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Q9CZS1

- AL1B1_MOUSE

UniProt

Q9CZS1 - AL1B1_MOUSE

Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

Aldh1b1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation By similarity.By similarity

    Catalytic activityi

    An aldehyde + NAD+ + H2O = a carboxylate + NADH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei188 – 1881Transition state stabilizerBy similarity
    Active sitei287 – 2871Proton acceptorPROSITE-ProRule annotation
    Active sitei321 – 3211NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi264 – 2696NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase (NAD) activity Source: UniProtKB-EC

    GO - Biological processi

    1. ethanol catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    UniPathwayiUPA00780; UER00768.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
    Alternative name(s):
    Aldehyde dehydrogenase family 1 member B1
    Gene namesi
    Name:Aldh1b1
    Synonyms:Aldhx
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1919785. Aldh1b1.

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1919MitochondrionSequence AnalysisAdd
    BLAST
    Chaini20 – 519500Aldehyde dehydrogenase X, mitochondrialPRO_0000271411Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei53 – 531N6-acetyllysine1 Publication
    Modified residuei54 – 541N6-acetyllysine; alternate1 Publication
    Modified residuei54 – 541N6-succinyllysine; alternate1 Publication
    Modified residuei83 – 831N6-succinyllysine1 Publication
    Modified residuei366 – 3661N6-acetyllysine; alternate1 Publication
    Modified residuei366 – 3661N6-succinyllysine; alternate1 Publication
    Modified residuei385 – 3851N6-acetyllysine; alternate1 Publication
    Modified residuei385 – 3851N6-succinyllysine; alternate1 Publication
    Modified residuei401 – 4011N6-acetyllysine; alternate1 Publication
    Modified residuei401 – 4011N6-succinyllysine; alternate1 Publication
    Modified residuei416 – 4161N6-acetyllysine; alternate1 Publication
    Modified residuei416 – 4161N6-succinyllysine; alternate1 Publication
    Modified residuei428 – 4281N6-acetyllysine; alternate1 Publication
    Modified residuei428 – 4281N6-succinyllysine; alternate1 Publication
    Modified residuei431 – 4311N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9CZS1.
    PaxDbiQ9CZS1.
    PRIDEiQ9CZS1.

    PTM databases

    PhosphoSiteiQ9CZS1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CZS1.
    BgeeiQ9CZS1.
    CleanExiMM_ALDH1B1.
    GenevestigatoriQ9CZS1.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiQ9CZS1. 1 interaction.
    MINTiMINT-1869729.
    STRINGi10090.ENSMUSP00000041260.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZS1.
    SMRiQ9CZS1. Positions 34-519.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG1012.
    GeneTreeiENSGT00550000074289.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ9CZS1.
    KOiK00128.
    OMAiHEGAEED.
    OrthoDBiEOG7PS1F7.
    PhylomeDBiQ9CZS1.
    TreeFamiTF300455.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CZS1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLTARLLLPR LLCLQGRTTS YSTAAALPNP IPNPEICYNK LFINNEWHDA    50
    VSKKTFPTVN PTTGEVIGHV AEGDRADVDL AVKAAREAFR LGSPWRRMDA 100
    SERGRLLNRL ADLVERDRVY LASLETLDNG KPFQESYVLD LDEVIKVYRY 150
    FAGWADKWHG KTIPMDGEHF CFTRHEPVGV CGQIIPWNFP LVMQGWKLAP 200
    ALATGNTVVM KVAEQTPLSA LYLASLIKEA GFPPGVVNII TGYGPTAGAA 250
    IAQHMDVDKV AFTGSTEVGH LIQKAAGESN LKRVTLELGG KSPSIVLADA 300
    DMEHAVDQCH EALFFNMGQC CCAGSRTFVE ESIYREFLER TVEKAKQRKV 350
    GNPFELDTQQ GPQVDKEQFE RILGYIRLGQ KEGAKLLCGG ERLGERGFFI 400
    KPTVFGDVQD GMRIAKEEIF GPVQPLFKFK KIEEVIQRAN NTRYGLAAAV 450
    FTRDLDKAIY FTQALQAGTV WVNTYNIVTC HTPFGGFKES GNGRELGEDG 500
    LRAYTEVKTV TIKVPEKNS 519
    Length:519
    Mass (Da):57,553
    Last modified:June 1, 2001 - v1
    Checksum:i69222D7409BFEEF3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti146 – 1461K → R in BAE30339. (PubMed:16141072)Curated
    Sequence conflicti261 – 2611A → T in BAE30339. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012213 mRNA. Translation: BAB28101.1.
    AK088396 mRNA. Translation: BAC40326.1.
    AK150992 mRNA. Translation: BAE30016.1.
    AK151349 mRNA. Translation: BAE30325.1.
    AK151364 mRNA. Translation: BAE30339.1.
    AK153416 mRNA. Translation: BAE31976.1.
    BC020001 mRNA. Translation: AAH20001.1.
    BC086768 mRNA. Translation: AAH86768.1.
    CCDSiCCDS18139.1.
    RefSeqiNP_082546.1. NM_028270.4.
    UniGeneiMm.331583.

    Genome annotation databases

    EnsembliENSMUST00000044384; ENSMUSP00000041260; ENSMUSG00000035561.
    GeneIDi72535.
    KEGGimmu:72535.
    UCSCiuc008ssx.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012213 mRNA. Translation: BAB28101.1 .
    AK088396 mRNA. Translation: BAC40326.1 .
    AK150992 mRNA. Translation: BAE30016.1 .
    AK151349 mRNA. Translation: BAE30325.1 .
    AK151364 mRNA. Translation: BAE30339.1 .
    AK153416 mRNA. Translation: BAE31976.1 .
    BC020001 mRNA. Translation: AAH20001.1 .
    BC086768 mRNA. Translation: AAH86768.1 .
    CCDSi CCDS18139.1.
    RefSeqi NP_082546.1. NM_028270.4.
    UniGenei Mm.331583.

    3D structure databases

    ProteinModelPortali Q9CZS1.
    SMRi Q9CZS1. Positions 34-519.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CZS1. 1 interaction.
    MINTi MINT-1869729.
    STRINGi 10090.ENSMUSP00000041260.

    PTM databases

    PhosphoSitei Q9CZS1.

    Proteomic databases

    MaxQBi Q9CZS1.
    PaxDbi Q9CZS1.
    PRIDEi Q9CZS1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044384 ; ENSMUSP00000041260 ; ENSMUSG00000035561 .
    GeneIDi 72535.
    KEGGi mmu:72535.
    UCSCi uc008ssx.1. mouse.

    Organism-specific databases

    CTDi 219.
    MGIi MGI:1919785. Aldh1b1.

    Phylogenomic databases

    eggNOGi COG1012.
    GeneTreei ENSGT00550000074289.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi Q9CZS1.
    KOi K00128.
    OMAi HEGAEED.
    OrthoDBi EOG7PS1F7.
    PhylomeDBi Q9CZS1.
    TreeFami TF300455.

    Enzyme and pathway databases

    UniPathwayi UPA00780 ; UER00768 .

    Miscellaneous databases

    NextBioi 336439.
    PROi Q9CZS1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CZS1.
    Bgeei Q9CZS1.
    CleanExi MM_ALDH1B1.
    Genevestigatori Q9CZS1.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Embryo and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N.
      Tissue: Brain and Colon.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-54; LYS-83; LYS-366; LYS-385; LYS-401; LYS-416 AND LYS-428, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways."
      Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B., Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.
      Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-53; LYS-54; LYS-366; LYS-385; LYS-401; LYS-416; LYS-428 AND LYS-431, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiAL1B1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZS1
    Secondary accession number(s): Q3UAH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3