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Protein

CKLF-like MARVEL transmembrane domain-containing protein 6

Gene

Cmtm6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 6
Alternative name(s):
Chemokine-like factor superfamily member 6
Gene namesi
Name:Cmtm6
Synonyms:Cklfsf6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2447165. Cmtm6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei68 – 8821HelicalSequence analysisAdd
BLAST
Transmembranei107 – 12721HelicalSequence analysisAdd
BLAST
Transmembranei135 – 15521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 183183CKLF-like MARVEL transmembrane domain-containing protein 6PRO_0000186108Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei8 – 81PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CZ69.
MaxQBiQ9CZ69.
PaxDbiQ9CZ69.
PRIDEiQ9CZ69.

PTM databases

iPTMnetiQ9CZ69.
PhosphoSiteiQ9CZ69.

Expressioni

Gene expression databases

BgeeiQ9CZ69.
GenevisibleiQ9CZ69. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035007.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 160128MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063578.
HOVERGENiHBG050980.
InParanoidiQ9CZ69.
OMAiHDRTSAE.
OrthoDBiEOG7FNC8Q.
PhylomeDBiQ9CZ69.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CZ69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENGAVYSPT TEAAPGTGRG ARSGLAAYFV LGRLPWHRRI LKGLQLLLSL
60 70 80 90 100
LAFICEEVVS ECGLCGGLYF FEFVSCSAFL LSLLLLIVYC TPVHDRVDTG
110 120 130 140 150
KVKSSDFYIT LGTGCVFLLA SIIFVSTHSG TSAEIAAIVF GFLASSMFLL
160 170 180
DFVVMLCEKL RESPLRKPEN NAKVEALTEP LNA
Length:183
Mass (Da):19,824
Last modified:June 1, 2001 - v1
Checksum:iE5EFC4C4AA16720F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti108 – 1114YITL → DAWV in AAH07194 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241868 mRNA. Translation: AAP33490.1.
AK012941 mRNA. Translation: BAB28562.1.
AK030885 mRNA. Translation: BAC27172.1.
AK152448 mRNA. Translation: BAE31227.1.
AK152723 mRNA. Translation: BAE31446.1.
AK152817 mRNA. Translation: BAE31520.1.
AK154481 mRNA. Translation: BAE32617.1.
AK159735 mRNA. Translation: BAE35329.1.
AK165948 mRNA. Translation: BAE38480.1.
AK167499 mRNA. Translation: BAE39575.1.
AK167854 mRNA. Translation: BAE39872.1.
AK170905 mRNA. Translation: BAE42106.1.
AK171394 mRNA. Translation: BAE42431.1.
BC007194 mRNA. Translation: AAH07194.1.
BC027248 mRNA. Translation: AAH27248.1.
CCDSiCCDS23596.1.
RefSeqiNP_080312.1. NM_026036.3.
UniGeneiMm.28858.

Genome annotation databases

EnsembliENSMUST00000035007; ENSMUSP00000035007; ENSMUSG00000032434.
GeneIDi67213.
KEGGimmu:67213.
UCSCiuc009ryb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY241868 mRNA. Translation: AAP33490.1.
AK012941 mRNA. Translation: BAB28562.1.
AK030885 mRNA. Translation: BAC27172.1.
AK152448 mRNA. Translation: BAE31227.1.
AK152723 mRNA. Translation: BAE31446.1.
AK152817 mRNA. Translation: BAE31520.1.
AK154481 mRNA. Translation: BAE32617.1.
AK159735 mRNA. Translation: BAE35329.1.
AK165948 mRNA. Translation: BAE38480.1.
AK167499 mRNA. Translation: BAE39575.1.
AK167854 mRNA. Translation: BAE39872.1.
AK170905 mRNA. Translation: BAE42106.1.
AK171394 mRNA. Translation: BAE42431.1.
BC007194 mRNA. Translation: AAH07194.1.
BC027248 mRNA. Translation: AAH27248.1.
CCDSiCCDS23596.1.
RefSeqiNP_080312.1. NM_026036.3.
UniGeneiMm.28858.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035007.

PTM databases

iPTMnetiQ9CZ69.
PhosphoSiteiQ9CZ69.

Proteomic databases

EPDiQ9CZ69.
MaxQBiQ9CZ69.
PaxDbiQ9CZ69.
PRIDEiQ9CZ69.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035007; ENSMUSP00000035007; ENSMUSG00000032434.
GeneIDi67213.
KEGGimmu:67213.
UCSCiuc009ryb.1. mouse.

Organism-specific databases

CTDi54918.
MGIiMGI:2447165. Cmtm6.

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00530000063578.
HOVERGENiHBG050980.
InParanoidiQ9CZ69.
OMAiHDRTSAE.
OrthoDBiEOG7FNC8Q.
PhylomeDBiQ9CZ69.
TreeFamiTF317387.

Miscellaneous databases

ChiTaRSiCmtm6. mouse.
PROiQ9CZ69.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZ69.
GenevisibleiQ9CZ69. MM.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Han W., Li T., Tan Y., Shi S., Ding P., Ma D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J, DBA/2J and NOD.
    Tissue: Embryo, Placenta and Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Heart, Kidney, Liver, Lung, Spleen and Testis.

Entry informationi

Entry nameiCKLF6_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ69
Secondary accession number(s): Q3U7C3, Q922J1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.