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Q9CZR4 (CKLF8_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
CKLF-like MARVEL transmembrane domain-containing protein 8
Alternative name(s):
Chemokine-like factor superfamily member 8
Gene names
Name:Cmtm8
Synonyms:Cklfsf8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the chemokine-like factor family.

Contains 1 MARVEL domain.

Ontologies

Keywords
   Biological processChemotaxis
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionCytokine
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processchemotaxis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

integral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 173173CKLF-like MARVEL transmembrane domain-containing protein 8
PRO_0000186113

Regions

Transmembrane41 – 6121Helical; Potential
Transmembrane70 – 9021Helical; Potential
Transmembrane105 – 12521Helical; Potential
Transmembrane147 – 16721Helical; Potential
Domain36 – 168133MARVEL

Sequences

Sequence LengthMass (Da)Tools
Q9CZR4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: B58E8E5C0E8539A1

FASTA17319,527
        10         20         30         40         50         60 
MEEQQRARSH TVTTTTSSFA ENFSTTSSSF AYDREFLRTP PGLLIVAEIV LGLLVWTLIA 

        70         80         90        100        110        120 
GTEYFRVPAF GWVMFVAVFY WVLTVFFLIV YITLTYTRIP QVPWTTVGLC FNGSAFVLYF 

       130        140        150        160        170 
SAAIVDASSV SPEKEGHNFN SWAASSFFAF LVTICYAGNT YFSFIAWRSR TAQ

« Hide

References

« Hide 'large scale' references
[1]Ding P., Han W., Li T., Yang T., Shi S., Tan Y., Ma D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Leukocyte.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY243513 mRNA. Translation: AAO89236.1.
AK012262 mRNA. Translation: BAB28125.1.
BC027554 mRNA. Translation: AAH27554.1.
IPIIPI00113045.
RefSeqNP_081570.1. NM_027294.2.
UniGeneMm.150064.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000043706.

PTM databases

PhosphoSiteQ9CZR4.

Proteomic databases

PRIDEQ9CZR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000047013; ENSMUSP00000043706; ENSMUSG00000041012.
GeneID70031.
KEGGmmu:70031.
UCSCuc009ryg.1. mouse.

Organism-specific databases

CTD152189.
MGIMGI:2447167. Cmtm8.

Phylogenomic databases

eggNOGNOG270058.
GeneTreeENSGT00530000062900.
HOGENOMHOG000247057.
HOVERGENHBG108271.
InParanoidQ9CZR4.
OMADSHNYNS.
OrthoDBEOG47H5R7.

Gene expression databases

BgeeQ9CZR4.
GenevestigatorQ9CZR4.
GermOnlineENSMUSG00000041012. Mus musculus.

Family and domain databases

InterProIPR013295. MAL.
IPR008253. Marvel.
IPR021128. MARVEL-like_dom.
[Graphical view]
PfamPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSPR01884. MALPROTEIN.
PROSITEPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio330865.
SOURCESearch...

Entry information

Entry nameCKLF8_MOUSE
AccessionPrimary (citable) accession number: Q9CZR4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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