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Protein

Histidine protein methyltransferase 1 homolog

Gene

Mettl18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable histidine methyltransferase.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 homolog
Alternative name(s):
Methyltransferase-like protein 18 (EC:2.1.1.-)
Gene namesi
Name:Mettl18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917212 Mettl18

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472001 – 362Histidine protein methyltransferase 1 homologAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZ09
MaxQBiQ9CZ09
PaxDbiQ9CZ09
PRIDEiQ9CZ09

PTM databases

iPTMnetiQ9CZ09
PhosphoSitePlusiQ9CZ09

Expressioni

Gene expression databases

BgeeiENSMUSG00000041396
CleanExiMM_2810422O20RIK
GenevisibleiQ9CZ09 MM

Interactioni

Subunit structurei

Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048636

Structurei

3D structure databases

ProteinModelPortaliQ9CZ09
SMRiQ9CZ09
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2920 Eukaryota
ENOG4111NE8 LUCA
GeneTreeiENSGT00390000000464
HOVERGENiHBG053309
InParanoidiQ9CZ09
OMAiEWSEFCK
OrthoDBiEOG091G0J2W
PhylomeDBiQ9CZ09
TreeFamiTF320884

Family and domain databases

InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 3 hits

Sequencei

Sequence statusi: Complete.

Q9CZ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQFNFSIE EDLENKLTSL DDGTCVLESQ KGKQDKRQST ERPGLPRDHS
60 70 80 90 100
WKCSSLGNAA SSEDTGSPPP IADRSDDPEA CKHQPSWKPA KEHVMPKDVN
110 120 130 140 150
HVLENTVLEM LPGPQHANTA VVKTVSLKEK FPGENIVSKS FSSHSDLIPG
160 170 180 190 200
VYEGGLKIWE CTFDLLTYFT KAKVKFAGQK VLDLGCGSGL LGITASKGGA
210 220 230 240 250
REVHFQDYNG LVIDEVTLPN VVANVPLQDD SNGKNEPDGK RQRKSEVGRE
260 270 280 290 300
ICKCRLFSGE WAEFCKLVLR EKLFVKYDLI LTSETIYNPD YYSTLHETFL
310 320 330 340 350
RLLSRSGRVL LASKAHYFGV GGGVHLFQKF VEEKGVFETR TLEVIDEGLK
360
RFLMEMTFKH PS
Length:362
Mass (Da):40,448
Last modified:July 25, 2006 - v2
Checksum:i9D291A856E631CC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233G → S in BAB28672 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013137 mRNA Translation: BAB28672.1
AK139786 mRNA Translation: BAE24137.1
BC050143 mRNA Translation: AAH50143.1
BC052693 mRNA Translation: AAH52693.1
CCDSiCCDS15431.1
RefSeqiNP_081555.2, NM_027279.2
XP_006497046.1, XM_006496983.2
UniGeneiMm.27284

Genome annotation databases

EnsembliENSMUST00000045694; ENSMUSP00000048636; ENSMUSG00000041396
ENSMUST00000111490; ENSMUSP00000107116; ENSMUSG00000041396
GeneIDi69962
KEGGimmu:69962
UCSCiuc007dhv.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMET18_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ09
Secondary accession number(s): Q810I8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 23, 2018
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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