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Protein

DNA replication complex GINS protein PSF1

Gene

Gins1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. GINS1 is essential for function (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: MGI
  • DNA strand elongation involved in mitotic DNA replication Source: GO_Central
  • inner cell mass cell proliferation Source: MGI
Complete GO annotation...

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176974. Unwinding of DNA.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF1
Alternative name(s):
GINS complex subunit 1
Gene namesi
Name:Gins1
Synonyms:Psf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1916520. Gins1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • GINS complex Source: GO_Central
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196DNA replication complex GINS protein PSF1PRO_0000219036Add
BLAST

Proteomic databases

EPDiQ9CZ15.
MaxQBiQ9CZ15.
PaxDbiQ9CZ15.
PeptideAtlasiQ9CZ15.
PRIDEiQ9CZ15.

PTM databases

iPTMnetiQ9CZ15.
PhosphoSiteiQ9CZ15.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027454.
CleanExiMM_GINS1.
GenevisibleiQ9CZ15. MM.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

BioGridi213326. 1 interaction.
STRINGi10090.ENSMUSP00000028948.

Structurei

3D structure databases

ProteinModelPortaliQ9CZ15.
SMRiQ9CZ15. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GINS1/PSF1 family.Curated

Phylogenomic databases

eggNOGiKOG3303. Eukaryota.
COG5230. LUCA.
GeneTreeiENSGT00390000013968.
HOGENOMiHOG000192102.
HOVERGENiHBG053743.
InParanoidiQ9CZ15.
KOiK10732.
OMAiAYLYERC.
OrthoDBiEOG091G0M3U.
PhylomeDBiQ9CZ15.
TreeFamiTF312848.

Family and domain databases

CDDicd11710. GINS_A_psf1. 1 hit.
InterProiIPR005339. GINS_Psf1.
[Graphical view]
PANTHERiPTHR12914. PTHR12914. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CZ15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCEKAMELV RELHRAPEGQ LPAFNEDGLR QVLEEMKALY EQNQSDVNEA
60 70 80 90 100
KSAGRGDLIP TVKFRHCALL RNRRCTIAYL YDRLLRIRAL RWEYGSVLPN
110 120 130 140 150
SLRFHMSAEE TEWFNHYKKS LATYMRSLGG DEGLDITQDV KPPKSLYIEV
160 170 180 190
RCLKDYGEFE VDDGTSVLLK KNSQHFLPRW KCEQLIRQGV LEHVLS
Length:196
Mass (Da):22,893
Last modified:June 1, 2001 - v1
Checksum:iEDA492802EDDEE0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013116 mRNA. Translation: BAB28658.1.
CCDSiCCDS50743.1.
RefSeqiNP_081290.1. NM_027014.1.
UniGeneiMm.271603.

Genome annotation databases

EnsembliENSMUST00000028948; ENSMUSP00000028948; ENSMUSG00000027454.
GeneIDi69270.
KEGGimmu:69270.
UCSCiuc008mus.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013116 mRNA. Translation: BAB28658.1.
CCDSiCCDS50743.1.
RefSeqiNP_081290.1. NM_027014.1.
UniGeneiMm.271603.

3D structure databases

ProteinModelPortaliQ9CZ15.
SMRiQ9CZ15. Positions 1-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi213326. 1 interaction.
STRINGi10090.ENSMUSP00000028948.

PTM databases

iPTMnetiQ9CZ15.
PhosphoSiteiQ9CZ15.

Proteomic databases

EPDiQ9CZ15.
MaxQBiQ9CZ15.
PaxDbiQ9CZ15.
PeptideAtlasiQ9CZ15.
PRIDEiQ9CZ15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028948; ENSMUSP00000028948; ENSMUSG00000027454.
GeneIDi69270.
KEGGimmu:69270.
UCSCiuc008mus.2. mouse.

Organism-specific databases

CTDi9837.
MGIiMGI:1916520. Gins1.

Phylogenomic databases

eggNOGiKOG3303. Eukaryota.
COG5230. LUCA.
GeneTreeiENSGT00390000013968.
HOGENOMiHOG000192102.
HOVERGENiHBG053743.
InParanoidiQ9CZ15.
KOiK10732.
OMAiAYLYERC.
OrthoDBiEOG091G0M3U.
PhylomeDBiQ9CZ15.
TreeFamiTF312848.

Enzyme and pathway databases

ReactomeiR-MMU-176974. Unwinding of DNA.

Miscellaneous databases

PROiQ9CZ15.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027454.
CleanExiMM_GINS1.
GenevisibleiQ9CZ15. MM.

Family and domain databases

CDDicd11710. GINS_A_psf1. 1 hit.
InterProiIPR005339. GINS_Psf1.
[Graphical view]
PANTHERiPTHR12914. PTHR12914. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPSF1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.