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Protein

Mitochondrial chaperone BCS1

Gene

Bcs1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone necessary for the assembly of mitochondrial respiratory chain complex III. Plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi230 – 2378ATPSequence Analysis

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. mitochondrial respiratory chain complex I assembly Source: MGI
  2. mitochondrial respiratory chain complex III assembly Source: MGI
  3. mitochondrial respiratory chain complex IV assembly Source: MGI
  4. mitochondrion organization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial chaperone BCS1
Alternative name(s):
BCS1-like protein
Gene namesi
Name:Bcs1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1914071. Bcs1l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1515Mitochondrial intermembraneSequence AnalysisAdd
BLAST
Transmembranei16 – 3217HelicalSequence AnalysisAdd
BLAST
Topological domaini33 – 418386Mitochondrial matrixSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 418418Mitochondrial chaperone BCS1PRO_0000084773Add
BLAST

Proteomic databases

MaxQBiQ9CZP5.
PaxDbiQ9CZP5.
PRIDEiQ9CZP5.

PTM databases

PhosphoSiteiQ9CZP5.

Expressioni

Gene expression databases

BgeeiQ9CZP5.
CleanExiMM_BCS1L.
GenevestigatoriQ9CZP5.

Interactioni

Subunit structurei

Interacts with LETM1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109362.

Structurei

3D structure databases

ProteinModelPortaliQ9CZP5.
SMRiQ9CZP5. Positions 202-394.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family. BCS1 subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0465.
GeneTreeiENSGT00390000005415.
HOGENOMiHOG000198799.
HOVERGENiHBG048759.
InParanoidiQ9CZP5.
KOiK08900.
OMAiRDKSYQW.
OrthoDBiEOG7P2XS1.
PhylomeDBiQ9CZP5.
TreeFamiTF315009.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027243. BCS1.
IPR014851. BCS1_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23070:SF17. PTHR23070:SF17. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF08740. BCS1_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01024. BCS1_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFSDFVLAL KDNPYFGAGF GLVGVGTALA MARKGAQLGL VAFRRHYMIT
60 70 80 90 100
LEVPARDRSY AWLLSWLTRH STRTQHLSVE TSYLQHESGR ISTKFEFIPS
110 120 130 140 150
PGNHFIWYQG KWIRVERNRD MQMVDLQTGT PWESVTFTAL GTDRKVFFNI
160 170 180 190 200
LEEARALALQ QEEGKTVMYT AVGSEWRTFG YPRRRRPLDS VVLQQGLADR
210 220 230 240 250
IVKDIREFID NPKWYIDRGI PYRRGYLLYG PPGCGKSSFI TALAGELEHS
260 270 280 290 300
ICLLSLTDSS LSDDRLNHLL SVAPQQSLVL LEDVDAAFLS RDLAVENPIK
310 320 330 340 350
YQGLGRLTFS GLLNALDGVA STEARIVFMT TNYIDRLDPA LIRPGRVDLK
360 370 380 390 400
EYVGYCSHWQ LTQMFQRFYP GQAPSLAENF AEHVLKATSE ISPAQVQGYF
410
MLYKNDPMGA VHNIESLR
Length:418
Mass (Da):47,406
Last modified:May 31, 2001 - v1
Checksum:i94905BA9B097F0DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012324 mRNA. Translation: BAB28162.1.
AK078925 mRNA. Translation: BAC37464.1.
AK079385 mRNA. Translation: BAC37629.1.
BC019781 mRNA. Translation: AAH19781.1.
CCDSiCCDS15051.1.
RefSeqiNP_080060.1. NM_025784.4.
XP_006496259.1. XM_006496196.2.
UniGeneiMm.358700.

Genome annotation databases

EnsembliENSMUST00000027358; ENSMUSP00000027358; ENSMUSG00000026172.
ENSMUST00000113732; ENSMUSP00000109361; ENSMUSG00000026172.
ENSMUST00000113733; ENSMUSP00000109362; ENSMUSG00000026172.
GeneIDi66821.
KEGGimmu:66821.
UCSCiuc007bmq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012324 mRNA. Translation: BAB28162.1.
AK078925 mRNA. Translation: BAC37464.1.
AK079385 mRNA. Translation: BAC37629.1.
BC019781 mRNA. Translation: AAH19781.1.
CCDSiCCDS15051.1.
RefSeqiNP_080060.1. NM_025784.4.
XP_006496259.1. XM_006496196.2.
UniGeneiMm.358700.

3D structure databases

ProteinModelPortaliQ9CZP5.
SMRiQ9CZP5. Positions 202-394.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109362.

PTM databases

PhosphoSiteiQ9CZP5.

Proteomic databases

MaxQBiQ9CZP5.
PaxDbiQ9CZP5.
PRIDEiQ9CZP5.

Protocols and materials databases

DNASUi66821.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027358; ENSMUSP00000027358; ENSMUSG00000026172.
ENSMUST00000113732; ENSMUSP00000109361; ENSMUSG00000026172.
ENSMUST00000113733; ENSMUSP00000109362; ENSMUSG00000026172.
GeneIDi66821.
KEGGimmu:66821.
UCSCiuc007bmq.1. mouse.

Organism-specific databases

CTDi617.
MGIiMGI:1914071. Bcs1l.

Phylogenomic databases

eggNOGiCOG0465.
GeneTreeiENSGT00390000005415.
HOGENOMiHOG000198799.
HOVERGENiHBG048759.
InParanoidiQ9CZP5.
KOiK08900.
OMAiRDKSYQW.
OrthoDBiEOG7P2XS1.
PhylomeDBiQ9CZP5.
TreeFamiTF315009.

Miscellaneous databases

NextBioi322735.
PROiQ9CZP5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZP5.
CleanExiMM_BCS1L.
GenevestigatoriQ9CZP5.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR027243. BCS1.
IPR014851. BCS1_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23070:SF17. PTHR23070:SF17. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF08740. BCS1_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM01024. BCS1_N. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00674. AAA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary tumor.
  3. Lubec G., Kang S.U.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiBCS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2004
Last sequence update: May 31, 2001
Last modified: March 31, 2015
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.