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Protein

Ribosome biogenesis regulatory protein homolog

Gene

Rrs1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in ribosome biogenesis.By similarity

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • mitotic metaphase plate congression Source: MGI
  • ribosome biogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosome biogenesis regulatory protein homolog
Gene namesi
Name:Rrs1
Synonyms:Rrr
ORF Names:MNCb-2643
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929721. Rrs1.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome Source: MGI
  • endoplasmic reticulum Source: UniProtKB
  • nucleolus Source: UniProtKB
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Ribosome biogenesis regulatory protein homologPRO_0000185375Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei273 – 2731Citrulline1 Publication

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination

Proteomic databases

EPDiQ9CYH6.
MaxQBiQ9CYH6.
PaxDbiQ9CYH6.
PRIDEiQ9CYH6.
TopDownProteomicsiQ9CYH6.

PTM databases

iPTMnetiQ9CYH6.
PhosphoSiteiQ9CYH6.
SwissPalmiQ9CYH6.

Expressioni

Gene expression databases

BgeeiQ9CYH6.
GenevisibleiQ9CYH6. MM.

Interactioni

Protein-protein interaction databases

BioGridi208485. 1 interaction.
IntActiQ9CYH6. 1 interaction.
MINTiMINT-4133154.
STRINGi10090.ENSMUSP00000071955.

Structurei

3D structure databases

ProteinModelPortaliQ9CYH6.
SMRiQ9CYH6. Positions 24-108.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi302 – 36564Arg/Gly/Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the RRS1 family.Curated

Phylogenomic databases

eggNOGiKOG1765. Eukaryota.
COG5225. LUCA.
GeneTreeiENSGT00390000005213.
HOVERGENiHBG036121.
InParanoidiQ9CYH6.
KOiK14852.
OMAiRRRWGYK.
OrthoDBiEOG73NG4D.
PhylomeDBiQ9CYH6.
TreeFamiTF313067.

Family and domain databases

InterProiIPR007023. Ribosom_reg.
[Graphical view]
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiPF04939. RRS1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CYH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGQRVEELL AKAEQEEAEK LQRITVHKEL ELEFDLGNLL ASDRNPPTVL
60 70 80 90 100
RQAGPSPEAE LRALARDNTQ LLINQLWRLP TERVEEAVVA RLPEPATRLP
110 120 130 140 150
REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEASGQW RRRWGYKRAR
160 170 180 190 200
DDTKEWLIEV PGSADPMEDQ FAKRTQAKKE RVAKNELNRL RNLARAHKMQ
210 220 230 240 250
MPSSAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKAPRGSGK
260 270 280 290 300
KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP RLDVTRATNK QMREEDQEEA
310 320 330 340 350
AKRRKMSQKG KRKGGRQGPS GKRKGGPPGQ GEKRKGGLGS KKHSWPSALA
360
GKKKGVPPQG GKRRK
Length:365
Mass (Da):41,552
Last modified:June 1, 2001 - v1
Checksum:iA99BDE7321652E66
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351E → V in BAB26750 (PubMed:16141072).Curated
Sequence conflicti185 – 1851N → G in BAB31912 (PubMed:16141072).Curated
Sequence conflicti324 – 3241K → R in BAA95072 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041589 mRNA. Translation: BAA95072.1.
AK010178 mRNA. Translation: BAB26750.1.
AK017683 mRNA. Translation: BAB30871.1.
AK019257 mRNA. Translation: BAB31631.1.
AK019913 mRNA. Translation: BAB31912.1.
AK142041 mRNA. Translation: BAE24922.1.
BC003481 mRNA. Translation: AAH03481.1.
BC055925 mRNA. Translation: AAH55925.1.
CCDSiCCDS14811.1.
RefSeqiNP_067486.2. NM_021511.2.
UniGeneiMm.29061.
Mm.467167.

Genome annotation databases

EnsembliENSMUST00000072079; ENSMUSP00000071955; ENSMUSG00000061024.
GeneIDi59014.
KEGGimmu:59014.
UCSCiuc007agk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041589 mRNA. Translation: BAA95072.1.
AK010178 mRNA. Translation: BAB26750.1.
AK017683 mRNA. Translation: BAB30871.1.
AK019257 mRNA. Translation: BAB31631.1.
AK019913 mRNA. Translation: BAB31912.1.
AK142041 mRNA. Translation: BAE24922.1.
BC003481 mRNA. Translation: AAH03481.1.
BC055925 mRNA. Translation: AAH55925.1.
CCDSiCCDS14811.1.
RefSeqiNP_067486.2. NM_021511.2.
UniGeneiMm.29061.
Mm.467167.

3D structure databases

ProteinModelPortaliQ9CYH6.
SMRiQ9CYH6. Positions 24-108.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208485. 1 interaction.
IntActiQ9CYH6. 1 interaction.
MINTiMINT-4133154.
STRINGi10090.ENSMUSP00000071955.

PTM databases

iPTMnetiQ9CYH6.
PhosphoSiteiQ9CYH6.
SwissPalmiQ9CYH6.

Proteomic databases

EPDiQ9CYH6.
MaxQBiQ9CYH6.
PaxDbiQ9CYH6.
PRIDEiQ9CYH6.
TopDownProteomicsiQ9CYH6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000072079; ENSMUSP00000071955; ENSMUSG00000061024.
GeneIDi59014.
KEGGimmu:59014.
UCSCiuc007agk.2. mouse.

Organism-specific databases

CTDi23212.
MGIiMGI:1929721. Rrs1.

Phylogenomic databases

eggNOGiKOG1765. Eukaryota.
COG5225. LUCA.
GeneTreeiENSGT00390000005213.
HOVERGENiHBG036121.
InParanoidiQ9CYH6.
KOiK14852.
OMAiRRRWGYK.
OrthoDBiEOG73NG4D.
PhylomeDBiQ9CYH6.
TreeFamiTF313067.

Miscellaneous databases

ChiTaRSiRrs1. mouse.
PROiQ9CYH6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CYH6.
GenevisibleiQ9CYH6. MM.

Family and domain databases

InterProiIPR007023. Ribosom_reg.
[Graphical view]
PANTHERiPTHR17602. PTHR17602. 1 hit.
PfamiPF04939. RRS1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of full-length cDNA clones from mouse brain cDNA library made by oligo-capping method."
    Osada N., Kusuda J., Tanuma R., Ito A., Hirata M., Sugano S., Hashimoto K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo, Eye, Pituitary and Tongue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney and Mammary gland.
  4. Cited for: CITRULLINATION AT ARG-273.

Entry informationi

Entry nameiRRS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CYH6
Secondary accession number(s): Q3UQW6
, Q9CS27, Q9D2B2, Q9D6M6, Q9JJC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.