Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Obg-like ATPase 1

Gene

Ola1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.UniRule annotation

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi36MagnesiumBy similarity1
Metal bindingi56MagnesiumBy similarity1
Binding sitei231ATP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi32 – 37ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Obg-like ATPase 1UniRule annotation
Alternative name(s):
GTP-binding protein 9
Gene namesi
Name:Ola1
Synonyms:Gtpbp9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1914309 Ola1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224571 – 396Obg-like ATPase 1Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei294N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9CZ30
PaxDbiQ9CZ30
PeptideAtlasiQ9CZ30
PRIDEiQ9CZ30

2D gel databases

REPRODUCTION-2DPAGEIPI00227836

PTM databases

iPTMnetiQ9CZ30
PhosphoSitePlusiQ9CZ30
SwissPalmiQ9CZ30

Expressioni

Gene expression databases

BgeeiENSMUSG00000027108
CleanExiMM_OLA1
ExpressionAtlasiQ9CZ30 baseline and differential
GenevisibleiQ9CZ30 MM

Interactioni

Subunit structurei

Monomer.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211910, 3 interactors
IntActiQ9CZ30, 3 interactors
MINTiQ9CZ30
STRINGi10090.ENSMUSP00000028517

Structurei

3D structure databases

ProteinModelPortaliQ9CZ30
SMRiQ9CZ30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 283OBG-type GAdd BLAST261

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi267 – 274Nuclear export signalUniRule annotation8

Sequence similaritiesi

Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1491 Eukaryota
COG0012 LUCA
GeneTreeiENSGT00390000000673
HOVERGENiHBG031861
InParanoidiQ9CZ30
KOiK19788
OMAiHKDFEKG
OrthoDBiEOG091G07UD
PhylomeDBiQ9CZ30
TreeFamiTF300774

Family and domain databases

Gene3Di1.10.150.300, 1 hit
3.10.20.30, 2 hits
HAMAPiMF_00944 YchF_OLA1_ATPase, 1 hit
InterProiView protein in InterPro
IPR004396 ATPase_YchF/OLA1
IPR012675 Beta-grasp_dom_sf
IPR031167 G_OBG
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
IPR012676 TGS-like
IPR023192 TGS-like_dom_sf
IPR013029 YchF_C
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
PF06071 YchF-GTPase_C, 1 hit
PIRSFiPIRSF006641 CHP00092, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF81271 SSF81271, 1 hit
TIGRFAMsiTIGR00092 TIGR00092, 1 hit
PROSITEiView protein in PROSITE
PS51710 G_OBG, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CZ30-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPPKKGGDGI KPPPIIGRFG TSLKIGIVGL PNVGKSTFFN VLTNSQASAE
60 70 80 90 100
NFPFCTIDPN ESRVPVPDER FDFLCQYHKP ASKIPAFLNV VDIAGLVKGA
110 120 130 140 150
HNGQGLGNAF LSHISACDGI FHLTRAFEDD DITHVEGSVD PIRDIEIIHE
160 170 180 190 200
ELQLKDEEMI GPILDKLEKV AVRGGDKKLK PEYDIMCKVK SWVIDQKKPV
210 220 230 240 250
RFYHDWNDKE IEVLNKHLFL TSKPMVYLVN LSEKDYIRKK NKWLIKIKEW
260 270 280 290 300
VDKYDPGALV IPFSGALELK LQELSAEERQ KYLEANMTQS ALPKIIKAGF
310 320 330 340 350
AALQLEYFFT AGPDEVRAWT IRKGTKAPQA AGKIHTDFEK GFIMAEVMKY
360 370 380 390
EDFKDEGSEN AVKAAGKYRQ QGRNYIVEDG DIIFFKFNTP QQPKKK
Length:396
Mass (Da):44,730
Last modified:June 1, 2001 - v1
Checksum:iCBBC54481E9B20CB
GO
Isoform 2 (identifier: Q9CZ30-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-270: WLIKIKEWVDKYDPGALVIPFSGALELK → CNFKFLSSGDGILVHIMRTMIIEVYLSL
     271-396: Missing.

Note: No experimental confirmation available.
Show »
Length:270
Mass (Da):30,376
Checksum:i266F143D1FAFC8FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti122H → Y in BAB31566 (PubMed:16141072).Curated1
Sequence conflicti358S → Y in BAB27201 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002054243 – 270WLIKI…ALELK → CNFKFLSSGDGILVHIMRTM IIEVYLSL in isoform 2. 1 PublicationAdd BLAST28
Alternative sequenceiVSP_002055271 – 396Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010817 mRNA Translation: BAB27201.1
AK013055 mRNA Translation: BAB28624.1
AK017803 mRNA No translation available.
AK019142 mRNA Translation: BAB31566.1
BX284615, AL928608 Genomic DNA Translation: CAM17550.1
BX284615, AL928608 Genomic DNA Translation: CAM17551.1
AL928608, BX284615 Genomic DNA Translation: CAM19352.1
AL928608, BX284615 Genomic DNA Translation: CAM19354.1
BC011318 mRNA Translation: AAH11318.1
BC029207 mRNA Translation: AAH29207.1
CCDSiCCDS16124.1 [Q9CZ30-1]
CCDS16125.1 [Q9CZ30-2]
RefSeqiNP_080218.1, NM_025942.2 [Q9CZ30-1]
NP_084367.1, NM_030091.1 [Q9CZ30-2]
UniGeneiMm.22661

Genome annotation databases

EnsembliENSMUST00000028517; ENSMUSP00000028517; ENSMUSG00000027108 [Q9CZ30-1]
ENSMUST00000100015; ENSMUSP00000097592; ENSMUSG00000027108 [Q9CZ30-2]
GeneIDi67059
KEGGimmu:67059
UCSCiuc008kcg.1 mouse [Q9CZ30-1]
uc008kch.1 mouse [Q9CZ30-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiOLA1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ30
Secondary accession number(s): B1AYJ8
, B1AYK0, Q9CWE2, Q9CX91, Q9CYC9, Q9CZ56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health