Q9CZK7 (Q9CZK7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative uncharacterized protein EMBL BAB28278.2

Gene names

Name:

Pax3 MGI 97487

Organism

Mus musculus (Mouse) EMBL BAB28278.2

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	488 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity RuleBase RU000491.
Sequence similarities	Contains 1 paired domain. RuleBase RU000491 SAAS SAAS001523

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU000491 SAAS SAAS001523
Cellular component	Nucleus RuleBase RU000491 SAAS SAAS001523
Domain	Homeobox RuleBase RU000682 Paired box RuleBase RU000491 SAAS SAAS001523
Ligand	DNA-binding RuleBase RU000491 SAAS SAAS001523
Molecular function	Developmental protein RuleBase RU000491 SAAS SAAS001523
Gene Ontology (GO)
Biological_process	cell proliferation Inferred from mutant phenotype PubMed 15132998. Source: MGI developmental pigmentation Inferred from mutant phenotype PubMed 15322542. Source: MGI heart development Inferred from mutant phenotype PubMed 10231856. Source: MGI mammary gland specification Inferred from mutant phenotype PubMed 16720875. Source: MGI muscle organ development Inferred from mutant phenotype PubMed 15132998. Source: MGI negative regulation of transcription from RNA polymerase II promoter Inferred from genetic interaction PubMed 15729346. Source: MGI neural crest cell migration Inferred from mutant phenotype PubMed 15384171. Source: MGI neural tube closure Inferred from mutant phenotype PubMed 15384171. Source: MGI neuron fate commitment Inferred from genetic interaction PubMed 9858722. Source: MGI positive regulation of cell proliferation Inferred from mutant phenotype PubMed 10946068. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 15729346PubMed 16300735. Source: MGI spinal cord association neuron differentiation Inferred from genetic interaction PubMed 9858722. Source: MGI
Cellular_component	transcription factor complex Traceable author statement PubMed 10197584. Source: MGI
Molecular_function	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 15729346. Source: MGI chromatin binding Inferred from direct assay PubMed 15729346. Source: MGI sequence-specific DNA binding Inferred from direct assay PubMed 11863357. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9CZK7 [UniParc]. Last modified March 1, 2003. Version 2. Checksum: AA071E949F61EFA6	FASTA	488	53,802
	10 20 30 40 50 60 MAPRMTTLAG AVPRMMRPGP GQNYPRSGFP LEVSTPLGQG RVNQLGGVFI NGRPLPNHIR 70 80 90 100 110 120 HKIVEMAHHG IRPCVISRQL RVSHGCVSKI LCRYQETGSI RPGAIGGSKP KQVTTPDVEK 130 140 150 160 170 180 KIEEYKRENP GMFSWEIRDK LLKDAVCDRN TVPSVSSISR ILRSKFGKGE EEEADLERKE 190 200 210 220 230 240 AEESEKKAKH SIDGILSERA SAPQSDEGSD IDSEPDLPLK RKQRGSRTTF TAEQLEELER 250 260 270 280 290 300 AFERTHYPDI YTREELAQRA KLTEARVQVW FSNRRARWRK QAGANQLMAF NHLIPGGFPP 310 320 330 340 350 360 TAMPTLPTYQ LSETSYQPTS IPQAVSDPSS TVHRPQPLPP STVHQSTIPS NADSSSAYCL 370 380 390 400 410 420 PSTRHGFSSY TDSFVPPSGP SNPMNPTIGN GLSPQVMGLL TNHGGVPHQP QTDYALSPLT 430 440 450 460 470 480 GGLEPTTTVS ASCSQRLEHM KNVDSLPTSQ PYCPPTYSTA GYSMDPVTGY QYGQYGQSAF HYLKPDIA

References

[1]	"High-efficiency full-length cDNA cloning." Carninci P., Hayashizaki Y. Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
[2]	"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes." Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y. Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
[3]	"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer." Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y. Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
[4]	Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
[5]	"Functional annotation of a full-length mouse cDNA collection." The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium Nature 409:685-690(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
[6]	"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs." The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team Nature 420:563-573(2002) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
[7]	"The Transcriptional Landscape of the Mammalian Genome." The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) Science 309:1559-1563(2005) Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
[8]	"Antisense Transcription in the Mammalian Transcriptome." RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: C57BL/6J EMBL BAB28278.2. Tissue: Whole body EMBL BAB28278.2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK012493 mRNA. Translation: BAB28278.2.
IPI	IPI00407505.
UniGene	Mm.1371.
3D structure databases
HSSP	HSSP built from PDB template 1FJL based on UniProtKB P06601.
ProteinModelPortal	Q9CZK7.
SMR	Q9CZK7. Positions 39-162, 222-281.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9CZK7.
Proteomic databases
PRIDE	Q9CZK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:97487. Pax3.
Phylogenomic databases
HOGENOM	HOG000230939.
HOVERGEN	HBG009115.
InParanoid	Q9CZK7.
Gene expression databases
ArrayExpress	Q9CZK7.
Genevestigator	Q9CZK7.
Family and domain databases
Gene3D	1.10.10.10. 2 hits. 1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR001523. Paired_dom. IPR022106. Pax7. IPR011991. WHTH_DNA-bd_dom. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF00292. PAX. 1 hit. PF12360. Pax7. 1 hit. [Graphical view]
PRINTS	PR00027. PAIREDBOX.
SMART	SM00389. HOX. 1 hit. SM00351. PAX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 2 hits.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. PS00034. PAIRED_1. 1 hit. PS51057. PAIRED_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PAX3. mouse.
SOURCE	Search...

Entry information

Entry name

Q9CZK7_MOUSE

Accession

Primary (citable) accession number: Q9CZK7

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)