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Protein

Mitochondrial import receptor subunit TOM40B

Gene

Tomm40l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential channel-forming protein implicated in import of protein precursors into mitochondria.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM40B
Alternative name(s):
Protein TOMM40-like
Gene namesi
Name:Tomm40l
Synonyms:Tomm40b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:3589112. Tomm40l.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
  • pore complex Source: UniProtKB-KW
  • protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Mitochondrial import receptor subunit TOM40BPRO_0000051537Add
BLAST

Proteomic databases

EPDiQ9CZR3.
MaxQBiQ9CZR3.
PaxDbiQ9CZR3.
PRIDEiQ9CZR3.

PTM databases

iPTMnetiQ9CZR3.
PhosphoSiteiQ9CZR3.

Expressioni

Gene expression databases

BgeeiQ9CZR3.
ExpressionAtlasiQ9CZR3. baseline and differential.
GenevisibleiQ9CZR3. MM.

Interactioni

Subunit structurei

Forms part of the preprotein translocase of the outer mitochondrial membrane (TOM complex) containing TOMM22, TOMM40, TOMM40L and TOMM70. Interacts with mitochondrial targeting sequences (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005817.

Structurei

3D structure databases

ProteinModelPortaliQ9CZR3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni281 – 30828Required for mitochondrial targetingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the Tom40 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3296. Eukaryota.
ENOG410XS2U. LUCA.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiQ9CZR3.
KOiK11518.
OMAiFLQSITH.
OrthoDBiEOG7GQXVZ.
PhylomeDBiQ9CZR3.
TreeFamiTF106204.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZR3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNTLGLAPM GTLPRRSHRR EEPLPNPGSF DELHRLCKDV FPAQMEGVKL
60 70 80 90 100
VVNKVLSSHF QVAHTVHMSA LGLPGYHLHT AYAGDWQLSP TEVFPTVVGD
110 120 130 140 150
MDSSGSLNAQ VLLLLAERLR AKAVFQTQQA KFLTWQFDGE YRGDDYTATL
160 170 180 190 200
TLGNPDLIGE SVIMVAHFLQ SITHRLVLGG ELVYHRRPGE EGAILTLAGK
210 220 230 240 250
YSAVHWVATL NVGSGGAHAS YYHKANEQVQ VGVEFEANTR LQDTTFSFGY
260 270 280 290 300
HLTLPQADMV FRGLVDSNWC VGAVLEKKMR PLPVTLALGA FLNHWRNRFH

CGFSITVG
Length:308
Mass (Da):34,005
Last modified:June 1, 2001 - v1
Checksum:i413D66AED372D967
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012264 mRNA. Translation: BAB28127.1.
AK028388 mRNA. Translation: BAC25924.1.
BC058978 mRNA. Translation: AAH58978.1.
CCDSiCCDS15481.1.
RefSeqiNP_001032247.1. NM_001037170.2.
XP_006497016.1. XM_006496953.2.
UniGeneiMm.288374.

Genome annotation databases

EnsembliENSMUST00000005817; ENSMUSP00000005817; ENSMUSG00000005674.
ENSMUST00000111327; ENSMUSP00000106959; ENSMUSG00000005674.
GeneIDi641376.
KEGGimmu:641376.
UCSCiuc007dni.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012264 mRNA. Translation: BAB28127.1.
AK028388 mRNA. Translation: BAC25924.1.
BC058978 mRNA. Translation: AAH58978.1.
CCDSiCCDS15481.1.
RefSeqiNP_001032247.1. NM_001037170.2.
XP_006497016.1. XM_006496953.2.
UniGeneiMm.288374.

3D structure databases

ProteinModelPortaliQ9CZR3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005817.

PTM databases

iPTMnetiQ9CZR3.
PhosphoSiteiQ9CZR3.

Proteomic databases

EPDiQ9CZR3.
MaxQBiQ9CZR3.
PaxDbiQ9CZR3.
PRIDEiQ9CZR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005817; ENSMUSP00000005817; ENSMUSG00000005674.
ENSMUST00000111327; ENSMUSP00000106959; ENSMUSG00000005674.
GeneIDi641376.
KEGGimmu:641376.
UCSCiuc007dni.1. mouse.

Organism-specific databases

CTDi84134.
MGIiMGI:3589112. Tomm40l.

Phylogenomic databases

eggNOGiKOG3296. Eukaryota.
ENOG410XS2U. LUCA.
GeneTreeiENSGT00390000003308.
HOGENOMiHOG000007440.
HOVERGENiHBG054707.
InParanoidiQ9CZR3.
KOiK11518.
OMAiFLQSITH.
OrthoDBiEOG7GQXVZ.
PhylomeDBiQ9CZR3.
TreeFamiTF106204.

Miscellaneous databases

ChiTaRSiTomm40l. mouse.
NextBioi425554.
PROiQ9CZR3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZR3.
ExpressionAtlasiQ9CZR3. baseline and differential.
GenevisibleiQ9CZR3. MM.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Placenta.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiTM40L_MOUSE
AccessioniPrimary (citable) accession number: Q9CZR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.