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Q9CY94 (PSF3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA replication complex GINS protein PSF3
Alternative name(s):
GINS complex subunit 3
Gene names
Name:Gins3
Synonyms:Psf3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length216 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA By similarity.

Subunit structure

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the GINS3/PSF3 family.

Ontologies

Keywords
   Biological processDNA replication
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 216216DNA replication complex GINS protein PSF3
PRO_0000327616

Regions

Region1 – 1616Not essential for folding and stability of GINS complex, but may regulate accessibility to the central complex pore By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CY94 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: A131F7176A2498C0

FASTA21624,577
        10         20         30         40         50         60 
MSEAYFPVES GALGPEENFL SLDDILMSQE KLPVRVETPM PRLGAFFLER GAGSEPDHPL 

        70         80         90        100        110        120 
PQGTKLELPL WLAKGLFDHK RRILSVELPK MYQEGWRTVF SADANVVDLH KMGPHFYGFG 

       130        140        150        160        170        180 
SQLLHFDSPE NADISQSLLK TFIGRFRRIM DSSQNSYNED TSALVARLDE TERGLFQIGQ 

       190        200        210 
RSLNDFQSWE KGQASQITAS SLVQNYKKRK FTNMED

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Bone marrow and Heart.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: CD-1 and Czech II.
Tissue: Lung and Neural stem cell.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK019225 mRNA. Translation: BAB31610.1.
AK146574 mRNA. Translation: BAE27270.1.
AK150602 mRNA. Translation: BAE29694.1.
AK151243 mRNA. Translation: BAE30235.1.
AK152572 mRNA. Translation: BAE31324.1.
AK160606 mRNA. Translation: BAE35909.1.
BC039794 mRNA. Translation: AAH39794.1.
BC064746 mRNA. Translation: AAH64746.1.
IPIIPI00111107.
RefSeqNP_084474.1. NM_030198.3.
UniGeneMm.35546.

3D structure databases

ProteinModelPortalQ9CY94.
SMRQ9CY94. Positions 2-193.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000034094.

PTM databases

PhosphoSiteQ9CY94.

Proteomic databases

PaxDbQ9CY94.
PRIDEQ9CY94.

Protocols and materials databases

DNASU78833.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000034094; ENSMUSP00000034094; ENSMUSG00000031669.
GeneID78833.
KEGGmmu:78833.
UCSCuc009myr.1. mouse.

Organism-specific databases

CTD64785.
MGIMGI:1926083. Gins3.

Phylogenomic databases

eggNOGCOG5138.
GeneTreeENSGT00390000001622.
HOGENOMHOG000007879.
HOVERGENHBG057574.
InParanoidQ9CY94.
KOK10734.
OMAMPRLGAF.
OrthoDBEOG43JC5M.

Gene expression databases

BgeeQ9CY94.
GenevestigatorQ9CY94.

Family and domain databases

InterProIPR021151. GINS_complex.
IPR010492. GINS_Psf3.
[Graphical view]
PANTHERPTHR22768. PTHR22768. 1 hit.
PfamPF05916. Sld5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio349616.
SOURCESearch...

Entry information

Entry namePSF3_MOUSE
AccessionPrimary (citable) accession number: Q9CY94
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: April 3, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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