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Protein

Anthrax toxin receptor 1

Gene

Antxr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi50 – 501Divalent metal cationBy similarity
Metal bindingi52 – 521Divalent metal cationBy similarity
Metal bindingi116 – 1161Divalent metal cationBy similarity

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton reorganization Source: UniProtKB
  • blood vessel development Source: MGI
  • negative regulation of extracellular matrix assembly Source: MGI
  • positive regulation of metallopeptidase activity Source: MGI
  • reproductive process Source: MGI
  • substrate adhesion-dependent cell spreading Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anthrax toxin receptor 1
Alternative name(s):
Tumor endothelial marker 8
Gene namesi
Name:Antxr1
Synonyms:Atr, Tem8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1916788. Antxr1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 319289ExtracellularSequence analysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence analysisAdd
BLAST
Topological domaini341 – 562222CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 562532Anthrax toxin receptor 1PRO_0000002693Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 218By similarity
Glycosylationi164 – 1641N-linked (GlcNAc...)Sequence analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence analysis
Glycosylationi260 – 2601N-linked (GlcNAc...)Sequence analysis
Modified residuei360 – 3601PhosphoserineCombined sources

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ9CZ52.
PaxDbiQ9CZ52.
PeptideAtlasiQ9CZ52.
PRIDEiQ9CZ52.

PTM databases

iPTMnetiQ9CZ52.
PhosphoSiteiQ9CZ52.
SwissPalmiQ9CZ52.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033420.
CleanExiMM_ANTXR1.
MM_ATR.
ExpressionAtlasiQ9CZ52. baseline and differential.
GenevisibleiQ9CZ52. MM.

Interactioni

Subunit structurei

Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045634.

Structurei

3D structure databases

ProteinModelPortaliQ9CZ52.
SMRiQ9CZ52. Positions 36-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini42 – 213172VWFAPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni152 – 1587Interaction with PABy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi358 – 3669Asp/Glu-rich (highly acidic)
Compositional biasi501 – 56262Pro-richAdd
BLAST

Domaini

Binding to PA occurs through the VWA domain.By similarity

Sequence similaritiesi

Belongs to the ATR family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1W. Eukaryota.
ENOG410YC57. LUCA.
GeneTreeiENSGT00430000031214.
HOGENOMiHOG000264249.
HOVERGENiHBG050514.
InParanoidiQ9CZ52.
OMAiFTVEDTY.
OrthoDBiEOG091G08TW.
PhylomeDBiQ9CZ52.
TreeFamiTF328943.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR017360. Anthrax_toxin_rcpt.
IPR008399. Anthrax_toxin_rcpt_C.
IPR008400. Anthrax_toxin_rcpt_extracel.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05586. Ant_C. 1 hit.
PF05587. Anth_Ig. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFiPIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDomiPD377005. Anthrax_toxin_rcpt_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CZ52-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDRAGRLGAG LRGLCVAALV LVCAGHGGRR EDGGPACYGG FDLYFILDKS
60 70 80 90 100
GSVLHHWNEI YYFVEQLAHR FISPQLRMSF IVFSTRGTTL MKLTEDREQI
110 120 130 140 150
RQGLEELQKV LPGGDTYMHE GFERASEQIY YENSQGYRTA SVIIALTDGE
160 170 180 190 200
LHEDLFFYSE REANRSRDLG AIVYCVGVKD FNETQLARIA DSKDHVFPVN
210 220 230 240 250
DGFQALQGII HSILKKSCIE ILAAEPSTIC AGESFQVVVR GNGFRHARNV
260 270 280 290 300
DRVLCSFKIN DSVTLNEKPF AVEDTYLLCP APILKEVGMK AALQVSMNDG
310 320 330 340 350
LSFISSSVII TTTHCSDGSI LAIALLVLFL LLALALLWWF WPLCCTVIIK
360 370 380 390 400
EVPPPPVEES EEEDDDGLPK KKWPTVDASY YGGRGVGGIK RMEVRWGEKG
410 420 430 440 450
STEEGAKLEK AKNARVKMPE QEYEFPEPRN LNNNMRRPSS PRKWYSPIKG
460 470 480 490 500
KLDALWVLLR KGYDRVSVMR PQPGDTGRCI NFTRVKNSQP AKYPLNNTYH
510 520 530 540 550
PSSPPPAPIY TPPPPAPHCP PPAPSAPTPP IPSPPSTLPP PPQAPPPNRA
560
PPPSRPPPRP SV
Length:562
Mass (Da):62,308
Last modified:November 2, 2001 - v2
Checksum:i6AC92049B4BB4F7C
GO
Isoform 2 (identifier: Q9CZ52-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-562: GRCINFTRVK...PSRPPPRPSV → RFRGWRLTIC...FSSFLERAFQ

Note: No experimental confirmation available.
Show »
Length:521
Mass (Da):58,615
Checksum:i95FC613140B6B790
GO

Sequence cautioni

The sequence BAB28591 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei477 – 56286GRCIN…PRPSV → RFRGWRLTICLGSKHVHPGR HDKGPETPLLKQAWMFSSFL ERAFQ in isoform 2. 1 PublicationVSP_000450Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378762 mRNA. Translation: AAL11999.1.
BC094544 mRNA. Translation: AAH94544.1.
AK013005 mRNA. Translation: BAB28591.1. Different initiation.
CCDSiCCDS20318.1. [Q9CZ52-1]
RefSeqiNP_473382.1. NM_054041.2. [Q9CZ52-1]
UniGeneiMm.232525.

Genome annotation databases

EnsembliENSMUST00000042025; ENSMUSP00000045634; ENSMUSG00000033420. [Q9CZ52-1]
ENSMUST00000204805; ENSMUSP00000145105; ENSMUSG00000033420. [Q9CZ52-2]
GeneIDi69538.
KEGGimmu:69538.
UCSCiuc009cte.1. mouse. [Q9CZ52-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF378762 mRNA. Translation: AAL11999.1.
BC094544 mRNA. Translation: AAH94544.1.
AK013005 mRNA. Translation: BAB28591.1. Different initiation.
CCDSiCCDS20318.1. [Q9CZ52-1]
RefSeqiNP_473382.1. NM_054041.2. [Q9CZ52-1]
UniGeneiMm.232525.

3D structure databases

ProteinModelPortaliQ9CZ52.
SMRiQ9CZ52. Positions 36-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045634.

PTM databases

iPTMnetiQ9CZ52.
PhosphoSiteiQ9CZ52.
SwissPalmiQ9CZ52.

Proteomic databases

MaxQBiQ9CZ52.
PaxDbiQ9CZ52.
PeptideAtlasiQ9CZ52.
PRIDEiQ9CZ52.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042025; ENSMUSP00000045634; ENSMUSG00000033420. [Q9CZ52-1]
ENSMUST00000204805; ENSMUSP00000145105; ENSMUSG00000033420. [Q9CZ52-2]
GeneIDi69538.
KEGGimmu:69538.
UCSCiuc009cte.1. mouse. [Q9CZ52-1]

Organism-specific databases

CTDi84168.
MGIiMGI:1916788. Antxr1.

Phylogenomic databases

eggNOGiENOG410IK1W. Eukaryota.
ENOG410YC57. LUCA.
GeneTreeiENSGT00430000031214.
HOGENOMiHOG000264249.
HOVERGENiHBG050514.
InParanoidiQ9CZ52.
OMAiFTVEDTY.
OrthoDBiEOG091G08TW.
PhylomeDBiQ9CZ52.
TreeFamiTF328943.

Miscellaneous databases

ChiTaRSiAntxr1. mouse.
PROiQ9CZ52.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033420.
CleanExiMM_ANTXR1.
MM_ATR.
ExpressionAtlasiQ9CZ52. baseline and differential.
GenevisibleiQ9CZ52. MM.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR017360. Anthrax_toxin_rcpt.
IPR008399. Anthrax_toxin_rcpt_C.
IPR008400. Anthrax_toxin_rcpt_extracel.
IPR002035. VWF_A.
[Graphical view]
PfamiPF05586. Ant_C. 1 hit.
PF05587. Anth_Ig. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PIRSFiPIRSF038023. Anthrax_toxin_receptor_2. 1 hit.
ProDomiPD377005. Anthrax_toxin_rcpt_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANTR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ52
Secondary accession number(s): Q505H2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 2, 2001
Last modified: September 7, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.