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Protein

DNA replication complex GINS protein PSF3

Gene

Gins3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176974. Unwinding of DNA.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF3
Alternative name(s):
GINS complex subunit 3
Gene namesi
Name:Gins3
Synonyms:Psf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1926083. Gins3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276161 – 216DNA replication complex GINS protein PSF3Add BLAST216

Proteomic databases

EPDiQ9CY94.
MaxQBiQ9CY94.
PaxDbiQ9CY94.
PeptideAtlasiQ9CY94.
PRIDEiQ9CY94.

PTM databases

PhosphoSitePlusiQ9CY94.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031669.
GenevisibleiQ9CY94. MM.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034094.

Structurei

3D structure databases

ProteinModelPortaliQ9CY94.
SMRiQ9CY94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 16Not essential for folding and stability of GINS complex, but may regulate accessibility to the central complex poreBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the GINS3/PSF3 family.Curated

Phylogenomic databases

eggNOGiKOG1106. Eukaryota.
COG5138. LUCA.
GeneTreeiENSGT00390000001622.
HOGENOMiHOG000007879.
HOVERGENiHBG057574.
InParanoidiQ9CY94.
KOiK10734.
OMAiYYYGLGS.
OrthoDBiEOG091G0QNW.
PhylomeDBiQ9CY94.
TreeFamiTF314626.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR010492. GINS_Psf3.
[Graphical view]
PANTHERiPTHR22768. PTHR22768. 1 hit.
PfamiPF05916. Sld5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CY94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAYFPVES GALGPEENFL SLDDILMSQE KLPVRVETPM PRLGAFFLER
60 70 80 90 100
GAGSEPDHPL PQGTKLELPL WLAKGLFDHK RRILSVELPK MYQEGWRTVF
110 120 130 140 150
SADANVVDLH KMGPHFYGFG SQLLHFDSPE NADISQSLLK TFIGRFRRIM
160 170 180 190 200
DSSQNSYNED TSALVARLDE TERGLFQIGQ RSLNDFQSWE KGQASQITAS
210
SLVQNYKKRK FTNMED
Length:216
Mass (Da):24,577
Last modified:June 1, 2001 - v1
Checksum:iA131F7176A2498C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019225 mRNA. Translation: BAB31610.1.
AK146574 mRNA. Translation: BAE27270.1.
AK150602 mRNA. Translation: BAE29694.1.
AK151243 mRNA. Translation: BAE30235.1.
AK152572 mRNA. Translation: BAE31324.1.
AK160606 mRNA. Translation: BAE35909.1.
BC039794 mRNA. Translation: AAH39794.1.
BC064746 mRNA. Translation: AAH64746.1.
CCDSiCCDS22564.1.
RefSeqiNP_084474.1. NM_030198.3.
UniGeneiMm.35546.

Genome annotation databases

EnsembliENSMUST00000034094; ENSMUSP00000034094; ENSMUSG00000031669.
GeneIDi78833.
KEGGimmu:78833.
UCSCiuc009myr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019225 mRNA. Translation: BAB31610.1.
AK146574 mRNA. Translation: BAE27270.1.
AK150602 mRNA. Translation: BAE29694.1.
AK151243 mRNA. Translation: BAE30235.1.
AK152572 mRNA. Translation: BAE31324.1.
AK160606 mRNA. Translation: BAE35909.1.
BC039794 mRNA. Translation: AAH39794.1.
BC064746 mRNA. Translation: AAH64746.1.
CCDSiCCDS22564.1.
RefSeqiNP_084474.1. NM_030198.3.
UniGeneiMm.35546.

3D structure databases

ProteinModelPortaliQ9CY94.
SMRiQ9CY94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034094.

PTM databases

PhosphoSitePlusiQ9CY94.

Proteomic databases

EPDiQ9CY94.
MaxQBiQ9CY94.
PaxDbiQ9CY94.
PeptideAtlasiQ9CY94.
PRIDEiQ9CY94.

Protocols and materials databases

DNASUi78833.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034094; ENSMUSP00000034094; ENSMUSG00000031669.
GeneIDi78833.
KEGGimmu:78833.
UCSCiuc009myr.1. mouse.

Organism-specific databases

CTDi64785.
MGIiMGI:1926083. Gins3.

Phylogenomic databases

eggNOGiKOG1106. Eukaryota.
COG5138. LUCA.
GeneTreeiENSGT00390000001622.
HOGENOMiHOG000007879.
HOVERGENiHBG057574.
InParanoidiQ9CY94.
KOiK10734.
OMAiYYYGLGS.
OrthoDBiEOG091G0QNW.
PhylomeDBiQ9CY94.
TreeFamiTF314626.

Enzyme and pathway databases

ReactomeiR-MMU-176974. Unwinding of DNA.

Miscellaneous databases

PROiQ9CY94.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031669.
GenevisibleiQ9CY94. MM.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR010492. GINS_Psf3.
[Graphical view]
PANTHERiPTHR22768. PTHR22768. 1 hit.
PfamiPF05916. Sld5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSF3_MOUSE
AccessioniPrimary (citable) accession number: Q9CY94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.