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Q9CZQ9

- BBS5_MOUSE

UniProt

Q9CZQ9 - BBS5_MOUSE

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Protein
Bardet-Biedl syndrome 5 protein homolog
Gene
Bbs5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly By similarity.

GO - Biological processi

  1. cell projection organization Source: UniProtKB-KW
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Bardet-Biedl syndrome 5 protein homolog
Gene namesi
Name:Bbs5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1919819. Bbs5.

Subcellular locationi

Cell projectioncilium membrane By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletoncilium basal body. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite By similarity
Note: Localizes to basal bodies.1 Publication

GO - Cellular componenti

  1. BBSome Source: UniProtKB
  2. ciliary basal body Source: BHF-UCL
  3. ciliary membrane Source: UniProtKB-SubCell
  4. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 341341Bardet-Biedl syndrome 5 protein homolog
PRO_0000223256Add
BLAST

Proteomic databases

PaxDbiQ9CZQ9.
PRIDEiQ9CZQ9.

PTM databases

PhosphoSiteiQ9CZQ9.

Expressioni

Gene expression databases

BgeeiQ9CZQ9.
CleanExiMM_BBS5.
GenevestigatoriQ9CZQ9.

Interactioni

Subunit structurei

PPart of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Binds to phosphoinositides. Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO.1 Publication

Protein-protein interaction databases

IntActiQ9CZQ9. 4 interactions.
STRINGi10090.ENSMUSP00000074494.

Structurei

3D structure databases

ProteinModelPortaliQ9CZQ9.

Family & Domainsi

Sequence similaritiesi

Belongs to the BBS5 family.

Phylogenomic databases

eggNOGiNOG82102.
GeneTreeiENSGT00390000002753.
HOGENOMiHOG000231964.
HOVERGENiHBG053449.
InParanoidiA2AUC7.
KOiK16748.
OMAiELGFAME.
PhylomeDBiQ9CZQ9.
TreeFamiTF106129.

Family and domain databases

InterProiIPR006606. BBL5.
[Graphical view]
PANTHERiPTHR21351. PTHR21351. 1 hit.
PfamiPF07289. DUF1448. 1 hit.
[Graphical view]
PIRSFiPIRSF010072. DUF1448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZQ9-1 [UniParc]FASTAAdd to Basket

« Hide

MSVLDVLWED RDVRFDVSSQ QMKTRPGEVL IDCLDSIEDT KGNNGDRGRL    50
LVTNLRIIWH SLALPRVNLS IGYNCILNIT TRTANSKLRG QTEALYILTK 100
CNTTRFEFIF TNLVPGSPRL FTSVIAVHRA YETSKMYRDF KLRSAVIQNK 150
QLRLLPQEHV YDKINGVWNL SSDQGNLGTF FITNVRIVWH ANMNDSFNVS 200
IPYLQIRSIK IRDSKFGLAL VIESSQQSGG YVLGFKIDPV EKLQESVKEI 250
NSLHKVYSAS PIFGVNYEME EKPQPLEALT VEQIQDDVEI DSDDHTDAFV 300
AYFADGNKQQ DREPVFSEEL GLAIEKLKDG FTLQGLWEVM S 341
Length:341
Mass (Da):38,862
Last modified:June 1, 2001 - v1
Checksum:i8FD2BF5943F72325
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012283 mRNA. Translation: BAB28141.1.
AL929083 Genomic DNA. Translation: CAM24291.1.
BC061031 mRNA. Translation: AAH61031.1.
CCDSiCCDS16094.1.
RefSeqiNP_082560.1. NM_028284.2.
UniGeneiMm.252136.

Genome annotation databases

EnsembliENSMUST00000074963; ENSMUSP00000074494; ENSMUSG00000063145.
GeneIDi72569.
KEGGimmu:72569.
UCSCiuc008jyf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012283 mRNA. Translation: BAB28141.1 .
AL929083 Genomic DNA. Translation: CAM24291.1 .
BC061031 mRNA. Translation: AAH61031.1 .
CCDSi CCDS16094.1.
RefSeqi NP_082560.1. NM_028284.2.
UniGenei Mm.252136.

3D structure databases

ProteinModelPortali Q9CZQ9.
ModBasei Search...

Protein-protein interaction databases

IntActi Q9CZQ9. 4 interactions.
STRINGi 10090.ENSMUSP00000074494.

PTM databases

PhosphoSitei Q9CZQ9.

Proteomic databases

PaxDbi Q9CZQ9.
PRIDEi Q9CZQ9.

Protocols and materials databases

DNASUi 72569.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000074963 ; ENSMUSP00000074494 ; ENSMUSG00000063145 .
GeneIDi 72569.
KEGGi mmu:72569.
UCSCi uc008jyf.1. mouse.

Organism-specific databases

CTDi 129880.
MGIi MGI:1919819. Bbs5.

Phylogenomic databases

eggNOGi NOG82102.
GeneTreei ENSGT00390000002753.
HOGENOMi HOG000231964.
HOVERGENi HBG053449.
InParanoidi A2AUC7.
KOi K16748.
OMAi ELGFAME.
PhylomeDBi Q9CZQ9.
TreeFami TF106129.

Miscellaneous databases

NextBioi 336521.
PROi Q9CZQ9.
SOURCEi Search...

Gene expression databases

Bgeei Q9CZQ9.
CleanExi MM_BBS5.
Genevestigatori Q9CZQ9.

Family and domain databases

InterProi IPR006606. BBL5.
[Graphical view ]
PANTHERi PTHR21351. PTHR21351. 1 hit.
Pfami PF07289. DUF1448. 1 hit.
[Graphical view ]
PIRSFi PIRSF010072. DUF1448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: SUBCELLULAR LOCATION.
  5. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."
    Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.
    PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE BBSOME COMPLEX, INTERACTION WITH SMO.

Entry informationi

Entry nameiBBS5_MOUSE
AccessioniPrimary (citable) accession number: Q9CZQ9
Secondary accession number(s): A2AUC7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi