Ndufs4

Functionⁱ

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functionⁱ

NADH dehydrogenase (ubiquinone) activity
Source: MGI
Inferred from direct assayⁱ
- 10747996

Complete GO annotation...

GO - Biological processⁱ

brain development Source: MGI
cAMP-mediated signaling Source: MGI
cellular respiration Source: MGI
electron transport chain Source: InterPro
mitochondrial respiratory chain complex I assembly Source: MGI
positive regulation of fibroblast proliferation Source: MGI
reactive oxygen species metabolic process Source: MGI
regulation of protein phosphorylation
Source: MGI
Inferred from sequence orthologyⁱ
- 11165261
response to cAMP Source: MGI

Complete GO annotation...

Keywordsⁱ

Biological process	Electron transport, Respiratory chain, Transport

Biological process

Electron transport, Respiratory chain, Transport

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial Alternative name(s): Complex I-18 kDa Short name: CI-18 kDa Complex I-AQDQ Short name: CI-AQDQ NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene namesⁱ	Name:Ndufs4
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Unplaced

Organism-specific databases

MGIⁱ	MGI:1343135. Ndufs4.

Subcellular locationⁱ

Mitochondrion inner membrane
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:O43181 (NDUS4_HUMAN)
; Peripheral membrane protein
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:O43181 (NDUS4_HUMAN)
; Matrix side
By similarity
Manual assertion inferred from sequence similarity toⁱ
- UniProtKB:O43181 (NDUS4_HUMAN)

GO - Cellular componentⁱ

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 42	MitochondrionBy similarityAdd BLAST		42
ChainⁱPRO_0000020039	43 – 175	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST		133

Proteomic databases

EPDⁱ	Q9CXZ1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CXZ1.
PaxDbⁱ	Q9CXZ1.
PeptideAtlas More...PeptideAtlasⁱ	Q9CXZ1.
PRIDEⁱ	Q9CXZ1.

PTM databases

iPTMnetⁱ	Q9CXZ1.
PhosphoSitePlusⁱ	Q9CXZ1.

Expressionⁱ

Gene expression databases

CleanExⁱ	MM_NDUFS4.

CleanExⁱ

MM_NDUFS4.

Interactionⁱ

Subunit structureⁱ

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridⁱ	201718. 1 interactor.
IntActⁱ	Q9CXZ1. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4104504.
STRINGⁱ	10090.ENSMUSP00000022286.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9CXZ1.
SMRⁱ	Q9CXZ1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG3389. Eukaryota. ENOG4111TR4. LUCA.
HOGENOMⁱ	HOG000140414.
HOVERGENⁱ	HBG003007.
InParanoidⁱ	Q9CXZ1.
KEGG Orthology (KO) More...KOⁱ	K03937.
PhylomeDBⁱ	Q9CXZ1.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006885. NADH_UbQ_FeS_4_mit.
PANTHERⁱ	PTHR12219. PTHR12219. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04800. ETC_C1_NDUFA4. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q9CXZ1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAAVSISVSL RQAMLGRRAM ATAAVSVCRV PSRLLSTSTW KLADNQTRDT 
        60         70         80         90        100
QLITVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME 
       110        120        130        140        150
FDTRERWENP LMGWASTADP LSNMVLTFSA KEDAIAFAEK NGWSYDVEEK 
       160        170 
KVPKPKSKSY GANFSWNKRT RVSTK

Length:175

Mass (Da):19,785

Last modified:May 10, 2004 - v3

Checksum:ⁱ33D565B204D1C7A2

GO

Sequence cautionⁱ

The sequence AAD30474 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	68	P → Q in BAB27417 (PubMed:16141072).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK011124 mRNA. Translation: BAB27417.2. AF124785 mRNA. Translation: AAD30474.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49368.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035017.2. NM_010887.2.
UniGeneⁱ	Mm.253142.

Genome annotation databases

GeneIDⁱ	17993.
KEGGⁱ	mmu:17993.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK011124 mRNA. Translation: BAB27417.2. AF124785 mRNA. Translation: AAD30474.1. Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS49368.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_035017.2. NM_010887.2.
UniGeneⁱ	Mm.253142.

3D structure databases

ProteinModelPortalⁱ	Q9CXZ1.
SMRⁱ	Q9CXZ1.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	201718. 1 interactor.
IntActⁱ	Q9CXZ1. 2 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-4104504.
STRINGⁱ	10090.ENSMUSP00000022286.

PTM databases

iPTMnetⁱ	Q9CXZ1.
PhosphoSitePlusⁱ	Q9CXZ1.

Proteomic databases

EPDⁱ	Q9CXZ1.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9CXZ1.
PaxDbⁱ	Q9CXZ1.
PeptideAtlas More...PeptideAtlasⁱ	Q9CXZ1.
PRIDEⁱ	Q9CXZ1.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	17993.
KEGGⁱ	mmu:17993.

Organism-specific databases

CTDⁱ	4724.
MGIⁱ	MGI:1343135. Ndufs4.

Phylogenomic databases

eggNOGⁱ	KOG3389. Eukaryota. ENOG4111TR4. LUCA.
HOGENOMⁱ	HOG000140414.
HOVERGENⁱ	HBG003007.
InParanoidⁱ	Q9CXZ1.
KEGG Orthology (KO) More...KOⁱ	K03937.
PhylomeDBⁱ	Q9CXZ1.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q9CXZ1.
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	MM_NDUFS4.

CleanExⁱ

MM_NDUFS4.

Family and domain databases

InterProⁱ	View protein in InterPro IPR006885. NADH_UbQ_FeS_4_mit.
PANTHERⁱ	PTHR12219. PTHR12219. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04800. ETC_C1_NDUFA4. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NDUS4_MOUSE
Accessionⁱ	Q9CXZ1Primary (citable) accession number: Q9CXZ1 Secondary accession number(s): Q9WUB1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
	Last sequence update:	May 10, 2004
	Last modified:	May 10, 2017
	This is version 108 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9CXZ1 (NDUS4_MOUSE)

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NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ