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Protein

Secernin-1

Gene

Scrn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).By similarity

Miscellaneous

'Secern' is an archaic English term meaning 'secrete'.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processExocytosis

Protein family/group databases

MEROPSiC69.003

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-1
Gene namesi
Name:Scrn1
Synonyms:Kiaa0193
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1917188 Scrn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002214371 – 414Secernin-1Add BLAST414

Proteomic databases

MaxQBiQ9CZC8
PaxDbiQ9CZC8
PeptideAtlasiQ9CZC8
PRIDEiQ9CZC8

PTM databases

iPTMnetiQ9CZC8
PhosphoSitePlusiQ9CZC8

Expressioni

Gene expression databases

BgeeiENSMUSG00000019124
CleanExiMM_SCRN1
ExpressionAtlasiQ9CZC8 baseline and differential
GenevisibleiQ9CZC8 MM

Interactioni

Protein-protein interaction databases

IntActiQ9CZC8, 2 interactors
MINTiQ9CZC8
STRINGi10090.ENSMUSP00000019268

Structurei

3D structure databases

ProteinModelPortaliQ9CZC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGQK Eukaryota
COG4690 LUCA
GeneTreeiENSGT00390000013474
HOGENOMiHOG000223307
HOVERGENiHBG056050
InParanoidiQ9CZC8
KOiK14358
OMAiKKEPRFQ
OrthoDBiEOG091G06OR
PhylomeDBiQ9CZC8
TreeFamiTF323890

Family and domain databases

InterProiView protein in InterPro
IPR005322 Peptidase_C69
PANTHERiPTHR12994 PTHR12994, 1 hit
PfamiView protein in Pfam
PF03577 Peptidase_C69, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CZC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAPPSYSF VALPPRAKDG LVVFGKNSAR PRDEVQEVVY FPAVDHDAES
60 70 80 90 100
KVECTYISID QVPRTHAIVI SRPAWLWGAE MGANEHGVCI ANEAINAREP
110 120 130 140 150
AAETEALLGM DLVRLGLERG TTAKEALDII VSLLDEHGQG GNYYEDAHSC
160 170 180 190 200
HSFQSAYLLV DRDEAWVLET VGKYWAAERI TEGVRCICNH LSLATKLDEE
210 220 230 240 250
HPELRTYAQS QGWWTGDDEF NFAQVFSPAD DRLDCCAGQD SLEKQEESIT
260 270 280 290 300
VQTMINILRD KASGVCIDSE SFLTTASIVS VLPQNRSSPC IHYFTGTPDP
310 320 330 340 350
SRSIFKPFIF VDDVKLVPKA QSPCFGDDDP AKKEPRFQEK PDRRHELYKA
360 370 380 390 400
HEWARAVIES DEEQGRTLRK TMLELEKQGL EAMDEILSSP EPPDPAEVGD
410
LFYDCVDTEM KFFK
Length:414
Mass (Da):46,326
Last modified:June 1, 2001 - v1
Checksum:iF5C530AC5562D3BA
GO

Sequence cautioni

The sequence BAC97894 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti127L → I in BAE26739 (PubMed:16141072).Curated1
Sequence conflicti391E → K in BAC27931 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012765 mRNA Translation: BAB28453.1
AK032573 mRNA Translation: BAC27931.1
AK050481 mRNA Translation: BAC34280.1
AK082953 mRNA Translation: BAC38706.1
AK145904 mRNA Translation: BAE26739.1
AK129084 mRNA Translation: BAC97894.1 Different initiation.
BC023889 mRNA Translation: AAH23889.1
CCDSiCCDS20156.1
RefSeqiNP_081544.1, NM_027268.2
XP_006506635.1, XM_006506572.2
XP_011239761.1, XM_011241459.2
UniGeneiMm.41557

Genome annotation databases

EnsembliENSMUST00000019268; ENSMUSP00000019268; ENSMUSG00000019124
GeneIDi69938
KEGGimmu:69938
UCSCiuc009bzw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSCRN1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZC8
Secondary accession number(s): Q3UKR2, Q8CCL3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health