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Protein

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Gene

Sdhc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Cofactori

hemeBy similarityNote: The heme is bound between the two transmembrane subunits SDHC and SDHD.By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi127Iron (heme axial ligand); shared with SDHDBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-71403. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Alternative name(s):
Integral membrane protein CII-3
QPs-1
Short name:
QPs1
Gene namesi
Name:Sdhc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1913302. Sdhc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 62Mitochondrial matrixBy similarityAdd BLAST33
Transmembranei63 – 92HelicalBy similarityAdd BLAST30
Topological domaini93 – 112Mitochondrial intermembraneBy similarityAdd BLAST20
Transmembranei113 – 137HelicalBy similarityAdd BLAST25
Topological domaini138 – 144Mitochondrial matrixBy similarity7
Transmembranei145 – 166HelicalBy similarityAdd BLAST22
Topological domaini167 – 169Mitochondrial intermembraneBy similarity3

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 29MitochondrionBy similarityAdd BLAST29
ChainiPRO_000000363530 – 169Succinate dehydrogenase cytochrome b560 subunit, mitochondrialAdd BLAST140

Proteomic databases

MaxQBiQ9CZB0.
PaxDbiQ9CZB0.
PeptideAtlasiQ9CZB0.
PRIDEiQ9CZB0.

PTM databases

PhosphoSitePlusiQ9CZB0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000058076.
ExpressionAtlasiQ9CZB0. baseline and differential.
GenevisibleiQ9CZB0. MM.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Protein-protein interaction databases

BioGridi211179. 1 interactor.
IntActiQ9CZB0. 4 interactors.
MINTiMINT-4089551.
STRINGi10090.ENSMUSP00000106968.

Structurei

3D structure databases

ProteinModelPortaliQ9CZB0.
SMRiQ9CZB0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome b560 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0449. Eukaryota.
COG2009. LUCA.
GeneTreeiENSGT00390000000566.
HOGENOMiHOG000160253.
HOVERGENiHBG003187.
InParanoidiQ9CZB0.
KOiK00236.
OMAiLSIMHRG.
OrthoDBiEOG091G0SR6.
PhylomeDBiQ9CZB0.
TreeFamiTF313317.

Family and domain databases

InterProiIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEiPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZB0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAFLLRHVS RHCLRAHLNA QLCIRNAAPL GTTAKEEMER FWKKNTSSNR
60 70 80 90 100
PLSPHLTIYK WSLPMALSVC HRGSGIALSG GVSLFGLSAL LLPGNFESYL
110 120 130 140 150
MFVKSLCLGP TLIYSAKFVL VFPLMYHSLN GIRHLLWDLG KGLAIPQVWL
160
SGVAVVVLAV LSSGGLAAL
Length:169
Mass (Da):18,382
Last modified:June 1, 2001 - v1
Checksum:iD9BFBCF936D0B9F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4F → L in AAH05779 (PubMed:15489334).Curated1
Sequence conflicti10S → G in AAH05779 (PubMed:15489334).Curated1
Sequence conflicti22L → R in BAB22116 (PubMed:16141072).Curated1
Sequence conflicti91L → V in AAH05779 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002459 mRNA. Translation: BAB22116.1.
AK012818 mRNA. Translation: BAB28491.1.
AK032458 mRNA. Translation: BAC27878.1.
AK135503 mRNA. Translation: BAE22557.1.
BC005779 mRNA. Translation: AAH05779.1.
CCDSiCCDS35772.1.
RefSeqiNP_079597.2. NM_025321.3.
UniGeneiMm.198138.

Genome annotation databases

EnsembliENSMUST00000111336; ENSMUSP00000106968; ENSMUSG00000058076.
GeneIDi66052.
KEGGimmu:66052.
UCSCiuc007dnb.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002459 mRNA. Translation: BAB22116.1.
AK012818 mRNA. Translation: BAB28491.1.
AK032458 mRNA. Translation: BAC27878.1.
AK135503 mRNA. Translation: BAE22557.1.
BC005779 mRNA. Translation: AAH05779.1.
CCDSiCCDS35772.1.
RefSeqiNP_079597.2. NM_025321.3.
UniGeneiMm.198138.

3D structure databases

ProteinModelPortaliQ9CZB0.
SMRiQ9CZB0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211179. 1 interactor.
IntActiQ9CZB0. 4 interactors.
MINTiMINT-4089551.
STRINGi10090.ENSMUSP00000106968.

PTM databases

PhosphoSitePlusiQ9CZB0.

Proteomic databases

MaxQBiQ9CZB0.
PaxDbiQ9CZB0.
PeptideAtlasiQ9CZB0.
PRIDEiQ9CZB0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111336; ENSMUSP00000106968; ENSMUSG00000058076.
GeneIDi66052.
KEGGimmu:66052.
UCSCiuc007dnb.2. mouse.

Organism-specific databases

CTDi6391.
MGIiMGI:1913302. Sdhc.

Phylogenomic databases

eggNOGiKOG0449. Eukaryota.
COG2009. LUCA.
GeneTreeiENSGT00390000000566.
HOGENOMiHOG000160253.
HOVERGENiHBG003187.
InParanoidiQ9CZB0.
KOiK00236.
OMAiLSIMHRG.
OrthoDBiEOG091G0SR6.
PhylomeDBiQ9CZB0.
TreeFamiTF313317.

Enzyme and pathway databases

UniPathwayiUPA00223.
ReactomeiR-MMU-71403. Citric acid cycle (TCA cycle).

Miscellaneous databases

ChiTaRSiSdhc. mouse.
PROiQ9CZB0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000058076.
ExpressionAtlasiQ9CZB0. baseline and differential.
GenevisibleiQ9CZB0. MM.

Family and domain databases

InterProiIPR018495. Succ_DH_cyt_bsu_CS.
IPR014314. Succ_DH_cytb556.
IPR000701. Succ_DH_Fumarate_Rdtase_TM-su.
[Graphical view]
PfamiPF01127. Sdh_cyt. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02970. succ_dehyd_cytB. 1 hit.
PROSITEiPS01000. SDH_CYT_1. 1 hit.
PS01001. SDH_CYT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC560_MOUSE
AccessioniPrimary (citable) accession number: Q9CZB0
Secondary accession number(s): Q544Q9, Q99JP2, Q9DCU7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.