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Protein

Plasminogen activator inhibitor 1 RNA-binding protein

Gene

Serbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Plasminogen activator inhibitor 1 RNA-binding protein
Alternative name(s):
PAI1 RNA-binding protein 1
Short name:
PAI-RBP1
SERPINE1 mRNA-binding protein 1
Gene namesi
Name:Serbp1
Synonyms:Pairbp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1914120. Serbp1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000581832 – 407Plasminogen activator inhibitor 1 RNA-binding proteinAdd BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineCombined sources1
Modified residuei52N6-acetyllysine; alternateCombined sources1
Cross-linki52Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Modified residuei68N6-acetyllysineBy similarity1
Cross-linki102Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei122N6-acetyllysineCombined sources1
Modified residuei140N6-acetyllysineBy similarity1
Modified residuei165Omega-N-methylarginineCombined sources1
Modified residuei188Omega-N-methylarginineCombined sources1
Modified residuei197PhosphoserineBy similarity1
Modified residuei203PhosphoserineBy similarity1
Modified residuei205PhosphoserineBy similarity1
Modified residuei208PhosphoserineBy similarity1
Modified residuei211N6-acetyllysineBy similarity1
Modified residuei216Omega-N-methylarginineCombined sources1
Modified residuei221PhosphoserineBy similarity1
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Cross-linki228Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei234PhosphoserineCombined sources1
Cross-linki280Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei328N6-acetyllysineCombined sources1
Modified residuei329PhosphoserineCombined sources1
Modified residuei363Omega-N-methylarginineCombined sources1
Modified residuei366Omega-N-methylarginineCombined sources1
Modified residuei369Omega-N-methylarginineCombined sources1
Modified residuei391PhosphoserineCombined sources1
Modified residuei393PhosphoserineBy similarity1
Isoform 3 (identifier: Q9CY58-3)
Modified residuei231PhosphoserineCombined sources1
Modified residuei234PhosphothreonineCombined sources1
Isoform 2 (identifier: Q9CY58-2)
Modified residuei237PhosphoserineCombined sources1
Modified residuei240PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9CY58.
PaxDbiQ9CY58.
PeptideAtlasiQ9CY58.
PRIDEiQ9CY58.
TopDownProteomicsiQ9CY58-1. [Q9CY58-1]
Q9CY58-3. [Q9CY58-3]

PTM databases

iPTMnetiQ9CY58.
PhosphoSitePlusiQ9CY58.
SwissPalmiQ9CY58.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036371.
CleanExiMM_SERBP1.
ExpressionAtlasiQ9CY58. baseline and differential.
GenevisibleiQ9CY58. MM.

Interactioni

Subunit structurei

Interacts with CHD3 and TDRD3 (By similarity). Interacts with SPIN1.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211777. 5 interactors.
IntActiQ9CY58. 6 interactors.
MINTiMINT-1863007.
STRINGi10090.ENSMUSP00000039110.

Structurei

3D structure databases

ProteinModelPortaliQ9CY58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ9CY58.
KOiK13199.
OMAiPNRGIRT.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ9CY58.
TreeFamiTF318374.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
IPR027205. SERBP1.
[Graphical view]
PANTHERiPTHR12299:SF29. PTHR12299:SF29. 1 hit.
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CY58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG
60 70 80 90 100
AKSAAQAAAQ TNSNAAGKQL RKESQKDRKN PLPPSVGVAD KKEETQPPVA
110 120 130 140 150
LKKEGIRRVG RRPDQQLQGD GKLIDRRAER RPPRERRFEK PLEEKGEGGE
160 170 180 190 200
FSVDRPIIER PIRGRGGLGR GRGGRGRGMG RGDGFDSRGK REFDRHSGSD
210 220 230 240 250
RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK QISYNCSDLD
260 270 280 290 300
QSNVTEETPE GEEHPVADTE NKENEVEEVK EEGPKEMTLD EWKAIQNKDR
310 320 330 340 350
AKVEFNIRKP NEGADGQWKK GFVLHKSKSE EAHAEDSVMD HHFRKPANDI
360 370 380 390 400
TSQLEINFGD LGRPGRGGRG GRGGRGRGGR PNRGSRTDKS SASAPDVDDP

EAFPALA
Length:407
Mass (Da):44,714
Last modified:September 27, 2004 - v2
Checksum:iAC4F61EF7F38A8E5
GO
Isoform 2 (identifier: Q9CY58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-247: Missing.

Show »
Length:392
Mass (Da):42,944
Checksum:i1569ACE4336B118B
GO
Isoform 3 (identifier: Q9CY58-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     203-208: Missing.
     233-247: Missing.

Show »
Length:386
Mass (Da):42,235
Checksum:iA22FB50BE68F72CB
GO
Isoform 4 (identifier: Q9CY58-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     233-235: ESP → LVF
     236-407: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:235
Mass (Da):25,679
Checksum:i687C4A3292F7B607
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5L → P in BAC40253 (PubMed:16141072).Curated1
Sequence conflicti403F → S in BAB23466 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011632203 – 208Missing in isoform 3. 2 Publications6
Alternative sequenceiVSP_011633233 – 247Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_011634233 – 235ESP → LVF in isoform 4. 1 Publication3
Alternative sequenceiVSP_011635236 – 407Missing in isoform 4. 1 PublicationAdd BLAST172

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004678 mRNA. Translation: BAB23466.1.
AK010860 mRNA. Translation: BAB27229.1.
AK012390 mRNA. Translation: BAB28207.1.
AK045190 mRNA. Translation: BAC32255.1.
AK088278 mRNA. Translation: BAC40253.1.
BC013665 mRNA. Translation: AAH13665.1.
BC030502 mRNA. Translation: AAH30502.1.
CCDSiCCDS20219.1. [Q9CY58-1]
RefSeqiNP_001107037.1. NM_001113565.1. [Q9CY58-2]
NP_001107038.1. NM_001113566.1. [Q9CY58-3]
NP_080090.2. NM_025814.2. [Q9CY58-1]
UniGeneiMm.240490.
Mm.440861.

Genome annotation databases

EnsembliENSMUST00000042990; ENSMUSP00000039110; ENSMUSG00000036371. [Q9CY58-1]
ENSMUST00000203077; ENSMUSP00000144913; ENSMUSG00000036371. [Q9CY58-2]
ENSMUST00000204293; ENSMUSP00000145472; ENSMUSG00000036371. [Q9CY58-3]
GeneIDi66870.
KEGGimmu:66870.
UCSCiuc009cfh.1. mouse. [Q9CY58-2]
uc009cfi.1. mouse. [Q9CY58-4]
uc009cfj.2. mouse. [Q9CY58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004678 mRNA. Translation: BAB23466.1.
AK010860 mRNA. Translation: BAB27229.1.
AK012390 mRNA. Translation: BAB28207.1.
AK045190 mRNA. Translation: BAC32255.1.
AK088278 mRNA. Translation: BAC40253.1.
BC013665 mRNA. Translation: AAH13665.1.
BC030502 mRNA. Translation: AAH30502.1.
CCDSiCCDS20219.1. [Q9CY58-1]
RefSeqiNP_001107037.1. NM_001113565.1. [Q9CY58-2]
NP_001107038.1. NM_001113566.1. [Q9CY58-3]
NP_080090.2. NM_025814.2. [Q9CY58-1]
UniGeneiMm.240490.
Mm.440861.

3D structure databases

ProteinModelPortaliQ9CY58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211777. 5 interactors.
IntActiQ9CY58. 6 interactors.
MINTiMINT-1863007.
STRINGi10090.ENSMUSP00000039110.

PTM databases

iPTMnetiQ9CY58.
PhosphoSitePlusiQ9CY58.
SwissPalmiQ9CY58.

Proteomic databases

EPDiQ9CY58.
PaxDbiQ9CY58.
PeptideAtlasiQ9CY58.
PRIDEiQ9CY58.
TopDownProteomicsiQ9CY58-1. [Q9CY58-1]
Q9CY58-3. [Q9CY58-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042990; ENSMUSP00000039110; ENSMUSG00000036371. [Q9CY58-1]
ENSMUST00000203077; ENSMUSP00000144913; ENSMUSG00000036371. [Q9CY58-2]
ENSMUST00000204293; ENSMUSP00000145472; ENSMUSG00000036371. [Q9CY58-3]
GeneIDi66870.
KEGGimmu:66870.
UCSCiuc009cfh.1. mouse. [Q9CY58-2]
uc009cfi.1. mouse. [Q9CY58-4]
uc009cfj.2. mouse. [Q9CY58-1]

Organism-specific databases

CTDi26135.
MGIiMGI:1914120. Serbp1.

Phylogenomic databases

eggNOGiKOG2945. Eukaryota.
ENOG410YBHR. LUCA.
GeneTreeiENSGT00520000055591.
HOGENOMiHOG000220826.
HOVERGENiHBG056357.
InParanoidiQ9CY58.
KOiK13199.
OMAiPNRGIRT.
OrthoDBiEOG091G0UA9.
PhylomeDBiQ9CY58.
TreeFamiTF318374.

Miscellaneous databases

ChiTaRSiSerbp1. mouse.
PROiQ9CY58.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036371.
CleanExiMM_SERBP1.
ExpressionAtlasiQ9CY58. baseline and differential.
GenevisibleiQ9CY58. MM.

Family and domain databases

InterProiIPR006861. HABP4_PAIRBP1-bd.
IPR032381. IHABP4_N.
IPR027205. SERBP1.
[Graphical view]
PANTHERiPTHR12299:SF29. PTHR12299:SF29. 1 hit.
PfamiPF04774. HABP4_PAI-RBP1. 1 hit.
PF16174. IHABP4_N. 1 hit.
[Graphical view]
SMARTiSM01233. HABP4_PAI-RBP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAIRB_MOUSE
AccessioniPrimary (citable) accession number: Q9CY58
Secondary accession number(s): Q8BHS2
, Q8BHU0, Q91WP3, Q9CSN0, Q9DBY6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.