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Protein

Translation initiation factor IF-3, mitochondrial

Gene

Mtif3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

IF-3 binds to the 28S ribosomal subunit and shifts the equilibrum between 55S ribosomes and their 39S and 28S subunits in favor of the free subunits, thus enhancing the availability of 28S subunits on which protein synthesis initiation begins.By similarity

GO - Molecular functioni

  • ribosomal small subunit binding Source: BHF-UCL
  • ribosome binding Source: GO_Central
  • translation factor activity, RNA binding Source: BHF-UCL
  • translation initiation factor activity Source: GO_Central

GO - Biological processi

  • mitochondrial translational initiation Source: BHF-UCL
  • ribosome disassembly Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Initiation factor

Keywords - Biological processi

Protein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor IF-3, mitochondrial
Short name:
IF-3(Mt)
Short name:
IF-3Mt
Short name:
IF3(mt)
Short name:
IF3mt
Gene namesi
Name:Mtif3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1923616. Mtif3.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 31MitochondrionBy similarityAdd BLAST31
PropeptideiPRO_000028003832 – 94Removed in mature formBy similarityAdd BLAST63
ChainiPRO_000028003995 – 276Translation initiation factor IF-3, mitochondrialAdd BLAST182

Proteomic databases

MaxQBiQ9CZD5.
PaxDbiQ9CZD5.
PRIDEiQ9CZD5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000016510.
CleanExiMM_MTIF3.
ExpressionAtlasiQ9CZD5. baseline and differential.
GenevisibleiQ9CZD5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016654.

Structurei

Secondary structure

1276
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi155 – 161Combined sources7
Helixi166 – 181Combined sources16
Beta strandi185 – 191Combined sources7
Helixi200 – 211Combined sources12
Turni215 – 217Combined sources3
Beta strandi219 – 227Combined sources9
Helixi228 – 230Combined sources3
Beta strandi232 – 238Combined sources7
Beta strandi241 – 243Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRQNMR-A148-246[»]
ProteinModelPortaliQ9CZD5.
SMRiQ9CZD5.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CZD5.

Family & Domainsi

Sequence similaritiesi

Belongs to the IF-3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IXD5. Eukaryota.
COG0290. LUCA.
GeneTreeiENSGT00390000014424.
HOGENOMiHOG000264227.
HOVERGENiHBG080563.
InParanoidiQ9CZD5.
KOiK02520.
OMAiQTMPGIA.
OrthoDBiEOG091G0GZ5.
PhylomeDBiQ9CZD5.
TreeFamiTF332326.

Family and domain databases

Gene3Di3.10.20.80. 1 hit.
3.30.110.10. 1 hit.
InterProiIPR001288. Translation_initiation_fac_3.
IPR019815. Translation_initiation_fac_3_C.
IPR019814. Translation_initiation_fac_3_N.
[Graphical view]
PANTHERiPTHR10938. PTHR10938. 1 hit.
PfamiPF00707. IF3_C. 1 hit.
PF05198. IF3_N. 1 hit.
[Graphical view]
SUPFAMiSSF54364. SSF54364. 1 hit.
SSF55200. SSF55200. 1 hit.
TIGRFAMsiTIGR00168. infC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLLMRLML QTTKLDHNLI GRCLQRHAVK PDPAQLSLSA STPKLLYLTS
60 70 80 90 100
AKGFSTAGDP QGERKQKRRD AFSNTGRKIS ERIIRVLDEK GMDLGMMHRA
110 120 130 140 150
DVIRLMNKQD LRLVQRNTSS EPPEYQLMTG EQIHQERLKL REQEKAKPKT
160 170 180 190 200
GPTMTKELVF SSNIGQHDLD TKSKQIQQWI EKKYHVQVTI KRRKDAEQSE
210 220 230 240 250
EETEEIFNQI LQTMPDIATF SSRPKAIRGG TASMCVFRHL SKKEEKAYRE
260 270
SQESQRRDTL SKDDDGNSKE SDVVCQ
Length:276
Mass (Da):31,739
Last modified:June 1, 2001 - v1
Checksum:i1D1D533F045F5AFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → T in AAI15686 (PubMed:15489334).Curated1
Sequence conflicti223R → I in AAI15685 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012733 mRNA. Translation: BAB28438.1.
AK147090 mRNA. Translation: BAE27670.1.
BC115684 mRNA. Translation: AAI15685.1.
BC115685 mRNA. Translation: AAI15686.1.
CCDSiCCDS19874.1.
RefSeqiNP_001243029.1. NM_001256100.1.
NP_001243030.1. NM_001256101.1.
NP_001243031.1. NM_001256102.1.
NP_083857.1. NM_029581.4.
XP_006504952.1. XM_006504889.3.
UniGeneiMm.486234.

Genome annotation databases

EnsembliENSMUST00000016654; ENSMUSP00000016654; ENSMUSG00000016510.
ENSMUST00000066675; ENSMUSP00000063398; ENSMUSG00000016510.
ENSMUST00000110564; ENSMUSP00000106193; ENSMUSG00000016510.
ENSMUST00000110566; ENSMUSP00000106195; ENSMUSG00000016510.
GeneIDi76366.
KEGGimmu:76366.
UCSCiuc009anp.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012733 mRNA. Translation: BAB28438.1.
AK147090 mRNA. Translation: BAE27670.1.
BC115684 mRNA. Translation: AAI15685.1.
BC115685 mRNA. Translation: AAI15686.1.
CCDSiCCDS19874.1.
RefSeqiNP_001243029.1. NM_001256100.1.
NP_001243030.1. NM_001256101.1.
NP_001243031.1. NM_001256102.1.
NP_083857.1. NM_029581.4.
XP_006504952.1. XM_006504889.3.
UniGeneiMm.486234.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRQNMR-A148-246[»]
ProteinModelPortaliQ9CZD5.
SMRiQ9CZD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000016654.

Proteomic databases

MaxQBiQ9CZD5.
PaxDbiQ9CZD5.
PRIDEiQ9CZD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000016654; ENSMUSP00000016654; ENSMUSG00000016510.
ENSMUST00000066675; ENSMUSP00000063398; ENSMUSG00000016510.
ENSMUST00000110564; ENSMUSP00000106193; ENSMUSG00000016510.
ENSMUST00000110566; ENSMUSP00000106195; ENSMUSG00000016510.
GeneIDi76366.
KEGGimmu:76366.
UCSCiuc009anp.2. mouse.

Organism-specific databases

CTDi219402.
MGIiMGI:1923616. Mtif3.

Phylogenomic databases

eggNOGiENOG410IXD5. Eukaryota.
COG0290. LUCA.
GeneTreeiENSGT00390000014424.
HOGENOMiHOG000264227.
HOVERGENiHBG080563.
InParanoidiQ9CZD5.
KOiK02520.
OMAiQTMPGIA.
OrthoDBiEOG091G0GZ5.
PhylomeDBiQ9CZD5.
TreeFamiTF332326.

Miscellaneous databases

EvolutionaryTraceiQ9CZD5.
PROiQ9CZD5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000016510.
CleanExiMM_MTIF3.
ExpressionAtlasiQ9CZD5. baseline and differential.
GenevisibleiQ9CZD5. MM.

Family and domain databases

Gene3Di3.10.20.80. 1 hit.
3.30.110.10. 1 hit.
InterProiIPR001288. Translation_initiation_fac_3.
IPR019815. Translation_initiation_fac_3_C.
IPR019814. Translation_initiation_fac_3_N.
[Graphical view]
PANTHERiPTHR10938. PTHR10938. 1 hit.
PfamiPF00707. IF3_C. 1 hit.
PF05198. IF3_N. 1 hit.
[Graphical view]
SUPFAMiSSF54364. SSF54364. 1 hit.
SSF55200. SSF55200. 1 hit.
TIGRFAMsiTIGR00168. infC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIF3M_MOUSE
AccessioniPrimary (citable) accession number: Q9CZD5
Secondary accession number(s): Q14BP1, Q14BP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.