Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9CYZ8

- SSBP2_MOUSE

UniProt

Q9CYZ8 - SSBP2_MOUSE

Protein

Single-stranded DNA-binding protein 2

Gene

Ssbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. single-stranded DNA binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Single-stranded DNA-binding protein 2
    Alternative name(s):
    Sequence-specific single-stranded-DNA-binding protein 2
    Gene namesi
    Name:Ssbp2
    Synonyms:Ssdp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1914220. Ssbp2.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 361361Single-stranded DNA-binding protein 2PRO_0000123827Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei6 – 61N6-acetyllysine1 Publication
    Modified residuei321 – 3211PhosphoserineBy similarity
    Modified residuei333 – 3331PhosphothreonineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    PaxDbiQ9CYZ8.
    PRIDEiQ9CYZ8.

    PTM databases

    PhosphoSiteiQ9CYZ8.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9CYZ8.
    BgeeiQ9CYZ8.
    CleanExiMM_SSBP2.
    GenevestigatoriQ9CYZ8.

    Interactioni

    Protein-protein interaction databases

    BioGridi211844. 18 interactions.
    IntActiQ9CYZ8. 3 interactions.
    MINTiMINT-2568100.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CYZ8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini18 – 5033LisHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi100 – 293194Pro-richAdd
    BLAST
    Compositional biasi147 – 312166Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 LisH domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG245801.
    GeneTreeiENSGT00390000009187.
    HOGENOMiHOG000037785.
    HOVERGENiHBG068487.
    InParanoidiQ9CYZ8.
    OMAiWQPNASA.
    OrthoDBiEOG7V4B0F.
    PhylomeDBiQ9CYZ8.
    TreeFamiTF318961.

    Family and domain databases

    InterProiIPR006594. LisH_dimerisation.
    IPR008116. SSDP_DNA-bd.
    [Graphical view]
    PRINTSiPR01743. SSDNABINDING.
    SMARTiSM00667. LisH. 1 hit.
    [Graphical view]
    PROSITEiPS50896. LISH. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9CYZ8-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK    50
    NITLGEPPGF LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP 100
    SPVLGNMPPG DGMPVGPVPP GFFQPFMSPR YPGGPRPPLR IPNQALGGVP 150
    GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL 200
    NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP 250
    GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM 300
    ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS 350
    ESYSPSMTMS V 361
    Length:361
    Mass (Da):37,846
    Last modified:June 1, 2001 - v1
    Checksum:iEC6F98DCEBFF662E
    GO
    Isoform 2 (identifier: Q9CYZ8-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         95-124: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:331
    Mass (Da):35,000
    Checksum:i3496A6875143F773
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei95 – 12430Missing in isoform 2. 1 PublicationVSP_006259Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037837 mRNA. Translation: AAK71881.1.
    AK013177 mRNA. Translation: BAB28693.1.
    CT009700, AC154320 Genomic DNA. Translation: CAO77907.1.
    BC002176 mRNA. Translation: AAH02176.1.
    CCDSiCCDS26676.1. [Q9CYZ8-2]
    CCDS26677.1. [Q9CYZ8-1]
    RefSeqiNP_077148.1. NM_024186.5. [Q9CYZ8-2]
    NP_077234.2. NM_024272.4. [Q9CYZ8-1]
    UniGeneiMm.343095.

    Genome annotation databases

    EnsembliENSMUST00000004094; ENSMUSP00000004094; ENSMUSG00000003992. [Q9CYZ8-1]
    ENSMUST00000042122; ENSMUSP00000037115; ENSMUSG00000003992. [Q9CYZ8-2]
    GeneIDi66970.
    KEGGimmu:66970.
    UCSCiuc007rjv.2. mouse. [Q9CYZ8-1]
    uc007rjw.2. mouse. [Q9CYZ8-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY037837 mRNA. Translation: AAK71881.1 .
    AK013177 mRNA. Translation: BAB28693.1 .
    CT009700 , AC154320 Genomic DNA. Translation: CAO77907.1 .
    BC002176 mRNA. Translation: AAH02176.1 .
    CCDSi CCDS26676.1. [Q9CYZ8-2 ]
    CCDS26677.1. [Q9CYZ8-1 ]
    RefSeqi NP_077148.1. NM_024186.5. [Q9CYZ8-2 ]
    NP_077234.2. NM_024272.4. [Q9CYZ8-1 ]
    UniGenei Mm.343095.

    3D structure databases

    ProteinModelPortali Q9CYZ8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211844. 18 interactions.
    IntActi Q9CYZ8. 3 interactions.
    MINTi MINT-2568100.

    PTM databases

    PhosphoSitei Q9CYZ8.

    Proteomic databases

    PaxDbi Q9CYZ8.
    PRIDEi Q9CYZ8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004094 ; ENSMUSP00000004094 ; ENSMUSG00000003992 . [Q9CYZ8-1 ]
    ENSMUST00000042122 ; ENSMUSP00000037115 ; ENSMUSG00000003992 . [Q9CYZ8-2 ]
    GeneIDi 66970.
    KEGGi mmu:66970.
    UCSCi uc007rjv.2. mouse. [Q9CYZ8-1 ]
    uc007rjw.2. mouse. [Q9CYZ8-2 ]

    Organism-specific databases

    CTDi 23635.
    MGIi MGI:1914220. Ssbp2.

    Phylogenomic databases

    eggNOGi NOG245801.
    GeneTreei ENSGT00390000009187.
    HOGENOMi HOG000037785.
    HOVERGENi HBG068487.
    InParanoidi Q9CYZ8.
    OMAi WQPNASA.
    OrthoDBi EOG7V4B0F.
    PhylomeDBi Q9CYZ8.
    TreeFami TF318961.

    Miscellaneous databases

    ChiTaRSi SSBP2. mouse.
    NextBioi 323165.
    PROi Q9CYZ8.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9CYZ8.
    Bgeei Q9CYZ8.
    CleanExi MM_SSBP2.
    Genevestigatori Q9CYZ8.

    Family and domain databases

    InterProi IPR006594. LisH_dimerisation.
    IPR008116. SSDP_DNA-bd.
    [Graphical view ]
    PRINTSi PR01743. SSDNABINDING.
    SMARTi SM00667. LisH. 1 hit.
    [Graphical view ]
    PROSITEi PS50896. LISH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel member of the SSDP gene family, SSDP2, is expressed in deep layers during murine cortical development."
      Speer N., Tarabykin V., Britanova O., Lukyanov S., Gruss P.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: NMRI.
      Tissue: Brain cortex.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Embryo.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSSBP2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CYZ8
    Secondary accession number(s): B1B188, Q99LX9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2003
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3