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Protein

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Gene

Sdhc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Cofactori

hemeBy similarityNote: The heme is bound between the two transmembrane subunits SDHC and SDHD.By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127Iron (heme axial ligand); shared with SDHDBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71403 Citric acid cycle (TCA cycle)
UniPathwayiUPA00223

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Alternative name(s):
Integral membrane protein CII-3
QPs-1
Short name:
QPs1
Gene namesi
Name:Sdhc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913302 Sdhc

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 62Mitochondrial matrixBy similarityAdd BLAST33
Transmembranei63 – 92HelicalBy similarityAdd BLAST30
Topological domaini93 – 112Mitochondrial intermembraneBy similarityAdd BLAST20
Transmembranei113 – 137HelicalBy similarityAdd BLAST25
Topological domaini138 – 144Mitochondrial matrixBy similarity7
Transmembranei145 – 166HelicalBy similarityAdd BLAST22
Topological domaini167 – 169Mitochondrial intermembraneBy similarity3

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000000363530 – 169Succinate dehydrogenase cytochrome b560 subunit, mitochondrialAdd BLAST140

Proteomic databases

MaxQBiQ9CZB0
PaxDbiQ9CZB0
PeptideAtlasiQ9CZB0
PRIDEiQ9CZB0

PTM databases

iPTMnetiQ9CZB0
PhosphoSitePlusiQ9CZB0
SwissPalmiQ9CZB0

Expressioni

Gene expression databases

BgeeiENSMUSG00000058076
ExpressionAtlasiQ9CZB0 baseline and differential
GenevisibleiQ9CZB0 MM

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Protein-protein interaction databases

BioGridi211179, 1 interactor
CORUMiQ9CZB0
IntActiQ9CZB0, 4 interactors
MINTiQ9CZB0
STRINGi10090.ENSMUSP00000106968

Structurei

3D structure databases

ProteinModelPortaliQ9CZB0
SMRiQ9CZB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b560 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0449 Eukaryota
COG2009 LUCA
GeneTreeiENSGT00390000000566
HOGENOMiHOG000160253
HOVERGENiHBG003187
InParanoidiQ9CZB0
KOiK00236
OMAiIPGGIPC
OrthoDBiEOG091G0SR6
PhylomeDBiQ9CZB0
TreeFamiTF313317

Family and domain databases

Gene3Di1.20.1300.10, 1 hit
InterProiView protein in InterPro
IPR034804 SQR/QFR_C/D
IPR018495 Succ_DH_cyt_bsu_CS
IPR014314 Succ_DH_cytb556
IPR000701 SuccDH_FuR_B_TM-su
PfamiView protein in Pfam
PF01127 Sdh_cyt, 1 hit
PIRSFiPIRSF000178 SDH_cyt_b560, 1 hit
SUPFAMiSSF81343 SSF81343, 1 hit
TIGRFAMsiTIGR02970 succ_dehyd_cytB, 1 hit
PROSITEiView protein in PROSITE
PS01000 SDH_CYT_1, 1 hit
PS01001 SDH_CYT_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFLLRHVS RHCLRAHLNA QLCIRNAAPL GTTAKEEMER FWKKNTSSNR
60 70 80 90 100
PLSPHLTIYK WSLPMALSVC HRGSGIALSG GVSLFGLSAL LLPGNFESYL
110 120 130 140 150
MFVKSLCLGP TLIYSAKFVL VFPLMYHSLN GIRHLLWDLG KGLAIPQVWL
160
SGVAVVVLAV LSSGGLAAL
Length:169
Mass (Da):18,382
Last modified:June 1, 2001 - v1
Checksum:iD9BFBCF936D0B9F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4F → L in AAH05779 (PubMed:15489334).Curated1
Sequence conflicti10S → G in AAH05779 (PubMed:15489334).Curated1
Sequence conflicti22L → R in BAB22116 (PubMed:16141072).Curated1
Sequence conflicti91L → V in AAH05779 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002459 mRNA Translation: BAB22116.1
AK012818 mRNA Translation: BAB28491.1
AK032458 mRNA Translation: BAC27878.1
AK135503 mRNA Translation: BAE22557.1
BC005779 mRNA Translation: AAH05779.1
CCDSiCCDS35772.1
RefSeqiNP_079597.2, NM_025321.3
UniGeneiMm.198138

Genome annotation databases

EnsembliENSMUST00000111336; ENSMUSP00000106968; ENSMUSG00000058076
GeneIDi66052
KEGGimmu:66052
UCSCiuc007dnb.2 mouse

Similar proteinsi

Entry informationi

Entry nameiC560_MOUSE
AccessioniPrimary (citable) accession number: Q9CZB0
Secondary accession number(s): Q544Q9, Q99JP2, Q9DCU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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