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Protein

CKLF-like MARVEL transmembrane domain-containing protein 6

Gene

Cmtm6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 6
Alternative name(s):
Chemokine-like factor superfamily member 6
Gene namesi
Name:Cmtm6
Synonyms:Cklfsf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2447165. Cmtm6.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei135 – 155HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001861081 – 183CKLF-like MARVEL transmembrane domain-containing protein 6Add BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei8PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CZ69.
MaxQBiQ9CZ69.
PaxDbiQ9CZ69.
PRIDEiQ9CZ69.

PTM databases

iPTMnetiQ9CZ69.
PhosphoSitePlusiQ9CZ69.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032434.
GenevisibleiQ9CZ69. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035007.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 160MARVELPROSITE-ProRule annotationAdd BLAST128

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063578.
HOVERGENiHBG050980.
InParanoidiQ9CZ69.
OMAiHDRTSAE.
OrthoDBiEOG091G0KPO.
PhylomeDBiQ9CZ69.
TreeFamiTF317387.

Family and domain databases

InterProiView protein in InterPro
IPR008253. Marvel.
PfamiView protein in Pfam
PF01284. MARVEL. 1 hit.
PROSITEiView protein in PROSITE
PS51225. MARVEL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZ69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGAVYSPT TEAAPGTGRG ARSGLAAYFV LGRLPWHRRI LKGLQLLLSL
60 70 80 90 100
LAFICEEVVS ECGLCGGLYF FEFVSCSAFL LSLLLLIVYC TPVHDRVDTG
110 120 130 140 150
KVKSSDFYIT LGTGCVFLLA SIIFVSTHSG TSAEIAAIVF GFLASSMFLL
160 170 180
DFVVMLCEKL RESPLRKPEN NAKVEALTEP LNA
Length:183
Mass (Da):19,824
Last modified:June 1, 2001 - v1
Checksum:iE5EFC4C4AA16720F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti108 – 111YITL → DAWV in AAH07194 (PubMed:15489334).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241868 mRNA. Translation: AAP33490.1.
AK012941 mRNA. Translation: BAB28562.1.
AK030885 mRNA. Translation: BAC27172.1.
AK152448 mRNA. Translation: BAE31227.1.
AK152723 mRNA. Translation: BAE31446.1.
AK152817 mRNA. Translation: BAE31520.1.
AK154481 mRNA. Translation: BAE32617.1.
AK159735 mRNA. Translation: BAE35329.1.
AK165948 mRNA. Translation: BAE38480.1.
AK167499 mRNA. Translation: BAE39575.1.
AK167854 mRNA. Translation: BAE39872.1.
AK170905 mRNA. Translation: BAE42106.1.
AK171394 mRNA. Translation: BAE42431.1.
BC007194 mRNA. Translation: AAH07194.1.
BC027248 mRNA. Translation: AAH27248.1.
CCDSiCCDS23596.1.
RefSeqiNP_080312.1. NM_026036.3.
UniGeneiMm.28858.

Genome annotation databases

EnsembliENSMUST00000035007; ENSMUSP00000035007; ENSMUSG00000032434.
GeneIDi67213.
KEGGimmu:67213.
UCSCiuc009ryb.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCKLF6_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ69
Secondary accession number(s): Q3U7C3, Q922J1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: August 30, 2017
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families