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Protein

Centrosomal protein of 97 kDa

Gene

Cep97

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation. Required for recruitment of CCP110 to the centrosome (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Centrosomal protein of 97 kDa
Short name:
Cep97
Alternative name(s):
Leucine-rich repeat and IQ domain-containing protein 2
Gene namesi
Name:Cep97
Synonyms:Lrriq2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1921451. Cep97.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 856856Centrosomal protein of 97 kDaPRO_0000263706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei308 – 3081PhosphoserineBy similarity
Modified residuei410 – 4101PhosphoserineBy similarity
Modified residuei521 – 5211PhosphoserineCombined sources
Modified residuei755 – 7551PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZ62.
MaxQBiQ9CZ62.
PaxDbiQ9CZ62.
PRIDEiQ9CZ62.

PTM databases

PhosphoSiteiQ9CZ62.

Expressioni

Gene expression databases

BgeeiQ9CZ62.
CleanExiMM_CEP97.
ExpressionAtlasiQ9CZ62. baseline and differential.
GenevisibleiQ9CZ62. MM.

Interactioni

Subunit structurei

Interacts with CALM1, CEP76 and CCP110. Via its interaction with CCP110, may indirectly interact with HERC2 and NEURL4. Interacts with KIF24 (By similarity).By similarity

Protein-protein interaction databases

BioGridi216572. 1 interaction.
IntActiQ9CZ62. 2 interactions.
STRINGi10090.ENSMUSP00000023270.

Structurei

3D structure databases

ProteinModelPortaliQ9CZ62.
SMRiQ9CZ62. Positions 41-250, 549-574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati37 – 5822LRR 1Add
BLAST
Repeati59 – 8022LRR 2Add
BLAST
Repeati81 – 10222LRR 3Add
BLAST
Repeati103 – 12422LRR 4Add
BLAST
Repeati125 – 14622LRR 5Add
BLAST
Repeati147 – 16822LRR 6Add
BLAST
Repeati171 – 19222LRR 7Add
BLAST
Repeati196 – 20510LRR 8
Domaini211 – 24939LRRCTAdd
BLAST
Domaini550 – 57930IQPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni300 – 742443CCP110-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00830000128399.
HOGENOMiHOG000111550.
HOVERGENiHBG061575.
InParanoidiQ9CZ62.
KOiK16717.
OMAiKEVRYEI.
OrthoDBiEOG7PGDQ1.
PhylomeDBiQ9CZ62.
TreeFamiTF320816.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CZ62-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVARVDGAL APGEGSVVNW SGQGLQKLGA NLPCEADVHT LILDKNQIIK
60 70 80 90 100
LENLEKCKQL IQLSVANNRL VRMMGVAKLT QLRVLNLPHN SIGCVEGLKD
110 120 130 140 150
LVHLEWLNLA GNNLKTMEQV NSCTALQHLD LSDNNIPQIG DVSKLISLKT
160 170 180 190 200
LLLHGNIITS LRMAPAYLPR NLSILSLAEN EIRDLNEISF LASLSELEQL
210 220 230 240 250
SIMNNPCVMA TPSIPGFDYR PFIVSWCLNL RVLDGYVISQ KESLKAEWLY
260 270 280 290 300
SQGKGRSYRP GQHIQLVQYL ATVCPLTSAL GLQTAEDAKL EKILSKQRFH
310 320 330 340 350
QRQLMSQSQD EELSPLAAVE TRVHRTPECS SPGQDFQESE PVLQINSWVG
360 370 380 390 400
ISSNDDQLYA VKNNFPAAAH AARYSRNDLH LEDIQTDEDK LNCSLLSSES
410 420 430 440 450
TFMPVASGLS PVSPTVELRL QGINLGLEDD DGADEFTKGL ENQDEDKDKE
460 470 480 490 500
KSLWDMSESC VEMLKRKIST EVSEAAGLLP CPKSVIISAA LKEDTHSLTS
510 520 530 540 550
LPESAGHSAS RTEANSEEAM SPATSEKFPC RILTQRPAAL GQDKVTLQKL
560 570 580 590 600
NAAATKLQAC WRGFYTRNYN QQAKGVRYEI RLRRMQEHIV CLTDEVRRLR
610 620 630 640 650
KERDEERVKT FVQEEAVRFL WNEVRSVQAW QQTVEQRLAS WPPDVPPISS
660 670 680 690 700
TLASPKPPLF PHHQDPSSDQ SSDWLVAEDE AAQGRSAPDF PDSGFHSSLT
710 720 730 740 750
EQVPCLQDSL DFEKSSVESS ENSVLGNSAD TVKCVKDRDS EATAEEHSDC
760 770 780 790 800
SRESSASEQD NTLLQQYLTS VQQLDDAAEA ADSDDVAGDG KRHLACSPER
810 820 830 840 850
FDASSDSETH RVASTSQDEI SQTPENCQLN EEAQGQPPEC DPAFQGLHVG

VTVQPV
Length:856
Mass (Da):94,641
Last modified:June 1, 2001 - v1
Checksum:i619F0B577D0C15A9
GO
Isoform 2 (identifier: Q9CZ62-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-72: Missing.

Show »
Length:784
Mass (Da):86,896
Checksum:i9FC1E774A81C81C4
GO

Sequence cautioni

The sequence BAC32752.1 differs from that shown. Reason: Frameshift at position 658. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 7272Missing in isoform 2. 1 PublicationVSP_021883Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012971 mRNA. Translation: BAB28575.1.
AK046486 mRNA. Translation: BAC32752.1. Frameshift.
AK154885 mRNA. Translation: BAE32902.1.
BC067049 mRNA. Translation: AAH67049.1.
CCDSiCCDS28217.1. [Q9CZ62-1]
RefSeqiNP_001152836.1. NM_001159364.1.
NP_001152837.1. NM_001159365.1.
NP_001152838.1. NM_001159366.1.
NP_083091.1. NM_028815.4. [Q9CZ62-1]
UniGeneiMm.178427.

Genome annotation databases

EnsembliENSMUST00000023270; ENSMUSP00000023270; ENSMUSG00000022604. [Q9CZ62-1]
ENSMUST00000117468; ENSMUSP00000112687; ENSMUSG00000022604. [Q9CZ62-2]
ENSMUST00000118500; ENSMUSP00000112663; ENSMUSG00000022604. [Q9CZ62-2]
GeneIDi74201.
KEGGimmu:74201.
UCSCiuc007zlr.2. mouse. [Q9CZ62-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012971 mRNA. Translation: BAB28575.1.
AK046486 mRNA. Translation: BAC32752.1. Frameshift.
AK154885 mRNA. Translation: BAE32902.1.
BC067049 mRNA. Translation: AAH67049.1.
CCDSiCCDS28217.1. [Q9CZ62-1]
RefSeqiNP_001152836.1. NM_001159364.1.
NP_001152837.1. NM_001159365.1.
NP_001152838.1. NM_001159366.1.
NP_083091.1. NM_028815.4. [Q9CZ62-1]
UniGeneiMm.178427.

3D structure databases

ProteinModelPortaliQ9CZ62.
SMRiQ9CZ62. Positions 41-250, 549-574.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216572. 1 interaction.
IntActiQ9CZ62. 2 interactions.
STRINGi10090.ENSMUSP00000023270.

PTM databases

PhosphoSiteiQ9CZ62.

Proteomic databases

EPDiQ9CZ62.
MaxQBiQ9CZ62.
PaxDbiQ9CZ62.
PRIDEiQ9CZ62.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023270; ENSMUSP00000023270; ENSMUSG00000022604. [Q9CZ62-1]
ENSMUST00000117468; ENSMUSP00000112687; ENSMUSG00000022604. [Q9CZ62-2]
ENSMUST00000118500; ENSMUSP00000112663; ENSMUSG00000022604. [Q9CZ62-2]
GeneIDi74201.
KEGGimmu:74201.
UCSCiuc007zlr.2. mouse. [Q9CZ62-1]

Organism-specific databases

CTDi79598.
MGIiMGI:1921451. Cep97.

Phylogenomic databases

eggNOGiKOG0531. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00830000128399.
HOGENOMiHOG000111550.
HOVERGENiHBG061575.
InParanoidiQ9CZ62.
KOiK16717.
OMAiKEVRYEI.
OrthoDBiEOG7PGDQ1.
PhylomeDBiQ9CZ62.
TreeFamiTF320816.

Enzyme and pathway databases

ReactomeiR-MMU-5620912. Anchoring of the basal body to the plasma membrane.

Miscellaneous databases

ChiTaRSiCep97. mouse.
NextBioi340090.
PROiQ9CZ62.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CZ62.
CleanExiMM_CEP97.
ExpressionAtlasiQ9CZ62. baseline and differential.
GenevisibleiQ9CZ62. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J and NOD.
    Tissue: Corpora quadrigemina.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-521, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Testis.

Entry informationi

Entry nameiCEP97_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ62
Secondary accession number(s): Q8BL35
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.