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Protein

COP9 signalosome complex subunit 7a

Gene

Cops7a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity).By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-5696394 DNA Damage Recognition in GG-NER
R-MMU-6781823 Formation of TC-NER Pre-Incision Complex
R-MMU-8856825 Cargo recognition for clathrin-mediated endocytosis
R-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COP9 signalosome complex subunit 7a
Short name:
SGN7a
Short name:
Signalosome subunit 7a
Alternative name(s):
JAB1-containing signalosome subunit 7a
Gene namesi
Name:Cops7a
Synonyms:Csn7a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1349400 Cops7a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Signalosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001209972 – 275COP9 signalosome complex subunit 7aAdd BLAST274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Post-translational modificationi

Phosphorylated by CK2 and PKD kinases.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CZ04
PaxDbiQ9CZ04
PeptideAtlasiQ9CZ04
PRIDEiQ9CZ04

PTM databases

iPTMnetiQ9CZ04
PhosphoSitePlusiQ9CZ04
SwissPalmiQ9CZ04

Expressioni

Gene expression databases

BgeeiENSMUSG00000030127
ExpressionAtlasiQ9CZ04 baseline and differential
GenevisibleiQ9CZ04 MM

Interactioni

Subunit structurei

Component of the CSN complex, composed of COPS1/GPS1, COPS2, COPS3, COPS4, COPS5, COPS6, COPS7 (COPS7A or COPS7B), COPS8 and COPS9 (PubMed:9707402). In the complex, it probably interacts directly with COPS1, COPS2, COPS4, COPS5, COPS6 and COPS8. Interacts with PMF1. Interacts with the translation initiation factor EIF3S6. Interacts with CK2 and PKD (By similarity). Interacts directly with ID3 (PubMed:15451666).By similarity2 Publications

Protein-protein interaction databases

BioGridi205045, 5 interactors
CORUMiQ9CZ04
STRINGi10090.ENSMUSP00000108058

Structurei

3D structure databases

ProteinModelPortaliQ9CZ04
SMRiQ9CZ04
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 159PCIPROSITE-ProRule annotationAdd BLAST158

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili185 – 233Sequence analysisAdd BLAST49

Sequence similaritiesi

Belongs to the CSN7/EIF3M family. CSN7 subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3250 Eukaryota
ENOG410XP7W LUCA
GeneTreeiENSGT00390000013069
HOGENOMiHOG000006003
HOVERGENiHBG051138
InParanoidiQ9CZ04
KOiK12180
OMAiHNVRQLE
OrthoDBiEOG091G0I8H
PhylomeDBiQ9CZ04
TreeFamiTF101149

Family and domain databases

InterProiView protein in InterPro
IPR037757 COPS7A
IPR000717 PCI_dom
PANTHERiPTHR15350:SF7 PTHR15350:SF7, 1 hit
PfamiView protein in Pfam
PF01399 PCI, 1 hit
SMARTiView protein in SMART
SM00088 PINT, 1 hit
PROSITEiView protein in PROSITE
PS50250 PCI, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CZ04-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP
60 70 80 90 100
NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTD AQKNKLRHLS
110 120 130 140 150
VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ
160 170 180 190 200
RLEVDYSIGR DIQRQDLSAI AQTLQEWCVG CEVVLSGIEE QVSRANQHKE
210 220 230 240 250
QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPASGTN
260 270
QRQPSKKASK GKGLRGSAKI WSKSN
Length:275
Mass (Da):30,224
Last modified:November 23, 2004 - v2
Checksum:iB104C9FA318FDE24
GO
Isoform 2 (identifier: Q9CZ04-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-275: LRGSAKIWSKSN → EKINPQSTVKPSAK

Note: No experimental confirmation available.
Show »
Length:277
Mass (Da):30,405
Checksum:i5ACADFD2B0CB2E4A
GO

Sequence cautioni

The sequence AAK43736 differs from that shown. Reason: Frameshift at position 35.Curated
The sequence BAB27144 differs from that shown. Reason: Frameshift at position 1.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153E → K in BAB28682 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011912264 – 275LRGSA…WSKSN → EKINPQSTVKPSAK in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF071316 mRNA Translation: AAC33903.1
AK010726 mRNA Translation: BAB27144.1 Frameshift.
AK013155 mRNA Translation: BAB28682.1
AK019122 mRNA Translation: BAB31554.1
BC003724 mRNA Translation: AAH03724.1
AF240179 mRNA Translation: AAK43736.1 Frameshift.
CCDSiCCDS20539.1 [Q9CZ04-1]
CCDS51909.1 [Q9CZ04-2]
RefSeqiNP_001157561.1, NM_001164089.1 [Q9CZ04-2]
NP_036133.1, NM_012003.2 [Q9CZ04-1]
XP_006506222.1, XM_006506159.3 [Q9CZ04-2]
XP_006506223.1, XM_006506160.2 [Q9CZ04-2]
XP_006506224.1, XM_006506161.2 [Q9CZ04-2]
XP_006506225.1, XM_006506162.3
XP_011239667.1, XM_011241365.2 [Q9CZ04-1]
XP_017177082.1, XM_017321593.1
UniGeneiMm.244536

Genome annotation databases

EnsembliENSMUST00000032220; ENSMUSP00000032220; ENSMUSG00000030127 [Q9CZ04-1]
ENSMUST00000112439; ENSMUSP00000108058; ENSMUSG00000030127 [Q9CZ04-2]
GeneIDi26894
KEGGimmu:26894
UCSCiuc009dsr.2 mouse [Q9CZ04-2]
uc009dss.2 mouse [Q9CZ04-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCSN7A_MOUSE
AccessioniPrimary (citable) accession number: Q9CZ04
Secondary accession number(s): O88546
, Q925R8, Q9CPQ4, Q9CWD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 23, 2004
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health