Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

EEF1A lysine methyltransferase 1

Gene

Eef1akmt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.UniRule annotation

Caution

Was originally thought to be an N6-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
EEF1A lysine methyltransferase 1UniRule annotationImported (EC:2.1.1.-UniRule annotation)
Alternative name(s):
N(6)-adenine-specific DNA methyltransferase 2UniRule annotation
Protein-lysine N-methyltransferase N6amt2UniRule annotation
Gene namesi
Name:Eef1akmt1UniRule annotationImported
Synonyms:N6amt2UniRule annotation
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915293 Eef1akmt1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003112952 – 214EEF1A lysine methyltransferase 1Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9CY45
MaxQBiQ9CY45
PaxDbiQ9CY45
PeptideAtlasiQ9CY45
PRIDEiQ9CY45

PTM databases

iPTMnetiQ9CY45
PhosphoSitePlusiQ9CY45

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022518

Structurei

3D structure databases

ProteinModelPortaliQ9CY45
SMRiQ9CY45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3350 Eukaryota
ENOG4111GGY LUCA
HOGENOMiHOG000240418
HOVERGENiHBG059901
InParanoidiQ9CY45
PhylomeDBiQ9CY45
TreeFamiTF106153

Family and domain databases

HAMAPiMF_03187 Methyltr_EFM5, 1 hit
InterProiView protein in InterPro
IPR002052 DNA_methylase_N6_adenine_CS
IPR019369 Efm5/EEF1AKMT1
IPR029063 SAM-dependent_MTases
SUPFAMiSSF53335 SSF53335, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CY45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESEDDDIP QLSSHTLAAL QEFYAEQKQS VNPRGDDKYN VGVIEENWQL
60 70 80 90 100
SQFWYSQDTA LRLAREAIDA AGEGGRIACV SAPSVYQKLR ELCREDSSVY
110 120 130 140 150
IFEYDRRFAI YGDEFIFYDY NHPLELPERI AAHSFDLVVA DPPYLSEECL
160 170 180 190 200
RKTSETIQFL TRGKILLCTG AIMEEQAAQL LGVKMCKFIP EHSRNLANEF
210
RCYTNYDSGL DCEA
Length:214
Mass (Da):24,499
Last modified:June 1, 2001 - v1
Checksum:iE658B75D9B8FF2C5
GO

Sequence cautioni

The sequence AAH51925 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB23947 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAB28017 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK005312 mRNA Translation: BAB23947.1 Different initiation.
AK010911 mRNA Translation: BAB27262.1
AK012083 mRNA Translation: BAB28017.1 Different initiation.
BC051925 mRNA Translation: AAH51925.1 Different initiation.
RefSeqiNP_080802.1, NM_026526.2
XP_006519546.1, XM_006519483.3
UniGeneiMm.45225

Genome annotation databases

GeneIDi68043
KEGGimmu:68043
UCSCiuc007udd.1 mouse

Similar proteinsi

Entry informationi

Entry nameiEFMT1_MOUSE
AccessioniPrimary (citable) accession number: Q9CY45
Secondary accession number(s): Q9CQR0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health