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Protein

60S ribosomal protein L15

Gene

Rpl15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L15
Gene namesi
Name:Rpl15
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1913730. Rpl15.

Subcellular locationi

  • Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001275282 – 20460S ribosomal protein L15Add BLAST203

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei34PhosphoserineBy similarity1
Modified residuei97PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ9CZM2.
MaxQBiQ9CZM2.
PaxDbiQ9CZM2.
PRIDEiQ9CZM2.

PTM databases

iPTMnetiQ9CZM2.
PhosphoSitePlusiQ9CZM2.
SwissPalmiQ9CZM2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000012405.
CleanExiMM_RPL15.
ExpressionAtlasiQ9CZM2. baseline and differential.
GenevisibleiQ9CZM2. MM.

Interactioni

Subunit structurei

Interacts with IFIT1 (via TPR repeats 1-4).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211504. 4 interactors.
IntActiQ9CZM2. 8 interactors.
MINTiMINT-1858379.
STRINGi10090.ENSMUSP00000078388.

Structurei

3D structure databases

ProteinModelPortaliQ9CZM2.
SMRiQ9CZM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L15e family.Curated

Phylogenomic databases

eggNOGiKOG1678. Eukaryota.
COG1632. LUCA.
GeneTreeiENSGT00390000005092.
HOGENOMiHOG000229584.
HOVERGENiHBG000443.
InParanoidiQ9CZM2.
KOiK02877.
OMAiQRKKQSD.
OrthoDBiEOG091G0LFF.
PhylomeDBiQ9CZM2.
TreeFamiTF300050.

Family and domain databases

Gene3Di3.40.1120.10. 1 hit.
InterProiIPR024794. Rbsml_L15e_core_dom.
IPR000439. Ribosomal_L15e.
IPR020925. Ribosomal_L15e_CS.
IPR012678. Ribosomal_L23/L15e_core_dom.
[Graphical view]
PANTHERiPTHR11847. PTHR11847. 1 hit.
PfamiPF00827. Ribosomal_L15e. 1 hit.
[Graphical view]
SMARTiSM01384. Ribosomal_L15e. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS01194. RIBOSOMAL_L15E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAYKYIQEL WRKKQSDVMR FLLRVRCWQY RQLSALHRAP RPTRPDKARR
60 70 80 90 100
LGYKAKQGYV IYRIRVRRGG RKRPVPKGAT YGKPVHHGVN QLKFARSLQS
110 120 130 140 150
VAEERAGRHC GALRVLNSYW VGEDSTYKFF EVILIDPFHK AIRRNPDTQW
160 170 180 190 200
ITKPVHKHRE MRGLTSAGRK SRGLGKGHKF HHTIGGSRRA AWRRRNTLQL

HRYR
Length:204
Mass (Da):24,146
Last modified:January 23, 2007 - v4
Checksum:iA6E3AD1A76C9506F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti194R → G in BAB27107 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002234 mRNA. Translation: BAB21952.1.
AK010319 mRNA. Translation: BAB26850.1.
AK010674 mRNA. Translation: BAB27107.1.
AK010916 mRNA. Translation: BAB27266.1.
AK010931 mRNA. Translation: BAB27275.1.
AK012025 mRNA. Translation: BAB27981.1.
BC079842 mRNA. Translation: AAH79842.1.
BC081441 mRNA. Translation: AAH81441.1.
BC081442 mRNA. Translation: AAH81442.1.
CCDSiCCDS36812.1.
RefSeqiNP_079862.1. NM_025586.3.
XP_006518143.1. XM_006518080.3.
XP_006518144.1. XM_006518081.3.
UniGeneiMm.2050.
Mm.387909.

Genome annotation databases

EnsembliENSMUST00000079419; ENSMUSP00000078388; ENSMUSG00000012405.
ENSMUST00000080281; ENSMUSP00000079163; ENSMUSG00000012405.
ENSMUST00000100799; ENSMUSP00000098362; ENSMUSG00000012405.
ENSMUST00000112598; ENSMUSP00000108217; ENSMUSG00000012405.
GeneIDi66480.
KEGGimmu:66480.
UCSCiuc007shr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002234 mRNA. Translation: BAB21952.1.
AK010319 mRNA. Translation: BAB26850.1.
AK010674 mRNA. Translation: BAB27107.1.
AK010916 mRNA. Translation: BAB27266.1.
AK010931 mRNA. Translation: BAB27275.1.
AK012025 mRNA. Translation: BAB27981.1.
BC079842 mRNA. Translation: AAH79842.1.
BC081441 mRNA. Translation: AAH81441.1.
BC081442 mRNA. Translation: AAH81442.1.
CCDSiCCDS36812.1.
RefSeqiNP_079862.1. NM_025586.3.
XP_006518143.1. XM_006518080.3.
XP_006518144.1. XM_006518081.3.
UniGeneiMm.2050.
Mm.387909.

3D structure databases

ProteinModelPortaliQ9CZM2.
SMRiQ9CZM2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211504. 4 interactors.
IntActiQ9CZM2. 8 interactors.
MINTiMINT-1858379.
STRINGi10090.ENSMUSP00000078388.

PTM databases

iPTMnetiQ9CZM2.
PhosphoSitePlusiQ9CZM2.
SwissPalmiQ9CZM2.

Proteomic databases

EPDiQ9CZM2.
MaxQBiQ9CZM2.
PaxDbiQ9CZM2.
PRIDEiQ9CZM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079419; ENSMUSP00000078388; ENSMUSG00000012405.
ENSMUST00000080281; ENSMUSP00000079163; ENSMUSG00000012405.
ENSMUST00000100799; ENSMUSP00000098362; ENSMUSG00000012405.
ENSMUST00000112598; ENSMUSP00000108217; ENSMUSG00000012405.
GeneIDi66480.
KEGGimmu:66480.
UCSCiuc007shr.1. mouse.

Organism-specific databases

CTDi6138.
MGIiMGI:1913730. Rpl15.

Phylogenomic databases

eggNOGiKOG1678. Eukaryota.
COG1632. LUCA.
GeneTreeiENSGT00390000005092.
HOGENOMiHOG000229584.
HOVERGENiHBG000443.
InParanoidiQ9CZM2.
KOiK02877.
OMAiQRKKQSD.
OrthoDBiEOG091G0LFF.
PhylomeDBiQ9CZM2.
TreeFamiTF300050.

Enzyme and pathway databases

ReactomeiR-MMU-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-MMU-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-MMU-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-MMU-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpl15. mouse.
PROiQ9CZM2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000012405.
CleanExiMM_RPL15.
ExpressionAtlasiQ9CZM2. baseline and differential.
GenevisibleiQ9CZM2. MM.

Family and domain databases

Gene3Di3.40.1120.10. 1 hit.
InterProiIPR024794. Rbsml_L15e_core_dom.
IPR000439. Ribosomal_L15e.
IPR020925. Ribosomal_L15e_CS.
IPR012678. Ribosomal_L23/L15e_core_dom.
[Graphical view]
PANTHERiPTHR11847. PTHR11847. 1 hit.
PfamiPF00827. Ribosomal_L15e. 1 hit.
[Graphical view]
SMARTiSM01384. Ribosomal_L15e. 1 hit.
[Graphical view]
SUPFAMiSSF54189. SSF54189. 1 hit.
PROSITEiPS01194. RIBOSOMAL_L15E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL15_MOUSE
AccessioniPrimary (citable) accession number: Q9CZM2
Secondary accession number(s): Q9CWI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2001
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 129 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.