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Protein

Cartilage-associated protein

Gene

Crtap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.1 Publication

GO - Molecular functioni

GO - Biological processi

  • chaperone-mediated protein folding Source: UniProtKB
  • negative regulation of post-translational protein modification Source: MGI
  • peptidyl-proline hydroxylation to 3-hydroxy-L-proline Source: MGI
  • protein stabilization Source: MGI
  • spermatogenesis Source: BHF-UCL

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes

Names & Taxonomyi

Protein namesi
Recommended name:
Cartilage-associated protein
Gene namesi
Name:Crtap
Synonyms:Casp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1891221 Crtap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Involvement in diseasei

Defects in Crtap are a cause of osteochondrodysplasia characterized by severe osteoporosis and decreased osteoid production.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000632026 – 400Cartilage-associated proteinAdd BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi86N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi362N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Hydroxylation

Proteomic databases

MaxQBiQ9CYD3
PaxDbiQ9CYD3
PeptideAtlasiQ9CYD3
PRIDEiQ9CYD3

PTM databases

PhosphoSitePlusiQ9CYD3

Expressioni

Tissue specificityi

Found in articular chondrocytes. Expressed in a variety of tissues.1 Publication

Gene expression databases

BgeeiENSMUSG00000032431
CleanExiMM_CRTAP
GenevisibleiQ9CYD3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081941

Structurei

3D structure databases

ProteinModelPortaliQ9CYD3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the leprecan family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IQZH Eukaryota
ENOG410Y7XP LUCA
GeneTreeiENSGT00550000074573
HOGENOMiHOG000247068
HOVERGENiHBG005540
InParanoidiQ9CYD3
KOiK19606
OMAiSEAFCNL
OrthoDBiEOG091G06WO
TreeFamiTF320837

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR033212 Crtap
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13986:SF3 PTHR13986:SF3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPRSPTAAL LVLLCVGCAP TPGRGQYERY SFRSFPRDEL MPLESAYRHA
60 70 80 90 100
LDQYSGEHWA ESVGYLEVSL RLHRLLRDSE AFCHRNCSAA TPAPAPAGPA
110 120 130 140 150
SHAELRLFGS VLRRAQCLKR CKQGLPAFRQ SQPSRSVLAD FQQREPYKFL
160 170 180 190 200
QFAYFKANDL PKAIAAAHTY LLKHPDDEMM KRNMEYYKSL PGAEDHIKDL
210 220 230 240 250
ETKSYESLFV RAVRAYNGEN WRTSISDMEL ALPDFLKAFY ECLAACEGSR
260 270 280 290 300
EIKDFKDFYL SIADHYVEVL ECKIRCEETL TPVIGGYPVE KFVATMYHYL
310 320 330 340 350
QFAYYKLNDL KNAAPCAVSY LLFDQSDRVM QQNLVYYQYH RDKWGLSDEH
360 370 380 390 400
FQPRPEAVQF FNVTTLQKEL YDFAQEHLMD DDEGEVVEYV DDLLETEESA
Length:400
Mass (Da):46,169
Last modified:July 27, 2011 - v3
Checksum:iF6080CEC275CC5A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7T → A in CAA07053 (PubMed:10429950).Curated1
Sequence conflicti34S → N in CAA07053 (PubMed:10429950).Curated1
Sequence conflicti79 – 80SE → RQ in BAB30938 (PubMed:16141072).Curated2
Sequence conflicti249 – 250SR → VA in BAB30938 (PubMed:16141072).Curated2
Sequence conflicti254D → T in BAB30938 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ006469 mRNA Translation: CAA07053.1
AK017797 mRNA Translation: BAB30938.1
AK047506 mRNA Translation: BAC33076.1
BC049890 mRNA Translation: AAH49890.1
CCDSiCCDS23592.1
RefSeqiNP_064306.2, NM_019922.2
UniGeneiMm.20904

Genome annotation databases

EnsembliENSMUST00000084881; ENSMUSP00000081941; ENSMUSG00000032431
GeneIDi56693
KEGGimmu:56693
UCSCiuc009rxg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiCRTAP_MOUSE
AccessioniPrimary (citable) accession number: Q9CYD3
Secondary accession number(s): O88698, Q8C8C5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 123 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health