Q9CXZ1 (NDUS4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

Alternative name(s):
Complex I-18 kDa
Short name=CI-18 kDa
Complex I-AQDQ
Short name=CI-AQDQ
NADH-ubiquinone oxidoreductase 18 kDa subunit

Gene names

Name:

Ndufs4

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Subunit structure	Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme By similarity.
Subcellular location	Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.
Sequence similarities	Belongs to the complex I NDUFS4 subunit family.
Sequence caution	The sequence AAD30474.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transit peptide
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: InterPro regulation of protein phosphorylation Inferred from sequence orthology PubMed 11165261. Source: MGI
Cellular_component	mitochondrial respiratory chain complex I Inferred from direct assay PubMed 10747996. Source: MGI mitochondrion Inferred from direct assay PubMed 14651853PubMed 18614015. Source: MGI
Molecular_function	NADH dehydrogenase (ubiquinone) activity Inferred from direct assay PubMed 10747996. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 42	42	Mitochondrion By similarity
	Chain	43 – 175	133	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial		PRO_0000020039
Experimental info
	Sequence conflict	68	1	P → Q in BAB27417. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9CXZ1 [UniParc]. Last modified May 10, 2004. Version 3. Checksum: 33D565B204D1C7A2	FASTA	175	19,785
	10 20 30 40 50 60 MAAVSISVSL RQAMLGRRAM ATAAVSVCRV PSRLLSTSTW KLADNQTRDT QLITVDEKLD 70 80 90 100 110 120 ITTLTGVPEE HIKTRKVRIF VPARNNMQSG VNNTKKWKME FDTRERWENP LMGWASTADP 130 140 150 160 170 LSNMVLTFSA KEDAIAFAEK NGWSYDVEEK KVPKPKSKSY GANFSWNKRT RVSTK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Liver.
[2]	"Up-regulation of nuclear and mitochondrial genes in the skeletal muscle of mice lacking the heart/muscle isoform of the adenine nucleotide translocator." Murdock D.G., Boone B.E., Esposito L.A., Wallace D.C. J. Biol. Chem. 274:14429-14433(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 7-175. Strain: BALB/c. Tissue: Skeletal muscle.
[3]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 49-73; 132-150 AND 159-168, IDENTIFICATION BY MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK011124 mRNA. Translation: BAB27417.2. AF124785 mRNA. Translation: AAD30474.1. Different initiation.
RefSeq	NP_035017.2. NM_010887.2.
UniGene	Mm.253142.
3D structure databases
ProteinModelPortal	Q9CXZ1.
SMR	Q9CXZ1. Positions 78-147.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	201718. 1 interaction.
IntAct	Q9CXZ1. 2 interactions.
MINT	MINT-4104504.
PTM databases
PhosphoSite	Q9CXZ1.
Proteomic databases
PaxDb	Q9CXZ1.
PRIDE	Q9CXZ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	17993.
KEGG	mmu:17993.
Organism-specific databases
CTD	4724.
MGI	MGI:1343135. Ndufs4.
Phylogenomic databases
eggNOG	NOG79671.
HOGENOM	HOG000140414.
HOVERGEN	HBG003007.
InParanoid	Q9CXZ1.
KO	K03937.
PhylomeDB	Q9CXZ1.
Gene expression databases
CleanEx	MM_NDUFS4.
Genevestigator	Q9CXZ1.
Family and domain databases
InterPro	IPR006885. NADH_UbQ_FeS_4_mit. [Graphical view]
PANTHER	PTHR12219. PTHR12219. 1 hit.
Pfam	PF04800. ETC_C1_NDUFA4. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	292975.
PRO	Q9CXZ1.
SOURCE	Search...

Entry information

Entry name

NDUS4_MOUSE

Accession

Primary (citable) accession number: Q9CXZ1
Secondary accession number(s): Q9WUB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 10, 2004
Last sequence update:	May 10, 2004
Last modified:	April 16, 2014
This is version 93 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program