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Protein

DNA replication complex GINS protein PSF1

Gene

Gins1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: MGI
  • DNA strand elongation involved in mitotic DNA replication Source: GO_Central
  • inner cell mass cell proliferation Source: MGI

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176974 Unwinding of DNA

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF1
Alternative name(s):
GINS complex subunit 1
Gene namesi
Name:Gins1
Synonyms:Psf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916520 Gins1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190361 – 196DNA replication complex GINS protein PSF1Add BLAST196

Proteomic databases

EPDiQ9CZ15
MaxQBiQ9CZ15
PaxDbiQ9CZ15
PeptideAtlasiQ9CZ15
PRIDEiQ9CZ15

PTM databases

iPTMnetiQ9CZ15
PhosphoSitePlusiQ9CZ15

Expressioni

Gene expression databases

BgeeiENSMUSG00000027454
CleanExiMM_GINS1
GenevisibleiQ9CZ15 MM

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

BioGridi213326, 1 interactor
STRINGi10090.ENSMUSP00000028948

Structurei

3D structure databases

ProteinModelPortaliQ9CZ15
SMRiQ9CZ15
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS1/PSF1 family.Curated

Phylogenomic databases

eggNOGiKOG3303 Eukaryota
COG5230 LUCA
GeneTreeiENSGT00390000013968
HOGENOMiHOG000192102
HOVERGENiHBG053743
InParanoidiQ9CZ15
KOiK10732
OMAiSMRRNKR
OrthoDBiEOG091G0M3U
PhylomeDBiQ9CZ15
TreeFamiTF312848

Family and domain databases

CDDicd11710 GINS_A_psf1, 1 hit
InterProiView protein in InterPro
IPR036224 GINS_bundle-like_dom_sf
IPR005339 GINS_Psf1
PANTHERiPTHR12914 PTHR12914, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CZ15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCEKAMELV RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA
60 70 80 90 100
KSAGRGDLIP TVKFRHCALL RNRRCTIAYL YDRLLRIRAL RWEYGSVLPN
110 120 130 140 150
SLRFHMSAEE TEWFNHYKKS LATYMRSLGG DEGLDITQDV KPPKSLYIEV
160 170 180 190
RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW KCEQLIRQGV LEHVLS
Length:196
Mass (Da):22,893
Last modified:June 1, 2001 - v1
Checksum:iEDA492802EDDEE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013116 mRNA Translation: BAB28658.1
CCDSiCCDS50743.1
RefSeqiNP_081290.1, NM_027014.1
UniGeneiMm.271603

Genome annotation databases

EnsembliENSMUST00000028948; ENSMUSP00000028948; ENSMUSG00000027454
GeneIDi69270
KEGGimmu:69270
UCSCiuc008mus.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPSF1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health