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Q9CZP5

- BCS1_MOUSE

UniProt

Q9CZP5 - BCS1_MOUSE

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Protein
Mitochondrial chaperone BCS1
Gene
Bcs1l
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi230 – 2378ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro

GO - Biological processi

  1. mitochondrial respiratory chain complex I assembly Source: Ensembl
  2. mitochondrial respiratory chain complex III assembly Source: MGI
  3. mitochondrial respiratory chain complex IV assembly Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial chaperone BCS1
Alternative name(s):
BCS1-like protein
Gene namesi
Name:Bcs1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1914071. Bcs1l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Mitochondrial intermembrane Reviewed prediction
Add
BLAST
Transmembranei16 – 3217Helical; Reviewed prediction
Add
BLAST
Topological domaini33 – 418386Mitochondrial matrix Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Mitochondrial chaperone BCS1
PRO_0000084773Add
BLAST

Proteomic databases

MaxQBiQ9CZP5.
PaxDbiQ9CZP5.
PRIDEiQ9CZP5.

PTM databases

PhosphoSiteiQ9CZP5.

Expressioni

Gene expression databases

BgeeiQ9CZP5.
CleanExiMM_BCS1L.
GenevestigatoriQ9CZP5.

Interactioni

Subunit structurei

Interacts with LETM1 By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109362.

Structurei

3D structure databases

ProteinModelPortaliQ9CZP5.
SMRiQ9CZP5. Positions 153-398.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0465.
GeneTreeiENSGT00390000005415.
HOGENOMiHOG000198799.
HOVERGENiHBG048759.
InParanoidiQ9CZP5.
KOiK08900.
OMAiAENPVKY.
OrthoDBiEOG7P2XS1.
PhylomeDBiQ9CZP5.
TreeFamiTF315009.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027243. BCS1.
IPR014851. BCS1_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23070:SF17. PTHR23070:SF17. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF08740. BCS1_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01024. BCS1_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZP5-1 [UniParc]FASTAAdd to Basket

« Hide

MPFSDFVLAL KDNPYFGAGF GLVGVGTALA MARKGAQLGL VAFRRHYMIT    50
LEVPARDRSY AWLLSWLTRH STRTQHLSVE TSYLQHESGR ISTKFEFIPS 100
PGNHFIWYQG KWIRVERNRD MQMVDLQTGT PWESVTFTAL GTDRKVFFNI 150
LEEARALALQ QEEGKTVMYT AVGSEWRTFG YPRRRRPLDS VVLQQGLADR 200
IVKDIREFID NPKWYIDRGI PYRRGYLLYG PPGCGKSSFI TALAGELEHS 250
ICLLSLTDSS LSDDRLNHLL SVAPQQSLVL LEDVDAAFLS RDLAVENPIK 300
YQGLGRLTFS GLLNALDGVA STEARIVFMT TNYIDRLDPA LIRPGRVDLK 350
EYVGYCSHWQ LTQMFQRFYP GQAPSLAENF AEHVLKATSE ISPAQVQGYF 400
MLYKNDPMGA VHNIESLR 418
Length:418
Mass (Da):47,406
Last modified:June 1, 2001 - v1
Checksum:i94905BA9B097F0DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012324 mRNA. Translation: BAB28162.1.
AK078925 mRNA. Translation: BAC37464.1.
AK079385 mRNA. Translation: BAC37629.1.
BC019781 mRNA. Translation: AAH19781.1.
CCDSiCCDS15051.1.
RefSeqiNP_080060.1. NM_025784.4.
XP_006496259.1. XM_006496196.1.
UniGeneiMm.358700.

Genome annotation databases

EnsembliENSMUST00000027358; ENSMUSP00000027358; ENSMUSG00000026172.
ENSMUST00000113732; ENSMUSP00000109361; ENSMUSG00000026172.
ENSMUST00000113733; ENSMUSP00000109362; ENSMUSG00000026172.
GeneIDi66821.
KEGGimmu:66821.
UCSCiuc007bmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK012324 mRNA. Translation: BAB28162.1 .
AK078925 mRNA. Translation: BAC37464.1 .
AK079385 mRNA. Translation: BAC37629.1 .
BC019781 mRNA. Translation: AAH19781.1 .
CCDSi CCDS15051.1.
RefSeqi NP_080060.1. NM_025784.4.
XP_006496259.1. XM_006496196.1.
UniGenei Mm.358700.

3D structure databases

ProteinModelPortali Q9CZP5.
SMRi Q9CZP5. Positions 153-398.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000109362.

PTM databases

PhosphoSitei Q9CZP5.

Proteomic databases

MaxQBi Q9CZP5.
PaxDbi Q9CZP5.
PRIDEi Q9CZP5.

Protocols and materials databases

DNASUi 66821.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027358 ; ENSMUSP00000027358 ; ENSMUSG00000026172 .
ENSMUST00000113732 ; ENSMUSP00000109361 ; ENSMUSG00000026172 .
ENSMUST00000113733 ; ENSMUSP00000109362 ; ENSMUSG00000026172 .
GeneIDi 66821.
KEGGi mmu:66821.
UCSCi uc007bmq.1. mouse.

Organism-specific databases

CTDi 617.
MGIi MGI:1914071. Bcs1l.

Phylogenomic databases

eggNOGi COG0465.
GeneTreei ENSGT00390000005415.
HOGENOMi HOG000198799.
HOVERGENi HBG048759.
InParanoidi Q9CZP5.
KOi K08900.
OMAi AENPVKY.
OrthoDBi EOG7P2XS1.
PhylomeDBi Q9CZP5.
TreeFami TF315009.

Miscellaneous databases

NextBioi 322735.
PROi Q9CZP5.
SOURCEi Search...

Gene expression databases

Bgeei Q9CZP5.
CleanExi MM_BCS1L.
Genevestigatori Q9CZP5.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027243. BCS1.
IPR014851. BCS1_N.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR23070:SF17. PTHR23070:SF17. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF08740. BCS1_N. 1 hit.
[Graphical view ]
SMARTi SM00382. AAA. 1 hit.
SM01024. BCS1_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00674. AAA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiBCS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3