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Q9CYK1

- SYWM_MOUSE

UniProt

Q9CYK1 - SYWM_MOUSE

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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

Wars2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. tryptophan-tRNA ligase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: InterPro
  2. vasculogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
(Mt)TrpRS
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:Wars2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1917810. Wars2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1818MitochondrionBy similarityAdd
BLAST
Chaini19 – 360342Tryptophan--tRNA ligase, mitochondrialPRO_0000035829Add
BLAST

Proteomic databases

MaxQBiQ9CYK1.
PaxDbiQ9CYK1.
PRIDEiQ9CYK1.

PTM databases

PhosphoSiteiQ9CYK1.

Expressioni

Gene expression databases

BgeeiQ9CYK1.
CleanExiMM_WARS2.
GenevestigatoriQ9CYK1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004343.

Structurei

3D structure databases

ProteinModelPortaliQ9CYK1.
SMRiQ9CYK1. Positions 37-359.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0180.
GeneTreeiENSGT00510000047425.
HOGENOMiHOG000059940.
HOVERGENiHBG027444.
InParanoidiQ9CYK1.
KOiK01867.
OMAiIDPKKHI.
OrthoDBiEOG7J447N.
TreeFamiTF314321.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00140_B. Trp_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYK1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALFSVRKAR ECWRFIRALH KGPAATLAPQ KESGERVFSG IQPTGILHLG
60 70 80 90 100
NYLGAIESWV NLQEEYDTVI YSIVDLHSIT VPQDPTVLQQ SILDMTAVLL
110 120 130 140 150
ACGINPEKSI LFQQSKVSEH TQLSWILTCM VRLPRLQHLH QWKAKAAKQK
160 170 180 190 200
HDGTVGLLTY PVLQAADILC YKSTHVPVGE DQVQHMELVQ DLARSFNQKY
210 220 230 240 250
GEFFPLPKSI LTSMKKVKSL RDPSSKMSKS DPDKLATVRI TDSPEEIVQK
260 270 280 290 300
FRKAVTDFTS EVTYEPDSRA GVSNMVAIHA AVSGLSVEEV VRSSAGLDTA
310 320 330 340 350
RYKLLVADAV IEKFAPIRKE IEKLKMDKDH LRKVLLVGSA KAKELASPVF
360
EEVKKLVGIL
Length:360
Mass (Da):40,153
Last modified:July 27, 2011 - v2
Checksum:iE777D70B3827807A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1492KQ → NR in BAB30833. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK017602 mRNA. Translation: BAB30833.1.
AK042715 mRNA. Translation: BAC31342.1.
AK042964 mRNA. Translation: BAC31422.1.
BC089583 mRNA. Translation: AAH89583.1.
CCDSiCCDS17672.1.
RefSeqiNP_081738.2. NM_027462.4.
UniGeneiMm.316754.

Genome annotation databases

EnsembliENSMUST00000004343; ENSMUSP00000004343; ENSMUSG00000004233.
GeneIDi70560.
KEGGimmu:70560.
UCSCiuc008qqk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK017602 mRNA. Translation: BAB30833.1 .
AK042715 mRNA. Translation: BAC31342.1 .
AK042964 mRNA. Translation: BAC31422.1 .
BC089583 mRNA. Translation: AAH89583.1 .
CCDSi CCDS17672.1.
RefSeqi NP_081738.2. NM_027462.4.
UniGenei Mm.316754.

3D structure databases

ProteinModelPortali Q9CYK1.
SMRi Q9CYK1. Positions 37-359.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000004343.

PTM databases

PhosphoSitei Q9CYK1.

Proteomic databases

MaxQBi Q9CYK1.
PaxDbi Q9CYK1.
PRIDEi Q9CYK1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004343 ; ENSMUSP00000004343 ; ENSMUSG00000004233 .
GeneIDi 70560.
KEGGi mmu:70560.
UCSCi uc008qqk.1. mouse.

Organism-specific databases

CTDi 10352.
MGIi MGI:1917810. Wars2.

Phylogenomic databases

eggNOGi COG0180.
GeneTreei ENSGT00510000047425.
HOGENOMi HOG000059940.
HOVERGENi HBG027444.
InParanoidi Q9CYK1.
KOi K01867.
OMAi IDPKKHI.
OrthoDBi EOG7J447N.
TreeFami TF314321.

Miscellaneous databases

NextBioi 331864.
PROi Q9CYK1.
SOURCEi Search...

Gene expression databases

Bgeei Q9CYK1.
CleanExi MM_WARS2.
Genevestigatori Q9CYK1.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00140_B. Trp_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR024109. Trp-tRNA-ligase_bac-type.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 1 hit.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
TIGRFAMsi TIGR00233. trpS. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiSYWM_MOUSE
AccessioniPrimary (citable) accession number: Q9CYK1
Secondary accession number(s): Q8BFV8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3