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Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

Ndufs4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity

GO - Molecular functioni

  • NADH dehydrogenase (ubiquinone) activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Alternative name(s):
Complex I-18 kDa
Short name:
CI-18 kDa
Complex I-AQDQ
Short name:
CI-AQDQ
NADH-ubiquinone oxidoreductase 18 kDa subunit
Gene namesi
Name:Ndufs4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1343135. Ndufs4.

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionBy similarityAdd BLAST42
ChainiPRO_000002003943 – 175NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST133

Proteomic databases

EPDiQ9CXZ1.
MaxQBiQ9CXZ1.
PaxDbiQ9CXZ1.
PeptideAtlasiQ9CXZ1.
PRIDEiQ9CXZ1.

PTM databases

iPTMnetiQ9CXZ1.
PhosphoSitePlusiQ9CXZ1.

Expressioni

Gene expression databases

CleanExiMM_NDUFS4.

Interactioni

Subunit structurei

Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity

Protein-protein interaction databases

BioGridi201718. 1 interactor.
IntActiQ9CXZ1. 2 interactors.
MINTiMINT-4104504.
STRINGi10090.ENSMUSP00000022286.

Structurei

3D structure databases

ProteinModelPortaliQ9CXZ1.
SMRiQ9CXZ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFS4 subunit family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3389. Eukaryota.
ENOG4111TR4. LUCA.
HOGENOMiHOG000140414.
HOVERGENiHBG003007.
InParanoidiQ9CXZ1.
KOiK03937.
PhylomeDBiQ9CXZ1.

Family and domain databases

InterProiIPR006885. NADH_UbQ_FeS_4_mit.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
PfamiPF04800. ETC_C1_NDUFA4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXZ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVSISVSL RQAMLGRRAM ATAAVSVCRV PSRLLSTSTW KLADNQTRDT
60 70 80 90 100
QLITVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME
110 120 130 140 150
FDTRERWENP LMGWASTADP LSNMVLTFSA KEDAIAFAEK NGWSYDVEEK
160 170
KVPKPKSKSY GANFSWNKRT RVSTK
Length:175
Mass (Da):19,785
Last modified:May 10, 2004 - v3
Checksum:i33D565B204D1C7A2
GO

Sequence cautioni

The sequence AAD30474 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti68P → Q in BAB27417 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011124 mRNA. Translation: BAB27417.2.
AF124785 mRNA. Translation: AAD30474.1. Different initiation.
CCDSiCCDS49368.1.
RefSeqiNP_035017.2. NM_010887.2.
UniGeneiMm.253142.

Genome annotation databases

GeneIDi17993.
KEGGimmu:17993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK011124 mRNA. Translation: BAB27417.2.
AF124785 mRNA. Translation: AAD30474.1. Different initiation.
CCDSiCCDS49368.1.
RefSeqiNP_035017.2. NM_010887.2.
UniGeneiMm.253142.

3D structure databases

ProteinModelPortaliQ9CXZ1.
SMRiQ9CXZ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201718. 1 interactor.
IntActiQ9CXZ1. 2 interactors.
MINTiMINT-4104504.
STRINGi10090.ENSMUSP00000022286.

PTM databases

iPTMnetiQ9CXZ1.
PhosphoSitePlusiQ9CXZ1.

Proteomic databases

EPDiQ9CXZ1.
MaxQBiQ9CXZ1.
PaxDbiQ9CXZ1.
PeptideAtlasiQ9CXZ1.
PRIDEiQ9CXZ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi17993.
KEGGimmu:17993.

Organism-specific databases

CTDi4724.
MGIiMGI:1343135. Ndufs4.

Phylogenomic databases

eggNOGiKOG3389. Eukaryota.
ENOG4111TR4. LUCA.
HOGENOMiHOG000140414.
HOVERGENiHBG003007.
InParanoidiQ9CXZ1.
KOiK03937.
PhylomeDBiQ9CXZ1.

Miscellaneous databases

PROiQ9CXZ1.
SOURCEiSearch...

Gene expression databases

CleanExiMM_NDUFS4.

Family and domain databases

InterProiIPR006885. NADH_UbQ_FeS_4_mit.
[Graphical view]
PANTHERiPTHR12219. PTHR12219. 1 hit.
PfamiPF04800. ETC_C1_NDUFA4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNDUS4_MOUSE
AccessioniPrimary (citable) accession number: Q9CXZ1
Secondary accession number(s): Q9WUB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: November 2, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.