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Q9CYD3

- CRTAP_MOUSE

UniProt

Q9CYD3 - CRTAP_MOUSE

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Protein

Cartilage-associated protein

Gene
Crtap, Casp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.1 Publication

GO - Molecular functioni

  1. protein complex binding Source: UniProt

GO - Biological processi

  1. chaperone-mediated protein folding Source: UniProt
  2. peptidyl-proline hydroxylation to 3-hydroxy-L-proline Source: MGI
  3. spermatogenesis Source: BHF-UCL
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage-associated protein
Gene namesi
Name:Crtap
Synonyms:Casp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1891221. Crtap.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. macromolecular complex Source: UniProt
  3. proteinaceous extracellular matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Crtap are a cause of osteochondrodysplasia characterized by severe osteoporosis and decreased osteoid production.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed predictionAdd
BLAST
Chaini26 – 400375Cartilage-associated proteinPRO_0000006320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi362 – 3621N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ9CYD3.
PaxDbiQ9CYD3.
PRIDEiQ9CYD3.

PTM databases

PhosphoSiteiQ9CYD3.

Expressioni

Tissue specificityi

Found in articular chondrocytes. Expressed in a variety of tissues.1 Publication

Gene expression databases

BgeeiQ9CYD3.
CleanExiMM_CRTAP.
GenevestigatoriQ9CYD3.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081941.

Structurei

3D structure databases

ProteinModelPortaliQ9CYD3.
SMRiQ9CYD3. Positions 147-179.

Family & Domainsi

Sequence similaritiesi

Belongs to the leprecan family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG306541.
GeneTreeiENSGT00550000074573.
HOGENOMiHOG000247068.
HOVERGENiHBG005540.
InParanoidiQ8C8C5.
OMAiKRAQCLK.
OrthoDBiEOG7F7W8W.
TreeFamiTF320837.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYD3-1 [UniParc]FASTAAdd to Basket

« Hide

MGPRSPTAAL LVLLCVGCAP TPGRGQYERY SFRSFPRDEL MPLESAYRHA    50
LDQYSGEHWA ESVGYLEVSL RLHRLLRDSE AFCHRNCSAA TPAPAPAGPA 100
SHAELRLFGS VLRRAQCLKR CKQGLPAFRQ SQPSRSVLAD FQQREPYKFL 150
QFAYFKANDL PKAIAAAHTY LLKHPDDEMM KRNMEYYKSL PGAEDHIKDL 200
ETKSYESLFV RAVRAYNGEN WRTSISDMEL ALPDFLKAFY ECLAACEGSR 250
EIKDFKDFYL SIADHYVEVL ECKIRCEETL TPVIGGYPVE KFVATMYHYL 300
QFAYYKLNDL KNAAPCAVSY LLFDQSDRVM QQNLVYYQYH RDKWGLSDEH 350
FQPRPEAVQF FNVTTLQKEL YDFAQEHLMD DDEGEVVEYV DDLLETEESA 400
Length:400
Mass (Da):46,169
Last modified:July 27, 2011 - v3
Checksum:iF6080CEC275CC5A4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 71T → A in CAA07053. 1 Publication
Sequence conflicti34 – 341S → N in CAA07053. 1 Publication
Sequence conflicti79 – 802SE → RQ in BAB30938. 1 Publication
Sequence conflicti249 – 2502SR → VA in BAB30938. 1 Publication
Sequence conflicti254 – 2541D → T in BAB30938. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006469 mRNA. Translation: CAA07053.1.
AK017797 mRNA. Translation: BAB30938.1.
AK047506 mRNA. Translation: BAC33076.1.
BC049890 mRNA. Translation: AAH49890.1.
CCDSiCCDS23592.1.
RefSeqiNP_064306.2. NM_019922.2.
UniGeneiMm.20904.

Genome annotation databases

EnsembliENSMUST00000084881; ENSMUSP00000081941; ENSMUSG00000032431.
GeneIDi56693.
KEGGimmu:56693.
UCSCiuc009rxg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ006469 mRNA. Translation: CAA07053.1 .
AK017797 mRNA. Translation: BAB30938.1 .
AK047506 mRNA. Translation: BAC33076.1 .
BC049890 mRNA. Translation: AAH49890.1 .
CCDSi CCDS23592.1.
RefSeqi NP_064306.2. NM_019922.2.
UniGenei Mm.20904.

3D structure databases

ProteinModelPortali Q9CYD3.
SMRi Q9CYD3. Positions 147-179.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000081941.

PTM databases

PhosphoSitei Q9CYD3.

Proteomic databases

MaxQBi Q9CYD3.
PaxDbi Q9CYD3.
PRIDEi Q9CYD3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000084881 ; ENSMUSP00000081941 ; ENSMUSG00000032431 .
GeneIDi 56693.
KEGGi mmu:56693.
UCSCi uc009rxg.2. mouse.

Organism-specific databases

CTDi 10491.
MGIi MGI:1891221. Crtap.

Phylogenomic databases

eggNOGi NOG306541.
GeneTreei ENSGT00550000074573.
HOGENOMi HOG000247068.
HOVERGENi HBG005540.
InParanoidi Q8C8C5.
OMAi KRAQCLK.
OrthoDBi EOG7F7W8W.
TreeFami TF320837.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.

Miscellaneous databases

NextBioi 313115.
PROi Q9CYD3.
SOURCEi Search...

Gene expression databases

Bgeei Q9CYD3.
CleanExi MM_CRTAP.
Genevestigatori Q9CYD3.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein."
    Morello R., Tonachini L., Monticone M., Viggiano L., Rocchi M., Cancedda R., Castagnola P.
    Matrix Biol. 18:319-324(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Embryo.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Olfactory epithelium.
  4. Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN OSTEOCHONDRODYSPLASIA.

Entry informationi

Entry nameiCRTAP_MOUSE
AccessioniPrimary (citable) accession number: Q9CYD3
Secondary accession number(s): O88698, Q8C8C5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: September 3, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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