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Protein

Elongation factor Ts, mitochondrial

Gene

Tsfm

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor Ts, mitochondrialUniRule annotation
Short name:
EF-TsUniRule annotation
Short name:
EF-TsMtUniRule annotation
Gene namesi
Name:Tsfm
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913649. Tsfm.

Subcellular locationi

  • Mitochondrion UniRule annotation

GO - Cellular componenti

  • mitochondrial matrix Source: GO_Central
  • mitochondrion Source: MGI
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 44MitochondrionUniRule annotationAdd BLAST44
ChainiPRO_000000746945 – 324Elongation factor Ts, mitochondrialAdd BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei75N6-succinyllysineCombined sources1
Modified residuei132N6-succinyllysineCombined sources1
Modified residuei191N6-succinyllysineCombined sources1
Modified residuei269PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZR8.
MaxQBiQ9CZR8.
PaxDbiQ9CZR8.
PRIDEiQ9CZR8.

PTM databases

iPTMnetiQ9CZR8.
PhosphoSitePlusiQ9CZR8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000040521.
CleanExiMM_TSFM.
ExpressionAtlasiQ9CZR8. baseline and differential.
GenevisibleiQ9CZR8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9CZR8. 1 interactor.
MINTiMINT-4094147.
STRINGi10090.ENSMUSP00000042134.

Structurei

3D structure databases

ProteinModelPortaliQ9CZR8.
SMRiQ9CZR8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the EF-Ts family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1071. Eukaryota.
COG0264. LUCA.
GeneTreeiENSGT00390000016293.
HOGENOMiHOG000220988.
HOVERGENiHBG005571.
InParanoidiQ9CZR8.
KOiK02357.
OMAiLVICETS.
OrthoDBiEOG091G0E11.
PhylomeDBiQ9CZR8.
TreeFamiTF314154.

Family and domain databases

Gene3Di3.30.479.20. 2 hits.
HAMAPiMF_00050. EF_Ts. 1 hit.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 2 hits.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLLRSLRFF PVACTGRSAR AVLLQPSQPW LTFHAGPSLS SAASSKELLM
60 70 80 90 100
KLRRKTGYSF VNCKKALETC GGDLKQAEDW LHKQAQKEGW SKAAKLHGRK
110 120 130 140 150
TKEGLIGLLQ EGNTAVLVEV NCETDFVSRN LKFQQLVQQV ALGTMAHCQN
160 170 180 190 200
LTDRLSTYSK GFLNSSELSE LAAGPDREGS LKDQLALAIG KLGENMILKR
210 220 230 240 250
AAWVKVPSGF YVGSYVHGVT QSPSLQNLVL GKYGALVICE TPEQIANLEE
260 270 280 290 300
VGRRLGQHVV GMAPLSVGSL DDEPGGETET RMLPQPYLLD PSITLGQYVQ
310 320
PQGVTVVDFV RFECGEDEQV AEAE
Length:324
Mass (Da):35,334
Last modified:June 1, 2001 - v1
Checksum:i6E8AFA409F62791F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012240 mRNA. Translation: BAB28113.1.
AK169164 mRNA. Translation: BAE40943.1.
BC057904 mRNA. Translation: AAH57904.1.
CCDSiCCDS24222.1.
RefSeqiNP_079813.1. NM_025537.3.
UniGeneiMm.29900.

Genome annotation databases

EnsembliENSMUST00000040560; ENSMUSP00000042134; ENSMUSG00000040521.
GeneIDi66399.
KEGGimmu:66399.
UCSCiuc007hhm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012240 mRNA. Translation: BAB28113.1.
AK169164 mRNA. Translation: BAE40943.1.
BC057904 mRNA. Translation: AAH57904.1.
CCDSiCCDS24222.1.
RefSeqiNP_079813.1. NM_025537.3.
UniGeneiMm.29900.

3D structure databases

ProteinModelPortaliQ9CZR8.
SMRiQ9CZR8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CZR8. 1 interactor.
MINTiMINT-4094147.
STRINGi10090.ENSMUSP00000042134.

PTM databases

iPTMnetiQ9CZR8.
PhosphoSitePlusiQ9CZR8.

Proteomic databases

EPDiQ9CZR8.
MaxQBiQ9CZR8.
PaxDbiQ9CZR8.
PRIDEiQ9CZR8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040560; ENSMUSP00000042134; ENSMUSG00000040521.
GeneIDi66399.
KEGGimmu:66399.
UCSCiuc007hhm.1. mouse.

Organism-specific databases

CTDi10102.
MGIiMGI:1913649. Tsfm.

Phylogenomic databases

eggNOGiKOG1071. Eukaryota.
COG0264. LUCA.
GeneTreeiENSGT00390000016293.
HOGENOMiHOG000220988.
HOVERGENiHBG005571.
InParanoidiQ9CZR8.
KOiK02357.
OMAiLVICETS.
OrthoDBiEOG091G0E11.
PhylomeDBiQ9CZR8.
TreeFamiTF314154.

Miscellaneous databases

ChiTaRSiTsfm. mouse.
PROiQ9CZR8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040521.
CleanExiMM_TSFM.
ExpressionAtlasiQ9CZR8. baseline and differential.
GenevisibleiQ9CZR8. MM.

Family and domain databases

Gene3Di3.30.479.20. 2 hits.
HAMAPiMF_00050. EF_Ts. 1 hit.
InterProiIPR001816. Transl_elong_EFTs/EF1B.
IPR014039. Transl_elong_EFTs/EF1B_dimer.
IPR018101. Transl_elong_Ts_CS.
IPR009060. UBA-like.
[Graphical view]
PANTHERiPTHR11741. PTHR11741. 1 hit.
PfamiPF00889. EF_TS. 1 hit.
[Graphical view]
SUPFAMiSSF46934. SSF46934. 1 hit.
SSF54713. SSF54713. 2 hits.
PROSITEiPS01126. EF_TS_1. 1 hit.
PS01127. EF_TS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFTS_MOUSE
AccessioniPrimary (citable) accession number: Q9CZR8
Secondary accession number(s): Q3TFF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.