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Protein

Vasorin

Gene

Vasn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May act as an inhibitor of TGF-beta signaling.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Vasorin
Alternative name(s):
Protein slit-like 2
Gene namesi
Name:Vasn
Synonyms:Slitl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2177651. Vasn.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 576ExtracellularSequence analysisAdd BLAST552
Transmembranei577 – 597HelicalSequence analysisAdd BLAST21
Topological domaini598 – 673CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000023263125 – 673VasorinAdd BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi410 ↔ 421
Disulfide bondi415 ↔ 431
Disulfide bondi433 ↔ 442
Glycosylationi501N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi555N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9CZT5.
PaxDbiQ9CZT5.
PeptideAtlasiQ9CZT5.
PRIDEiQ9CZT5.

PTM databases

iPTMnetiQ9CZT5.
PhosphoSitePlusiQ9CZT5.
SwissPalmiQ9CZT5.

Expressioni

Developmental stagei

Expression begins at E10.5 and increases as development progresses to E17.5. Expression rises in parallel with the differentiation of vascular smooth muscle cells (VSMCs) of the aorta.1 Publication

Inductioni

Upon retinoic acid-induced differentiation of smooth muscle cells in vitro.1 Publication

Gene expression databases

BgeeiENSMUSG00000039646.
GenevisibleiQ9CZT5. MM.

Interactioni

Subunit structurei

Interacts with TGFB1, TGFB2 and TGFB3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045162.

Structurei

3D structure databases

ProteinModelPortaliQ9CZT5.
SMRiQ9CZT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 53LRRNTAdd BLAST29
Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 170LRR 5Add BLAST21
Repeati171 – 192LRR 6Add BLAST22
Repeati194 – 215LRR 7Add BLAST22
Repeati218 – 239LRR 8Add BLAST22
Repeati241 – 265LRR 9Add BLAST25
Repeati266 – 288LRR 10Add BLAST23
Domaini299 – 352LRRCTAdd BLAST54
Domaini406 – 443EGF-likeAdd BLAST38
Domaini463 – 559Fibronectin type-IIIAdd BLAST97

Keywords - Domaini

EGF-like domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00900000140864.
HOGENOMiHOG000261606.
HOVERGENiHBG084318.
InParanoidiQ9CZT5.
OMAiECEVPLM.
OrthoDBiEOG091G04XS.
PhylomeDBiQ9CZT5.
TreeFamiTF351825.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR003961. FN3_dom.
IPR036116. FN3_sf.
IPR013783. Ig-like_fold.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR032675. LRR_dom_sf.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF00008. EGF. 1 hit.
PF00041. fn3. 1 hit.
PF13855. LRR_8. 2 hits.
SMARTiView protein in SMART
SM00181. EGF. 1 hit.
SM00060. FN3. 1 hit.
SM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 1 hit.
PS50853. FN3. 1 hit.
PS51450. LRR. 8 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSRSCLPPL LLLLLVLLGS GVQGCPSGCQ CNQPQTVFCT ARQGTTVPRD
60 70 80 90 100
VPPDTVGLYI FENGITTLDV GCFAGLPGLQ LLDLSQNQIT SLPGGIFQPL
110 120 130 140 150
VNLSNLDLTA NKLHEISNET FRGLRRLERL YLGKNRIRHI QPGAFDALDR
160 170 180 190 200
LLELKLPDNE LRVLPPLHLP RLLLLDLSHN SIPALEAGIL DTANVEALRL
210 220 230 240 250
AGLGLRQLDE GLFGRLLNLH DLDVSDNQLE HMPSVIQGLR GLTRLRLAGN
260 270 280 290 300
TRIAQIRPED LAGLTALQEL DVSNLSLQAL PSDLSSLFPR LRLLAAARNP
310 320 330 340 350
FNCLCPLSWF GPWVRENHVV LASPEETRCH FPPKNAGRLL LDLDYADFGC
360 370 380 390 400
PVTTTTATVP TIRSTIREPT LSTSSQAPTW PSLTEPTTQA STVLSTAPPT
410 420 430 440 450
MRPAPQPQDC PASICLNGGS CRLGARHHWE CLCPEGFIGL YCESPVEQGM
460 470 480 490 500
KPSSIPDTPR PPPLLPLSIE PVSPTSLRVK LQRYLQGNTV QLRSLRLTYR
510 520 530 540 550
NLSGPDKRLV TLRLPASLAE YTVTQLRPNA TYSICVTPLG AGRTPEGEEA
560 570 580 590 600
CGEANTSQAV RSNHAPVTQA REGNLPLLIA PALAAVLLAV LAAAGAAYCV
610 620 630 640 650
RRARATSTAQ DKGQVGPGTG PLELEGVKAP LEPGSKATEG GGEALSGGPE
660 670
CEVPLMGYPG PSLQGVLPAK HYI
Length:673
Mass (Da):72,261
Last modified:April 18, 2006 - v2
Checksum:iAAB8DA82DA8E9D32
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti225S → Y in BAB28075 (PubMed:16141072).Curated1
Sequence conflicti383L → H in BAC38992 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ458938 mRNA. Translation: CAD30331.1.
AK012169 mRNA. Translation: BAB28075.1.
AK083684 mRNA. Translation: BAC38992.1.
AK132325 mRNA. Translation: BAE21105.1.
BC050274 mRNA. Translation: AAH50274.1.
CCDSiCCDS27921.1.
RefSeqiNP_647468.2. NM_139307.3.
UniGeneiMm.482140.

Genome annotation databases

EnsembliENSMUST00000038770; ENSMUSP00000045162; ENSMUSG00000039646.
GeneIDi246154.
KEGGimmu:246154.
UCSCiuc007xzz.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiVASN_MOUSE
AccessioniPrimary (citable) accession number: Q9CZT5
Secondary accession number(s): Q8BJJ0, Q8R2G5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: April 18, 2006
Last modified: November 22, 2017
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot