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Protein

Heat shock 70 kDa protein 12B

Gene

Hspa12b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock 70 kDa protein 12B
Gene namesi
Name:Hspa12b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1919880. Hspa12b.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Heat shock 70 kDa protein 12BPRO_0000078295Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei29 – 291PhosphoserineBy similarity
Modified residuei42 – 421PhosphothreonineCombined sources
Modified residuei44 – 441PhosphoserineCombined sources
Modified residuei46 – 461PhosphoserineCombined sources
Modified residuei276 – 2761PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CZJ2.
PaxDbiQ9CZJ2.
PeptideAtlasiQ9CZJ2.
PRIDEiQ9CZJ2.

PTM databases

iPTMnetiQ9CZJ2.
PhosphoSiteiQ9CZJ2.

Expressioni

Tissue specificityi

Expressed most strongly in heart with little or no expression in other tissues. In the aorta, preferentially expressed in lesions.1 Publication

Gene expression databases

BgeeiENSMUSG00000074793.
CleanExiMM_HSPA12B.
ExpressionAtlasiQ9CZJ2. baseline and differential.
GenevisibleiQ9CZJ2. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9CZJ2. 2 interactions.
MINTiMINT-4098029.
STRINGi10090.ENSMUSP00000096950.

Structurei

3D structure databases

ProteinModelPortaliQ9CZJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heat shock protein 70 family.Curated

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000014360.
HOGENOMiHOG000231707.
HOVERGENiHBG051928.
InParanoidiQ9CZJ2.
OMAiKIHSATD.
OrthoDBiEOG091G03BF.
PhylomeDBiQ9CZJ2.
TreeFamiTF329492.

Family and domain databases

InterProiIPR029509. HSPA12B.
[Graphical view]
PANTHERiPTHR14187:SF39. PTHR14187:SF39. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZJ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTVPEMGLQ GLYISSSPER SPVPSPPGSP RTQESCGIAP LTPSQSPKPE
60 70 80 90 100
ARALQQASFS VVVAIDFGTT SSGYAFSFAS DPEAIHMMRK WEGGDPGVAH
110 120 130 140 150
QKTPTCLLLT PEGIFHSFGY TARDYYHDLD PEEARDWLYF EKFKMKIHSA
160 170 180 190 200
TDLTLKTQLE AVNGKKMLAL EVFAHALRFF KEHALQELRE QSECMLEKGA
210 220 230 240 250
VRWVLTVPAI WKQPAKQFMR EAAYLAGLVS REDAEKLLIA LEPEAASVYC
260 270 280 290 300
RKLRLHQLMD LSSRTAGRGR LGERRSIDSS FRHAREQLRR SRHSRTFLVE
310 320 330 340 350
AGVGELWAEM QEGDRYMVAD CGGGTVDLTV HQLEQPHGTL KELYKASGGP
360 370 380 390 400
YGAVGVDLAF EQLLCRIFGE DFIAKFKRQR PAAWVDLTIA FEARKRTAGP
410 420 430 440 450
HRAGALNISL PFSFIDFYRK QRGHNVETAL RRSSVNLVKW SSQGMLRMSC
460 470 480 490 500
EAMNELFQPT VSGIIQHIEM LLAKPEVQGV KLLFLVGGFA ESAVLQHAVQ
510 520 530 540 550
EALGTRGLRV VVPHDVGLTI LKGAVLFGQA PGVVRVRRSP LTYGVGVLNR
560 570 580 590 600
FVPGHHPPEK LLVRDGRRWC TDVFERFVAA EQSVALGEEV RRSYCPARPG
610 620 630 640 650
QRRVLINLYC CAAEDARFIT DPGVRKCGAL SLELEPEGCP ENTGTSPSRR
660 670 680
EIRAAMQFGD TEIKVTAVDV STNRSVRAAI DFLSN
Length:685
Mass (Da):76,119
Last modified:June 1, 2001 - v1
Checksum:i641FE753180EBE2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012548 mRNA. Translation: BAB28308.1.
BC011103 mRNA. Translation: AAH11103.1.
AY196790 mRNA. Translation: AAO37639.1.
CCDSiCCDS16755.1.
RefSeqiNP_082582.1. NM_028306.3.
UniGeneiMm.277465.

Genome annotation databases

EnsembliENSMUST00000099349; ENSMUSP00000096950; ENSMUSG00000074793.
GeneIDi72630.
KEGGimmu:72630.
UCSCiuc008mkr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012548 mRNA. Translation: BAB28308.1.
BC011103 mRNA. Translation: AAH11103.1.
AY196790 mRNA. Translation: AAO37639.1.
CCDSiCCDS16755.1.
RefSeqiNP_082582.1. NM_028306.3.
UniGeneiMm.277465.

3D structure databases

ProteinModelPortaliQ9CZJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CZJ2. 2 interactions.
MINTiMINT-4098029.
STRINGi10090.ENSMUSP00000096950.

PTM databases

iPTMnetiQ9CZJ2.
PhosphoSiteiQ9CZJ2.

Proteomic databases

MaxQBiQ9CZJ2.
PaxDbiQ9CZJ2.
PeptideAtlasiQ9CZJ2.
PRIDEiQ9CZJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099349; ENSMUSP00000096950; ENSMUSG00000074793.
GeneIDi72630.
KEGGimmu:72630.
UCSCiuc008mkr.1. mouse.

Organism-specific databases

CTDi116835.
MGIiMGI:1919880. Hspa12b.

Phylogenomic databases

eggNOGiKOG0101. Eukaryota.
COG0443. LUCA.
GeneTreeiENSGT00390000014360.
HOGENOMiHOG000231707.
HOVERGENiHBG051928.
InParanoidiQ9CZJ2.
OMAiKIHSATD.
OrthoDBiEOG091G03BF.
PhylomeDBiQ9CZJ2.
TreeFamiTF329492.

Miscellaneous databases

PROiQ9CZJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074793.
CleanExiMM_HSPA12B.
ExpressionAtlasiQ9CZJ2. baseline and differential.
GenevisibleiQ9CZJ2. MM.

Family and domain databases

InterProiIPR029509. HSPA12B.
[Graphical view]
PANTHERiPTHR14187:SF39. PTHR14187:SF39. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHS12B_MOUSE
AccessioniPrimary (citable) accession number: Q9CZJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.