Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CZM9

- KCMB2_MOUSE

UniProt

Q9CZM9 - KCMB2_MOUSE

Protein

Calcium-activated potassium channel subunit beta-2

Gene

Kcnmb2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex By similarity.By similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: InterPro

    GO - Biological processi

    1. detection of calcium ion Source: Ensembl
    2. neuronal action potential Source: Ensembl

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199092. Ca2+ activated K+ channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-activated potassium channel subunit beta-2
    Alternative name(s):
    BK channel subunit beta-2
    Short name:
    BKbeta2
    Calcium-activated potassium channel, subfamily M subunit beta-2
    Charybdotoxin receptor subunit beta-2
    K(VCA)beta-2
    Maxi K channel subunit beta-2
    Slo-beta-2
    Gene namesi
    Name:Kcnmb2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1919663. Kcnmb2.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235Calcium-activated potassium channel subunit beta-2PRO_0000187052Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi88 – 881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9CZM9.

    PTM databases

    PhosphoSiteiQ9CZM9.

    Expressioni

    Gene expression databases

    BgeeiQ9CZM9.
    GenevestigatoriQ9CZM9.

    Interactioni

    Subunit structurei

    Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB2 per KCNMA1 tetramer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZM9.
    SMRiQ9CZM9. Positions 1-45.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4646CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini68 – 194127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 23520CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei47 – 6721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 4545Ball and chainAdd
    BLAST

    Domaini

    The ball and chain domain mediates the inactivation of KCNMA1. It occludes the conduction pathway of KCNMA1 channels, and comprises the pore-blocking ball domain (residues 1-17) and the chain domain (residues 20-45) linking it to the transmembrane segment. The ball domain is made up of a flexible N-terminus anchored at a well ordered loop-helix motif. The chain domain consists of a 4-turn helix with an unfolded linker at its C-terminus By similarity.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG44064.
    GeneTreeiENSGT00390000015997.
    HOGENOMiHOG000290180.
    HOVERGENiHBG052223.
    InParanoidiQ9CZM9.
    KOiK04938.
    OMAiMKINQKC.
    OrthoDBiEOG77WWDC.
    PhylomeDBiQ9CZM9.
    TreeFamiTF328589.

    Family and domain databases

    Gene3Di4.10.81.20. 1 hit.
    InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
    IPR015382. KCNMB2_ball_chain_dom.
    [Graphical view]
    PANTHERiPTHR10258. PTHR10258. 1 hit.
    PfamiPF03185. CaKB. 1 hit.
    PF09303. KcnmB2_inactiv. 1 hit.
    [Graphical view]
    PRINTSiPR01450. BKCHANNELB.

    Sequencei

    Sequence statusi: Complete.

    Q9CZM9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFIWTSGRTS SSYRQDEKRN IYQKIRDHDL LDKRKTVTAL KAGEDRAILL    50
    GLAMMVCSIM MYFLLGITLL RSYMQSVWTE EAQCALLNVS ITETFNCSFS 100
    CGPDCWKLSQ YPCLQVYVNL TSSGERLLLY HTEETMKINQ KCSYIPKCGN 150
    NFEESMSLVS VVMENFRRHQ HFPCYSDPEG NQKSVILTKL YSSNVLFHSL 200
    FWPTCMMAGG VAIVAMVKLT QYLSLLCERI QRINR 235
    Length:235
    Mass (Da):27,120
    Last modified:June 1, 2001 - v1
    Checksum:iF87D3D91C22BBDF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY062429 mRNA. Translation: AAL38982.1.
    AK012400 mRNA. Translation: BAB28216.1.
    BC046227 mRNA. Translation: AAH46227.1.
    BC058957 mRNA. Translation: AAH58957.1.
    CCDSiCCDS17292.1.
    RefSeqiNP_082507.1. NM_028231.2.
    XP_006535612.1. XM_006535549.1.
    XP_006535613.1. XM_006535550.1.
    XP_006535614.1. XM_006535551.1.
    XP_006535615.1. XM_006535552.1.
    UniGeneiMm.64790.

    Genome annotation databases

    EnsembliENSMUST00000119310; ENSMUSP00000112531; ENSMUSG00000037610.
    ENSMUST00000119970; ENSMUSP00000113234; ENSMUSG00000037610.
    ENSMUST00000178668; ENSMUSP00000136596; ENSMUSG00000037610.
    GeneIDi72413.
    KEGGimmu:72413.
    UCSCiuc008owa.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY062429 mRNA. Translation: AAL38982.1 .
    AK012400 mRNA. Translation: BAB28216.1 .
    BC046227 mRNA. Translation: AAH46227.1 .
    BC058957 mRNA. Translation: AAH58957.1 .
    CCDSi CCDS17292.1.
    RefSeqi NP_082507.1. NM_028231.2.
    XP_006535612.1. XM_006535549.1.
    XP_006535613.1. XM_006535550.1.
    XP_006535614.1. XM_006535551.1.
    XP_006535615.1. XM_006535552.1.
    UniGenei Mm.64790.

    3D structure databases

    ProteinModelPortali Q9CZM9.
    SMRi Q9CZM9. Positions 1-45.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CZM9.

    Proteomic databases

    PRIDEi Q9CZM9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000119310 ; ENSMUSP00000112531 ; ENSMUSG00000037610 .
    ENSMUST00000119970 ; ENSMUSP00000113234 ; ENSMUSG00000037610 .
    ENSMUST00000178668 ; ENSMUSP00000136596 ; ENSMUSG00000037610 .
    GeneIDi 72413.
    KEGGi mmu:72413.
    UCSCi uc008owa.1. mouse.

    Organism-specific databases

    CTDi 10242.
    MGIi MGI:1919663. Kcnmb2.

    Phylogenomic databases

    eggNOGi NOG44064.
    GeneTreei ENSGT00390000015997.
    HOGENOMi HOG000290180.
    HOVERGENi HBG052223.
    InParanoidi Q9CZM9.
    KOi K04938.
    OMAi MKINQKC.
    OrthoDBi EOG77WWDC.
    PhylomeDBi Q9CZM9.
    TreeFami TF328589.

    Enzyme and pathway databases

    Reactomei REACT_199092. Ca2+ activated K+ channels.

    Miscellaneous databases

    NextBioi 336214.
    PROi Q9CZM9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CZM9.
    Genevestigatori Q9CZM9.

    Family and domain databases

    Gene3Di 4.10.81.20. 1 hit.
    InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
    IPR015382. KCNMB2_ball_chain_dom.
    [Graphical view ]
    PANTHERi PTHR10258. PTHR10258. 1 hit.
    Pfami PF03185. CaKB. 1 hit.
    PF09303. KcnmB2_inactiv. 1 hit.
    [Graphical view ]
    PRINTSi PR01450. BKCHANNELB.
    ProtoNeti Search...

    Publicationsi

    1. "Mouse kcnmb2 subunit of the large conductance calcium-activated K channel (MaxiK, BK)."
      Garcia-Valdes J., Eghbali M., Stefani E., Toro L.
      Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Kidney.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiKCMB2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZM9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3