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Protein

Very-long-chain enoyl-CoA reductase

Gene

Tecr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.By similarity

Catalytic activityi

A very-long-chain acyl-CoA + NADP+ = a very-long-chain trans-2,3-dehydroacyl-CoA + NADPH.By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.By similarity
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNADP

Enzyme and pathway databases

BRENDAi1.3.1.38 3474
ReactomeiR-MMU-75876 Synthesis of very long-chain fatty acyl-CoAs
UniPathwayiUPA00094

Chemistry databases

SwissLipidsiSLP:000000437

Names & Taxonomyi

Protein namesi
Recommended name:
Very-long-chain enoyl-CoA reductaseCurated (EC:1.3.1.93By similarity)
Alternative name(s):
Synaptic glycoprotein SC2
Trans-2,3-enoyl-CoA reductase
Short name:
TER
Gene namesi
Name:Tecr
Synonyms:Gpsn2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1915408 Tecr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002136841 – 308Very-long-chain enoyl-CoA reductaseAdd BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22N6-acetyllysineBy similarity1
Modified residuei58PhosphoserineCombined sources1
Modified residuei60N6-acetyllysineCombined sources1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi247N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ9CY27
MaxQBiQ9CY27
PaxDbiQ9CY27
PeptideAtlasiQ9CY27
PRIDEiQ9CY27

PTM databases

iPTMnetiQ9CY27
PhosphoSitePlusiQ9CY27
SwissPalmiQ9CY27

Expressioni

Gene expression databases

BgeeiENSMUSG00000031708
CleanExiMM_GPSN2
ExpressionAtlasiQ9CY27 baseline and differential
GenevisibleiQ9CY27 MM

Interactioni

Subunit structurei

Interacts with ELOVL1 and LASS2.By similarity

Protein-protein interaction databases

BioGridi223073, 2 interactors
IntActiQ9CY27, 3 interactors
MINTiQ9CY27
STRINGi10090.ENSMUSP00000019382

Structurei

3D structure databases

ProteinModelPortaliQ9CY27
SMRiQ9CY27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the steroid 5-alpha reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1639 Eukaryota
ENOG410XR2S LUCA
GeneTreeiENSGT00510000046645
HOGENOMiHOG000190918
InParanoidiQ9CY27
KOiK10258
PhylomeDBiQ9CY27

Family and domain databases

InterProiView protein in InterPro
IPR001104 3-oxo-5_a-steroid_4-DH_C
IPR029071 Ubiquitin-like_domsf
PfamiView protein in Pfam
PF02544 Steroid_dh, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50244 S5A_REDUCTASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CY27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHYEVEIRD AKTREKLCFL DKVEPQATIS EIKTLFTKTH PQWYPARQSL
60 70 80 90 100
RLDPKGKSLK DEDVLQKLPV GTTATLYFRD LGAQISWVTV FLTEYAGPLF
110 120 130 140 150
IYLLFYFRVP FIYGRKYDFT SSRHTVVHLA CMCHSFHYIK RLLETLFVHR
160 170 180 190 200
FSHGTMPLRN IFKNCTYYWG FAAWMAYYIN HPLYTPPTYG VQQVKLALAV
210 220 230 240 250
FVICQLGNFS IHMALRDLRP AGSKTRKIPY PTKNPFTWLF LLVSCPNYTY
260 270 280 290 300
EVGSWIGFAI LTQCVPVALF SLVGFTQMTI WAKGKHRSYL KEFRDYPPLR

MPIIPFLL
Length:308
Mass (Da):36,090
Last modified:June 1, 2001 - v1
Checksum:i0576C2813F2C5E4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010984 mRNA Translation: BAB27305.1
BC019984 mRNA Translation: AAH19984.1
CCDSiCCDS40403.1
RefSeqiNP_081455.1, NM_027179.1
NP_598879.1, NM_134118.5
UniGeneiMm.352239

Genome annotation databases

EnsembliENSMUST00000019382; ENSMUSP00000019382; ENSMUSG00000031708
GeneIDi106529
KEGGimmu:106529
UCSCiuc009mkl.2 mouse

Entry informationi

Entry nameiTECR_MOUSE
AccessioniPrimary (citable) accession number: Q9CY27
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: June 1, 2001
Last modified: March 28, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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