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Q9CZQ9

- BBS5_MOUSE

UniProt

Q9CZQ9 - BBS5_MOUSE

Protein

Bardet-Biedl syndrome 5 protein homolog

Gene

Bbs5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for BBSome complex ciliary localization but not for the proper complex assembly By similarity.By similarity

    GO - Biological processi

    1. cell projection organization Source: UniProtKB-KW
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Cilium biogenesis/degradation, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bardet-Biedl syndrome 5 protein homolog
    Gene namesi
    Name:Bbs5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:1919819. Bbs5.

    Subcellular locationi

    Cell projectioncilium membrane By similarity. Cytoplasm By similarity. Cytoplasmcytoskeletoncilium basal body 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriolar satellite By similarity
    Note: Localizes to basal bodies.

    GO - Cellular componenti

    1. BBSome Source: UniProtKB
    2. ciliary basal body Source: BHF-UCL
    3. ciliary membrane Source: UniProtKB-SubCell
    4. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Bardet-Biedl syndrome 5 protein homologPRO_0000223256Add
    BLAST

    Proteomic databases

    PaxDbiQ9CZQ9.
    PRIDEiQ9CZQ9.

    PTM databases

    PhosphoSiteiQ9CZQ9.

    Expressioni

    Gene expression databases

    BgeeiQ9CZQ9.
    CleanExiMM_BBS5.
    GenevestigatoriQ9CZQ9.

    Interactioni

    Subunit structurei

    PPart of BBSome complex, that contains BBS1, BBS2, BBS4, BBS5, BBS7, BBS8/TTC8, BBS9 and BBIP10. Binds to phosphoinositides. Interacts with CCDC28B. Interacts with SMO; the interaction is indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO.1 Publication

    Protein-protein interaction databases

    IntActiQ9CZQ9. 4 interactions.
    STRINGi10090.ENSMUSP00000074494.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZQ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the BBS5 family.Curated

    Phylogenomic databases

    eggNOGiNOG82102.
    GeneTreeiENSGT00390000002753.
    HOGENOMiHOG000231964.
    HOVERGENiHBG053449.
    InParanoidiA2AUC7.
    KOiK16748.
    OMAiELGFAME.
    PhylomeDBiQ9CZQ9.
    TreeFamiTF106129.

    Family and domain databases

    InterProiIPR006606. BBL5.
    [Graphical view]
    PANTHERiPTHR21351. PTHR21351. 1 hit.
    PfamiPF07289. DUF1448. 1 hit.
    [Graphical view]
    PIRSFiPIRSF010072. DUF1448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CZQ9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVLDVLWED RDVRFDVSSQ QMKTRPGEVL IDCLDSIEDT KGNNGDRGRL    50
    LVTNLRIIWH SLALPRVNLS IGYNCILNIT TRTANSKLRG QTEALYILTK 100
    CNTTRFEFIF TNLVPGSPRL FTSVIAVHRA YETSKMYRDF KLRSAVIQNK 150
    QLRLLPQEHV YDKINGVWNL SSDQGNLGTF FITNVRIVWH ANMNDSFNVS 200
    IPYLQIRSIK IRDSKFGLAL VIESSQQSGG YVLGFKIDPV EKLQESVKEI 250
    NSLHKVYSAS PIFGVNYEME EKPQPLEALT VEQIQDDVEI DSDDHTDAFV 300
    AYFADGNKQQ DREPVFSEEL GLAIEKLKDG FTLQGLWEVM S 341
    Length:341
    Mass (Da):38,862
    Last modified:June 1, 2001 - v1
    Checksum:i8FD2BF5943F72325
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012283 mRNA. Translation: BAB28141.1.
    AL929083 Genomic DNA. Translation: CAM24291.1.
    BC061031 mRNA. Translation: AAH61031.1.
    CCDSiCCDS16094.1.
    RefSeqiNP_082560.1. NM_028284.2.
    UniGeneiMm.252136.

    Genome annotation databases

    EnsembliENSMUST00000074963; ENSMUSP00000074494; ENSMUSG00000063145.
    GeneIDi72569.
    KEGGimmu:72569.
    UCSCiuc008jyf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK012283 mRNA. Translation: BAB28141.1 .
    AL929083 Genomic DNA. Translation: CAM24291.1 .
    BC061031 mRNA. Translation: AAH61031.1 .
    CCDSi CCDS16094.1.
    RefSeqi NP_082560.1. NM_028284.2.
    UniGenei Mm.252136.

    3D structure databases

    ProteinModelPortali Q9CZQ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CZQ9. 4 interactions.
    STRINGi 10090.ENSMUSP00000074494.

    PTM databases

    PhosphoSitei Q9CZQ9.

    Proteomic databases

    PaxDbi Q9CZQ9.
    PRIDEi Q9CZQ9.

    Protocols and materials databases

    DNASUi 72569.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074963 ; ENSMUSP00000074494 ; ENSMUSG00000063145 .
    GeneIDi 72569.
    KEGGi mmu:72569.
    UCSCi uc008jyf.1. mouse.

    Organism-specific databases

    CTDi 129880.
    MGIi MGI:1919819. Bbs5.

    Phylogenomic databases

    eggNOGi NOG82102.
    GeneTreei ENSGT00390000002753.
    HOGENOMi HOG000231964.
    HOVERGENi HBG053449.
    InParanoidi A2AUC7.
    KOi K16748.
    OMAi ELGFAME.
    PhylomeDBi Q9CZQ9.
    TreeFami TF106129.

    Miscellaneous databases

    NextBioi 336521.
    PROi Q9CZQ9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CZQ9.
    CleanExi MM_BBS5.
    Genevestigatori Q9CZQ9.

    Family and domain databases

    InterProi IPR006606. BBL5.
    [Graphical view ]
    PANTHERi PTHR21351. PTHR21351. 1 hit.
    Pfami PF07289. DUF1448. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF010072. DUF1448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: SUBCELLULAR LOCATION.
    5. "A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened."
      Seo S., Zhang Q., Bugge K., Breslow D.K., Searby C.C., Nachury M.V., Sheffield V.C.
      PLoS Genet. 7:E1002358-E1002358(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE BBSOME COMPLEX, INTERACTION WITH SMO.

    Entry informationi

    Entry nameiBBS5_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZQ9
    Secondary accession number(s): A2AUC7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 7, 2006
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3