene namesi
Name:Vasn
Synonyms:Slitl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2177651. Vasn.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 576552Extracellular Reviewed prediction
Add
BLAST
Transmembranei577 – 59721Helical; Reviewed prediction
Add
BLAST
Topological domaini598 – 67376Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. lysosomal membrane Source: Ensembl
  3. mitochondrion Source: MGI
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed prediction
Add
BLAST
Chaini25 – 673649Vasorin
PRO_0000232631Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi102 – 1021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi118 – 1181N-linked (GlcNAc...) Reviewed prediction
Glycosylationi274 – 2741N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi410 ↔ 421 By similarity
Disulfide bondi415 ↔ 431 By similarity
Disulfide bondi433 ↔ 442 By similarity
Glycosylationi501 – 5011N-linked (GlcNAc...) Reviewed prediction
Glycosylationi529 – 5291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi555 – 5551N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9CZT5.
PRIDEiQ9CZT5.

PTM databases

PhosphoSiteiQ9CZT5.

Expressioni

Developmental stagei

Expression begins at E10.5 and increases as development progresses to E17.5. Expression rises in parallel with the differentiation of vascular smooth muscle cells (VSMCs) of the aorta.1 Publication

Inductioni

Upon retinoic acid-induced differentiation of smooth muscle cells in vitro.1 Publication

Gene expression databases

BgeeiQ9CZT5.
GenevestigatoriQ9CZT5.

Interactioni

Subunit structurei

Interacts with TGFB1, TGFB2 and TGFB3 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ9CZT5.
SMRiQ9CZT5. Positions 24-386, 464-543.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini25 – 5329LRRNT
Add
BLAST
Repeati54 – 7522LRR 1
Add
BLAST
Repeati78 – 9922LRR 2
Add
BLAST
Repeati102 – 12322LRR 3
Add
BLAST
Repeati126 – 14722LRR 4
Add
BLAST
Repeati150 – 17021LRR 5
Add
BLAST
Repeati171 – 19222LRR 6
Add
BLAST
Repeati194 – 21522LRR 7
Add
BLAST
Repeati218 – 23922LRR 8
Add
BLAST
Repeati241 – 26525LRR 9
Add
BLAST
Repeati266 – 28823LRR 10
Add
BLAST
Domaini299 – 35254LRRCT
Add
BLAST
Domaini406 – 44338EGF-like
Add
BLAST
Domaini463 – 55997Fibronectin type-III
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG273568.
GeneTreeiENSGT00730000111167.
HOGENOMiHOG000261606.
HOVERGENiHBG084318.
InParanoidiQ9CZT5.
OMAiVTQLRPN.
OrthoDBiEOG71ZP1F.
PhylomeDBiQ9CZT5.
TreeFamiTF351825.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF00008. EGF. 1 hit.
PF00041. fn3. 1 hit.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
SM00060. FN3. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZT5-1 [UniParc]FASTAAdd to Basket

« Hide

MHSRSCLPPL LLLLLVLLGS GVQGCPSGCQ CNQPQTVFCT ARQGTTVPRD    50
VPPDTVGLYI FENGITTLDV GCFAGLPGLQ LLDLSQNQIT SLPGGIFQPL 100
VNLSNLDLTA NKLHEISNET FRGLRRLERL YLGKNRIRHI QPGAFDALDR 150
LLELKLPDNE LRVLPPLHLP RLLLLDLSHN SIPALEAGIL DTANVEALRL 200
AGLGLRQLDE GLFGRLLNLH DLDVSDNQLE HMPSVIQGLR GLTRLRLAGN 250
TRIAQIRPED LAGLTALQEL DVSNLSLQAL PSDLSSLFPR LRLLAAARNP 300
FNCLCPLSWF GPWVRENHVV LASPEETRCH FPPKNAGRLL LDLDYADFGC 350
PVTTTTATVP TIRSTIREPT LSTSSQAPTW PSLTEPTTQA STVLSTAPPT 400
MRPAPQPQDC PASICLNGGS CRLGARHHWE CLCPEGFIGL YCESPVEQGM 450
KPSSIPDTPR PPPLLPLSIE PVSPTSLRVK LQRYLQGNTV QLRSLRLTYR 500
NLSGPDKRLV TLRLPASLAE YTVTQLRPNA TYSICVTPLG AGRTPEGEEA 550
CGEANTSQAV RSNHAPVTQA REGNLPLLIA PALAAVLLAV LAAAGAAYCV 600
RRARATSTAQ DKGQVGPGTG PLELEGVKAP LEPGSKATEG GGEALSGGPE 650
CEVPLMGYPG PSLQGVLPAK HYI 673
Length:673
Mass (Da):72,261
Last modified:April 18, 2006 - v2
Checksum:iAAB8DA82DA8E9D32
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti225 – 2251S → Y in BAB28075. 1 Publication
Sequence conflicti383 – 3831L → H in BAC38992. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ458938 mRNA. Translation: CAD30331.1.
AK012169 mRNA. Translation: BAB28075.1.
AK083684 mRNA. Translation: BAC38992.1.
AK132325 mRNA. Translation: BAE21105.1.
BC050274 mRNA. Translation: AAH50274.1.
CCDSiCCDS27921.1.
RefSeqiNP_647468.2. NM_139307.3.
UniGeneiMm.482140.

Genome annotation databases

EnsembliENSMUST00000038770; ENSMUSP00000045162; ENSMUSG00000039646.
GeneIDi246154.
KEGGimmu:246154.
UCSCiuc007xzz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ458938 mRNA. Translation: CAD30331.1 .
AK012169 mRNA. Translation: BAB28075.1 .
AK083684 mRNA. Translation: BAC38992.1 .
AK132325 mRNA. Translation: BAE21105.1 .
BC050274 mRNA. Translation: AAH50274.1 .
CCDSi CCDS27921.1.
RefSeqi NP_647468.2. NM_139307.3.
UniGenei Mm.482140.

3D structure databases

ProteinModelPortali Q9CZT5.
SMRi Q9CZT5. Positions 24-386, 464-543.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9CZT5.

Proteomic databases

PaxDbi Q9CZT5.
PRIDEi Q9CZT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038770 ; ENSMUSP00000045162 ; ENSMUSG00000039646 .
GeneIDi 246154.
KEGGi mmu:246154.
UCSCi uc007xzz.2. mouse.

Organism-specific databases

CTDi 114990.
MGIi MGI:2177651. Vasn.

Phylogenomic databases

eggNOGi NOG273568.
GeneTreei ENSGT00730000111167.
HOGENOMi HOG000261606.
HOVERGENi HBG084318.
InParanoidi Q9CZT5.
OMAi VTQLRPN.
OrthoDBi EOG71ZP1F.
PhylomeDBi Q9CZT5.
TreeFami TF351825.

Miscellaneous databases

NextBioi 387103.
PROi Q9CZT5.
SOURCEi Search...

Gene expression databases

Bgeei Q9CZT5.
Genevestigatori Q9CZT5.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF00008. EGF. 1 hit.
PF00041. fn3. 1 hit.
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
SM00060. FN3. 1 hit.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression analysis of the mouse Slit-like 2 (Slitl2) gene."
    Schrewe H., Kutejova E.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.
  4. "Vasorin, a transforming growth factor beta-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo."
    Ikeda Y., Imai Y., Kumagai H., Nosaka T., Morikawa Y., Hisaoka T., Manabe I., Maemura K., Nakaoka T., Imamura T., Miyazono K., Komuro I., Nagai R., Kitamura T.
    Proc. Natl. Acad. Sci. U.S.A. 101:10732-10737(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, INDUCTION.

Entry informationi

Entry nameiVASN_MOUSE
AccessioniPrimary (citable) accession number: Q9CZT5
Secondary accession number(s): Q8BJJ0, Q8R2G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi