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Protein

Glucose-fructose oxidoreductase domain-containing protein 2

Gene

Gfod2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes matrix assembly.1 Publication

GO - Molecular functioni

GO - Biological processi

  • extracellular matrix organization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-fructose oxidoreductase domain-containing protein 2 (EC:1.-.-.-)
Gene namesi
Name:Gfod2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1917825. Gfod2.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 385360Glucose-fructose oxidoreductase domain-containing protein 2PRO_0000282973Add
BLAST

Proteomic databases

MaxQBiQ9CYH5.
PaxDbiQ9CYH5.
PRIDEiQ9CYH5.

PTM databases

iPTMnetiQ9CYH5.
PhosphoSiteiQ9CYH5.

Expressioni

Gene expression databases

BgeeiQ9CYH5.
ExpressionAtlasiQ9CYH5. baseline and differential.
GenevisibleiQ9CYH5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000013294.

Structurei

3D structure databases

ProteinModelPortaliQ9CYH5.
SMRiQ9CYH5. Positions 8-363.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Gfo/Idh/MocA family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2742. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000001507.
HOGENOMiHOG000010274.
HOVERGENiHBG054911.
InParanoidiQ9CYH5.
OMAiRRTWDHT.
OrthoDBiEOG7FJH0S.
PhylomeDBiQ9CYH5.
TreeFamiTF323246.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLPGVGVF GTGSSARVLV PLLRAEGFTV EALWGKTEEE AKQLAEEMNI
60 70 80 90 100
TFYTSRTDDV LLHQDVDLVC INIPPPLTRQ ISVKALGIGK NVVCEKAATS
110 120 130 140 150
MDAFRMVTAS RYYPQLMSLV GNVLRFLPAF VRMKQLIAEH YVGAVMICDA
160 170 180 190 200
RIYSGSLLSP SYGWICDELM GGGGLHTMGT YIVDLLTHLT GQKAEKVHGL
210 220 230 240 250
LKTFVRQNAT IRGIRHVTSD DFCFFQMLMG GGVCSTVTLN FNMPGAFVHE
260 270 280 290 300
VMVVGSAGRL VARGADLYGQ KNSAAQEELL VRDSLAVGAG LPEQGPQDVP
310 320 330 340 350
LLYLKGMVYM VQALRQSFQG QGDRRTWDRT PVSMAASFED GLYMQSVVDA
360 370 380
IKRSSRSGEW ETVEMLAEEP DANQNLSETL QRNNL
Length:385
Mass (Da):42,242
Last modified:June 1, 2001 - v1
Checksum:iB99702BBCFEA4210
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017684 mRNA. Translation: BAB30872.1.
AK141521 mRNA. Translation: BAE24716.1.
BC013623 mRNA. Translation: AAH13623.1.
CCDSiCCDS22612.1.
RefSeqiNP_081745.1. NM_027469.4.
UniGeneiMm.40954.

Genome annotation databases

EnsembliENSMUST00000013294; ENSMUSP00000013294; ENSMUSG00000013150.
GeneIDi70575.
KEGGimmu:70575.
UCSCiuc009neb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017684 mRNA. Translation: BAB30872.1.
AK141521 mRNA. Translation: BAE24716.1.
BC013623 mRNA. Translation: AAH13623.1.
CCDSiCCDS22612.1.
RefSeqiNP_081745.1. NM_027469.4.
UniGeneiMm.40954.

3D structure databases

ProteinModelPortaliQ9CYH5.
SMRiQ9CYH5. Positions 8-363.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000013294.

PTM databases

iPTMnetiQ9CYH5.
PhosphoSiteiQ9CYH5.

Proteomic databases

MaxQBiQ9CYH5.
PaxDbiQ9CYH5.
PRIDEiQ9CYH5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013294; ENSMUSP00000013294; ENSMUSG00000013150.
GeneIDi70575.
KEGGimmu:70575.
UCSCiuc009neb.1. mouse.

Organism-specific databases

CTDi81577.
MGIiMGI:1917825. Gfod2.

Phylogenomic databases

eggNOGiKOG2742. Eukaryota.
COG0673. LUCA.
GeneTreeiENSGT00390000001507.
HOGENOMiHOG000010274.
HOVERGENiHBG054911.
InParanoidiQ9CYH5.
OMAiRRTWDHT.
OrthoDBiEOG7FJH0S.
PhylomeDBiQ9CYH5.
TreeFamiTF323246.

Miscellaneous databases

PROiQ9CYH5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CYH5.
ExpressionAtlasiQ9CYH5. baseline and differential.
GenevisibleiQ9CYH5. MM.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR000683. Oxidoreductase_N.
[Graphical view]
PfamiPF01408. GFO_IDH_MocA. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Hippocampus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  3. Cited for: SUBCELLULAR LOCATION, FUNCTION.

Entry informationi

Entry nameiGFOD2_MOUSE
AccessioniPrimary (citable) accession number: Q9CYH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.