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Protein

Proteasome assembly chaperone 3

Gene

Psmg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Chaperone protein which promotes assembly of the 20S proteasome. May cooperate with PSMG1-PSMG2 heterodimers to orchestrate the correct assembly of proteasomes.1 Publication

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome assembly chaperone 3
Short name:
PAC-3
Short name:
mPAC3
Gene namesi
Name:Psmg3
Synonyms:Pac3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913756. Psmg3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002713591 – 122Proteasome assembly chaperone 3Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CZH3.
MaxQBiQ9CZH3.
PaxDbiQ9CZH3.
PeptideAtlasiQ9CZH3.
PRIDEiQ9CZH3.

PTM databases

PhosphoSitePlusiQ9CZH3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029551.
GenevisibleiQ9CZH3. MM.

Interactioni

Subunit structurei

Homodimer. Interacts directly with alpha and beta subunits of the 20S proteasome but dissociates before the formation of half-proteasomes, probably upon recruitment of POMP (By similarity). Interacts with PSMG4.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9CZH3. 2 interactors.
MINTiMINT-8178445.
STRINGi10090.ENSMUSP00000031531.

Structurei

3D structure databases

ProteinModelPortaliQ9CZH3.
SMRiQ9CZH3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PSMG3 family.Curated

Phylogenomic databases

eggNOGiKOG4828. Eukaryota.
ENOG410Y6DC. LUCA.
GeneTreeiENSGT00390000000324.
HOGENOMiHOG000006024.
HOVERGENiHBG061282.
InParanoidiQ9CZH3.
KOiK11877.
OMAiKDHSQAT.
OrthoDBiEOG091G10BI.
PhylomeDBiQ9CZH3.
TreeFamiTF300294.

Family and domain databases

InterProiView protein in InterPro
IPR018788. Proteasome_assmbl_chp_3.
PfamiView protein in Pfam
PF10178. PAC3. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZH3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDKPLVVSK QKTEVVCGVP TQVVCTAFSS HILVVVTQFG KMGTLVSLEP
60 70 80 90 100
SNVANDISKP VLTTRVLLGQ DEPLIHVFAK NLVAFVSQEA GNRAVLLAMA
110 120
VKDKSMERLK ALKEVIRLCQ VW
Length:122
Mass (Da):13,331
Last modified:June 1, 2001 - v1
Checksum:i1B98DF16491B6D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012616 mRNA. Translation: BAB28357.1.
BC027410 mRNA. Translation: AAH27410.1.
BC058692 mRNA. Translation: AAH58692.1.
CCDSiCCDS19815.1.
RefSeqiNP_079880.1. NM_025604.3.
XP_006504789.1. XM_006504726.3.
UniGeneiMm.29070.

Genome annotation databases

EnsembliENSMUST00000031531; ENSMUSP00000031531; ENSMUSG00000029551.
ENSMUST00000182602; ENSMUSP00000138161; ENSMUSG00000029551.
GeneIDi66506.
KEGGimmu:66506.
UCSCiuc009ahg.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiPSMG3_MOUSE
AccessioniPrimary (citable) accession number: Q9CZH3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: June 7, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families