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Protein

Aldehyde dehydrogenase X, mitochondrial

Gene

Aldh1b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation (By similarity).By similarity

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Pathwayi: ethanol degradation

This protein is involved in step 2 of the subpathway that synthesizes acetate from ethanol.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Aldehyde dehydrogenase, mitochondrial (Aldh2), Aldehyde dehydrogenase family 3 member B2 (Aldh3b2), Aldehyde dehydrogenase X, mitochondrial (Aldh1b1), Aldehyde dehydrogenase family 3 member B1 (Aldh3b1), Aldehyde dehydrogenase, cytosolic 1 (Aldh1a7)
This subpathway is part of the pathway ethanol degradation, which is itself part of Alcohol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetate from ethanol, the pathway ethanol degradation and in Alcohol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei188Transition state stabilizerBy similarity1
Active sitei287Proton acceptorPROSITE-ProRule annotation1
Active sitei321NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi264 – 269NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.3. 3474.
ReactomeiR-MMU-71384. Ethanol oxidation.
UniPathwayiUPA00780; UER00768.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase X, mitochondrial (EC:1.2.1.3)
Alternative name(s):
Aldehyde dehydrogenase family 1 member B1
Gene namesi
Name:Aldh1b1
Synonyms:Aldhx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1919785. Aldh1b1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 19MitochondrionSequence analysisAdd BLAST19
ChainiPRO_000027141120 – 519Aldehyde dehydrogenase X, mitochondrialAdd BLAST500

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei54N6-acetyllysine; alternateCombined sources1
Modified residuei54N6-succinyllysine; alternateCombined sources1
Modified residuei83N6-succinyllysineCombined sources1
Modified residuei366N6-acetyllysine; alternateCombined sources1
Modified residuei366N6-succinyllysine; alternateCombined sources1
Modified residuei385N6-acetyllysine; alternateCombined sources1
Modified residuei385N6-succinyllysine; alternateCombined sources1
Modified residuei401N6-acetyllysine; alternateCombined sources1
Modified residuei401N6-succinyllysine; alternateCombined sources1
Modified residuei416N6-acetyllysine; alternateCombined sources1
Modified residuei416N6-succinyllysine; alternateCombined sources1
Modified residuei428N6-acetyllysine; alternateCombined sources1
Modified residuei428N6-succinyllysine; alternateCombined sources1
Modified residuei431N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CZS1.
MaxQBiQ9CZS1.
PaxDbiQ9CZS1.
PeptideAtlasiQ9CZS1.
PRIDEiQ9CZS1.

PTM databases

iPTMnetiQ9CZS1.
PhosphoSitePlusiQ9CZS1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000035561.
CleanExiMM_ALDH1B1.
ExpressionAtlasiQ9CZS1. baseline and differential.
GenevisibleiQ9CZS1. MM.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ9CZS1. 1 interactor.
MINTiMINT-1869729.
STRINGi10090.ENSMUSP00000041260.

Structurei

3D structure databases

ProteinModelPortaliQ9CZS1.
SMRiQ9CZS1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ9CZS1.
KOiK00128.
OMAiAIWKIVP.
OrthoDBiEOG091G05E8.
PhylomeDBiQ9CZS1.
TreeFamiTF300455.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTARLLLPR LLCLQGRTTS YSTAAALPNP IPNPEICYNK LFINNEWHDA
60 70 80 90 100
VSKKTFPTVN PTTGEVIGHV AEGDRADVDL AVKAAREAFR LGSPWRRMDA
110 120 130 140 150
SERGRLLNRL ADLVERDRVY LASLETLDNG KPFQESYVLD LDEVIKVYRY
160 170 180 190 200
FAGWADKWHG KTIPMDGEHF CFTRHEPVGV CGQIIPWNFP LVMQGWKLAP
210 220 230 240 250
ALATGNTVVM KVAEQTPLSA LYLASLIKEA GFPPGVVNII TGYGPTAGAA
260 270 280 290 300
IAQHMDVDKV AFTGSTEVGH LIQKAAGESN LKRVTLELGG KSPSIVLADA
310 320 330 340 350
DMEHAVDQCH EALFFNMGQC CCAGSRTFVE ESIYREFLER TVEKAKQRKV
360 370 380 390 400
GNPFELDTQQ GPQVDKEQFE RILGYIRLGQ KEGAKLLCGG ERLGERGFFI
410 420 430 440 450
KPTVFGDVQD GMRIAKEEIF GPVQPLFKFK KIEEVIQRAN NTRYGLAAAV
460 470 480 490 500
FTRDLDKAIY FTQALQAGTV WVNTYNIVTC HTPFGGFKES GNGRELGEDG
510
LRAYTEVKTV TIKVPEKNS
Length:519
Mass (Da):57,553
Last modified:June 1, 2001 - v1
Checksum:i69222D7409BFEEF3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146K → R in BAE30339 (PubMed:16141072).Curated1
Sequence conflicti261A → T in BAE30339 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012213 mRNA. Translation: BAB28101.1.
AK088396 mRNA. Translation: BAC40326.1.
AK150992 mRNA. Translation: BAE30016.1.
AK151349 mRNA. Translation: BAE30325.1.
AK151364 mRNA. Translation: BAE30339.1.
AK153416 mRNA. Translation: BAE31976.1.
BC020001 mRNA. Translation: AAH20001.1.
BC086768 mRNA. Translation: AAH86768.1.
CCDSiCCDS18139.1.
RefSeqiNP_082546.1. NM_028270.4.
UniGeneiMm.331583.

Genome annotation databases

EnsembliENSMUST00000044384; ENSMUSP00000041260; ENSMUSG00000035561.
GeneIDi72535.
KEGGimmu:72535.
UCSCiuc008ssx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012213 mRNA. Translation: BAB28101.1.
AK088396 mRNA. Translation: BAC40326.1.
AK150992 mRNA. Translation: BAE30016.1.
AK151349 mRNA. Translation: BAE30325.1.
AK151364 mRNA. Translation: BAE30339.1.
AK153416 mRNA. Translation: BAE31976.1.
BC020001 mRNA. Translation: AAH20001.1.
BC086768 mRNA. Translation: AAH86768.1.
CCDSiCCDS18139.1.
RefSeqiNP_082546.1. NM_028270.4.
UniGeneiMm.331583.

3D structure databases

ProteinModelPortaliQ9CZS1.
SMRiQ9CZS1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CZS1. 1 interactor.
MINTiMINT-1869729.
STRINGi10090.ENSMUSP00000041260.

PTM databases

iPTMnetiQ9CZS1.
PhosphoSitePlusiQ9CZS1.

Proteomic databases

EPDiQ9CZS1.
MaxQBiQ9CZS1.
PaxDbiQ9CZS1.
PeptideAtlasiQ9CZS1.
PRIDEiQ9CZS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000044384; ENSMUSP00000041260; ENSMUSG00000035561.
GeneIDi72535.
KEGGimmu:72535.
UCSCiuc008ssx.1. mouse.

Organism-specific databases

CTDi219.
MGIiMGI:1919785. Aldh1b1.

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
GeneTreeiENSGT00760000118999.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ9CZS1.
KOiK00128.
OMAiAIWKIVP.
OrthoDBiEOG091G05E8.
PhylomeDBiQ9CZS1.
TreeFamiTF300455.

Enzyme and pathway databases

UniPathwayiUPA00780; UER00768.
BRENDAi1.2.1.3. 3474.
ReactomeiR-MMU-71384. Ethanol oxidation.

Miscellaneous databases

PROiQ9CZS1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000035561.
CleanExiMM_ALDH1B1.
ExpressionAtlasiQ9CZS1. baseline and differential.
GenevisibleiQ9CZS1. MM.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAL1B1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZS1
Secondary accession number(s): Q3UAH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.