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Protein

Mitochondrial chaperone BCS1

Gene

Bcs1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi230 – 237ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial chaperone BCS1
Alternative name(s):
BCS1-like protein
Gene namesi
Name:Bcs1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914071 Bcs1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 15Mitochondrial intermembraneSequence analysisAdd BLAST14
Transmembranei16 – 32HelicalSequence analysisAdd BLAST17
Topological domaini33 – 418Mitochondrial matrixSequence analysisAdd BLAST386

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000847732 – 418Mitochondrial chaperone BCS1Add BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei181PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZP5
MaxQBiQ9CZP5
PaxDbiQ9CZP5
PeptideAtlasiQ9CZP5
PRIDEiQ9CZP5

PTM databases

iPTMnetiQ9CZP5
PhosphoSitePlusiQ9CZP5

Expressioni

Gene expression databases

BgeeiENSMUSG00000026172
CleanExiMM_BCS1L
GenevisibleiQ9CZP5 MM

Interactioni

Subunit structurei

Interacts with LETM1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027358

Structurei

3D structure databases

ProteinModelPortaliQ9CZP5
SMRiQ9CZP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. BCS1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0743 Eukaryota
COG0465 LUCA
GeneTreeiENSGT00390000005415
HOGENOMiHOG000198799
HOVERGENiHBG048759
InParanoidiQ9CZP5
KOiK08900
OMAiYQWLLQW
OrthoDBiEOG091G08O3
PhylomeDBiQ9CZP5
TreeFamiTF315009

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027243 BCS1
IPR014851 BCS1_N
IPR027417 P-loop_NTPase
PANTHERiPTHR23070:SF17 PTHR23070:SF17, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF08740 BCS1_N, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM01024 BCS1_N, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFSDFVLAL KDNPYFGAGF GLVGVGTALA MARKGAQLGL VAFRRHYMIT
60 70 80 90 100
LEVPARDRSY AWLLSWLTRH STRTQHLSVE TSYLQHESGR ISTKFEFIPS
110 120 130 140 150
PGNHFIWYQG KWIRVERNRD MQMVDLQTGT PWESVTFTAL GTDRKVFFNI
160 170 180 190 200
LEEARALALQ QEEGKTVMYT AVGSEWRTFG YPRRRRPLDS VVLQQGLADR
210 220 230 240 250
IVKDIREFID NPKWYIDRGI PYRRGYLLYG PPGCGKSSFI TALAGELEHS
260 270 280 290 300
ICLLSLTDSS LSDDRLNHLL SVAPQQSLVL LEDVDAAFLS RDLAVENPIK
310 320 330 340 350
YQGLGRLTFS GLLNALDGVA STEARIVFMT TNYIDRLDPA LIRPGRVDLK
360 370 380 390 400
EYVGYCSHWQ LTQMFQRFYP GQAPSLAENF AEHVLKATSE ISPAQVQGYF
410
MLYKNDPMGA VHNIESLR
Length:418
Mass (Da):47,406
Last modified:June 1, 2001 - v1
Checksum:i94905BA9B097F0DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012324 mRNA Translation: BAB28162.1
AK078925 mRNA Translation: BAC37464.1
AK079385 mRNA Translation: BAC37629.1
BC019781 mRNA Translation: AAH19781.1
CCDSiCCDS15051.1
RefSeqiNP_001292581.1, NM_001305652.1
NP_080060.1, NM_025784.5
UniGeneiMm.358700

Genome annotation databases

EnsembliENSMUST00000027358; ENSMUSP00000027358; ENSMUSG00000026172
ENSMUST00000113732; ENSMUSP00000109361; ENSMUSG00000026172
ENSMUST00000113733; ENSMUSP00000109362; ENSMUSG00000026172
GeneIDi66821
KEGGimmu:66821
UCSCiuc007bmq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiBCS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZP5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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