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Q9CZK7 (Q9CZK7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Pax3 MGI 97487
OrganismMus musculus (Mouse) EMBL BAB28278.2
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity SAAS SAAS001523 RuleBase RU000491.

Sequence similarities

Contains 1 paired domain. RuleBase RU000491

Contains paired domain. SAAS SAAS001523

Ontologies

Keywords
   Biological processTranscription
Transcription regulation SAAS SAAS001523 RuleBase RU000491
   Cellular componentNucleus RuleBase RU000491 SAAS SAAS001523
   DomainHomeobox RuleBase RU000682
Paired box RuleBase RU000491 SAAS SAAS001523
   LigandDNA-binding RuleBase RU000491 SAAS SAAS001523
   Molecular functionDevelopmental protein RuleBase RU000491 SAAS SAAS001523
Gene Ontology (GO)
   Biological_processcell migration

Inferred from mutant phenotype PubMed 15132998PubMed 17974128. Source: MGI

cell proliferation

Inferred from mutant phenotype PubMed 15132998. Source: MGI

developmental pigmentation

Inferred from mutant phenotype PubMed 15322542. Source: MGI

heart development

Inferred from mutant phenotype PubMed 10231856. Source: MGI

mammary gland specification

Inferred from mutant phenotype PubMed 16720875. Source: MGI

muscle organ development

Inferred from mutant phenotype PubMed 15132998. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from genetic interaction PubMed 15729346. Source: MGI

neural crest cell migration

Inferred from mutant phenotype PubMed 15384171. Source: MGI

neural tube closure

Inferred from mutant phenotype PubMed 15384171. Source: MGI

neural tube development

Inferred from genetic interaction PubMed 10419687. Source: MGI

neuron fate commitment

Inferred from genetic interaction PubMed 9858722. Source: MGI

positive regulation of cell proliferation

Inferred from mutant phenotype PubMed 10946068. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15729346PubMed 16300735. Source: MGI

positive regulation of transcription, DNA-templated

Inferred from sequence orthology PubMed 11863357. Source: MGI

regulation of somitogenesis

Inferred from mutant phenotype PubMed 17974128. Source: MGI

spinal cord association neuron differentiation

Inferred from genetic interaction PubMed 9858722. Source: MGI

transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 15729346. Source: GOC

   Cellular_componentnucleus

Inferred from direct assay PubMed 21177767. Source: MGI

transcription factor complex

Traceable author statement PubMed 10197584. Source: MGI

   Molecular_functionRNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 15729346. Source: MGI

chromatin binding

Inferred from direct assay PubMed 15729346. Source: MGI

protein binding

Inferred from physical interaction PubMed 15729346PubMed 16300735PubMed 22862948. Source: MGI

sequence-specific DNA binding

Inferred from direct assay PubMed 11863357. Source: MGI

sequence-specific DNA binding transcription factor activity

Traceable author statement PubMed 10197584. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q9CZK7 [UniParc].

Last modified March 1, 2003. Version 2.
Checksum: AA071E949F61EFA6

FASTA48853,802
        10         20         30         40         50         60 
MAPRMTTLAG AVPRMMRPGP GQNYPRSGFP LEVSTPLGQG RVNQLGGVFI NGRPLPNHIR 

        70         80         90        100        110        120 
HKIVEMAHHG IRPCVISRQL RVSHGCVSKI LCRYQETGSI RPGAIGGSKP KQVTTPDVEK 

       130        140        150        160        170        180 
KIEEYKRENP GMFSWEIRDK LLKDAVCDRN TVPSVSSISR ILRSKFGKGE EEEADLERKE 

       190        200        210        220        230        240 
AEESEKKAKH SIDGILSERA SAPQSDEGSD IDSEPDLPLK RKQRGSRTTF TAEQLEELER 

       250        260        270        280        290        300 
AFERTHYPDI YTREELAQRA KLTEARVQVW FSNRRARWRK QAGANQLMAF NHLIPGGFPP 

       310        320        330        340        350        360 
TAMPTLPTYQ LSETSYQPTS IPQAVSDPSS TVHRPQPLPP STVHQSTIPS NADSSSAYCL 

       370        380        390        400        410        420 
PSTRHGFSSY TDSFVPPSGP SNPMNPTIGN GLSPQVMGLL TNHGGVPHQP QTDYALSPLT 

       430        440        450        460        470        480 
GGLEPTTTVS ASCSQRLEHM KNVDSLPTSQ PYCPPTYSTA GYSMDPVTGY QYGQYGQSAF 


HYLKPDIA 

« Hide

References

[1]"High-efficiency full-length cDNA cloning."
Carninci P., Hayashizaki Y.
Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
[2]"Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
[3]"RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer."
Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P., Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A. expand/collapse author list , Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.
Genome Res. 10:1757-1771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
[4]Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H., Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M., Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F. expand/collapse author list , Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H., Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M., Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K., Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T., Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T., Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M., Muramatsu M., Hayashizaki Y.
Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
[5]"Functional annotation of a full-length mouse cDNA collection."
The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
Nature 409:685-690(2001)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
[6]"Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
Nature 420:563-573(2002)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
[7]"The Transcriptional Landscape of the Mammalian Genome."
The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
Science 309:1559-1563(2005)
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
[8]"Antisense Transcription in the Mammalian Transcriptome."
RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium
Science 309:1564-1566(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: C57BL/6J EMBL BAB28278.2.
Tissue: Whole body EMBL BAB28278.2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK012493 mRNA. Translation: BAB28278.2.
UniGeneMm.1371.

3D structure databases

ProteinModelPortalQ9CZK7.
SMRQ9CZK7. Positions 39-162, 222-281.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ9CZK7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97487. Pax3.

Phylogenomic databases

HOGENOMHOG000230939.
HOVERGENHBG009115.
InParanoidQ9CZK7.

Gene expression databases

GenevestigatorQ9CZK7.

Family and domain databases

Gene3D1.10.10.10. 2 hits.
1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR001523. Paired_dom.
IPR022106. Pax7.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF00292. PAX. 1 hit.
PF12360. Pax7. 1 hit.
[Graphical view]
PRINTSPR00027. PAIREDBOX.
SMARTSM00389. HOX. 1 hit.
SM00351. PAX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPAX3. mouse.
SOURCESearch...

Entry information

Entry nameQ9CZK7_MOUSE
AccessionPrimary (citable) accession number: Q9CZK7
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)