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Q9CYK1

- SYWM_MOUSE

UniProt

Q9CYK1 - SYWM_MOUSE

Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

Wars2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. tryptophan-tRNA ligase activity Source: UniProtKB-EC

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: InterPro
    2. vasculogenesis Source: MGI

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
    Alternative name(s):
    (Mt)TrpRS
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:Wars2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1917810. Wars2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 1818MitochondrionBy similarityAdd
    BLAST
    Chaini19 – 360342Tryptophan--tRNA ligase, mitochondrialPRO_0000035829Add
    BLAST

    Proteomic databases

    MaxQBiQ9CYK1.
    PaxDbiQ9CYK1.
    PRIDEiQ9CYK1.

    PTM databases

    PhosphoSiteiQ9CYK1.

    Expressioni

    Gene expression databases

    BgeeiQ9CYK1.
    CleanExiMM_WARS2.
    GenevestigatoriQ9CYK1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000004343.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CYK1.
    SMRiQ9CYK1. Positions 37-359.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0180.
    GeneTreeiENSGT00510000047425.
    HOGENOMiHOG000059940.
    HOVERGENiHBG027444.
    InParanoidiQ8BFV8.
    KOiK01867.
    OMAiIDPKKHI.
    OrthoDBiEOG7J447N.
    TreeFamiTF314321.

    Family and domain databases

    Gene3Di3.40.50.620. 1 hit.
    HAMAPiMF_00140_B. Trp_tRNA_synth_B.
    InterProiIPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 1 hit.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.
    TIGRFAMsiTIGR00233. trpS. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CYK1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALFSVRKAR ECWRFIRALH KGPAATLAPQ KESGERVFSG IQPTGILHLG    50
    NYLGAIESWV NLQEEYDTVI YSIVDLHSIT VPQDPTVLQQ SILDMTAVLL 100
    ACGINPEKSI LFQQSKVSEH TQLSWILTCM VRLPRLQHLH QWKAKAAKQK 150
    HDGTVGLLTY PVLQAADILC YKSTHVPVGE DQVQHMELVQ DLARSFNQKY 200
    GEFFPLPKSI LTSMKKVKSL RDPSSKMSKS DPDKLATVRI TDSPEEIVQK 250
    FRKAVTDFTS EVTYEPDSRA GVSNMVAIHA AVSGLSVEEV VRSSAGLDTA 300
    RYKLLVADAV IEKFAPIRKE IEKLKMDKDH LRKVLLVGSA KAKELASPVF 350
    EEVKKLVGIL 360
    Length:360
    Mass (Da):40,153
    Last modified:July 27, 2011 - v2
    Checksum:iE777D70B3827807A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti148 – 1492KQ → NR in BAB30833. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK017602 mRNA. Translation: BAB30833.1.
    AK042715 mRNA. Translation: BAC31342.1.
    AK042964 mRNA. Translation: BAC31422.1.
    BC089583 mRNA. Translation: AAH89583.1.
    CCDSiCCDS17672.1.
    RefSeqiNP_081738.2. NM_027462.4.
    UniGeneiMm.316754.

    Genome annotation databases

    EnsembliENSMUST00000004343; ENSMUSP00000004343; ENSMUSG00000004233.
    GeneIDi70560.
    KEGGimmu:70560.
    UCSCiuc008qqk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK017602 mRNA. Translation: BAB30833.1 .
    AK042715 mRNA. Translation: BAC31342.1 .
    AK042964 mRNA. Translation: BAC31422.1 .
    BC089583 mRNA. Translation: AAH89583.1 .
    CCDSi CCDS17672.1.
    RefSeqi NP_081738.2. NM_027462.4.
    UniGenei Mm.316754.

    3D structure databases

    ProteinModelPortali Q9CYK1.
    SMRi Q9CYK1. Positions 37-359.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000004343.

    PTM databases

    PhosphoSitei Q9CYK1.

    Proteomic databases

    MaxQBi Q9CYK1.
    PaxDbi Q9CYK1.
    PRIDEi Q9CYK1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004343 ; ENSMUSP00000004343 ; ENSMUSG00000004233 .
    GeneIDi 70560.
    KEGGi mmu:70560.
    UCSCi uc008qqk.1. mouse.

    Organism-specific databases

    CTDi 10352.
    MGIi MGI:1917810. Wars2.

    Phylogenomic databases

    eggNOGi COG0180.
    GeneTreei ENSGT00510000047425.
    HOGENOMi HOG000059940.
    HOVERGENi HBG027444.
    InParanoidi Q8BFV8.
    KOi K01867.
    OMAi IDPKKHI.
    OrthoDBi EOG7J447N.
    TreeFami TF314321.

    Miscellaneous databases

    NextBioi 331864.
    PROi Q9CYK1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CYK1.
    CleanExi MM_WARS2.
    Genevestigatori Q9CYK1.

    Family and domain databases

    Gene3Di 3.40.50.620. 1 hit.
    HAMAPi MF_00140_B. Trp_tRNA_synth_B.
    InterProi IPR001412. aa-tRNA-synth_I_CS.
    IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR024109. Trp-tRNA-ligase_bac-type.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 1 hit.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    TIGRFAMsi TIGR00233. trpS. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry nameiSYWM_MOUSE
    AccessioniPrimary (citable) accession number: Q9CYK1
    Secondary accession number(s): Q8BFV8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3