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Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

Aldh1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity).By similarity

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase family 3 member B2 (Aldh3b2), Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei188Transition state stabilizerBy similarity1
Active sitei287Proton acceptorPROSITE-ProRule annotation1
Active sitei321NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 269NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.2.1.3 3474
ReactomeiR-MMU-71384 Ethanol oxidation
UniPathwayiUPA00780; UER00768

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase family 1 member B1
Gene namesi
Name:Aldh1b1
Synonyms:Aldhx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919785 Aldh1b1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000027141120 – 519Aldehyde dehydrogenase X, mitochondrialAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei54N6-acetyllysine; alternateCombined sources1
Modified residuei54N6-succinyllysine; alternateCombined sources1
Modified residuei83N6-succinyllysineCombined sources1
Modified residuei366N6-acetyllysine; alternateCombined sources1
Modified residuei366N6-succinyllysine; alternateCombined sources1
Modified residuei385N6-acetyllysine; alternateCombined sources1
Modified residuei385N6-succinyllysine; alternateCombined sources1
Modified residuei401N6-acetyllysine; alternateCombined sources1
Modified residuei401N6-succinyllysine; alternateCombined sources1
Modified residuei416N6-acetyllysine; alternateCombined sources1
Modified residuei416N6-succinyllysine; alternateCombined sources1
Modified residuei428N6-acetyllysine; alternateCombined sources1
Modified residuei428N6-succinyllysine; alternateCombined sources1
Modified residuei431N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CZS1
MaxQBiQ9CZS1
PaxDbiQ9CZS1
PeptideAtlasiQ9CZS1
PRIDEiQ9CZS1

PTM databases

iPTMnetiQ9CZS1
PhosphoSitePlusiQ9CZS1
SwissPalmiQ9CZS1

Expressioni

Gene expression databases

BgeeiENSMUSG00000035561
CleanExiMM_ALDH1B1
ExpressionAtlasiQ9CZS1 baseline and differential
GenevisibleiQ9CZS1 MM

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi215422, 1 interactor
IntActiQ9CZS1, 1 interactor
MINTiQ9CZS1
STRINGi10090.ENSMUSP00000041260

Structurei

3D structure databases

ProteinModelPortaliQ9CZS1
SMRiQ9CZS1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450 Eukaryota
COG1012 LUCA
GeneTreeiENSGT00760000118999
HOGENOMiHOG000271505
HOVERGENiHBG000097
InParanoidiQ9CZS1
KOiK00128
OMAiCHEALFF
OrthoDBiEOG091G05E8
PhylomeDBiQ9CZS1
TreeFamiTF300455

Family and domain databases

Gene3Di3.40.309.10, 1 hit
3.40.605.10, 2 hits
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
PfamiView protein in Pfam
PF00171 Aldedh, 1 hit
SUPFAMiSSF53720 SSF53720, 1 hit
PROSITEiView protein in PROSITE
PS00070 ALDEHYDE_DEHYDR_CYS, 1 hit
PS00687 ALDEHYDE_DEHYDR_GLU, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTARLLLPR LLCLQGRTTS YSTAAALPNP IPNPEICYNK LFINNEWHDA
60 70 80 90 100
VSKKTFPTVN PTTGEVIGHV AEGDRADVDL AVKAAREAFR LGSPWRRMDA
110 120 130 140 150
SERGRLLNRL ADLVERDRVY LASLETLDNG KPFQESYVLD LDEVIKVYRY
160 170 180 190 200
FAGWADKWHG KTIPMDGEHF CFTRHEPVGV CGQIIPWNFP LVMQGWKLAP
210 220 230 240 250
ALATGNTVVM KVAEQTPLSA LYLASLIKEA GFPPGVVNII TGYGPTAGAA
260 270 280 290 300
IAQHMDVDKV AFTGSTEVGH LIQKAAGESN LKRVTLELGG KSPSIVLADA
310 320 330 340 350
DMEHAVDQCH EALFFNMGQC CCAGSRTFVE ESIYREFLER TVEKAKQRKV
360 370 380 390 400
GNPFELDTQQ GPQVDKEQFE RILGYIRLGQ KEGAKLLCGG ERLGERGFFI
410 420 430 440 450
KPTVFGDVQD GMRIAKEEIF GPVQPLFKFK KIEEVIQRAN NTRYGLAAAV
460 470 480 490 500
FTRDLDKAIY FTQALQAGTV WVNTYNIVTC HTPFGGFKES GNGRELGEDG
510
LRAYTEVKTV TIKVPEKNS
Length:519
Mass (Da):57,553
Last modified:June 1, 2001 - v1
Checksum:i69222D7409BFEEF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146K → R in BAE30339 (PubMed:16141072).Curated1
Sequence conflicti261A → T in BAE30339 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012213 mRNA Translation: BAB28101.1
AK088396 mRNA Translation: BAC40326.1
AK150992 mRNA Translation: BAE30016.1
AK151349 mRNA Translation: BAE30325.1
AK151364 mRNA Translation: BAE30339.1
AK153416 mRNA Translation: BAE31976.1
BC020001 mRNA Translation: AAH20001.1
BC086768 mRNA Translation: AAH86768.1
CCDSiCCDS18139.1
RefSeqiNP_082546.1, NM_028270.4
UniGeneiMm.331583

Genome annotation databases

EnsembliENSMUST00000044384; ENSMUSP00000041260; ENSMUSG00000035561
GeneIDi72535
KEGGimmu:72535
UCSCiuc008ssx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAL1B1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZS1
Secondary accession number(s): Q3UAH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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