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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

Wars2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.By similarity

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei42ATPBy similarity1
Binding sitei167L-tryptophanBy similarity1
Binding sitei217ATP; via amide nitrogen and carbonyl oxygenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi48 – 51ATPBy similarity4
Nucleotide bindingi179 – 181ATPBy similarity3
Nucleotide bindingi226 – 230ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

  • tryptophanyl-tRNA aminoacylation Source: InterPro
  • vasculogenesis Source: MGI

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
(Mt)TrpRS
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:Wars2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1917810 Wars2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 18MitochondrionBy similarityAdd BLAST18
ChainiPRO_000003582919 – 360Tryptophan--tRNA ligase, mitochondrialAdd BLAST342

Proteomic databases

EPDiQ9CYK1
MaxQBiQ9CYK1
PaxDbiQ9CYK1
PeptideAtlasiQ9CYK1
PRIDEiQ9CYK1

PTM databases

iPTMnetiQ9CYK1
PhosphoSitePlusiQ9CYK1

Expressioni

Gene expression databases

BgeeiENSMUSG00000004233
CleanExiMM_WARS2
ExpressionAtlasiQ9CYK1 baseline and differential
GenevisibleiQ9CYK1 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004343

Structurei

3D structure databases

ProteinModelPortaliQ9CYK1
SMRiQ9CYK1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2713 Eukaryota
COG0180 LUCA
GeneTreeiENSGT00510000047425
HOGENOMiHOG000059940
HOVERGENiHBG027444
InParanoidiQ9CYK1
KOiK01867
OMAiQRMTQFK
OrthoDBiEOG091G04TZ
TreeFamiTF314321

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 2 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 1 hit
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYK1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALFSVRKAR ECWRFIRALH KGPAATLAPQ KESGERVFSG IQPTGILHLG
60 70 80 90 100
NYLGAIESWV NLQEEYDTVI YSIVDLHSIT VPQDPTVLQQ SILDMTAVLL
110 120 130 140 150
ACGINPEKSI LFQQSKVSEH TQLSWILTCM VRLPRLQHLH QWKAKAAKQK
160 170 180 190 200
HDGTVGLLTY PVLQAADILC YKSTHVPVGE DQVQHMELVQ DLARSFNQKY
210 220 230 240 250
GEFFPLPKSI LTSMKKVKSL RDPSSKMSKS DPDKLATVRI TDSPEEIVQK
260 270 280 290 300
FRKAVTDFTS EVTYEPDSRA GVSNMVAIHA AVSGLSVEEV VRSSAGLDTA
310 320 330 340 350
RYKLLVADAV IEKFAPIRKE IEKLKMDKDH LRKVLLVGSA KAKELASPVF
360
EEVKKLVGIL
Length:360
Mass (Da):40,153
Last modified:July 27, 2011 - v2
Checksum:iE777D70B3827807A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148 – 149KQ → NR in BAB30833 (PubMed:16141072).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017602 mRNA Translation: BAB30833.1
AK042715 mRNA Translation: BAC31342.1
AK042964 mRNA Translation: BAC31422.1
BC089583 mRNA Translation: AAH89583.1
CCDSiCCDS17672.1
RefSeqiNP_081738.2, NM_027462.4
UniGeneiMm.316754

Genome annotation databases

EnsembliENSMUST00000004343; ENSMUSP00000004343; ENSMUSG00000004233
GeneIDi70560
KEGGimmu:70560
UCSCiuc008qqk.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSYWM_MOUSE
AccessioniPrimary (citable) accession number: Q9CYK1
Secondary accession number(s): Q8BFV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health