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Q9CXZ1

- NDUS4_MOUSE

UniProt

Q9CXZ1 - NDUS4_MOUSE

Protein

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Gene

Ndufs4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 3 (10 May 2004)
      Previous versions | rss
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    Functioni

    Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

    GO - Molecular functioni

    1. NADH dehydrogenase (ubiquinone) activity Source: MGI

    GO - Biological processi

    1. electron transport chain Source: InterPro
    2. regulation of protein phosphorylation Source: MGI

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
    Alternative name(s):
    Complex I-18 kDa
    Short name:
    CI-18 kDa
    Complex I-AQDQ
    Short name:
    CI-AQDQ
    NADH-ubiquinone oxidoreductase 18 kDa subunit
    Gene namesi
    Name:Ndufs4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1343135. Ndufs4.

    Subcellular locationi

    Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

    GO - Cellular componenti

    1. mitochondrial respiratory chain complex I Source: MGI
    2. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4242MitochondrionBy similarityAdd
    BLAST
    Chaini43 – 175133NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrialPRO_0000020039Add
    BLAST

    Proteomic databases

    MaxQBiQ9CXZ1.
    PaxDbiQ9CXZ1.
    PRIDEiQ9CXZ1.

    PTM databases

    PhosphoSiteiQ9CXZ1.

    Expressioni

    Gene expression databases

    CleanExiMM_NDUFS4.
    GenevestigatoriQ9CXZ1.

    Interactioni

    Subunit structurei

    Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201718. 1 interaction.
    IntActiQ9CXZ1. 2 interactions.
    MINTiMINT-4104504.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXZ1.
    SMRiQ9CXZ1. Positions 78-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I NDUFS4 subunit family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG79671.
    HOGENOMiHOG000140414.
    HOVERGENiHBG003007.
    InParanoidiQ9CXZ1.
    KOiK03937.
    PhylomeDBiQ9CXZ1.

    Family and domain databases

    InterProiIPR006885. NADH_UbQ_FeS_4_mit.
    [Graphical view]
    PANTHERiPTHR12219. PTHR12219. 1 hit.
    PfamiPF04800. ETC_C1_NDUFA4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CXZ1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAVSISVSL RQAMLGRRAM ATAAVSVCRV PSRLLSTSTW KLADNQTRDT    50
    QLITVDEKLD ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME 100
    FDTRERWENP LMGWASTADP LSNMVLTFSA KEDAIAFAEK NGWSYDVEEK 150
    KVPKPKSKSY GANFSWNKRT RVSTK 175
    Length:175
    Mass (Da):19,785
    Last modified:May 10, 2004 - v3
    Checksum:i33D565B204D1C7A2
    GO

    Sequence cautioni

    The sequence AAD30474.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 681P → Q in BAB27417. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011124 mRNA. Translation: BAB27417.2.
    AF124785 mRNA. Translation: AAD30474.1. Different initiation.
    CCDSiCCDS49368.1.
    RefSeqiNP_035017.2. NM_010887.2.
    UniGeneiMm.253142.

    Genome annotation databases

    GeneIDi17993.
    KEGGimmu:17993.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK011124 mRNA. Translation: BAB27417.2 .
    AF124785 mRNA. Translation: AAD30474.1 . Different initiation.
    CCDSi CCDS49368.1.
    RefSeqi NP_035017.2. NM_010887.2.
    UniGenei Mm.253142.

    3D structure databases

    ProteinModelPortali Q9CXZ1.
    SMRi Q9CXZ1. Positions 78-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201718. 1 interaction.
    IntActi Q9CXZ1. 2 interactions.
    MINTi MINT-4104504.

    PTM databases

    PhosphoSitei Q9CXZ1.

    Proteomic databases

    MaxQBi Q9CXZ1.
    PaxDbi Q9CXZ1.
    PRIDEi Q9CXZ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 17993.
    KEGGi mmu:17993.

    Organism-specific databases

    CTDi 4724.
    MGIi MGI:1343135. Ndufs4.

    Phylogenomic databases

    eggNOGi NOG79671.
    HOGENOMi HOG000140414.
    HOVERGENi HBG003007.
    InParanoidi Q9CXZ1.
    KOi K03937.
    PhylomeDBi Q9CXZ1.

    Miscellaneous databases

    NextBioi 292975.
    PROi Q9CXZ1.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_NDUFS4.
    Genevestigatori Q9CXZ1.

    Family and domain databases

    InterProi IPR006885. NADH_UbQ_FeS_4_mit.
    [Graphical view ]
    PANTHERi PTHR12219. PTHR12219. 1 hit.
    Pfami PF04800. ETC_C1_NDUFA4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Liver.
    2. "Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator."
      Murdock D.G., Boone B.E., Esposito L.A., Wallace D.C.
      J. Biol. Chem. 274:14429-14433(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-175.
      Strain: BALB/c.
      Tissue: Skeletal muscle.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 49-73; 132-150 AND 159-168, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiNDUS4_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXZ1
    Secondary accession number(s): Q9WUB1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2004
    Last sequence update: May 10, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3