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Q9CZB6

- MED7_MOUSE

UniProt

Q9CZB6 - MED7_MOUSE

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Protein

Mediator of RNA polymerase II transcription subunit 7

Gene

Med7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

  1. RNA polymerase II transcription cofactor activity Source: InterPro

GO - Biological processi

  1. stem cell maintenance Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_198602. PPARA activates gene expression.
REACT_206529. Generic Transcription Pathway.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 7
Alternative name(s):
Cofactor required for Sp1 transcriptional activation subunit 9
Short name:
CRSP complex subunit 9
Mediator complex subunit 7
Gene namesi
Name:Med7
Synonyms:Crsp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1913463. Med7.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. mediator complex Source: MGI
  2. mitochondrion Source: Ensembl
  3. nuclear membrane Source: Ensembl
  4. nucleoplasm Source: Reactome
  5. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Mediator of RNA polymerase II transcription subunit 7PRO_0000079409Add
BLAST

Proteomic databases

MaxQBiQ9CZB6.
PaxDbiQ9CZB6.
PRIDEiQ9CZB6.

PTM databases

PhosphoSiteiQ9CZB6.

Expressioni

Gene expression databases

BgeeiQ9CZB6.
CleanExiMM_MED7.
ExpressionAtlasiQ9CZB6. baseline and differential.
GenevestigatoriQ9CZB6.

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity).By similarity

Protein-protein interaction databases

BioGridi211303. 2 interactions.
IntActiQ9CZB6. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9CZB6.
SMRiQ9CZB6. Positions 106-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi11 – 144Poly-Pro
Compositional biasi32 – 376Poly-Pro

Sequence similaritiesi

Belongs to the Mediator complex subunit 7 family.Curated

Phylogenomic databases

eggNOGiNOG274591.
GeneTreeiENSGT00530000064187.
HOGENOMiHOG000241102.
HOVERGENiHBG002997.
InParanoidiQ9CZB6.
KOiK15148.
OMAiLLNEFRP.
PhylomeDBiQ9CZB6.
TreeFamiTF314411.

Family and domain databases

InterProiIPR009244. Mediatior_Med7.
[Graphical view]
PfamiPF05983. Med7. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZB6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ
60 70 80 90 100
CDDLIIRPLE SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP
110 120 130 140 150
GSIKREEKLE DLKLLFVHVH HLINEYRPHQ ARETLRVMME VQKRQRLETA
160 170 180 190 200
ERFQKHLERV IEMIQNCLAS LPDDLPHSEA GMRVKAEPMD TDDNSNCPGQ
210 220 230
NEQQRESSGH RRDQIIEKDA ALCVLIDEMN ERP
Length:233
Mass (Da):27,205
Last modified:April 12, 2005 - v2
Checksum:iCB340CCF5770541C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261I → S in AAH11333. (PubMed:15489334)Curated
Sequence conflicti33 – 342KP → GR in AAH11333. (PubMed:15489334)Curated
Sequence conflicti49 – 502FQ → KR in AAH11333. (PubMed:15489334)Curated
Sequence conflicti73 – 731D → Y in BAB23272. (PubMed:16141072)Curated
Sequence conflicti88 – 881N → T in BAB23272. (PubMed:16141072)Curated
Sequence conflicti91 – 911D → N in BAB28478. (PubMed:16141072)Curated
Sequence conflicti104 – 1041K → N in BAB28478. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004354 mRNA. Translation: BAB23272.1.
AK010357 mRNA. Translation: BAB26877.1.
AK012799 mRNA. Translation: BAB28478.1.
AK144918 mRNA. Translation: BAE26135.1.
AK147739 mRNA. Translation: BAE28106.1.
AK167407 mRNA. Translation: BAE39496.1.
AL669948 Genomic DNA. No translation available.
BC011333 mRNA. Translation: AAH11333.1.
CCDSiCCDS36134.1.
RefSeqiNP_001098000.1. NM_001104530.1.
NP_001098026.1. NM_001104556.1.
NP_001098027.1. NM_001104557.1.
NP_079702.3. NM_025426.3.
XP_006533994.1. XM_006533931.1.
XP_006533995.1. XM_006533932.1.
XP_006533996.1. XM_006533933.1.
XP_006533997.1. XM_006533934.1.
UniGeneiMm.24159.

Genome annotation databases

EnsembliENSMUST00000020665; ENSMUSP00000020665; ENSMUSG00000020397.
ENSMUST00000109232; ENSMUSP00000104855; ENSMUSG00000020397.
ENSMUST00000170928; ENSMUSP00000131852; ENSMUSG00000020397.
GeneIDi66213.
KEGGimmu:66213.
UCSCiuc007iok.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004354 mRNA. Translation: BAB23272.1 .
AK010357 mRNA. Translation: BAB26877.1 .
AK012799 mRNA. Translation: BAB28478.1 .
AK144918 mRNA. Translation: BAE26135.1 .
AK147739 mRNA. Translation: BAE28106.1 .
AK167407 mRNA. Translation: BAE39496.1 .
AL669948 Genomic DNA. No translation available.
BC011333 mRNA. Translation: AAH11333.1 .
CCDSi CCDS36134.1.
RefSeqi NP_001098000.1. NM_001104530.1.
NP_001098026.1. NM_001104556.1.
NP_001098027.1. NM_001104557.1.
NP_079702.3. NM_025426.3.
XP_006533994.1. XM_006533931.1.
XP_006533995.1. XM_006533932.1.
XP_006533996.1. XM_006533933.1.
XP_006533997.1. XM_006533934.1.
UniGenei Mm.24159.

3D structure databases

ProteinModelPortali Q9CZB6.
SMRi Q9CZB6. Positions 106-170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211303. 2 interactions.
IntActi Q9CZB6. 2 interactions.

PTM databases

PhosphoSitei Q9CZB6.

Proteomic databases

MaxQBi Q9CZB6.
PaxDbi Q9CZB6.
PRIDEi Q9CZB6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020665 ; ENSMUSP00000020665 ; ENSMUSG00000020397 .
ENSMUST00000109232 ; ENSMUSP00000104855 ; ENSMUSG00000020397 .
ENSMUST00000170928 ; ENSMUSP00000131852 ; ENSMUSG00000020397 .
GeneIDi 66213.
KEGGi mmu:66213.
UCSCi uc007iok.2. mouse.

Organism-specific databases

CTDi 9443.
MGIi MGI:1913463. Med7.

Phylogenomic databases

eggNOGi NOG274591.
GeneTreei ENSGT00530000064187.
HOGENOMi HOG000241102.
HOVERGENi HBG002997.
InParanoidi Q9CZB6.
KOi K15148.
OMAi LLNEFRP.
PhylomeDBi Q9CZB6.
TreeFami TF314411.

Enzyme and pathway databases

Reactomei REACT_198602. PPARA activates gene expression.
REACT_206529. Generic Transcription Pathway.
REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

Miscellaneous databases

ChiTaRSi MED7. mouse.
NextBioi 320983.
PROi Q9CZB6.
SOURCEi Search...

Gene expression databases

Bgeei Q9CZB6.
CleanExi MM_MED7.
ExpressionAtlasi Q9CZB6. baseline and differential.
Genevestigatori Q9CZB6.

Family and domain databases

InterProi IPR009244. Mediatior_Med7.
[Graphical view ]
Pfami PF05983. Med7. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Embryonic stem cell, Mammary gland, Melanocyte and Placenta.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiMED7_MOUSE
AccessioniPrimary (citable) accession number: Q9CZB6
Secondary accession number(s): Q3UGV1
, Q91VN3, Q9CWV8, Q9D0V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: April 12, 2005
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3