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Protein

THUMP domain-containing protein 2

Gene

Thumpd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
THUMP domain-containing protein 2
Gene namesi
Name:Thumpd2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1919417. Thumpd2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000725331 – 528THUMP domain-containing protein 2Add BLAST528

Proteomic databases

EPDiQ9CZB3.
MaxQBiQ9CZB3.
PaxDbiQ9CZB3.
PeptideAtlasiQ9CZB3.
PRIDEiQ9CZB3.

PTM databases

iPTMnetiQ9CZB3.
PhosphoSitePlusiQ9CZB3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024246.
CleanExiMM_THUMPD2.
GenevisibleiQ9CZB3. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9CZB3. 2 interactors.
MINTiMINT-4137758.
STRINGi10090.ENSMUSP00000025093.

Structurei

3D structure databases

ProteinModelPortaliQ9CZB3.
SMRiQ9CZB3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 266THUMPPROSITE-ProRule annotationAdd BLAST105

Sequence similaritiesi

Belongs to the methyltransferase superfamily.Curated

Phylogenomic databases

eggNOGiENOG410KCNV. Eukaryota.
COG1041. LUCA.
GeneTreeiENSGT00530000063557.
HOGENOMiHOG000013141.
HOVERGENiHBG061192.
InParanoidiQ9CZB3.
OMAiWKADLRN.
OrthoDBiEOG091G1D46.
TreeFamiTF313093.

Family and domain databases

InterProiView protein in InterPro
IPR000241. RNA_methylase_dom.
IPR029063. SAM-dependent_MTases.
IPR004114. THUMP_dom.
PfamiView protein in Pfam
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
SMARTiView protein in SMART
SM00981. THUMP. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiView protein in PROSITE
PS51165. THUMP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZB3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAQADPGS DPAGGARFFC TAGRGLEPFL MREVRARLEA TQVEYISGKV
60 70 80 90 100
FFTTCSDLPS MKKLKSAERL FVLIKKQLPI AVSSLHKGKI LNEMQRFVND
110 120 130 140 150
DPGSWLEAIS LWKKLLEHDP KREKVSQRDA NPLKRKAGEN ETIIAKKLKV
160 170 180 190 200
EEKQEVAKDH GESQEDKLLQ GSPEQGEAVT RTELQDHRLN STTEKAADAQ
210 220 230 240 250
DQEDLTFRVS CRCTGNVRKV ITGQEAGRVI GLALMRQFGW KADLRNPNIE
260 270 280 290 300
IFMHLSDAYS VVGIPLLRMP LASRTYIQTA GLRSTIAWAM ASIAEIKAGA
310 320 330 340 350
LVLDPMCGLG TILVEAAEEW PDVFYMGADM SDAQLLGACD NLKAAGLTDR
360 370 380 390 400
IELLKSSVTD LPLPSQSTDV IISDIPFGKK FKLGKDIKSI LQEMERVLRV
410 420 430 440 450
GGAMVLLLSE DHHRHLTDCG GSSIPLTSKG HIAEPEMKTL SNPDRTGAPD
460 470 480 490 500
TASPSQRASS VQCLGRMRPC GSLVPVESFK VSLGKTDAFI CKYKKAQASG
510 520
LSSAECHEPG AHTEMAAMQE SPSLQDSL
Length:528
Mass (Da):57,669
Last modified:July 27, 2011 - v3
Checksum:i6242BC0BC3976CC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012806 mRNA. Translation: BAB28484.1.
AC165966 Genomic DNA. No translation available.
CCDSiCCDS50190.1.
RefSeqiNP_082414.1. NM_028138.1.
UniGeneiMm.273257.

Genome annotation databases

EnsembliENSMUST00000025093; ENSMUSP00000025093; ENSMUSG00000024246.
GeneIDi72167.
KEGGimmu:72167.
UCSCiuc008drp.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiTHUM2_MOUSE
AccessioniPrimary (citable) accession number: Q9CZB3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2004
Last sequence update: July 27, 2011
Last modified: July 5, 2017
This is version 98 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families