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Q9CYD3 (CRTAP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cartilage-associated protein
Gene names
Name:Crtap
Synonyms:Casp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length400 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues. Ref.4

Subcellular location

Secretedextracellular spaceextracellular matrix.

Tissue specificity

Found in articular chondrocytes. Expressed in a variety of tissues. Ref.4

Involvement in disease

Defects in Crtap are a cause of osteochondrodysplasia characterized by severe osteoporosis and decreased osteoid production.

Sequence similarities

Belongs to the leprecan family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 400375Cartilage-associated protein
PRO_0000006320

Amino acid modifications

Glycosylation861N-linked (GlcNAc...) Potential
Glycosylation3621N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict71T → A in CAA07053. Ref.1
Sequence conflict341S → N in CAA07053. Ref.1
Sequence conflict79 – 802SE → RQ in BAB30938. Ref.2
Sequence conflict249 – 2502SR → VA in BAB30938. Ref.2
Sequence conflict2541D → T in BAB30938. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9CYD3 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: F6080CEC275CC5A4

FASTA40046,169
        10         20         30         40         50         60 
MGPRSPTAAL LVLLCVGCAP TPGRGQYERY SFRSFPRDEL MPLESAYRHA LDQYSGEHWA 

        70         80         90        100        110        120 
ESVGYLEVSL RLHRLLRDSE AFCHRNCSAA TPAPAPAGPA SHAELRLFGS VLRRAQCLKR 

       130        140        150        160        170        180 
CKQGLPAFRQ SQPSRSVLAD FQQREPYKFL QFAYFKANDL PKAIAAAHTY LLKHPDDEMM 

       190        200        210        220        230        240 
KRNMEYYKSL PGAEDHIKDL ETKSYESLFV RAVRAYNGEN WRTSISDMEL ALPDFLKAFY 

       250        260        270        280        290        300 
ECLAACEGSR EIKDFKDFYL SIADHYVEVL ECKIRCEETL TPVIGGYPVE KFVATMYHYL 

       310        320        330        340        350        360 
QFAYYKLNDL KNAAPCAVSY LLFDQSDRVM QQNLVYYQYH RDKWGLSDEH FQPRPEAVQF 

       370        380        390        400 
FNVTTLQKEL YDFAQEHLMD DDEGEVVEYV DDLLETEESA 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein."
Morello R., Tonachini L., Monticone M., Viggiano L., Rocchi M., Cancedda R., Castagnola P.
Matrix Biol. 18:319-324(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum and Embryo.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Olfactory epithelium.
[4]"CRTAP is required for prolyl 3-hydroxylation and mutations cause recessive osteogenesis imperfecta."
Morello R., Bertin T.K., Chen Y., Hicks J., Tonachini L., Monticone M., Castagnola P., Rauch F., Glorieux F.H., Vranka J., Baechinger H.P., Pace J.M., Schwarze U., Byers P.H., Weis M., Fernandes R.J., Eyre D.R., Yao Z., Boyce B.F., Lee B.
Cell 127:291-304(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN OSTEOCHONDRODYSPLASIA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ006469 mRNA. Translation: CAA07053.1.
AK017797 mRNA. Translation: BAB30938.1.
AK047506 mRNA. Translation: BAC33076.1.
BC049890 mRNA. Translation: AAH49890.1.
CCDSCCDS23592.1.
RefSeqNP_064306.2. NM_019922.2.
UniGeneMm.20904.

3D structure databases

ProteinModelPortalQ9CYD3.
SMRQ9CYD3. Positions 147-179.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000081941.

PTM databases

PhosphoSiteQ9CYD3.

Proteomic databases

MaxQBQ9CYD3.
PaxDbQ9CYD3.
PRIDEQ9CYD3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000084881; ENSMUSP00000081941; ENSMUSG00000032431.
GeneID56693.
KEGGmmu:56693.
UCSCuc009rxg.2. mouse.

Organism-specific databases

CTD10491.
MGIMGI:1891221. Crtap.

Phylogenomic databases

eggNOGNOG306541.
GeneTreeENSGT00550000074573.
HOGENOMHOG000247068.
HOVERGENHBG005540.
InParanoidQ8C8C5.
OMAKRAQCLK.
OrthoDBEOG7F7W8W.
TreeFamTF320837.

Gene expression databases

BgeeQ9CYD3.
CleanExMM_CRTAP.
GenevestigatorQ9CYD3.

Family and domain databases

ProtoNetSearch...

Other

NextBio313115.
PROQ9CYD3.
SOURCESearch...

Entry information

Entry nameCRTAP_MOUSE
AccessionPrimary (citable) accession number: Q9CYD3
Secondary accession number(s): O88698, Q8C8C5
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 92 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot