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Q9CY94

- PSF3_MOUSE

UniProt

Q9CY94 - PSF3_MOUSE

Protein

DNA replication complex GINS protein PSF3

Gene

Gins3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA By similarity.By similarity

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Biological processi

    DNA replication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA replication complex GINS protein PSF3
    Alternative name(s):
    GINS complex subunit 3
    Gene namesi
    Name:Gins3
    Synonyms:Psf3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1926083. Gins3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 216216DNA replication complex GINS protein PSF3PRO_0000327616Add
    BLAST

    Proteomic databases

    MaxQBiQ9CY94.
    PaxDbiQ9CY94.
    PRIDEiQ9CY94.

    PTM databases

    PhosphoSiteiQ9CY94.

    Expressioni

    Gene expression databases

    BgeeiQ9CY94.
    GenevestigatoriQ9CY94.

    Interactioni

    Subunit structurei

    Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000034094.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CY94.
    SMRiQ9CY94. Positions 2-193.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 1616Not essential for folding and stability of GINS complex, but may regulate accessibility to the central complex poreBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GINS3/PSF3 family.Curated

    Phylogenomic databases

    eggNOGiCOG5138.
    GeneTreeiENSGT00390000001622.
    HOGENOMiHOG000007879.
    HOVERGENiHBG057574.
    InParanoidiQ9CY94.
    KOiK10734.
    OMAiQQGWRTV.
    OrthoDBiEOG7HXCS9.
    PhylomeDBiQ9CY94.
    TreeFamiTF314626.

    Family and domain databases

    InterProiIPR021151. GINS_complex.
    IPR010492. GINS_Psf3.
    [Graphical view]
    PANTHERiPTHR22768. PTHR22768. 1 hit.
    PfamiPF05916. Sld5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CY94-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEAYFPVES GALGPEENFL SLDDILMSQE KLPVRVETPM PRLGAFFLER    50
    GAGSEPDHPL PQGTKLELPL WLAKGLFDHK RRILSVELPK MYQEGWRTVF 100
    SADANVVDLH KMGPHFYGFG SQLLHFDSPE NADISQSLLK TFIGRFRRIM 150
    DSSQNSYNED TSALVARLDE TERGLFQIGQ RSLNDFQSWE KGQASQITAS 200
    SLVQNYKKRK FTNMED 216
    Length:216
    Mass (Da):24,577
    Last modified:June 1, 2001 - v1
    Checksum:iA131F7176A2498C0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019225 mRNA. Translation: BAB31610.1.
    AK146574 mRNA. Translation: BAE27270.1.
    AK150602 mRNA. Translation: BAE29694.1.
    AK151243 mRNA. Translation: BAE30235.1.
    AK152572 mRNA. Translation: BAE31324.1.
    AK160606 mRNA. Translation: BAE35909.1.
    BC039794 mRNA. Translation: AAH39794.1.
    BC064746 mRNA. Translation: AAH64746.1.
    CCDSiCCDS22564.1.
    RefSeqiNP_084474.1. NM_030198.3.
    UniGeneiMm.35546.

    Genome annotation databases

    EnsembliENSMUST00000034094; ENSMUSP00000034094; ENSMUSG00000031669.
    GeneIDi78833.
    KEGGimmu:78833.
    UCSCiuc009myr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK019225 mRNA. Translation: BAB31610.1 .
    AK146574 mRNA. Translation: BAE27270.1 .
    AK150602 mRNA. Translation: BAE29694.1 .
    AK151243 mRNA. Translation: BAE30235.1 .
    AK152572 mRNA. Translation: BAE31324.1 .
    AK160606 mRNA. Translation: BAE35909.1 .
    BC039794 mRNA. Translation: AAH39794.1 .
    BC064746 mRNA. Translation: AAH64746.1 .
    CCDSi CCDS22564.1.
    RefSeqi NP_084474.1. NM_030198.3.
    UniGenei Mm.35546.

    3D structure databases

    ProteinModelPortali Q9CY94.
    SMRi Q9CY94. Positions 2-193.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000034094.

    PTM databases

    PhosphoSitei Q9CY94.

    Proteomic databases

    MaxQBi Q9CY94.
    PaxDbi Q9CY94.
    PRIDEi Q9CY94.

    Protocols and materials databases

    DNASUi 78833.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000034094 ; ENSMUSP00000034094 ; ENSMUSG00000031669 .
    GeneIDi 78833.
    KEGGi mmu:78833.
    UCSCi uc009myr.1. mouse.

    Organism-specific databases

    CTDi 64785.
    MGIi MGI:1926083. Gins3.

    Phylogenomic databases

    eggNOGi COG5138.
    GeneTreei ENSGT00390000001622.
    HOGENOMi HOG000007879.
    HOVERGENi HBG057574.
    InParanoidi Q9CY94.
    KOi K10734.
    OMAi QQGWRTV.
    OrthoDBi EOG7HXCS9.
    PhylomeDBi Q9CY94.
    TreeFami TF314626.

    Miscellaneous databases

    NextBioi 349616.
    PROi Q9CY94.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CY94.
    Genevestigatori Q9CY94.

    Family and domain databases

    InterProi IPR021151. GINS_complex.
    IPR010492. GINS_Psf3.
    [Graphical view ]
    PANTHERi PTHR22768. PTHR22768. 1 hit.
    Pfami PF05916. Sld5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Bone marrow and Heart.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: CD-1 and Czech II.
      Tissue: Lung and Neural stem cell.

    Entry informationi

    Entry nameiPSF3_MOUSE
    AccessioniPrimary (citable) accession number: Q9CY94
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3