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Protein

DNA replication complex GINS protein PSF3

Gene

Gins3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-MMU-176974 Unwinding of DNA

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF3
Alternative name(s):
GINS complex subunit 3
Gene namesi
Name:Gins3
Synonyms:Psf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1926083 Gins3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003276161 – 216DNA replication complex GINS protein PSF3Add BLAST216

Proteomic databases

EPDiQ9CY94
MaxQBiQ9CY94
PaxDbiQ9CY94
PeptideAtlasiQ9CY94
PRIDEiQ9CY94

PTM databases

PhosphoSitePlusiQ9CY94

Expressioni

Gene expression databases

BgeeiENSMUSG00000031669
ExpressionAtlasiQ9CY94 baseline and differential
GenevisibleiQ9CY94 MM

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034094

Structurei

3D structure databases

ProteinModelPortaliQ9CY94
SMRiQ9CY94
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 16Not essential for folding and stability of GINS complex, but may regulate accessibility to the central complex poreBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the GINS3/PSF3 family.Curated

Phylogenomic databases

eggNOGiKOG1106 Eukaryota
COG5138 LUCA
GeneTreeiENSGT00390000001622
HOGENOMiHOG000007879
HOVERGENiHBG057574
InParanoidiQ9CY94
KOiK10734
OMAiGTKMELP
OrthoDBiEOG091G0QNW
PhylomeDBiQ9CY94
TreeFamiTF314626

Family and domain databases

Gene3Di1.20.58.2050, 1 hit
InterProiView protein in InterPro
IPR021151 GINS_A
IPR036224 GINS_bundle-like_dom_sf
IPR010492 GINS_Psf3
IPR038437 GINS_Psf3_sf
PANTHERiPTHR22768 PTHR22768, 1 hit
PfamiView protein in Pfam
PF05916 Sld5, 1 hit
SUPFAMiSSF158573 SSF158573, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CY94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAYFPVES GALGPEENFL SLDDILMSQE KLPVRVETPM PRLGAFFLER
60 70 80 90 100
GAGSEPDHPL PQGTKLELPL WLAKGLFDHK RRILSVELPK MYQEGWRTVF
110 120 130 140 150
SADANVVDLH KMGPHFYGFG SQLLHFDSPE NADISQSLLK TFIGRFRRIM
160 170 180 190 200
DSSQNSYNED TSALVARLDE TERGLFQIGQ RSLNDFQSWE KGQASQITAS
210
SLVQNYKKRK FTNMED
Length:216
Mass (Da):24,577
Last modified:June 1, 2001 - v1
Checksum:iA131F7176A2498C0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019225 mRNA Translation: BAB31610.1
AK146574 mRNA Translation: BAE27270.1
AK150602 mRNA Translation: BAE29694.1
AK151243 mRNA Translation: BAE30235.1
AK152572 mRNA Translation: BAE31324.1
AK160606 mRNA Translation: BAE35909.1
BC039794 mRNA Translation: AAH39794.1
BC064746 mRNA Translation: AAH64746.1
CCDSiCCDS22564.1
RefSeqiNP_084474.1, NM_030198.3
UniGeneiMm.35546

Genome annotation databases

EnsembliENSMUST00000034094; ENSMUSP00000034094; ENSMUSG00000031669
GeneIDi78833
KEGGimmu:78833
UCSCiuc009myr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiPSF3_MOUSE
AccessioniPrimary (citable) accession number: Q9CY94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health