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Protein

Bardet-Biedl syndrome 5 protein homolog

Gene

Bbs5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_362338. BBSome-mediated cargo-targeting to cilium.

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 5 protein homolog
Gene namesi
Name:Bbs5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919819. Bbs5.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: MGI
  • BBSome Source: UniProtKB
  • ciliary basal body Source: BHF-UCL
  • ciliary membrane Source: UniProtKB-SubCell
  • intracellular Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Bardet-Biedl syndrome 5 protein homologPRO_0000223256Add
BLAST

Proteomic databases

PaxDbiQ9CZQ9.
PRIDEiQ9CZQ9.

PTM databases

PhosphoSiteiQ9CZQ9.

Expressioni

Gene expression databases

BgeeiQ9CZQ9.
CleanExiMM_BBS5.
ExpressionAtlasiQ9CZQ9. baseline and differential.
GenevisibleiQ9CZQ9. MM.

Interactioni

Subunit structurei

PPart of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Binds to phosphoinositides. Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO. Interacts with PKD1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ9CZQ9. 4 interactions.
STRINGi10090.ENSMUSP00000074494.

Structurei

3D structure databases

ProteinModelPortaliQ9CZQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the BBS5 family.Curated

Phylogenomic databases

eggNOGiNOG82102.
GeneTreeiENSGT00390000002753.
HOGENOMiHOG000231964.
HOVERGENiHBG053449.
InParanoidiQ9CZQ9.
KOiK16748.
OMAiELGFAME.
PhylomeDBiQ9CZQ9.
TreeFamiTF106129.

Family and domain databases

InterProiIPR006606. BBL5.
IPR030804. BBS5/fem-3.
[Graphical view]
PANTHERiPTHR21351. PTHR21351. 1 hit.
PfamiPF07289. DUF1448. 1 hit.
[Graphical view]
PIRSFiPIRSF010072. DUF1448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVLDVLWED RDVRFDVSSQ QMKTRPGEVL IDCLDSIEDT KGNNGDRGRL
60 70 80 90 100
LVTNLRIIWH SLALPRVNLS IGYNCILNIT TRTANSKLRG QTEALYILTK
110 120 130 140 150
CNTTRFEFIF TNLVPGSPRL FTSVIAVHRA YETSKMYRDF KLRSAVIQNK
160 170 180 190 200
QLRLLPQEHV YDKINGVWNL SSDQGNLGTF FITNVRIVWH ANMNDSFNVS
210 220 230 240 250
IPYLQIRSIK IRDSKFGLAL VIESSQQSGG YVLGFKIDPV EKLQESVKEI
260 270 280 290 300
NSLHKVYSAS PIFGVNYEME EKPQPLEALT VEQIQDDVEI DSDDHTDAFV
310 320 330 340
AYFADGNKQQ DREPVFSEEL GLAIEKLKDG FTLQGLWEVM S
Length:341
Mass (Da):38,862
Last modified:June 1, 2001 - v1
Checksum:i8FD2BF5943F72325
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012283 mRNA. Translation: BAB28141.1.
AL929083 Genomic DNA. Translation: CAM24291.1.
BC061031 mRNA. Translation: AAH61031.1.
CCDSiCCDS16094.1.
RefSeqiNP_082560.1. NM_028284.2.
UniGeneiMm.252136.

Genome annotation databases

EnsembliENSMUST00000074963; ENSMUSP00000074494; ENSMUSG00000063145.
GeneIDi72569.
KEGGimmu:72569.
UCSCiuc008jyf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012283 mRNA. Translation: BAB28141.1.
AL929083 Genomic DNA. Translation: CAM24291.1.
BC061031 mRNA. Translation: AAH61031.1.
CCDSiCCDS16094.1.
RefSeqiNP_082560.1. NM_028284.2.
UniGeneiMm.252136.

3D structure databases

ProteinModelPortaliQ9CZQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CZQ9. 4 interactions.
STRINGi10090.ENSMUSP00000074494.

PTM databases

PhosphoSiteiQ9CZQ9.

Proteomic databases

PaxDbiQ9CZQ9.
PRIDEiQ9CZQ9.

Protocols and materials databases

DNASUi72569.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074963; ENSMUSP00000074494; ENSMUSG00000063145.
GeneIDi72569.
KEGGimmu:72569.
UCSCiuc008jyf.1. mouse.

Organism-specific databases

CTDi129880.
MGIiMGI:1919819. Bbs5.

Phylogenomic databases

eggNOGiNOG82102.
GeneTreeiENSGT00390000002753.
HOGENOMiHOG000231964.
HOVERGENiHBG053449.
InParanoidiQ9CZQ9.
KOiK16748.
OMAiELGFAME.
PhylomeDBiQ9CZQ9.
TreeFamiTF106129.

Enzyme and pathway databases

ReactomeiREACT_362338. BBSome-mediated cargo-targeting to cilium.

Miscellaneous databases

NextBioi336521.
PROiQ9CZQ9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZQ9.
CleanExiMM_BBS5.
ExpressionAtlasiQ9CZQ9. baseline and differential.
GenevisibleiQ9CZQ9. MM.

Family and domain databases

InterProiIPR006606. BBL5.
IPR030804. BBS5/fem-3.
[Graphical view]
PANTHERiPTHR21351. PTHR21351. 1 hit.
PfamiPF07289. DUF1448. 1 hit.
[Graphical view]
PIRSFiPIRSF010072. DUF1448. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: SUBCELLULAR LOCATION.
  5. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."
    Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.
    PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BBSOME COMPLEX, INTERACTION WITH SMO.

Entry informationi

Entry nameiBBS5_MOUSE
AccessioniPrimary (citable) accession number: Q9CZQ9
Secondary accession number(s): A2AUC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: June 24, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.