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Protein

Probable 18S rRNA (guanine-N(7))-methyltransferase

Gene

Wbscr22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N7 position of a guanine in 18S rRNA. Important for biogenesis end export of the 40S ribosomal subunit independent on its methyltransferase activity. Locus-specific steroid receptor coactivator. Potentiates transactivation by glucocorticoid (NR3C1), mineralocorticoid (NR3C2), androgen (AR) and progesterone (PGR) receptors. Required for the maintenance of open chromatin at the TSC22D3/GILZ locus to facilitate NR3C1 loading on the response elements. Required for maintenance of dimethylation on histone H3 'Lys-79' (H3K79me2) (By similarity).By similarity

Catalytic activityi

S-adenosyl-L-methionine + guanine in 18S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine in 18S rRNA.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Ribosome biogenesis, rRNA processing, Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 18S rRNA (guanine-N(7))-methyltransferase (EC:2.1.1.-)
Alternative name(s):
Bud site selection protein 23 homolog
Williams-Beuren syndrome chromosomal region 22 protein homolog
Gene namesi
Name:Wbscr22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913388. Wbscr22.

Subcellular locationi

  • Nucleus By similarity
  • Nucleusnucleolus By similarity
  • Cytoplasm By similarity

  • Note: Localized diffusely throughout the nucleus and the cytoplasm. Localization is not affected by glucocorticoid treatment.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Probable 18S rRNA (guanine-N(7))-methyltransferasePRO_0000204451Add
BLAST

Post-translational modificationi

May be ubiquitinated and targeted to degradation in response to proinflammatory cytokine signaling.By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ9CY21.
MaxQBiQ9CY21.
PaxDbiQ9CY21.
PRIDEiQ9CY21.

PTM databases

iPTMnetiQ9CY21.
PhosphoSiteiQ9CY21.

Expressioni

Gene expression databases

BgeeiENSMUSG00000005378.
CleanExiMM_WBSCR22.
ExpressionAtlasiQ9CY21. baseline and differential.
GenevisibleiQ9CY21. MM.

Interactioni

Subunit structurei

Interacts with GRIP1.By similarity

Protein-protein interaction databases

IntActiQ9CY21. 1 interaction.
MINTiMINT-4140292.
STRINGi10090.ENSMUSP00000083146.

Structurei

3D structure databases

ProteinModelPortaliQ9CY21.
SMRiQ9CY21. Positions 16-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1541. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00390000014737.
HOGENOMiHOG000111527.
HOVERGENiHBG054765.
InParanoidiQ9CY21.
KOiK19306.
OMAiQAKFTNE.
OrthoDBiEOG091G0EVK.
PhylomeDBiQ9CY21.
TreeFamiTF300750.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
IPR022238. Unchr_MeTrfase_Williams-Beuren.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF12589. WBS_methylT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CY21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRSRRPEH SGPPELFYDQ NEARKYVRNS RMIDIQTKMT ERALELLCLP
60 70 80 90 100
EGQPSYLLDI GCGSGLSGDY ISEEGHYWVG IDISPAMLDA ALDRDTEGDL
110 120 130 140 150
LLGDMGQGVP FRPGSFDGCI SISAVQWLCN ANKKSDVPAR RLYCFFSSLY
160 170 180 190 200
SALVRGARAV LQLYPENSEQ LELITTQATR AGFTGGVVVD FPNSAKAKKF
210 220 230 240 250
YLCLFSGPST SLPKGLTESQ DADQASESMF TSERAPHKKA RRDLVKKSRE
260 270 280
WVLEKKERRR RQGKEVRPDT QYTGRKRKPR F
Length:281
Mass (Da):31,587
Last modified:June 1, 2001 - v1
Checksum:i5A71DDB525453FDC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412035 mRNA. Translation: AAM62317.1.
AK011005 mRNA. Translation: BAB27324.1.
AK151986 mRNA. Translation: BAE30852.1.
CCDSiCCDS19732.2.
RefSeqiNP_079651.2. NM_025375.3.
UniGeneiMm.439878.

Genome annotation databases

EnsembliENSMUST00000085984; ENSMUSP00000083146; ENSMUSG00000005378.
GeneIDi66138.
KEGGimmu:66138.
UCSCiuc008zxn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412035 mRNA. Translation: AAM62317.1.
AK011005 mRNA. Translation: BAB27324.1.
AK151986 mRNA. Translation: BAE30852.1.
CCDSiCCDS19732.2.
RefSeqiNP_079651.2. NM_025375.3.
UniGeneiMm.439878.

3D structure databases

ProteinModelPortaliQ9CY21.
SMRiQ9CY21. Positions 16-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9CY21. 1 interaction.
MINTiMINT-4140292.
STRINGi10090.ENSMUSP00000083146.

PTM databases

iPTMnetiQ9CY21.
PhosphoSiteiQ9CY21.

Proteomic databases

EPDiQ9CY21.
MaxQBiQ9CY21.
PaxDbiQ9CY21.
PRIDEiQ9CY21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000085984; ENSMUSP00000083146; ENSMUSG00000005378.
GeneIDi66138.
KEGGimmu:66138.
UCSCiuc008zxn.1. mouse.

Organism-specific databases

CTDi114049.
MGIiMGI:1913388. Wbscr22.

Phylogenomic databases

eggNOGiKOG1541. Eukaryota.
COG0500. LUCA.
GeneTreeiENSGT00390000014737.
HOGENOMiHOG000111527.
HOVERGENiHBG054765.
InParanoidiQ9CY21.
KOiK19306.
OMAiQAKFTNE.
OrthoDBiEOG091G0EVK.
PhylomeDBiQ9CY21.
TreeFamiTF300750.

Miscellaneous databases

ChiTaRSiWbscr22. mouse.
PROiQ9CY21.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005378.
CleanExiMM_WBSCR22.
ExpressionAtlasiQ9CY21. baseline and differential.
GenevisibleiQ9CY21. MM.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013216. Methyltransf_11.
IPR029063. SAM-dependent_MTases.
IPR022238. Unchr_MeTrfase_Williams-Beuren.
[Graphical view]
PfamiPF08241. Methyltransf_11. 1 hit.
PF12589. WBS_methylT. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWBS22_MOUSE
AccessioniPrimary (citable) accession number: Q9CY21
Secondary accession number(s): Q3U915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: June 1, 2001
Last modified: September 7, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.