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Protein

Secernin-1

Gene

Scrn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Regulates exocytosis in mast cells. Increases both the extent of secretion and the sensitivity of mast cells to stimulation with calcium (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Exocytosis

Protein family/group databases

MEROPSiC69.003.

Names & Taxonomyi

Protein namesi
Recommended name:
Secernin-1
Gene namesi
Name:Scrn1
Synonyms:Kiaa0193
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1917188. Scrn1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 414413Secernin-1PRO_0000221437Add
BLAST

Proteomic databases

MaxQBiQ9CZC8.
PaxDbiQ9CZC8.
PeptideAtlasiQ9CZC8.
PRIDEiQ9CZC8.

PTM databases

iPTMnetiQ9CZC8.
PhosphoSiteiQ9CZC8.

Expressioni

Gene expression databases

BgeeiQ9CZC8.
CleanExiMM_SCRN1.
ExpressionAtlasiQ9CZC8. baseline and differential.
GenevisibleiQ9CZC8. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9CZC8. 2 interactions.
MINTiMINT-4133985.
STRINGi10090.ENSMUSP00000019268.

Structurei

3D structure databases

ProteinModelPortaliQ9CZC8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ9CZC8.
KOiK14358.
OMAiRSFPCIH.
OrthoDBiEOG7W1545.
PhylomeDBiQ9CZC8.
TreeFamiTF323890.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZC8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGAPPSYSF VALPPRAKDG LVVFGKNSAR PRDEVQEVVY FPAVDHDAES
60 70 80 90 100
KVECTYISID QVPRTHAIVI SRPAWLWGAE MGANEHGVCI ANEAINAREP
110 120 130 140 150
AAETEALLGM DLVRLGLERG TTAKEALDII VSLLDEHGQG GNYYEDAHSC
160 170 180 190 200
HSFQSAYLLV DRDEAWVLET VGKYWAAERI TEGVRCICNH LSLATKLDEE
210 220 230 240 250
HPELRTYAQS QGWWTGDDEF NFAQVFSPAD DRLDCCAGQD SLEKQEESIT
260 270 280 290 300
VQTMINILRD KASGVCIDSE SFLTTASIVS VLPQNRSSPC IHYFTGTPDP
310 320 330 340 350
SRSIFKPFIF VDDVKLVPKA QSPCFGDDDP AKKEPRFQEK PDRRHELYKA
360 370 380 390 400
HEWARAVIES DEEQGRTLRK TMLELEKQGL EAMDEILSSP EPPDPAEVGD
410
LFYDCVDTEM KFFK
Length:414
Mass (Da):46,326
Last modified:June 1, 2001 - v1
Checksum:iF5C530AC5562D3BA
GO

Sequence cautioni

The sequence BAC97894.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271L → I in BAE26739 (PubMed:16141072).Curated
Sequence conflicti391 – 3911E → K in BAC27931 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012765 mRNA. Translation: BAB28453.1.
AK032573 mRNA. Translation: BAC27931.1.
AK050481 mRNA. Translation: BAC34280.1.
AK082953 mRNA. Translation: BAC38706.1.
AK145904 mRNA. Translation: BAE26739.1.
AK129084 mRNA. Translation: BAC97894.1. Different initiation.
BC023889 mRNA. Translation: AAH23889.1.
CCDSiCCDS20156.1.
RefSeqiNP_081544.1. NM_027268.2.
XP_006506635.1. XM_006506572.1.
XP_011239761.1. XM_011241459.1.
UniGeneiMm.41557.

Genome annotation databases

EnsembliENSMUST00000019268; ENSMUSP00000019268; ENSMUSG00000019124.
GeneIDi69938.
KEGGimmu:69938.
UCSCiuc009bzw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012765 mRNA. Translation: BAB28453.1.
AK032573 mRNA. Translation: BAC27931.1.
AK050481 mRNA. Translation: BAC34280.1.
AK082953 mRNA. Translation: BAC38706.1.
AK145904 mRNA. Translation: BAE26739.1.
AK129084 mRNA. Translation: BAC97894.1. Different initiation.
BC023889 mRNA. Translation: AAH23889.1.
CCDSiCCDS20156.1.
RefSeqiNP_081544.1. NM_027268.2.
XP_006506635.1. XM_006506572.1.
XP_011239761.1. XM_011241459.1.
UniGeneiMm.41557.

3D structure databases

ProteinModelPortaliQ9CZC8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CZC8. 2 interactions.
MINTiMINT-4133985.
STRINGi10090.ENSMUSP00000019268.

Protein family/group databases

MEROPSiC69.003.

PTM databases

iPTMnetiQ9CZC8.
PhosphoSiteiQ9CZC8.

Proteomic databases

MaxQBiQ9CZC8.
PaxDbiQ9CZC8.
PeptideAtlasiQ9CZC8.
PRIDEiQ9CZC8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019268; ENSMUSP00000019268; ENSMUSG00000019124.
GeneIDi69938.
KEGGimmu:69938.
UCSCiuc009bzw.1. mouse.

Organism-specific databases

CTDi9805.
MGIiMGI:1917188. Scrn1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGQK. Eukaryota.
COG4690. LUCA.
GeneTreeiENSGT00390000013474.
HOGENOMiHOG000223307.
HOVERGENiHBG056050.
InParanoidiQ9CZC8.
KOiK14358.
OMAiRSFPCIH.
OrthoDBiEOG7W1545.
PhylomeDBiQ9CZC8.
TreeFamiTF323890.

Miscellaneous databases

PROiQ9CZC8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZC8.
CleanExiMM_SCRN1.
ExpressionAtlasiQ9CZC8. baseline and differential.
GenevisibleiQ9CZC8. MM.

Family and domain databases

InterProiIPR005322. Peptidase_C69.
[Graphical view]
PfamiPF03577. Peptidase_C69. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Pancreas, Placenta and Spinal cord.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary tumor.
  4. Lubec G., Klug S.
    Submitted (MAR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 33-51 AND 262-302, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hippocampus.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Lung and Testis.

Entry informationi

Entry nameiSCRN1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZC8
Secondary accession number(s): Q3UKR2, Q8CCL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2003
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Secern' is an archaic English term meaning 'secrete'.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.