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Protein

Centromere protein P

Gene

Cenpp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-MMU-68877. Mitotic Prometaphase.

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein P
Short name:
CENP-P
Gene namesi
Name:Cenpp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1913586. Cenpp.

Subcellular locationi

  • Nucleus By similarity
  • Chromosomecentromere By similarity

  • Note: Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Centromere protein PPRO_0000249507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9CZ92.
PaxDbiQ9CZ92.
PeptideAtlasiQ9CZ92.
PRIDEiQ9CZ92.

PTM databases

iPTMnetiQ9CZ92.
PhosphoSiteiQ9CZ92.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021391.
CleanExiMM_CENPP.
ExpressionAtlasiQ9CZ92. baseline and differential.
GenevisibleiQ9CZ92. MM.

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (By similarity).By similarity

Protein-protein interaction databases

IntActiQ9CZ92. 1 interaction.
MINTiMINT-8174102.
STRINGi10090.ENSMUSP00000021818.

Structurei

3D structure databases

ProteinModelPortaliQ9CZ92.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1 – 7373Sequence analysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IJM3. Eukaryota.
ENOG410YMCC. LUCA.
GeneTreeiENSGT00390000011897.
HOGENOMiHOG000060252.
HOVERGENiHBG081087.
InParanoidiQ9CZ92.
KOiK11508.
OMAiQILEIQX.
OrthoDBiEOG091G0P30.
PhylomeDBiQ9CZ92.
TreeFamiTF333784.

Family and domain databases

InterProiIPR027801. CENP-P.
[Graphical view]
PfamiPF13096. CENP-P. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CZ92-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSETRELRA LEAEVAALQR ECRMLQNAGE KASGAWKSFQ KISQSDSEEW
60 70 80 90 100
ESLKDLRSQL EHLRSEHSFL SKLTGFNIRN YSKMEDIVNT EETEKDTKKV
110 120 130 140 150
LQKHRLSGNC NMVTFQLEFE VLEMETKEKK SSIITDLSII MEPTEYSELS
160 170 180 190 200
EFASRAEEKR DLLMFFRSLH FFVEWCEYRE NTFKHFKEKY PDTVYLLEGT
210 220 230 240 250
CSHCMEIRST RQPGFELVIV WKIQIDEEGM VFPKLDLLTK VPERALGLDK
260 270 280
NRVIETAPLS FRSLLGVLGI EAALDSLIRL FSGDNN
Length:286
Mass (Da):33,288
Last modified:June 1, 2001 - v1
Checksum:i2D58C5766D0B37D6
GO
Isoform 2 (identifier: Q9CZ92-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     188-240: EKYPDTVYLL...VFPKLDLLTK → THSLSISSQE...WFPWLTQLAL
     241-286: Missing.

Note: No experimental confirmation available.
Show »
Length:240
Mass (Da):28,089
Checksum:iEFA32BDCD48EDCDC
GO

Sequence cautioni

The sequence BAB24472 differs from that shown. Reason: Frameshift at position 26. Curated
The sequence BAB29620 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC36401 differs from that shown. Reason: Frameshift at position 18. Curated
The sequence BC094280 differs from that shown. Reason: Frameshift at position 119. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti177 – 1771E → G in BAC36401 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei188 – 24053EKYPD…DLLTK → THSLSISSQERAGLQETTTK HDQTRNLEAGTYAEAIEGCC LLDWFPWLTQLAL in isoform 2. 1 PublicationVSP_020449Add
BLAST
Alternative sequencei241 – 28646Missing in isoform 2. 1 PublicationVSP_020450Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006234 mRNA. Translation: BAB24472.1. Frameshift.
AK012863 mRNA. Translation: BAB28519.1.
AK014919 mRNA. Translation: BAB29620.1. Different initiation.
AK076577 mRNA. Translation: BAC36401.1. Frameshift.
BC094280 mRNA. No translation available.
CCDSiCCDS26501.1. [Q9CZ92-1]
RefSeqiNP_079771.1. NM_025495.3. [Q9CZ92-1]
UniGeneiMm.440323.

Genome annotation databases

EnsembliENSMUST00000021818; ENSMUSP00000021818; ENSMUSG00000021391. [Q9CZ92-1]
GeneIDi66336.
KEGGimmu:66336.
UCSCiuc007qjk.1. mouse. [Q9CZ92-1]
uc007qjo.1. mouse. [Q9CZ92-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK006234 mRNA. Translation: BAB24472.1. Frameshift.
AK012863 mRNA. Translation: BAB28519.1.
AK014919 mRNA. Translation: BAB29620.1. Different initiation.
AK076577 mRNA. Translation: BAC36401.1. Frameshift.
BC094280 mRNA. No translation available.
CCDSiCCDS26501.1. [Q9CZ92-1]
RefSeqiNP_079771.1. NM_025495.3. [Q9CZ92-1]
UniGeneiMm.440323.

3D structure databases

ProteinModelPortaliQ9CZ92.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CZ92. 1 interaction.
MINTiMINT-8174102.
STRINGi10090.ENSMUSP00000021818.

PTM databases

iPTMnetiQ9CZ92.
PhosphoSiteiQ9CZ92.

Proteomic databases

MaxQBiQ9CZ92.
PaxDbiQ9CZ92.
PeptideAtlasiQ9CZ92.
PRIDEiQ9CZ92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021818; ENSMUSP00000021818; ENSMUSG00000021391. [Q9CZ92-1]
GeneIDi66336.
KEGGimmu:66336.
UCSCiuc007qjk.1. mouse. [Q9CZ92-1]
uc007qjo.1. mouse. [Q9CZ92-2]

Organism-specific databases

CTDi401541.
MGIiMGI:1913586. Cenpp.

Phylogenomic databases

eggNOGiENOG410IJM3. Eukaryota.
ENOG410YMCC. LUCA.
GeneTreeiENSGT00390000011897.
HOGENOMiHOG000060252.
HOVERGENiHBG081087.
InParanoidiQ9CZ92.
KOiK11508.
OMAiQILEIQX.
OrthoDBiEOG091G0P30.
PhylomeDBiQ9CZ92.
TreeFamiTF333784.

Enzyme and pathway databases

ReactomeiR-MMU-2467813. Separation of Sister Chromatids.
R-MMU-2500257. Resolution of Sister Chromatid Cohesion.
R-MMU-5663220. RHO GTPases Activate Formins.
R-MMU-606279. Deposition of new CENPA-containing nucleosomes at the centromere.
R-MMU-68877. Mitotic Prometaphase.

Miscellaneous databases

ChiTaRSiCenpp. mouse.
PROiQ9CZ92.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021391.
CleanExiMM_CENPP.
ExpressionAtlasiQ9CZ92. baseline and differential.
GenevisibleiQ9CZ92. MM.

Family and domain databases

InterProiIPR027801. CENP-P.
[Graphical view]
PfamiPF13096. CENP-P. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCENPP_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ92
Secondary accession number(s): Q52KM2
, Q8C647, Q9CVW9, Q9D5U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.