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Q9CYD3

- CRTAP_MOUSE

UniProt

Q9CYD3 - CRTAP_MOUSE

Protein

Cartilage-associated protein

Gene

Crtap

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.1 Publication

    GO - Molecular functioni

    1. protein complex binding Source: UniProt

    GO - Biological processi

    1. chaperone-mediated protein folding Source: UniProt
    2. peptidyl-proline hydroxylation to 3-hydroxy-L-proline Source: MGI
    3. spermatogenesis Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cartilage-associated protein
    Gene namesi
    Name:Crtap
    Synonyms:Casp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1891221. Crtap.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. macromolecular complex Source: UniProt
    3. proteinaceous extracellular matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    Defects in Crtap are a cause of osteochondrodysplasia characterized by severe osteoporosis and decreased osteoid production.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 400375Cartilage-associated proteinPRO_0000006320Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi86 – 861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein, Hydroxylation

    Proteomic databases

    MaxQBiQ9CYD3.
    PaxDbiQ9CYD3.
    PRIDEiQ9CYD3.

    PTM databases

    PhosphoSiteiQ9CYD3.

    Expressioni

    Tissue specificityi

    Found in articular chondrocytes. Expressed in a variety of tissues.1 Publication

    Gene expression databases

    BgeeiQ9CYD3.
    CleanExiMM_CRTAP.
    GenevestigatoriQ9CYD3.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000081941.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CYD3.
    SMRiQ9CYD3. Positions 147-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the leprecan family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG306541.
    GeneTreeiENSGT00550000074573.
    HOGENOMiHOG000247068.
    HOVERGENiHBG005540.
    InParanoidiQ8C8C5.
    OMAiKRAQCLK.
    OrthoDBiEOG7F7W8W.
    TreeFamiTF320837.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CYD3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPRSPTAAL LVLLCVGCAP TPGRGQYERY SFRSFPRDEL MPLESAYRHA    50
    LDQYSGEHWA ESVGYLEVSL RLHRLLRDSE AFCHRNCSAA TPAPAPAGPA 100
    SHAELRLFGS VLRRAQCLKR CKQGLPAFRQ SQPSRSVLAD FQQREPYKFL 150
    QFAYFKANDL PKAIAAAHTY LLKHPDDEMM KRNMEYYKSL PGAEDHIKDL 200
    ETKSYESLFV RAVRAYNGEN WRTSISDMEL ALPDFLKAFY ECLAACEGSR 250
    EIKDFKDFYL SIADHYVEVL ECKIRCEETL TPVIGGYPVE KFVATMYHYL 300
    QFAYYKLNDL KNAAPCAVSY LLFDQSDRVM QQNLVYYQYH RDKWGLSDEH 350
    FQPRPEAVQF FNVTTLQKEL YDFAQEHLMD DDEGEVVEYV DDLLETEESA 400
    Length:400
    Mass (Da):46,169
    Last modified:July 27, 2011 - v3
    Checksum:iF6080CEC275CC5A4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71T → A in CAA07053. (PubMed:10429950)Curated
    Sequence conflicti34 – 341S → N in CAA07053. (PubMed:10429950)Curated
    Sequence conflicti79 – 802SE → RQ in BAB30938. (PubMed:16141072)Curated
    Sequence conflicti249 – 2502SR → VA in BAB30938. (PubMed:16141072)Curated
    Sequence conflicti254 – 2541D → T in BAB30938. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006469 mRNA. Translation: CAA07053.1.
    AK017797 mRNA. Translation: BAB30938.1.
    AK047506 mRNA. Translation: BAC33076.1.
    BC049890 mRNA. Translation: AAH49890.1.
    CCDSiCCDS23592.1.
    RefSeqiNP_064306.2. NM_019922.2.
    UniGeneiMm.20904.

    Genome annotation databases

    EnsembliENSMUST00000084881; ENSMUSP00000081941; ENSMUSG00000032431.
    GeneIDi56693.
    KEGGimmu:56693.
    UCSCiuc009rxg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ006469 mRNA. Translation: CAA07053.1 .
    AK017797 mRNA. Translation: BAB30938.1 .
    AK047506 mRNA. Translation: BAC33076.1 .
    BC049890 mRNA. Translation: AAH49890.1 .
    CCDSi CCDS23592.1.
    RefSeqi NP_064306.2. NM_019922.2.
    UniGenei Mm.20904.

    3D structure databases

    ProteinModelPortali Q9CYD3.
    SMRi Q9CYD3. Positions 147-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000081941.

    PTM databases

    PhosphoSitei Q9CYD3.

    Proteomic databases

    MaxQBi Q9CYD3.
    PaxDbi Q9CYD3.
    PRIDEi Q9CYD3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000084881 ; ENSMUSP00000081941 ; ENSMUSG00000032431 .
    GeneIDi 56693.
    KEGGi mmu:56693.
    UCSCi uc009rxg.2. mouse.

    Organism-specific databases

    CTDi 10491.
    MGIi MGI:1891221. Crtap.

    Phylogenomic databases

    eggNOGi NOG306541.
    GeneTreei ENSGT00550000074573.
    HOGENOMi HOG000247068.
    HOVERGENi HBG005540.
    InParanoidi Q8C8C5.
    OMAi KRAQCLK.
    OrthoDBi EOG7F7W8W.
    TreeFami TF320837.

    Enzyme and pathway databases

    Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    NextBioi 313115.
    PROi Q9CYD3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CYD3.
    CleanExi MM_CRTAP.
    Genevestigatori Q9CYD3.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning, characterization and chromosome mapping of Crtap encoding the mouse cartilage associated protein."
      Morello R., Tonachini L., Monticone M., Viggiano L., Rocchi M., Cancedda R., Castagnola P.
      Matrix Biol. 18:319-324(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Embryo.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Olfactory epithelium.
    4. Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN OSTEOCHONDRODYSPLASIA.

    Entry informationi

    Entry nameiCRTAP_MOUSE
    AccessioniPrimary (citable) accession number: Q9CYD3
    Secondary accession number(s): O88698, Q8C8C5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3