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Protein

Histidine protein methyltransferase 1 homolog

Gene

Mettl18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable histidine methyltransferase.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histidine protein methyltransferase 1 homolog
Alternative name(s):
Methyltransferase-like protein 18 (EC:2.1.1.-)
Gene namesi
Name:Mettl18
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1917212. Mettl18.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472001 – 362Histidine protein methyltransferase 1 homologAdd BLAST362

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei67PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CZ09.
MaxQBiQ9CZ09.
PaxDbiQ9CZ09.
PRIDEiQ9CZ09.

PTM databases

PhosphoSitePlusiQ9CZ09.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041396.
CleanExiMM_2810422O20RIK.
GenevisibleiQ9CZ09. MM.

Interactioni

Subunit structurei

Interacts with GRWD1, RPL3 and members of the heat shock protein 90 and 70 families; these proteins may possibly be methylation substrates for the enzyme.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048636.

Structurei

3D structure databases

ProteinModelPortaliQ9CZ09.
SMRiQ9CZ09.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2920. Eukaryota.
ENOG4111NE8. LUCA.
GeneTreeiENSGT00390000000464.
HOVERGENiHBG053309.
InParanoidiQ9CZ09.
OMAiEWSEFCK.
OrthoDBiEOG091G0J2W.
PhylomeDBiQ9CZ09.
TreeFamiTF320884.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9CZ09-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFQFNFSIE EDLENKLTSL DDGTCVLESQ KGKQDKRQST ERPGLPRDHS
60 70 80 90 100
WKCSSLGNAA SSEDTGSPPP IADRSDDPEA CKHQPSWKPA KEHVMPKDVN
110 120 130 140 150
HVLENTVLEM LPGPQHANTA VVKTVSLKEK FPGENIVSKS FSSHSDLIPG
160 170 180 190 200
VYEGGLKIWE CTFDLLTYFT KAKVKFAGQK VLDLGCGSGL LGITASKGGA
210 220 230 240 250
REVHFQDYNG LVIDEVTLPN VVANVPLQDD SNGKNEPDGK RQRKSEVGRE
260 270 280 290 300
ICKCRLFSGE WAEFCKLVLR EKLFVKYDLI LTSETIYNPD YYSTLHETFL
310 320 330 340 350
RLLSRSGRVL LASKAHYFGV GGGVHLFQKF VEEKGVFETR TLEVIDEGLK
360
RFLMEMTFKH PS
Length:362
Mass (Da):40,448
Last modified:July 25, 2006 - v2
Checksum:i9D291A856E631CC1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti233G → S in BAB28672 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013137 mRNA. Translation: BAB28672.1.
AK139786 mRNA. Translation: BAE24137.1.
BC050143 mRNA. Translation: AAH50143.1.
BC052693 mRNA. Translation: AAH52693.1.
CCDSiCCDS15431.1.
RefSeqiNP_081555.2. NM_027279.2.
XP_006497046.1. XM_006496983.2.
UniGeneiMm.27284.

Genome annotation databases

EnsembliENSMUST00000045694; ENSMUSP00000048636; ENSMUSG00000041396.
ENSMUST00000111490; ENSMUSP00000107116; ENSMUSG00000041396.
GeneIDi69962.
KEGGimmu:69962.
UCSCiuc007dhv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013137 mRNA. Translation: BAB28672.1.
AK139786 mRNA. Translation: BAE24137.1.
BC050143 mRNA. Translation: AAH50143.1.
BC052693 mRNA. Translation: AAH52693.1.
CCDSiCCDS15431.1.
RefSeqiNP_081555.2. NM_027279.2.
XP_006497046.1. XM_006496983.2.
UniGeneiMm.27284.

3D structure databases

ProteinModelPortaliQ9CZ09.
SMRiQ9CZ09.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048636.

PTM databases

PhosphoSitePlusiQ9CZ09.

Proteomic databases

EPDiQ9CZ09.
MaxQBiQ9CZ09.
PaxDbiQ9CZ09.
PRIDEiQ9CZ09.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045694; ENSMUSP00000048636; ENSMUSG00000041396.
ENSMUST00000111490; ENSMUSP00000107116; ENSMUSG00000041396.
GeneIDi69962.
KEGGimmu:69962.
UCSCiuc007dhv.2. mouse.

Organism-specific databases

CTDi92342.
MGIiMGI:1917212. Mettl18.

Phylogenomic databases

eggNOGiKOG2920. Eukaryota.
ENOG4111NE8. LUCA.
GeneTreeiENSGT00390000000464.
HOVERGENiHBG053309.
InParanoidiQ9CZ09.
OMAiEWSEFCK.
OrthoDBiEOG091G0J2W.
PhylomeDBiQ9CZ09.
TreeFamiTF320884.

Miscellaneous databases

PROiQ9CZ09.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041396.
CleanExiMM_2810422O20RIK.
GenevisibleiQ9CZ09. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR029063. SAM-dependent_MTases.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMET18_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ09
Secondary accession number(s): Q810I8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: November 2, 2016
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.