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Protein

Renin receptor

Gene

Atp6ap2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-2022377. Metabolism of Angiotensinogen to Angiotensins.

Names & Taxonomyi

Protein namesi
Recommended name:
Renin receptor
Alternative name(s):
ATPase H(+)-transporting lysosomal accessory protein 2
ATPase H(+)-transporting lysosomal-interacting protein 2
Renin/prorenin receptor
Gene namesi
Name:Atp6ap2
Synonyms:Atp6ip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1917745. Atp6ap2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 302285ExtracellularSequence analysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence analysisAdd
BLAST
Topological domaini324 – 35027CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 350333Renin receptorPRO_0000022204Add
BLAST

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9CYN9.
MaxQBiQ9CYN9.
PaxDbiQ9CYN9.
PRIDEiQ9CYN9.
TopDownProteomicsiQ9CYN9.

PTM databases

iPTMnetiQ9CYN9.
PhosphoSiteiQ9CYN9.

Expressioni

Gene expression databases

BgeeiQ9CYN9.
ExpressionAtlasiQ9CYN9. baseline and differential.
GenevisibleiQ9CYN9. MM.

Interactioni

Subunit structurei

Interacts with renin and the vacuolar proton-ATPase.By similarity

Protein-protein interaction databases

BioGridi214094. 1 interaction.
IntActiQ9CYN9. 1 interaction.
MINTiMINT-4125981.
STRINGi10090.ENSMUSP00000033313.

Structurei

3D structure databases

ProteinModelPortaliQ9CYN9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4737. Eukaryota.
ENOG4111F0U. LUCA.
GeneTreeiENSGT00390000008856.
HOGENOMiHOG000232083.
HOVERGENiHBG056579.
InParanoidiQ9CYN9.
KOiK19514.
OMAiNLWNMDP.
OrthoDBiEOG7R56VH.
PhylomeDBiQ9CYN9.
TreeFamiTF106137.

Family and domain databases

InterProiIPR012493. Renin_rcpt.
[Graphical view]
PANTHERiPTHR13351. PTHR13351. 1 hit.
PfamiPF07850. Renin_r. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYN9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLVVLLFF LVAGALGNEF SILRSPGSVV FRNGNWPIPG DRIPDVAALS
60 70 80 90 100
MGFSVKEDLS WPGLAVGNLF HRPRATIMVM VKGVDKLALP AGSVISYPLE
110 120 130 140 150
NAVPFSLDSV ANSIHSLFSE ETPVVLQLAP SEERVYMVGK ANSVFEDLSV
160 170 180 190 200
TLRQLRNRLF QENSLLNSLP LNSLSRNNEV DLLFLSELQV LHDISSLLSR
210 220 230 240 250
HKHLAKDHSP DLYSLELAGL DELGKRYGED SEQFRDASKI LVDALQKFAD
260 270 280 290 300
DMYSLYGGNA VVELVTVKSF DTSLVRKSRT ILEAKQENTQ SPYNLAYKYN
310 320 330 340 350
LEYSVVFNLV LWIMIGLALA VIITSYNIWN MDPGYDSIIY RMTNQKIRID
Length:350
Mass (Da):39,092
Last modified:March 1, 2003 - v2
Checksum:i3A90E0C586E7BAC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti157 – 1571N → K in BAC36365 (PubMed:16141072).Curated
Sequence conflicti169 – 1691L → H in BAC36365 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017482 mRNA. Translation: BAB30766.2.
AK029405 mRNA. Translation: BAC26436.1.
AK076495 mRNA. Translation: BAC36365.1.
BX000537 Genomic DNA. Translation: CAM27889.1.
BC014706 mRNA. Translation: AAH14706.1.
CCDSiCCDS30023.1.
RefSeqiNP_081715.1. NM_027439.4.
UniGeneiMm.25148.

Genome annotation databases

EnsembliENSMUST00000033313; ENSMUSP00000033313; ENSMUSG00000031007.
GeneIDi70495.
KEGGimmu:70495.
UCSCiuc009sqx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017482 mRNA. Translation: BAB30766.2.
AK029405 mRNA. Translation: BAC26436.1.
AK076495 mRNA. Translation: BAC36365.1.
BX000537 Genomic DNA. Translation: CAM27889.1.
BC014706 mRNA. Translation: AAH14706.1.
CCDSiCCDS30023.1.
RefSeqiNP_081715.1. NM_027439.4.
UniGeneiMm.25148.

3D structure databases

ProteinModelPortaliQ9CYN9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi214094. 1 interaction.
IntActiQ9CYN9. 1 interaction.
MINTiMINT-4125981.
STRINGi10090.ENSMUSP00000033313.

PTM databases

iPTMnetiQ9CYN9.
PhosphoSiteiQ9CYN9.

Proteomic databases

EPDiQ9CYN9.
MaxQBiQ9CYN9.
PaxDbiQ9CYN9.
PRIDEiQ9CYN9.
TopDownProteomicsiQ9CYN9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033313; ENSMUSP00000033313; ENSMUSG00000031007.
GeneIDi70495.
KEGGimmu:70495.
UCSCiuc009sqx.2. mouse.

Organism-specific databases

CTDi10159.
MGIiMGI:1917745. Atp6ap2.

Phylogenomic databases

eggNOGiKOG4737. Eukaryota.
ENOG4111F0U. LUCA.
GeneTreeiENSGT00390000008856.
HOGENOMiHOG000232083.
HOVERGENiHBG056579.
InParanoidiQ9CYN9.
KOiK19514.
OMAiNLWNMDP.
OrthoDBiEOG7R56VH.
PhylomeDBiQ9CYN9.
TreeFamiTF106137.

Enzyme and pathway databases

ReactomeiR-MMU-2022377. Metabolism of Angiotensinogen to Angiotensins.

Miscellaneous databases

ChiTaRSiAtp6ap2. mouse.
PROiQ9CYN9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CYN9.
ExpressionAtlasiQ9CYN9. baseline and differential.
GenevisibleiQ9CYN9. MM.

Family and domain databases

InterProiIPR012493. Renin_rcpt.
[Graphical view]
PANTHERiPTHR13351. PTHR13351. 1 hit.
PfamiPF07850. Renin_r. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Head.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Testis.

Entry informationi

Entry nameiRENR_MOUSE
AccessioniPrimary (citable) accession number: Q9CYN9
Secondary accession number(s): A2BDN5, Q8BVU6, Q91YU5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: March 1, 2003
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.