Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

GTP-binding protein 8

Gene

Gtpbp8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi125MagnesiumBy similarity1
Metal bindingi149MagnesiumBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 125GTPBy similarity8
Nucleotide bindingi147 – 151GTPBy similarity5
Nucleotide bindingi165 – 168GTPBy similarity4
Nucleotide bindingi227 – 230GTPBy similarity4
Nucleotide bindingi262 – 264GTPBy similarity3

GO - Molecular functioni

Keywordsi

LigandGTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 8
Gene namesi
Name:Gtpbp8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1913317 Gtpbp8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003386131 – 285GTP-binding protein 8Add BLAST285

Proteomic databases

PaxDbiQ9CY28
PeptideAtlasiQ9CY28
PRIDEiQ9CY28

PTM databases

PhosphoSitePlusiQ9CY28

Expressioni

Gene expression databases

BgeeiENSMUSG00000022668
ExpressionAtlasiQ9CY28 baseline and differential
GenevisibleiQ9CY28 MM

Interactioni

Protein-protein interaction databases

BioGridi211190, 1 interactor
STRINGi10090.ENSMUSP00000125352

Structurei

3D structure databases

ProteinModelPortaliQ9CY28
SMRiQ9CY28
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini110 – 283EngB-type GAdd BLAST174

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2486 Eukaryota
COG0218 LUCA
GeneTreeiENSGT00390000001083
HOGENOMiHOG000009834
HOVERGENiHBG055007
InParanoidiQ9CY28
OMAiQTQGCFP
OrthoDBiEOG091G0UQR
PhylomeDBiQ9CY28
TreeFamiTF331089

Family and domain databases

HAMAPiMF_00321 GTPase_EngB, 1 hit
InterProiView protein in InterPro
IPR030393 G_ENGB_dom
IPR019987 GTP-bd_ribosome_bio_YsxC
IPR006073 GTP_binding_domain
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF01926 MMR_HSR1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03598 GTPase_YsxC, 1 hit
PROSITEiView protein in PROSITE
PS51706 G_ENGB, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9CY28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAARLSHRM GRLLEKAPAL GPWTRVYSTS PAFAEVLRLP QKQLTKVVYP
60 70 80 90 100
LRELGQHLAA DSGPGLIEQR LFDPSLEDIG RAESIFEATA RNRIEYLSSA
110 120 130 140 150
VRLDHAPSLQ QPEVCFIGRS NVGKSSLIKA LFSLAPDVEV RISKKPGHTK
160 170 180 190 200
KMNFFKVGKH FTLVDMPGYG YRAPEDFVDM VETYLKERNN LKRTFLLVDS
210 220 230 240 250
VVGITKLDNI AIEMCEEFAL PYVMILTKID KSSKGYLLKQ VLQIQKFVNT
260 270 280
QTQGCFPQLF PISAVTNSGV HLLKCFIADI TGSLK
Length:285
Mass (Da):31,872
Last modified:June 1, 2001 - v1
Checksum:iD5561D52525253BF
GO
Isoform 2 (identifier: Q9CY28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-113: Missing.

Show »
Length:218
Mass (Da):24,446
Checksum:iA7F72A536EA4C1F9
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03405847 – 113Missing in isoform 2. 1 PublicationAdd BLAST67

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010979 mRNA Translation: BAB27301.1
AK147840 mRNA Translation: BAE28175.1
BC107216 mRNA Translation: AAI07217.1
BC107217 mRNA Translation: AAI07218.1
CCDSiCCDS28188.1 [Q9CY28-1]
CCDS49855.1 [Q9CY28-2]
RefSeqiNP_001152801.1, NM_001159329.1 [Q9CY28-2]
NP_079608.1, NM_025332.3 [Q9CY28-1]
UniGeneiMm.34520
Mm.443456

Genome annotation databases

EnsembliENSMUST00000023348; ENSMUSP00000023348; ENSMUSG00000022668 [Q9CY28-2]
ENSMUST00000162512; ENSMUSP00000125352; ENSMUSG00000022668 [Q9CY28-1]
GeneIDi66067
KEGGimmu:66067
UCSCiuc007zhq.2 mouse [Q9CY28-1]
uc012agd.1 mouse [Q9CY28-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGTPB8_MOUSE
AccessioniPrimary (citable) accession number: Q9CY28
Secondary accession number(s): Q3KNM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health