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Protein

Renin receptor

Gene

Atp6ap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • angiotensin maturation Source: Ensembl
  • positive regulation of Wnt signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-MMU-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin receptor
Alternative name(s):
ATPase H(+)-transporting lysosomal accessory protein 2
ATPase H(+)-transporting lysosomal-interacting protein 2
Renin/prorenin receptor
Gene namesi
Name:Atp6ap2
Synonyms:Atp6ip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1917745. Atp6ap2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 302ExtracellularSequence analysisAdd BLAST285
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 350CytoplasmicSequence analysisAdd BLAST27

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002220418 – 350Renin receptorAdd BLAST333

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CYN9.
MaxQBiQ9CYN9.
PaxDbiQ9CYN9.
PeptideAtlasiQ9CYN9.
PRIDEiQ9CYN9.
TopDownProteomicsiQ9CYN9.

PTM databases

iPTMnetiQ9CYN9.
PhosphoSitePlusiQ9CYN9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031007.
ExpressionAtlasiQ9CYN9. baseline and differential.
GenevisibleiQ9CYN9. MM.

Interactioni

Subunit structurei

Interacts with renin and the vacuolar proton-ATPase.By similarity

Protein-protein interaction databases

BioGridi214094. 1 interactor.
IntActiQ9CYN9. 1 interactor.
MINTiMINT-4125981.
STRINGi10090.ENSMUSP00000033313.

Structurei

3D structure databases

ProteinModelPortaliQ9CYN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4737. Eukaryota.
ENOG4111F0U. LUCA.
GeneTreeiENSGT00390000008856.
HOGENOMiHOG000232083.
HOVERGENiHBG056579.
InParanoidiQ9CYN9.
KOiK19514.
OMAiNLWNMDP.
OrthoDBiEOG091G0HQ3.
PhylomeDBiQ9CYN9.
TreeFamiTF106137.

Family and domain databases

InterProiIPR012493. Renin_rcpt.
[Graphical view]
PANTHERiPTHR13351. PTHR13351. 1 hit.
PfamiPF07850. Renin_r. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLVVLLFF LVAGALGNEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS
60 70 80 90 100
MGFSVKEDLS WPGLAVGNLF HRPRATIMVM VKGVDKLALP AGSVISYPLE
110 120 130 140 150
NAVPFSLDSV ANSIHSLFSE ETPVVLQLAP SEERVYMVGK ANSVFEDLSV
160 170 180 190 200
TLRQLRNRLF QENSLLNSLP LNSLSRNNEV DLLFLSELQV LHDISSLLSR
210 220 230 240 250
HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASKI LVDALQKFAD
260 270 280 290 300
DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILEAKQENTQ SPYNLAYKYN
310 320 330 340 350
LEYSVVFNLV LWIMIGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRID
Length:350
Mass (Da):39,092
Last modified:March 1, 2003 - v2
Checksum:i3A90E0C586E7BAC7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157N → K in BAC36365 (PubMed:16141072).Curated1
Sequence conflicti169L → H in BAC36365 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017482 mRNA. Translation: BAB30766.2.
AK029405 mRNA. Translation: BAC26436.1.
AK076495 mRNA. Translation: BAC36365.1.
BX000537 Genomic DNA. Translation: CAM27889.1.
BC014706 mRNA. Translation: AAH14706.1.
CCDSiCCDS30023.1.
RefSeqiNP_081715.1. NM_027439.4.
UniGeneiMm.25148.

Genome annotation databases

EnsembliENSMUST00000033313; ENSMUSP00000033313; ENSMUSG00000031007.
GeneIDi70495.
KEGGimmu:70495.
UCSCiuc009sqx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017482 mRNA. Translation: BAB30766.2.
AK029405 mRNA. Translation: BAC26436.1.
AK076495 mRNA. Translation: BAC36365.1.
BX000537 Genomic DNA. Translation: CAM27889.1.
BC014706 mRNA. Translation: AAH14706.1.
CCDSiCCDS30023.1.
RefSeqiNP_081715.1. NM_027439.4.
UniGeneiMm.25148.

3D structure databases

ProteinModelPortaliQ9CYN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214094. 1 interactor.
IntActiQ9CYN9. 1 interactor.
MINTiMINT-4125981.
STRINGi10090.ENSMUSP00000033313.

PTM databases

iPTMnetiQ9CYN9.
PhosphoSitePlusiQ9CYN9.

Proteomic databases

EPDiQ9CYN9.
MaxQBiQ9CYN9.
PaxDbiQ9CYN9.
PeptideAtlasiQ9CYN9.
PRIDEiQ9CYN9.
TopDownProteomicsiQ9CYN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033313; ENSMUSP00000033313; ENSMUSG00000031007.
GeneIDi70495.
KEGGimmu:70495.
UCSCiuc009sqx.2. mouse.

Organism-specific databases

CTDi10159.
MGIiMGI:1917745. Atp6ap2.

Phylogenomic databases

eggNOGiKOG4737. Eukaryota.
ENOG4111F0U. LUCA.
GeneTreeiENSGT00390000008856.
HOGENOMiHOG000232083.
HOVERGENiHBG056579.
InParanoidiQ9CYN9.
KOiK19514.
OMAiNLWNMDP.
OrthoDBiEOG091G0HQ3.
PhylomeDBiQ9CYN9.
TreeFamiTF106137.

Enzyme and pathway databases

ReactomeiR-MMU-2022377. Metabolism of Angiotensinogen to Angiotensins.
R-MMU-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiAtp6ap2. mouse.
PROiQ9CYN9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031007.
ExpressionAtlasiQ9CYN9. baseline and differential.
GenevisibleiQ9CYN9. MM.

Family and domain databases

InterProiIPR012493. Renin_rcpt.
[Graphical view]
PANTHERiPTHR13351. PTHR13351. 1 hit.
PfamiPF07850. Renin_r. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRENR_MOUSE
AccessioniPrimary (citable) accession number: Q9CYN9
Secondary accession number(s): A2BDN5, Q8BVU6, Q91YU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.