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Q9CYZ2

- TPD54_MOUSE

UniProt

Q9CYZ2 - TPD54_MOUSE

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Protein

Tumor protein D54

Gene

Tpd52l2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor protein D54
Alternative name(s):
Tumor protein D52-like 2
Gene namesi
Name:Tpd52l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:1913564. Tpd52l2.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Tumor protein D54PRO_0000185745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei3 – 31PhosphoserineBy similarity
Modified residuei12 – 121PhosphoserineBy similarity
Modified residuei19 – 191PhosphoserineBy similarity
Modified residuei96 – 961PhosphoserineBy similarity
Modified residuei149 – 1491PhosphoserineBy similarity
Modified residuei180 – 1801Phosphoserine2 Publications
Modified residuei206 – 2061Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CYZ2.
PaxDbiQ9CYZ2.
PRIDEiQ9CYZ2.

PTM databases

PhosphoSiteiQ9CYZ2.

Expressioni

Gene expression databases

BgeeiQ9CYZ2.
CleanExiMM_TPD52L2.
ExpressionAtlasiQ9CYZ2. baseline and differential.
GenevestigatoriQ9CYZ2.

Interactioni

Subunit structurei

Forms a homodimer or heterodimer with other members of the family. Interacts with MAL2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211377. 1 interaction.
IntActiQ9CYZ2. 2 interactions.
MINTiMINT-4126050.

Structurei

3D structure databases

ProteinModelPortaliQ9CYZ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili40 – 8243Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the TPD52 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG329468.
GeneTreeiENSGT00390000015988.
HOGENOMiHOG000231968.
HOVERGENiHBG058643.
InParanoidiQ9CYZ2.
OrthoDBiEOG744TBQ.
PhylomeDBiQ9CYZ2.
TreeFamiTF317562.

Family and domain databases

InterProiIPR007327. TPD52.
[Graphical view]
PANTHERiPTHR19307. PTHR19307. 1 hit.
PfamiPF04201. TPD52. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CYZ2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSASQDINL NSPNKGVLSD FMTDVPVDPG VVHRTPVVEG LTEGEEEELR
60 70 80 90 100
AELAKVEEEI VTLRQVLAAK ERHCGELKRR LGLSTLGELK QNLSRSWHDV
110 120 130 140 150
QVSTAYVKTS EKLGEWNEKV TQSDLYKKTQ ETLSQAGQKT SAALSTMGSA
160 170 180 190 200
ISRKLGDMSS YSIRHSISMP VMRNSATFKS FEDRVGTIKS KVVGGRENGS
210 220
DNLPPSPGSG DQTLPDHAPF
Length:220
Mass (Da):24,043
Last modified:June 1, 2001 - v1
Checksum:i276776288500D9C8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013188 mRNA. Translation: BAB28701.1.
AK159925 mRNA. Translation: BAE35487.1.
BC006886 mRNA. Translation: AAH06886.1.
CCDSiCCDS17214.1.
RefSeqiNP_001278126.1. NM_001291197.1.
NP_079758.2. NM_025482.3.
UniGeneiMm.136648.

Genome annotation databases

EnsembliENSMUST00000149163; ENSMUSP00000117690; ENSMUSG00000000827.
GeneIDi66314.
KEGGimmu:66314.
UCSCiuc008oml.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013188 mRNA. Translation: BAB28701.1 .
AK159925 mRNA. Translation: BAE35487.1 .
BC006886 mRNA. Translation: AAH06886.1 .
CCDSi CCDS17214.1.
RefSeqi NP_001278126.1. NM_001291197.1.
NP_079758.2. NM_025482.3.
UniGenei Mm.136648.

3D structure databases

ProteinModelPortali Q9CYZ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211377. 1 interaction.
IntActi Q9CYZ2. 2 interactions.
MINTi MINT-4126050.

PTM databases

PhosphoSitei Q9CYZ2.

Proteomic databases

MaxQBi Q9CYZ2.
PaxDbi Q9CYZ2.
PRIDEi Q9CYZ2.

Protocols and materials databases

DNASUi 66314.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000149163 ; ENSMUSP00000117690 ; ENSMUSG00000000827 .
GeneIDi 66314.
KEGGi mmu:66314.
UCSCi uc008oml.1. mouse.

Organism-specific databases

CTDi 7165.
MGIi MGI:1913564. Tpd52l2.

Phylogenomic databases

eggNOGi NOG329468.
GeneTreei ENSGT00390000015988.
HOGENOMi HOG000231968.
HOVERGENi HBG058643.
InParanoidi Q9CYZ2.
OrthoDBi EOG744TBQ.
PhylomeDBi Q9CYZ2.
TreeFami TF317562.

Miscellaneous databases

ChiTaRSi TPD52L2. mouse.
NextBioi 321291.
PROi Q9CYZ2.
SOURCEi Search...

Gene expression databases

Bgeei Q9CYZ2.
CleanExi MM_TPD52L2.
ExpressionAtlasi Q9CYZ2. baseline and differential.
Genevestigatori Q9CYZ2.

Family and domain databases

InterProi IPR007327. TPD52.
[Graphical view ]
PANTHERi PTHR19307. PTHR19307. 1 hit.
Pfami PF04201. TPD52. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  4. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-180 AND SER-206, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiTPD54_MOUSE
AccessioniPrimary (citable) accession number: Q9CYZ2
Secondary accession number(s): Q3TVY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3