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Q9CZB0 (C560_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Alternative name(s):
Integral membrane protein CII-3
QPs-1
Short name=QPs1
Gene names
Name:Sdhc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Cofactor

Heme group. The heme is bound between the two transmembrane subunits SDHC and SDHD By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD By similarity.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome b560 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2929Mitochondrion By similarity
Chain30 – 169140Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
PRO_0000003635

Regions

Topological domain30 – 6233Mitochondrial matrix By similarity
Transmembrane63 – 9230Helical; By similarity
Topological domain93 – 11220Mitochondrial intermembrane By similarity
Transmembrane113 – 13725Helical; By similarity
Topological domain138 – 1447Mitochondrial matrix By similarity
Transmembrane145 – 16622Helical; By similarity
Topological domain167 – 1693Mitochondrial intermembrane By similarity

Sites

Metal binding1271Iron (heme axial ligand); shared with SDHD By similarity

Experimental info

Sequence conflict41F → L in AAH05779. Ref.2
Sequence conflict101S → G in AAH05779. Ref.2
Sequence conflict221L → R in BAB22116. Ref.1
Sequence conflict911L → V in AAH05779. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CZB0 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: D9BFBCF936D0B9F5

FASTA16918,382
        10         20         30         40         50         60 
MAAFLLRHVS RHCLRAHLNA QLCIRNAAPL GTTAKEEMER FWKKNTSSNR PLSPHLTIYK 

        70         80         90        100        110        120 
WSLPMALSVC HRGSGIALSG GVSLFGLSAL LLPGNFESYL MFVKSLCLGP TLIYSAKFVL 

       130        140        150        160 
VFPLMYHSLN GIRHLLWDLG KGLAIPQVWL SGVAVVVLAV LSSGGLAAL 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Brain, Embryo, Kidney and Muellerian duct.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK002459 mRNA. Translation: BAB22116.1.
AK012818 mRNA. Translation: BAB28491.1.
AK032458 mRNA. Translation: BAC27878.1.
AK135503 mRNA. Translation: BAE22557.1.
BC005779 mRNA. Translation: AAH05779.1.
CCDSCCDS35772.1.
RefSeqNP_079597.2. NM_025321.3.
UniGeneMm.198138.

3D structure databases

ProteinModelPortalQ9CZB0.
SMRQ9CZB0. Positions 32-169.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9CZB0. 4 interactions.
MINTMINT-4089551.

PTM databases

PhosphoSiteQ9CZB0.

Proteomic databases

MaxQBQ9CZB0.
PaxDbQ9CZB0.
PRIDEQ9CZB0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111336; ENSMUSP00000106968; ENSMUSG00000058076.
GeneID66052.
KEGGmmu:66052.
UCSCuc007dnb.2. mouse.

Organism-specific databases

CTD6391.
MGIMGI:1913302. Sdhc.

Phylogenomic databases

eggNOGCOG2009.
GeneTreeENSGT00390000000566.
HOGENOMHOG000160253.
HOVERGENHBG003187.
InParanoidQ9CZB0.
KOK00236.
OMAWNKNTSS.
OrthoDBEOG7SV0WV.
PhylomeDBQ9CZB0.
TreeFamTF313317.

Enzyme and pathway databases

UniPathwayUPA00223.

Gene expression databases

ArrayExpressQ9CZB0.
BgeeQ9CZB0.
GenevestigatorQ9CZB0.

Family and domain databases

InterProIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR014361. Succ_DH_cytb560.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamPF01127. Sdh_cyt. 1 hit.
[Graphical view]
PIRSFPIRSF000178. SDH_cyt_b560. 1 hit.
TIGRFAMsTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSDHC. mouse.
NextBio320482.
PROQ9CZB0.
SOURCESearch...

Entry information

Entry nameC560_MOUSE
AccessionPrimary (citable) accession number: Q9CZB0
Secondary accession number(s): Q544Q9, Q99JP2, Q9DCU7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot