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Q9CY94

- PSF3_MOUSE

UniProt

Q9CY94 - PSF3_MOUSE

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Protein

DNA replication complex GINS protein PSF3

Gene

Gins3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA (By similarity).By similarity

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA replication complex GINS protein PSF3
Alternative name(s):
GINS complex subunit 3
Gene namesi
Name:Gins3
Synonyms:Psf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1926083. Gins3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 216216DNA replication complex GINS protein PSF3PRO_0000327616Add
BLAST

Proteomic databases

MaxQBiQ9CY94.
PaxDbiQ9CY94.
PRIDEiQ9CY94.

PTM databases

PhosphoSiteiQ9CY94.

Expressioni

Gene expression databases

BgeeiQ9CY94.
GenevestigatoriQ9CY94.

Interactioni

Subunit structurei

Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS2. GINS complex interacts with DNA primase in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034094.

Structurei

3D structure databases

ProteinModelPortaliQ9CY94.
SMRiQ9CY94. Positions 2-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1616Not essential for folding and stability of GINS complex, but may regulate accessibility to the central complex poreBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the GINS3/PSF3 family.Curated

Phylogenomic databases

eggNOGiCOG5138.
GeneTreeiENSGT00390000001622.
HOGENOMiHOG000007879.
HOVERGENiHBG057574.
InParanoidiQ9CY94.
KOiK10734.
OMAiQQGWRTV.
OrthoDBiEOG7HXCS9.
PhylomeDBiQ9CY94.
TreeFamiTF314626.

Family and domain databases

InterProiIPR021151. GINS_complex.
IPR010492. GINS_Psf3.
[Graphical view]
PANTHERiPTHR22768. PTHR22768. 1 hit.
PfamiPF05916. Sld5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CY94-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEAYFPVES GALGPEENFL SLDDILMSQE KLPVRVETPM PRLGAFFLER
60 70 80 90 100
GAGSEPDHPL PQGTKLELPL WLAKGLFDHK RRILSVELPK MYQEGWRTVF
110 120 130 140 150
SADANVVDLH KMGPHFYGFG SQLLHFDSPE NADISQSLLK TFIGRFRRIM
160 170 180 190 200
DSSQNSYNED TSALVARLDE TERGLFQIGQ RSLNDFQSWE KGQASQITAS
210
SLVQNYKKRK FTNMED
Length:216
Mass (Da):24,577
Last modified:June 1, 2001 - v1
Checksum:iA131F7176A2498C0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK019225 mRNA. Translation: BAB31610.1.
AK146574 mRNA. Translation: BAE27270.1.
AK150602 mRNA. Translation: BAE29694.1.
AK151243 mRNA. Translation: BAE30235.1.
AK152572 mRNA. Translation: BAE31324.1.
AK160606 mRNA. Translation: BAE35909.1.
BC039794 mRNA. Translation: AAH39794.1.
BC064746 mRNA. Translation: AAH64746.1.
CCDSiCCDS22564.1.
RefSeqiNP_084474.1. NM_030198.3.
UniGeneiMm.35546.

Genome annotation databases

EnsembliENSMUST00000034094; ENSMUSP00000034094; ENSMUSG00000031669.
GeneIDi78833.
KEGGimmu:78833.
UCSCiuc009myr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK019225 mRNA. Translation: BAB31610.1 .
AK146574 mRNA. Translation: BAE27270.1 .
AK150602 mRNA. Translation: BAE29694.1 .
AK151243 mRNA. Translation: BAE30235.1 .
AK152572 mRNA. Translation: BAE31324.1 .
AK160606 mRNA. Translation: BAE35909.1 .
BC039794 mRNA. Translation: AAH39794.1 .
BC064746 mRNA. Translation: AAH64746.1 .
CCDSi CCDS22564.1.
RefSeqi NP_084474.1. NM_030198.3.
UniGenei Mm.35546.

3D structure databases

ProteinModelPortali Q9CY94.
SMRi Q9CY94. Positions 2-193.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000034094.

PTM databases

PhosphoSitei Q9CY94.

Proteomic databases

MaxQBi Q9CY94.
PaxDbi Q9CY94.
PRIDEi Q9CY94.

Protocols and materials databases

DNASUi 78833.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000034094 ; ENSMUSP00000034094 ; ENSMUSG00000031669 .
GeneIDi 78833.
KEGGi mmu:78833.
UCSCi uc009myr.1. mouse.

Organism-specific databases

CTDi 64785.
MGIi MGI:1926083. Gins3.

Phylogenomic databases

eggNOGi COG5138.
GeneTreei ENSGT00390000001622.
HOGENOMi HOG000007879.
HOVERGENi HBG057574.
InParanoidi Q9CY94.
KOi K10734.
OMAi QQGWRTV.
OrthoDBi EOG7HXCS9.
PhylomeDBi Q9CY94.
TreeFami TF314626.

Miscellaneous databases

NextBioi 349616.
PROi Q9CY94.
SOURCEi Search...

Gene expression databases

Bgeei Q9CY94.
Genevestigatori Q9CY94.

Family and domain databases

InterProi IPR021151. GINS_complex.
IPR010492. GINS_Psf3.
[Graphical view ]
PANTHERi PTHR22768. PTHR22768. 1 hit.
Pfami PF05916. Sld5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Heart.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: CD-1 and Czech II.
    Tissue: Lung and Neural stem cell.

Entry informationi

Entry nameiPSF3_MOUSE
AccessioniPrimary (citable) accession number: Q9CY94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3