UniProtKB - Q9CXZ1 (NDUS4_MOUSE)
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Protein
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Gene
Ndufs4
Organism
Mus musculus (Mouse)
Status
Functioni
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.By similarity
GO - Molecular functioni
- NADH dehydrogenase (ubiquinone) activity Source: MGI
GO - Biological processi
- brain development Source: MGI
- cAMP-mediated signaling Source: MGI
- cellular respiration Source: MGI
- electron transport chain Source: InterPro
- mitochondrial respiratory chain complex I assembly Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- reactive oxygen species metabolic process Source: MGI
- regulation of protein phosphorylation Source: MGI
- response to cAMP Source: MGI
Keywordsi
Biological process | Electron transport, Respiratory chain, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAlternative name(s): Complex I-18 kDa Short name: CI-18 kDa Complex I-AQDQ Short name: CI-AQDQ NADH-ubiquinone oxidoreductase 18 kDa subunit |
Gene namesi | Name:Ndufs4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1343135. Ndufs4. |
Subcellular locationi
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 42 | MitochondrionBy similarityAdd BLAST | 42 | |
ChainiPRO_0000020039 | 43 – 175 | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialAdd BLAST | 133 |
Proteomic databases
EPDi | Q9CXZ1. |
MaxQBi | Q9CXZ1. |
PaxDbi | Q9CXZ1. |
PeptideAtlasi | Q9CXZ1. |
PRIDEi | Q9CXZ1. |
PTM databases
iPTMneti | Q9CXZ1. |
PhosphoSitePlusi | Q9CXZ1. |
Interactioni
Subunit structurei
Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.By similarity
Protein-protein interaction databases
BioGridi | 201718. 1 interactor. |
CORUMi | Q9CXZ1. |
IntActi | Q9CXZ1. 2 interactors. |
MINTi | Q9CXZ1. |
STRINGi | 10090.ENSMUSP00000022286. |
Structurei
3D structure databases
ProteinModelPortali | Q9CXZ1. |
SMRi | Q9CXZ1. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the complex I NDUFS4 subunit family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3389. Eukaryota. ENOG4111TR4. LUCA. |
HOGENOMi | HOG000140414. |
HOVERGENi | HBG003007. |
InParanoidi | Q9CXZ1. |
KOi | K03937. |
PhylomeDBi | Q9CXZ1. |
Family and domain databases
Gene3Di | 3.30.160.190. 1 hit. |
InterProi | View protein in InterPro IPR006885. NADH_UbQ_FeS_4_mit. IPR038532. NDUFS4-like_sf. |
PANTHERi | PTHR12219. PTHR12219. 1 hit. |
Pfami | View protein in Pfam PF04800. ETC_C1_NDUFA4. 1 hit. |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9CXZ1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAAVSISVSL RQAMLGRRAM ATAAVSVCRV PSRLLSTSTW KLADNQTRDT
60 70 80 90 100
QLITVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME
110 120 130 140 150
FDTRERWENP LMGWASTADP LSNMVLTFSA KEDAIAFAEK NGWSYDVEEK
160 170
KVPKPKSKSY GANFSWNKRT RVSTK
Sequence cautioni
The sequence AAD30474 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 68 | P → Q in BAB27417 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK011124 mRNA. Translation: BAB27417.2. AF124785 mRNA. Translation: AAD30474.1. Different initiation. |
CCDSi | CCDS49368.1. |
RefSeqi | NP_035017.2. NM_010887.2. |
UniGenei | Mm.253142. |
Genome annotation databases
GeneIDi | 17993. |
KEGGi | mmu:17993. |
Similar proteinsi
Entry informationi
Entry namei | NDUS4_MOUSE | |
Accessioni | Q9CXZ1Primary (citable) accession number: Q9CXZ1 Secondary accession number(s): Q9WUB1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 10, 2004 |
Last sequence update: | May 10, 2004 | |
Last modified: | March 28, 2018 | |
This is version 111 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |