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Protein

Williams-Beuren syndrome chromosomal region 16 protein homolog

Gene

Wbscr16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: MGI
  • Ran guanyl-nucleotide exchange factor activity Source: UniProtKB

GO - Biological processi

  • positive regulation of GTPase activity Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Williams-Beuren syndrome chromosomal region 16 protein homolog
Gene namesi
Name:Wbscr16
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2137600. Wbscr16.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Williams-Beuren syndrome chromosomal region 16 protein homologPRO_0000206657Add
BLAST

Proteomic databases

EPDiQ9CYF5.
MaxQBiQ9CYF5.
PaxDbiQ9CYF5.
PRIDEiQ9CYF5.

PTM databases

PhosphoSiteiQ9CYF5.

Expressioni

Gene expression databases

BgeeiQ9CYF5.
ExpressionAtlasiQ9CYF5. baseline and differential.
GenevisibleiQ9CYF5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075581.

Structurei

3D structure databases

ProteinModelPortaliQ9CYF5.
SMRiQ9CYF5. Positions 58-459.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati126 – 18964RCC1 1Add
BLAST
Repeati190 – 24556RCC1 2Add
BLAST
Repeati246 – 29853RCC1 3Add
BLAST
Repeati299 – 35153RCC1 4Add
BLAST
Repeati352 – 40958RCC1 5Add
BLAST
Repeati410 – 45950RCC1 6Add
BLAST

Sequence similaritiesi

Contains 6 RCC1 repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00840000129719.
HOGENOMiHOG000232125.
HOVERGENiHBG054246.
InParanoidiQ9CYF5.
OMAiNVPRCLP.
OrthoDBiEOG7CZK5Q.
PhylomeDBiQ9CYF5.
TreeFamiTF317425.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 3 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS50012. RCC1_3. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CYF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLAAARALRG PRPRWPTPAR EHWTPAGRSR SRREAAEAEA DVPVFQYVGE
60 70 80 90 100
RAARADRVFV WGFSFSGALG VPSFVVPSSG PGPRAGLRPR RRIQPVPYRL
110 120 130 140 150
ELDHKISSAA CGYGFTLLSS KTKDVTKVWG MGLNKDSQLG FHRSRKDKTR
160 170 180 190 200
GYEYVLEPSP VPLPLDRPQE TKVLQVSCGR AHSLVLTDRE GVFSMGNNSH
210 220 230 240 250
GQCGRKVVED EVYSESHKVH RMQDFDGQVV QVVCGQDHSL FLTDKGEVYS
260 270 280 290 300
CGWGADGQTG LGHYNITSTP SKLGGDLAGV TVVQVATYGD CCLALSADGG
310 320 330 340 350
VFGWGNSEYL QLASVTDSTQ VNVPRCLPFS GVGKVKQVAC GGTGCAVLNA
360 370 380 390 400
EGHVFVWGYG ILGKGPKLLE TAIPEMIPPT LFGLTEFNPE VQVSQIRCGL
410 420 430 440 450
SHFAALTNKG ELFVWGKNIR GCLGIGRLED QYFPWRVTMP GEPVDVACGV
460
DHMVTLAKSF I
Length:461
Mass (Da):49,995
Last modified:June 1, 2001 - v1
Checksum:i52B31CF2D31C2221
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017733 mRNA. Translation: BAB30902.1.
BC024714 mRNA. Translation: AAH24714.1.
BC055335 mRNA. Translation: AAH55335.1.
CCDSiCCDS19718.1.
RefSeqiNP_291050.1. NM_033572.2.
UniGeneiMm.29508.

Genome annotation databases

EnsembliENSMUST00000076228; ENSMUSP00000075581; ENSMUSG00000061979.
GeneIDi94254.
KEGGimmu:94254.
UCSCiuc008zvc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017733 mRNA. Translation: BAB30902.1.
BC024714 mRNA. Translation: AAH24714.1.
BC055335 mRNA. Translation: AAH55335.1.
CCDSiCCDS19718.1.
RefSeqiNP_291050.1. NM_033572.2.
UniGeneiMm.29508.

3D structure databases

ProteinModelPortaliQ9CYF5.
SMRiQ9CYF5. Positions 58-459.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000075581.

PTM databases

PhosphoSiteiQ9CYF5.

Proteomic databases

EPDiQ9CYF5.
MaxQBiQ9CYF5.
PaxDbiQ9CYF5.
PRIDEiQ9CYF5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000076228; ENSMUSP00000075581; ENSMUSG00000061979.
GeneIDi94254.
KEGGimmu:94254.
UCSCiuc008zvc.2. mouse.

Organism-specific databases

CTDi81554.
MGIiMGI:2137600. Wbscr16.

Phylogenomic databases

eggNOGiKOG1426. Eukaryota.
COG5184. LUCA.
GeneTreeiENSGT00840000129719.
HOGENOMiHOG000232125.
HOVERGENiHBG054246.
InParanoidiQ9CYF5.
OMAiNVPRCLP.
OrthoDBiEOG7CZK5Q.
PhylomeDBiQ9CYF5.
TreeFamiTF317425.

Miscellaneous databases

NextBioi352275.
PROiQ9CYF5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CYF5.
ExpressionAtlasiQ9CYF5. baseline and differential.
GenevisibleiQ9CYF5. MM.

Family and domain databases

Gene3Di2.130.10.30. 1 hit.
InterProiIPR009091. RCC1/BLIP-II.
IPR000408. Reg_chr_condens.
[Graphical view]
PfamiPF00415. RCC1. 3 hits.
[Graphical view]
PRINTSiPR00633. RCCNDNSATION.
SUPFAMiSSF50985. SSF50985. 1 hit.
PROSITEiPS50012. RCC1_3. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Brain and Liver.

Entry informationi

Entry nameiWBS16_MOUSE
AccessioniPrimary (citable) accession number: Q9CYF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: May 11, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.