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Protein

39S ribosomal protein L44, mitochondrial

Gene

Mrpl44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the 39S subunit of mitochondrial ribosome. May have a function in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease, Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L44, mitochondrial (EC:3.1.26.-)
Short name:
L44mt
Short name:
MRP-L44
Gene namesi
Name:Mrpl44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1916413. Mrpl44.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3030MitochondrionBy similarityAdd
BLAST
Chaini31 – 33330339S ribosomal protein L44, mitochondrialPRO_0000030822Add
BLAST

Proteomic databases

EPDiQ9CY73.
MaxQBiQ9CY73.
PaxDbiQ9CY73.
PeptideAtlasiQ9CY73.
PRIDEiQ9CY73.

PTM databases

iPTMnetiQ9CY73.
PhosphoSiteiQ9CY73.

Expressioni

Gene expression databases

BgeeiENSMUSG00000026248.
CleanExiMM_MRPL44.
GenevisibleiQ9CY73. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027464.

Structurei

3D structure databases

ProteinModelPortaliQ9CY73.
SMRiQ9CY73. Positions 32-319.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 228143RNase IIIAdd
BLAST
Domaini236 – 30671DRBMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi54 – 574Poly-Pro

Sequence similaritiesi

Contains 1 DRBM (double-stranded RNA-binding) domain.PROSITE-ProRule annotation
Contains 1 RNase III domain.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IUHB. Eukaryota.
ENOG410XS28. LUCA.
GeneTreeiENSGT00390000016956.
HOGENOMiHOG000046065.
HOVERGENiHBG054127.
InParanoidiQ9CY73.
KOiK17425.
OMAiNRRPFDF.
OrthoDBiEOG091G0MBG.
TreeFamiTF324185.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000999. RNase_III_dom.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CY73-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASAVFRLLQ QGPRRLLAPA VPTLAPPVRG VKKGFRAAFR FQKELERWRL
60 70 80 90 100
LRCPPPPVRR SEKPNWDYHA EVQAFGSRLQ ETFSLDLLKT AFINSCYIKS
110 120 130 140 150
EEAKRQSLGI EKEAALLNLK DNQELFEQGL SFSHRCLTQF LEDEFPDLPA
160 170 180 190 200
EGTESLVSFL TGEAVVCHVA RNLAVEQLTL SAEFPVPLPV LRQTFFAVIG
210 220 230 240 250
ALLQSSGPER AALFIRDFLI TQMTGKELFE MWTVVNPMGL LVEELKKRNI
260 270 280 290 300
SAPESRLTRQ SGSTTALPLY FVGLYCDRKL IAEGPGETVL VAEEEAARVA
310 320 330
LRKLYGFTEN RRPWDYSKPK ESPKRAEQTS VAS
Note: No experimental confirmation available.
Length:333
Mass (Da):37,527
Last modified:July 27, 2011 - v3
Checksum:iD67C3BAC854DFD32
GO
Isoform 2 (identifier: Q9CY73-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-220: DFLI → VGNG
     221-333: Missing.

Show »
Length:220
Mass (Da):24,633
Checksum:iA7CE97BCF95071F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti233 – 2331T → P in AAH19727 (PubMed:15489334).Curated
Sequence conflicti249 – 2491N → D in AAH19727 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei217 – 2204DFLI → VGNG in isoform 2. 1 PublicationVSP_014126
Alternative sequencei221 – 333113Missing in isoform 2. 1 PublicationVSP_014127Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019986 mRNA. Translation: BAB31953.1.
AK156814 mRNA. Translation: BAE33863.1.
CH466687 Genomic DNA. Translation: EDL16270.1.
BC019727 mRNA. Translation: AAH19727.1.
CCDSiCCDS35629.1. [Q9CY73-1]
RefSeqiNP_001074679.1. NM_001081210.1. [Q9CY73-1]
UniGeneiMm.238455.

Genome annotation databases

EnsembliENSMUST00000027464; ENSMUSP00000027464; ENSMUSG00000026248. [Q9CY73-1]
GeneIDi69163.
KEGGimmu:69163.
UCSCiuc007bqx.1. mouse. [Q9CY73-2]
uc007bqy.1. mouse. [Q9CY73-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK019986 mRNA. Translation: BAB31953.1.
AK156814 mRNA. Translation: BAE33863.1.
CH466687 Genomic DNA. Translation: EDL16270.1.
BC019727 mRNA. Translation: AAH19727.1.
CCDSiCCDS35629.1. [Q9CY73-1]
RefSeqiNP_001074679.1. NM_001081210.1. [Q9CY73-1]
UniGeneiMm.238455.

3D structure databases

ProteinModelPortaliQ9CY73.
SMRiQ9CY73. Positions 32-319.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027464.

PTM databases

iPTMnetiQ9CY73.
PhosphoSiteiQ9CY73.

Proteomic databases

EPDiQ9CY73.
MaxQBiQ9CY73.
PaxDbiQ9CY73.
PeptideAtlasiQ9CY73.
PRIDEiQ9CY73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000027464; ENSMUSP00000027464; ENSMUSG00000026248. [Q9CY73-1]
GeneIDi69163.
KEGGimmu:69163.
UCSCiuc007bqx.1. mouse. [Q9CY73-2]
uc007bqy.1. mouse. [Q9CY73-1]

Organism-specific databases

CTDi65080.
MGIiMGI:1916413. Mrpl44.

Phylogenomic databases

eggNOGiENOG410IUHB. Eukaryota.
ENOG410XS28. LUCA.
GeneTreeiENSGT00390000016956.
HOGENOMiHOG000046065.
HOVERGENiHBG054127.
InParanoidiQ9CY73.
KOiK17425.
OMAiNRRPFDF.
OrthoDBiEOG091G0MBG.
TreeFamiTF324185.

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Miscellaneous databases

PROiQ9CY73.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026248.
CleanExiMM_MRPL44.
GenevisibleiQ9CY73. MM.

Family and domain databases

Gene3Di1.10.1520.10. 1 hit.
3.30.160.20. 1 hit.
InterProiIPR014720. dsRBD_dom.
IPR000999. RNase_III_dom.
[Graphical view]
SUPFAMiSSF69065. SSF69065. 1 hit.
PROSITEiPS50137. DS_RBD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRM44_MOUSE
AccessioniPrimary (citable) accession number: Q9CY73
Secondary accession number(s): Q3U0J0, Q8VE61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.