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Q9CZB0

- C560_MOUSE

UniProt

Q9CZB0 - C560_MOUSE

Protein

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Gene

Sdhc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Cofactori

    Heme group. The heme is bound between the two transmembrane subunits SDHC and SDHD By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi127 – 1271Iron (heme axial ligand); shared with SDHDBy similarity

    GO - Molecular functioni

    1. electron carrier activity Source: InterPro
    2. heme binding Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. succinate dehydrogenase activity Source: InterPro

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
    Alternative name(s):
    Integral membrane protein CII-3
    QPs-1
    Short name:
    QPs1
    Gene namesi
    Name:Sdhc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1913302. Sdhc.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB
    3. mitochondrial respiratory chain complex II Source: UniProtKB
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2929MitochondrionBy similarityAdd
    BLAST
    Chaini30 – 169140Succinate dehydrogenase cytochrome b560 subunit, mitochondrialPRO_0000003635Add
    BLAST

    Proteomic databases

    MaxQBiQ9CZB0.
    PaxDbiQ9CZB0.
    PRIDEiQ9CZB0.

    PTM databases

    PhosphoSiteiQ9CZB0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CZB0.
    BgeeiQ9CZB0.
    GenevestigatoriQ9CZB0.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

    Protein-protein interaction databases

    IntActiQ9CZB0. 4 interactions.
    MINTiMINT-4089551.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CZB0.
    SMRiQ9CZB0. Positions 32-169.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini30 – 6233Mitochondrial matrixBy similarityAdd
    BLAST
    Topological domaini93 – 11220Mitochondrial intermembraneBy similarityAdd
    BLAST
    Topological domaini138 – 1447Mitochondrial matrixBy similarity
    Topological domaini167 – 1693Mitochondrial intermembraneBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei63 – 9230HelicalBy similarityAdd
    BLAST
    Transmembranei113 – 13725HelicalBy similarityAdd
    BLAST
    Transmembranei145 – 16622HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome b560 family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2009.
    GeneTreeiENSGT00390000000566.
    HOGENOMiHOG000160253.
    HOVERGENiHBG003187.
    InParanoidiQ9CZB0.
    KOiK00236.
    OMAiWNKNTSS.
    OrthoDBiEOG7SV0WV.
    PhylomeDBiQ9CZB0.
    TreeFamiTF313317.

    Family and domain databases

    InterProiIPR018495. Succ_DH_cyt_bsu_CS.
    IPR014314. Succ_DH_cytb556.
    IPR014361. Succ_DH_cytb560.
    IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
    [Graphical view]
    PfamiPF01127. Sdh_cyt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000178. SDH_cyt_b560. 1 hit.
    TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
    PROSITEiPS01000. SDH_CYT_1. 1 hit.
    PS01001. SDH_CYT_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CZB0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAFLLRHVS RHCLRAHLNA QLCIRNAAPL GTTAKEEMER FWKKNTSSNR    50
    PLSPHLTIYK WSLPMALSVC HRGSGIALSG GVSLFGLSAL LLPGNFESYL 100
    MFVKSLCLGP TLIYSAKFVL VFPLMYHSLN GIRHLLWDLG KGLAIPQVWL 150
    SGVAVVVLAV LSSGGLAAL 169
    Length:169
    Mass (Da):18,382
    Last modified:June 1, 2001 - v1
    Checksum:iD9BFBCF936D0B9F5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti4 – 41F → L in AAH05779. (PubMed:15489334)Curated
    Sequence conflicti10 – 101S → G in AAH05779. (PubMed:15489334)Curated
    Sequence conflicti22 – 221L → R in BAB22116. (PubMed:16141072)Curated
    Sequence conflicti91 – 911L → V in AAH05779. (PubMed:15489334)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002459 mRNA. Translation: BAB22116.1.
    AK012818 mRNA. Translation: BAB28491.1.
    AK032458 mRNA. Translation: BAC27878.1.
    AK135503 mRNA. Translation: BAE22557.1.
    BC005779 mRNA. Translation: AAH05779.1.
    CCDSiCCDS35772.1.
    RefSeqiNP_079597.2. NM_025321.3.
    UniGeneiMm.198138.

    Genome annotation databases

    EnsembliENSMUST00000111336; ENSMUSP00000106968; ENSMUSG00000058076.
    GeneIDi66052.
    KEGGimmu:66052.
    UCSCiuc007dnb.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002459 mRNA. Translation: BAB22116.1 .
    AK012818 mRNA. Translation: BAB28491.1 .
    AK032458 mRNA. Translation: BAC27878.1 .
    AK135503 mRNA. Translation: BAE22557.1 .
    BC005779 mRNA. Translation: AAH05779.1 .
    CCDSi CCDS35772.1.
    RefSeqi NP_079597.2. NM_025321.3.
    UniGenei Mm.198138.

    3D structure databases

    ProteinModelPortali Q9CZB0.
    SMRi Q9CZB0. Positions 32-169.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9CZB0. 4 interactions.
    MINTi MINT-4089551.

    PTM databases

    PhosphoSitei Q9CZB0.

    Proteomic databases

    MaxQBi Q9CZB0.
    PaxDbi Q9CZB0.
    PRIDEi Q9CZB0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000111336 ; ENSMUSP00000106968 ; ENSMUSG00000058076 .
    GeneIDi 66052.
    KEGGi mmu:66052.
    UCSCi uc007dnb.2. mouse.

    Organism-specific databases

    CTDi 6391.
    MGIi MGI:1913302. Sdhc.

    Phylogenomic databases

    eggNOGi COG2009.
    GeneTreei ENSGT00390000000566.
    HOGENOMi HOG000160253.
    HOVERGENi HBG003187.
    InParanoidi Q9CZB0.
    KOi K00236.
    OMAi WNKNTSS.
    OrthoDBi EOG7SV0WV.
    PhylomeDBi Q9CZB0.
    TreeFami TF313317.

    Enzyme and pathway databases

    UniPathwayi UPA00223 .

    Miscellaneous databases

    ChiTaRSi SDHC. mouse.
    NextBioi 320482.
    PROi Q9CZB0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CZB0.
    Bgeei Q9CZB0.
    Genevestigatori Q9CZB0.

    Family and domain databases

    InterProi IPR018495. Succ_DH_cyt_bsu_CS.
    IPR014314. Succ_DH_cytb556.
    IPR014361. Succ_DH_cytb560.
    IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
    [Graphical view ]
    Pfami PF01127. Sdh_cyt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000178. SDH_cyt_b560. 1 hit.
    TIGRFAMsi TIGR02970. succ_dehyd_cytB. 1 hit.
    PROSITEi PS01000. SDH_CYT_1. 1 hit.
    PS01001. SDH_CYT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Brain, Embryo, Kidney and Muellerian duct.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiC560_MOUSE
    AccessioniPrimary (citable) accession number: Q9CZB0
    Secondary accession number(s): Q544Q9, Q99JP2, Q9DCU7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 103 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3