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Q9CYZ8

- SSBP2_MOUSE

UniProt

Q9CYZ8 - SSBP2_MOUSE

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Protein

Single-stranded DNA-binding protein 2

Gene

Ssbp2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. single-stranded DNA binding Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Single-stranded DNA-binding protein 2
Alternative name(s):
Sequence-specific single-stranded-DNA-binding protein 2
Gene namesi
Name:Ssbp2
Synonyms:Ssdp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1914220. Ssbp2.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Single-stranded DNA-binding protein 2PRO_0000123827Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei6 – 61N6-acetyllysine1 Publication
Modified residuei321 – 3211PhosphoserineBy similarity
Modified residuei333 – 3331PhosphothreonineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CYZ8.
PaxDbiQ9CYZ8.
PRIDEiQ9CYZ8.

PTM databases

PhosphoSiteiQ9CYZ8.

Expressioni

Gene expression databases

BgeeiQ9CYZ8.
CleanExiMM_SSBP2.
ExpressionAtlasiQ9CYZ8. baseline and differential.
GenevestigatoriQ9CYZ8.

Interactioni

Protein-protein interaction databases

BioGridi211844. 18 interactions.
IntActiQ9CYZ8. 3 interactions.
MINTiMINT-2568100.

Structurei

3D structure databases

ProteinModelPortaliQ9CYZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini18 – 5033LisHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi100 – 293194Pro-richAdd
BLAST
Compositional biasi147 – 312166Gly-richAdd
BLAST

Sequence similaritiesi

Contains 1 LisH domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG245801.
GeneTreeiENSGT00390000009187.
HOGENOMiHOG000037785.
HOVERGENiHBG068487.
InParanoidiQ9CYZ8.
OMAiWQPNASA.
OrthoDBiEOG7V4B0F.
PhylomeDBiQ9CYZ8.
TreeFamiTF318961.

Family and domain databases

InterProiIPR006594. LisH_dimerisation.
IPR008116. SSDP_DNA-bd.
[Graphical view]
PRINTSiPR01743. SSDNABINDING.
SMARTiSM00667. LisH. 1 hit.
[Graphical view]
PROSITEiPS50896. LISH. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9CYZ8-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYGKGKSNSS AVPSDSQARE KLALYVYEYL LHVGAQKSAQ TFLSEIRWEK
60 70 80 90 100
NITLGEPPGF LHSWWCVFWD LYCAAPERRE TCEHSSEAKA FHDYSAAAAP
110 120 130 140 150
SPVLGNMPPG DGMPVGPVPP GFFQPFMSPR YPGGPRPPLR IPNQALGGVP
160 170 180 190 200
GSQPLLPSGM DPTRQQGHPN MGGPMQRMTP PRGMVPLGPQ NYGGAMRPPL
210 220 230 240 250
NALGGPGMPG MNMGPGGGRP WPNPTNANSI PYSSASPGNY VGPPGGGGPP
260 270 280 290 300
GTPIMPSPAD STNSGDNMYT LMNAVPPGPN RPNFPMGPGS DGPMGGLGGM
310 320 330 340 350
ESHHMNGSLG SGDMDSISKN SPNNMSLSNQ PGTPRDDGEM GGNFLNPFQS
360
ESYSPSMTMS V
Length:361
Mass (Da):37,846
Last modified:June 1, 2001 - v1
Checksum:iEC6F98DCEBFF662E
GO
Isoform 2 (identifier: Q9CYZ8-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-124: Missing.

Note: No experimental confirmation available.

Show »
Length:331
Mass (Da):35,000
Checksum:i3496A6875143F773
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei95 – 12430Missing in isoform 2. 1 PublicationVSP_006259Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037837 mRNA. Translation: AAK71881.1.
AK013177 mRNA. Translation: BAB28693.1.
CT009700, AC154320 Genomic DNA. Translation: CAO77907.1.
BC002176 mRNA. Translation: AAH02176.1.
CCDSiCCDS26676.1. [Q9CYZ8-2]
CCDS26677.1. [Q9CYZ8-1]
RefSeqiNP_077148.1. NM_024186.5. [Q9CYZ8-2]
NP_077234.2. NM_024272.4. [Q9CYZ8-1]
UniGeneiMm.343095.

Genome annotation databases

EnsembliENSMUST00000004094; ENSMUSP00000004094; ENSMUSG00000003992. [Q9CYZ8-1]
ENSMUST00000042122; ENSMUSP00000037115; ENSMUSG00000003992. [Q9CYZ8-2]
GeneIDi66970.
KEGGimmu:66970.
UCSCiuc007rjv.2. mouse. [Q9CYZ8-1]
uc007rjw.2. mouse. [Q9CYZ8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY037837 mRNA. Translation: AAK71881.1 .
AK013177 mRNA. Translation: BAB28693.1 .
CT009700 , AC154320 Genomic DNA. Translation: CAO77907.1 .
BC002176 mRNA. Translation: AAH02176.1 .
CCDSi CCDS26676.1. [Q9CYZ8-2 ]
CCDS26677.1. [Q9CYZ8-1 ]
RefSeqi NP_077148.1. NM_024186.5. [Q9CYZ8-2 ]
NP_077234.2. NM_024272.4. [Q9CYZ8-1 ]
UniGenei Mm.343095.

3D structure databases

ProteinModelPortali Q9CYZ8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211844. 18 interactions.
IntActi Q9CYZ8. 3 interactions.
MINTi MINT-2568100.

PTM databases

PhosphoSitei Q9CYZ8.

Proteomic databases

MaxQBi Q9CYZ8.
PaxDbi Q9CYZ8.
PRIDEi Q9CYZ8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004094 ; ENSMUSP00000004094 ; ENSMUSG00000003992 . [Q9CYZ8-1 ]
ENSMUST00000042122 ; ENSMUSP00000037115 ; ENSMUSG00000003992 . [Q9CYZ8-2 ]
GeneIDi 66970.
KEGGi mmu:66970.
UCSCi uc007rjv.2. mouse. [Q9CYZ8-1 ]
uc007rjw.2. mouse. [Q9CYZ8-2 ]

Organism-specific databases

CTDi 23635.
MGIi MGI:1914220. Ssbp2.

Phylogenomic databases

eggNOGi NOG245801.
GeneTreei ENSGT00390000009187.
HOGENOMi HOG000037785.
HOVERGENi HBG068487.
InParanoidi Q9CYZ8.
OMAi WQPNASA.
OrthoDBi EOG7V4B0F.
PhylomeDBi Q9CYZ8.
TreeFami TF318961.

Miscellaneous databases

ChiTaRSi Ssbp2. mouse.
NextBioi 323165.
PROi Q9CYZ8.
SOURCEi Search...

Gene expression databases

Bgeei Q9CYZ8.
CleanExi MM_SSBP2.
ExpressionAtlasi Q9CYZ8. baseline and differential.
Genevestigatori Q9CYZ8.

Family and domain databases

InterProi IPR006594. LisH_dimerisation.
IPR008116. SSDP_DNA-bd.
[Graphical view ]
PRINTSi PR01743. SSDNABINDING.
SMARTi SM00667. LisH. 1 hit.
[Graphical view ]
PROSITEi PS50896. LISH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel member of the SSDP gene family, SSDP2, is expressed in deep layers during murine cortical development."
    Speer N., Tarabykin V., Britanova O., Lukyanov S., Gruss P.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: NMRI.
    Tissue: Brain cortex.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Embryo.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSSBP2_MOUSE
AccessioniPrimary (citable) accession number: Q9CYZ8
Secondary accession number(s): B1B188, Q99LX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3