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Protein

Cysteine-rich with EGF-like domain protein 2

Gene

Creld2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May regulate transport of alpha4-beta2 neuronal acetylcholine receptor.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich with EGF-like domain protein 2
Gene namesi
Name:Creld2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1923987. Creld2.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • extracellular space Source: MGI
  • Golgi apparatus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000025624623 – 350Cysteine-rich with EGF-like domain protein 2Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi138 ↔ 152PROSITE-ProRule annotation
Disulfide bondi146 ↔ 164PROSITE-ProRule annotation
Disulfide bondi166 ↔ 175PROSITE-ProRule annotation
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi292 ↔ 306PROSITE-ProRule annotation
Disulfide bondi299 ↔ 315PROSITE-ProRule annotation
Disulfide bondi317 ↔ 328PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9CYA0.
MaxQBiQ9CYA0.
PaxDbiQ9CYA0.
PeptideAtlasiQ9CYA0.
PRIDEiQ9CYA0.

PTM databases

iPTMnetiQ9CYA0.
PhosphoSitePlusiQ9CYA0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023272.
CleanExiMM_CRELD2.
GenevisibleiQ9CYA0. MM.

Interactioni

Subunit structurei

May interact with CHRNA4.By similarity

Protein-protein interaction databases

IntActiQ9CYA0. 3 interactors.
MINTiMINT-4125931.
STRINGi10090.ENSMUSP00000024042.

Structurei

3D structure databases

ProteinModelPortaliQ9CYA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 176EGF-like 1PROSITE-ProRule annotationAdd BLAST43
Repeati191 – 238FU 1Add BLAST48
Repeati251 – 298FU 2Add BLAST48
Domaini288 – 329EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42

Sequence similaritiesi

Belongs to the CRELD family.Curated
Contains 2 EGF-like domains.PROSITE-ProRule annotation
Contains 2 FU (furin-like) repeats.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
GeneTreeiENSGT00680000100014.
HOGENOMiHOG000004778.
HOVERGENiHBG081344.
InParanoidiQ9CYA0.
OMAiECDSTCV.
OrthoDBiEOG091G09AA.
PhylomeDBiQ9CYA0.
TreeFamiTF316507.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CYA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHLLLAAAFG LLLLLPPPGA VASRKPTMCQ RCRTLVDKFN QGMANTARKN
60 70 80 90 100
FGGGNTAWEE KTLSKYEFSE IRLLEIMEGL CDSSDFECNQ LLEQQEEQLE
110 120 130 140 150
AWWQTLKKEH PNLFEWFCVH TLKACCLPGT YGPDCQECQG GSERPCSGNG
160 170 180 190 200
YCSGDGSRQG DGSCQCHTGY KGPLCIDCTD GFFSLQRNET HSICSACDES
210 220 230 240 250
CKTCSGPSNK DCIQCEVGWA RVEDACVDVD ECAAETSPCS DGQYCENVNG
260 270 280 290 300
SYTCEDCDST CVGCTGKGPA NCKECIAGYT KESGQCTDID ECSLEEKACK
310 320 330 340 350
RKNENCYNVP GSFVCVCPEG FEETEDACVQ TAEGKVTEEN PTQPPSREDL
Length:350
Mass (Da):38,220
Last modified:June 1, 2001 - v1
Checksum:i781D7389B1944231
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017880 mRNA. Translation: BAB30986.1.
AK165884 mRNA. Translation: BAE38436.1.
BC047370 mRNA. Translation: AAH47370.1.
CCDSiCCDS27733.1.
RefSeqiNP_083996.1. NM_029720.2.
UniGeneiMm.292567.

Genome annotation databases

EnsembliENSMUST00000024042; ENSMUSP00000024042; ENSMUSG00000023272.
GeneIDi76737.
KEGGimmu:76737.
UCSCiuc007xep.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017880 mRNA. Translation: BAB30986.1.
AK165884 mRNA. Translation: BAE38436.1.
BC047370 mRNA. Translation: AAH47370.1.
CCDSiCCDS27733.1.
RefSeqiNP_083996.1. NM_029720.2.
UniGeneiMm.292567.

3D structure databases

ProteinModelPortaliQ9CYA0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CYA0. 3 interactors.
MINTiMINT-4125931.
STRINGi10090.ENSMUSP00000024042.

PTM databases

iPTMnetiQ9CYA0.
PhosphoSitePlusiQ9CYA0.

Proteomic databases

EPDiQ9CYA0.
MaxQBiQ9CYA0.
PaxDbiQ9CYA0.
PeptideAtlasiQ9CYA0.
PRIDEiQ9CYA0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024042; ENSMUSP00000024042; ENSMUSG00000023272.
GeneIDi76737.
KEGGimmu:76737.
UCSCiuc007xep.1. mouse.

Organism-specific databases

CTDi79174.
MGIiMGI:1923987. Creld2.

Phylogenomic databases

eggNOGiKOG4260. Eukaryota.
ENOG41107X2. LUCA.
GeneTreeiENSGT00680000100014.
HOGENOMiHOG000004778.
HOVERGENiHBG081344.
InParanoidiQ9CYA0.
OMAiECDSTCV.
OrthoDBiEOG091G09AA.
PhylomeDBiQ9CYA0.
TreeFamiTF316507.

Miscellaneous databases

ChiTaRSiCreld2. mouse.
PROiQ9CYA0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023272.
CleanExiMM_CRELD2.
GenevisibleiQ9CYA0. MM.

Family and domain databases

InterProiIPR021852. DUF3456.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt_.
IPR002049. Laminin_EGF.
[Graphical view]
PfamiPF11938. DUF3456. 1 hit.
PF07645. EGF_CA. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00179. EGF_CA. 2 hits.
SM00261. FU. 2 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 2 hits.
PS50026. EGF_3. 2 hits.
PS01187. EGF_CA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCREL2_MOUSE
AccessioniPrimary (citable) accession number: Q9CYA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.