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Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

Uqcrc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity).By similarity

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105 Respiratory electron transport

Protein family/group databases

MEROPSiM16.975

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:Uqcrc1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107876 Uqcrc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000002678735 – 480Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysineCombined sources1
Modified residuei138N6-acetyllysineCombined sources1
Modified residuei163N6-acetyllysine; alternateCombined sources1
Modified residuei163N6-succinyllysine; alternateCombined sources1
Modified residuei212PhosphoserineBy similarity1
Modified residuei214PhosphothreonineBy similarity1
Modified residuei248N6-acetyllysineCombined sources1

Post-translational modificationi

Acetylation of Lys-138 is observed in liver mitochondria from fasted mice but not from fed mice.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CZ13
MaxQBiQ9CZ13
PaxDbiQ9CZ13
PeptideAtlasiQ9CZ13
PRIDEiQ9CZ13
TopDownProteomicsiQ9CZ13

2D gel databases

REPRODUCTION-2DPAGEiIPI00111885
Q9CZ13
UCD-2DPAGEiQ9CZ13

PTM databases

iPTMnetiQ9CZ13
PhosphoSitePlusiQ9CZ13
SwissPalmiQ9CZ13

Expressioni

Gene expression databases

BgeeiENSMUSG00000025651
CleanExiMM_UQCRC1
ExpressionAtlasiQ9CZ13 baseline and differential
GenevisibleiQ9CZ13 MM

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2044595 interactors.
CORUMiQ9CZ13
IntActiQ9CZ13 12 interactors.
MINTiQ9CZ13
STRINGi10090.ENSMUSP00000026743

Structurei

3D structure databases

ProteinModelPortaliQ9CZ13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960 Eukaryota
COG0612 LUCA
GeneTreeiENSGT00550000074701
HOGENOMiHOG000242450
HOVERGENiHBG006393
InParanoidiQ9CZ13
KOiK00414
OMAiFFLQGQW
OrthoDBiEOG091G05W9
TreeFamiTF105032

Family and domain databases

InterProiView protein in InterPro
IPR011249 Metalloenz_LuxS/M16
IPR011765 Pept_M16_N
IPR007863 Peptidase_M16_C
PfamiView protein in Pfam
PF00675 Peptidase_M16, 1 hit
PF05193 Peptidase_M16_C, 1 hit
SUPFAMiSSF63411 SSF63411, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CZ13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASAVCRAA CSGTQVLLRT RRSPALLRLP ALRGTATFAQ ALQSVPETQV
60 70 80 90 100
SILDNGLRVA SEQSSHATCT VGVWIDAGSR YETEKNNGAG YFLEHLAFKG
110 120 130 140 150
TKNRPGNALE KEVESIGAHL NAYSTREHTA YLIKALSKDL PKVVELLADI
160 170 180 190 200
VQNSSLEDSQ IEKERDVILR EMQENDASMQ NVVFDYLHAT AFQGTPLAQA
210 220 230 240 250
VEGPSENVRR LSRTDLTDYL NRHYKAPRMV LAAAGGVEHQ QLLDLAQKHL
260 270 280 290 300
SSVSRVYEED AVPGLTPCRF TGSEIRHRDD ALPLAHVAIA VEGPGWANPD
310 320 330 340 350
NVTLQVANAI IGHYDCTYGG GVHLSSPLAS VAVANKLCQS FQTFNISYSD
360 370 380 390 400
TGLLGAHFVC DAMSIDDMVF FLQGQWMRLC TSATESEVTR GKNILRNALV
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIQEVDAQM LRDICSKYFY
460 470 480
DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF
Length:480
Mass (Da):52,852
Last modified:July 27, 2011 - v2
Checksum:i8150C97C655A91C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223H → N in BAB28666 (PubMed:16141072).Curated1
Sequence conflicti318Y → C in BAB28666 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013128 mRNA Translation: BAB28666.1
AK010553 mRNA Translation: BAB27022.1
AK151764 mRNA Translation: BAE30670.1
AK160337 mRNA Translation: BAE35744.1
CH466560 Genomic DNA Translation: EDL21324.1
CCDSiCCDS23540.1
RefSeqiNP_079683.2, NM_025407.2
UniGeneiMm.335460

Genome annotation databases

EnsembliENSMUST00000026743; ENSMUSP00000026743; ENSMUSG00000025651
ENSMUST00000202750; ENSMUSP00000144124; ENSMUSG00000107235
GeneIDi22273
KEGGimmu:22273
UCSCiuc009rrg.1 mouse

Similar proteinsi

Entry informationi

Entry nameiQCR1_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ13
Secondary accession number(s): Q3TV75, Q9CWL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome