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Protein

Zinc finger CCHC domain-containing protein 12

Gene

Zcchc12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 363CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

  • ligand-dependent nuclear receptor transcription coactivator activity Source: MGI
  • nucleic acid binding Source: InterPro
  • SUMO binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • BMP signaling pathway Source: MGI
  • positive regulation of ligand-dependent nuclear receptor transcription coactivator activity Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCHC domain-containing protein 12
Alternative name(s):
Smad-interacting zinc finger protein 1
Gene namesi
Name:Zcchc12
Synonyms:Sizn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1919943. Zcchc12.

Subcellular locationi

GO - Cellular componenti

  • nuclear speck Source: MGI
  • nucleus Source: MGI

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001509721 – 402Zinc finger CCHC domain-containing protein 12Add BLAST402

Proteomic databases

MaxQBiQ9CZA5.
PaxDbiQ9CZA5.
PRIDEiQ9CZA5.

PTM databases

PhosphoSitePlusiQ9CZA5.

Expressioni

Tissue specificityi

In embryonic brains expression is restricted to the ventral region of the forebrain, including the septum, amygdala, caudal putamen, and in the basal-forebrain cholinergic neurons. In adults, expressed in the brain, and at low levels in the testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000036699.
CleanExiMM_ZCCHC12.
GenevisibleiQ9CZA5. MM.

Interactioni

Subunit structurei

Interacts with SMAD1 and CREB-binding protein (CBP). Forms a protein-DNA complex through its association with SMAD1.1 Publication

GO - Molecular functioni

  • SUMO binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044550.

Structurei

3D structure databases

ProteinModelPortaliQ9CZA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi218 – 224Poly-Glu7

Sequence similaritiesi

Belongs to the ZCCHC12 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri346 – 363CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410J95G. Eukaryota.
ENOG4111945. LUCA.
GeneTreeiENSGT00530000062986.
HOGENOMiHOG000230940.
HOVERGENiHBG073535.
InParanoidiQ9CZA5.
OMAiRSEPIME.
OrthoDBiEOG091G0AM8.
PhylomeDBiQ9CZA5.
TreeFamiTF335054.

Family and domain databases

Gene3Di4.10.60.10. 1 hit.
InterProiView protein in InterPro
IPR026523. PNMA.
IPR001878. Znf_CCHC.
PANTHERiPTHR23095. PTHR23095. 1 hit.
PfamiView protein in Pfam
PF14893. PNMA. 1 hit.
PROSITEiView protein in PROSITE
PS50158. ZF_CCHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZA5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASILSRLGS SRGQNSPLPP WAHSMLRSLG RSLGPLMASM AERNMRLFSG
60 70 80 90 100
RAEPAQGEET FENWLSQVTG VLPDWHMPEE EKVRRLMRTL RGPAREVMRL
110 120 130 140 150
LQAANPGLDV EDFLRAMKLV FGESESSVTA HSKFVNTVQE HGEKPSLYVI
160 170 180 190 200
RLEVQLQNAI QAGVFAEREA NQARLHQLLV GAEMSTDLRF RLKNLLRVYA
210 220 230 240 250
NEPERLPNFL ELIRMIREEE EWEETFINPK RPRRAESVME RALSPMAFQS
260 270 280 290 300
SPPIMISSID CNVIEIDDSP DDSDEDVILV EPEDPPLPSS SASSFLGRAV
310 320 330 340 350
SEDQVLVIES PNIFEIQAPS TSSGAGRKNN RGFGELRRAR KRKHTIHCSH
360 370 380 390 400
CGEEGHSKET CDNESDKGQV FENLIITLQE LTHAEERARG APGEPIGLSE

PQ
Length:402
Mass (Da):45,107
Last modified:June 1, 2001 - v1
Checksum:i3603A26F2CCD5C3D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY466375 mRNA. Translation: AAR85891.1.
AK012833 mRNA. Translation: BAB28501.1.
BC049071 mRNA. Translation: AAH49071.1.
BC055714 mRNA. Translation: AAH55714.1.
CCDSiCCDS30058.1.
RefSeqiNP_082601.1. NM_028325.3.
XP_006541458.1. XM_006541395.1.
XP_006541460.1. XM_006541397.1.
XP_006541461.1. XM_006541398.1.
XP_006541462.1. XM_006541399.1.
XP_006541463.1. XM_006541400.2.
XP_006541464.1. XM_006541401.1.
XP_006541466.1. XM_006541403.1.
XP_011249276.1. XM_011250974.2.
XP_017174118.1. XM_017318629.1.
XP_017174119.1. XM_017318630.1.
UniGeneiMm.297698.

Genome annotation databases

EnsembliENSMUST00000048067; ENSMUSP00000044550; ENSMUSG00000036699.
ENSMUST00000115256; ENSMUSP00000110911; ENSMUSG00000036699.
ENSMUST00000115257; ENSMUSP00000110912; ENSMUSG00000036699.
ENSMUST00000115258; ENSMUSP00000110913; ENSMUSG00000036699.
GeneIDi72693.
KEGGimmu:72693.
UCSCiuc009sxk.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZCH12_MOUSE
AccessioniPrimary (citable) accession number: Q9CZA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: June 1, 2001
Last modified: May 10, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families