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Q9CZB6

- MED7_MOUSE

UniProt

Q9CZB6 - MED7_MOUSE

Protein

Mediator of RNA polymerase II transcription subunit 7

Gene

Med7

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (12 Apr 2005)
      Previous versions | rss
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    Functioni

    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors By similarity.By similarity

    GO - Molecular functioni

    1. RNA polymerase II transcription cofactor activity Source: InterPro

    GO - Biological processi

    1. stem cell maintenance Source: MGI

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_198602. PPARA activates gene expression.
    REACT_206529. Generic Transcription Pathway.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mediator of RNA polymerase II transcription subunit 7
    Alternative name(s):
    Cofactor required for Sp1 transcriptional activation subunit 9
    Short name:
    CRSP complex subunit 9
    Mediator complex subunit 7
    Gene namesi
    Name:Med7
    Synonyms:Crsp9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1913463. Med7.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. mediator complex Source: MGI
    2. nucleoplasm Source: Reactome
    3. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 233233Mediator of RNA polymerase II transcription subunit 7PRO_0000079409Add
    BLAST

    Proteomic databases

    PaxDbiQ9CZB6.
    PRIDEiQ9CZB6.

    PTM databases

    PhosphoSiteiQ9CZB6.

    Expressioni

    Gene expression databases

    BgeeiQ9CZB6.
    CleanExiMM_MED7.
    GenevestigatoriQ9CZB6.

    Interactioni

    Subunit structurei

    Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211303. 2 interactions.
    IntActiQ9CZB6. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZB6.
    SMRiQ9CZB6. Positions 106-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi11 – 144Poly-Pro
    Compositional biasi32 – 376Poly-Pro

    Sequence similaritiesi

    Belongs to the Mediator complex subunit 7 family.Curated

    Phylogenomic databases

    eggNOGiNOG274591.
    GeneTreeiENSGT00530000064187.
    HOGENOMiHOG000241102.
    HOVERGENiHBG002997.
    InParanoidiQ9CZB6.
    KOiK15148.
    OMAiLLNEFRP.
    PhylomeDBiQ9CZB6.
    TreeFamiTF314411.

    Family and domain databases

    InterProiIPR009244. Mediatior_Med7.
    [Graphical view]
    PfamiPF05983. Med7. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CZB6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEPQQVSAL PPPPMQYIKE YTDENIQEGL APKPPPPIKD SYMMFGNQFQ    50
    CDDLIIRPLE SQGIERLHPM QFDHKKELRK LNMSILINFL DLLDILIRSP 100
    GSIKREEKLE DLKLLFVHVH HLINEYRPHQ ARETLRVMME VQKRQRLETA 150
    ERFQKHLERV IEMIQNCLAS LPDDLPHSEA GMRVKAEPMD TDDNSNCPGQ 200
    NEQQRESSGH RRDQIIEKDA ALCVLIDEMN ERP 233
    Length:233
    Mass (Da):27,205
    Last modified:April 12, 2005 - v2
    Checksum:iCB340CCF5770541C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti26 – 261I → S in AAH11333. (PubMed:15489334)Curated
    Sequence conflicti33 – 342KP → GR in AAH11333. (PubMed:15489334)Curated
    Sequence conflicti49 – 502FQ → KR in AAH11333. (PubMed:15489334)Curated
    Sequence conflicti73 – 731D → Y in BAB23272. (PubMed:16141072)Curated
    Sequence conflicti88 – 881N → T in BAB23272. (PubMed:16141072)Curated
    Sequence conflicti91 – 911D → N in BAB28478. (PubMed:16141072)Curated
    Sequence conflicti104 – 1041K → N in BAB28478. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004354 mRNA. Translation: BAB23272.1.
    AK010357 mRNA. Translation: BAB26877.1.
    AK012799 mRNA. Translation: BAB28478.1.
    AK144918 mRNA. Translation: BAE26135.1.
    AK147739 mRNA. Translation: BAE28106.1.
    AK167407 mRNA. Translation: BAE39496.1.
    AL669948 Genomic DNA. No translation available.
    BC011333 mRNA. Translation: AAH11333.1.
    CCDSiCCDS36134.1.
    RefSeqiNP_001098000.1. NM_001104530.1.
    NP_001098026.1. NM_001104556.1.
    NP_001098027.1. NM_001104557.1.
    NP_079702.3. NM_025426.3.
    XP_006533994.1. XM_006533931.1.
    XP_006533995.1. XM_006533932.1.
    XP_006533996.1. XM_006533933.1.
    XP_006533997.1. XM_006533934.1.
    UniGeneiMm.24159.

    Genome annotation databases

    EnsembliENSMUST00000020665; ENSMUSP00000020665; ENSMUSG00000020397.
    ENSMUST00000109232; ENSMUSP00000104855; ENSMUSG00000020397.
    ENSMUST00000170928; ENSMUSP00000131852; ENSMUSG00000020397.
    GeneIDi66213.
    KEGGimmu:66213.
    UCSCiuc007iok.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004354 mRNA. Translation: BAB23272.1 .
    AK010357 mRNA. Translation: BAB26877.1 .
    AK012799 mRNA. Translation: BAB28478.1 .
    AK144918 mRNA. Translation: BAE26135.1 .
    AK147739 mRNA. Translation: BAE28106.1 .
    AK167407 mRNA. Translation: BAE39496.1 .
    AL669948 Genomic DNA. No translation available.
    BC011333 mRNA. Translation: AAH11333.1 .
    CCDSi CCDS36134.1.
    RefSeqi NP_001098000.1. NM_001104530.1.
    NP_001098026.1. NM_001104556.1.
    NP_001098027.1. NM_001104557.1.
    NP_079702.3. NM_025426.3.
    XP_006533994.1. XM_006533931.1.
    XP_006533995.1. XM_006533932.1.
    XP_006533996.1. XM_006533933.1.
    XP_006533997.1. XM_006533934.1.
    UniGenei Mm.24159.

    3D structure databases

    ProteinModelPortali Q9CZB6.
    SMRi Q9CZB6. Positions 106-170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211303. 2 interactions.
    IntActi Q9CZB6. 2 interactions.

    PTM databases

    PhosphoSitei Q9CZB6.

    Proteomic databases

    PaxDbi Q9CZB6.
    PRIDEi Q9CZB6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020665 ; ENSMUSP00000020665 ; ENSMUSG00000020397 .
    ENSMUST00000109232 ; ENSMUSP00000104855 ; ENSMUSG00000020397 .
    ENSMUST00000170928 ; ENSMUSP00000131852 ; ENSMUSG00000020397 .
    GeneIDi 66213.
    KEGGi mmu:66213.
    UCSCi uc007iok.2. mouse.

    Organism-specific databases

    CTDi 9443.
    MGIi MGI:1913463. Med7.

    Phylogenomic databases

    eggNOGi NOG274591.
    GeneTreei ENSGT00530000064187.
    HOGENOMi HOG000241102.
    HOVERGENi HBG002997.
    InParanoidi Q9CZB6.
    KOi K15148.
    OMAi LLNEFRP.
    PhylomeDBi Q9CZB6.
    TreeFami TF314411.

    Enzyme and pathway databases

    Reactomei REACT_198602. PPARA activates gene expression.
    REACT_206529. Generic Transcription Pathway.
    REACT_27166. Transcriptional Regulation of Adipocyte Differentiation in 3T3-L1 Pre-adipocytes.

    Miscellaneous databases

    ChiTaRSi MED7. mouse.
    NextBioi 320983.
    PROi Q9CZB6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CZB6.
    CleanExi MM_MED7.
    Genevestigatori Q9CZB6.

    Family and domain databases

    InterProi IPR009244. Mediatior_Med7.
    [Graphical view ]
    Pfami PF05983. Med7. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo, Embryonic stem cell, Mammary gland, Melanocyte and Placenta.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiMED7_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZB6
    Secondary accession number(s): Q3UGV1
    , Q91VN3, Q9CWV8, Q9D0V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: April 12, 2005
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3