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Q9CXY6

- ILF2_MOUSE

UniProt

Q9CXY6 - ILF2_MOUSE

Protein

Interleukin enhancer-binding factor 2

Gene

Ilf2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA By similarity. Essential for the efficient reshuttling of ILF3 into the nucleus By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. DNA binding Source: UniProtKB
    3. double-stranded RNA binding Source: UniProtKB
    4. transferase activity Source: InterPro

    GO - Biological processi

    1. immune response Source: InterPro
    2. positive regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription, DNA-templated Source: UniProtKB

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin enhancer-binding factor 2
    Alternative name(s):
    Nuclear factor of activated T-cells 45 kDa
    Gene namesi
    Name:Ilf2
    Synonyms:Nf45
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1915031. Ilf2.

    Subcellular locationi

    Nucleusnucleolus 1 Publication. Cytoplasm By similarity. Nucleus By similarity
    Note: Localized in cytoplasmic mRNP granules containing untranslated mRNAs.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: UniProtKB
    3. nucleus Source: UniProtKB
    4. ribonucleoprotein complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 390390Interleukin enhancer-binding factor 2PRO_0000126064Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei388 – 3881PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9CXY6.
    PaxDbiQ9CXY6.
    PRIDEiQ9CXY6.

    PTM databases

    PhosphoSiteiQ9CXY6.

    Expressioni

    Tissue specificityi

    Expressed in brain, kidney and ovary; highly expressed in testis, particularly within pachytene cells.1 Publication

    Developmental stagei

    Expression in testis begins with developmental differentiation of pachytene spermatocytes.1 Publication

    Gene expression databases

    BgeeiQ9CXY6.
    CleanExiMM_ILF2.
    GenevestigatoriQ9CXY6.

    Interactioni

    Subunit structurei

    Forms heterodimers with ILF3. ILF2-ILF3 heterodimers may also bind to PRKDC/XRCC7: this may stabilize the interaction of PRKDC/XRCC7 and the heterodimeric complex of G22P1/KU70 and XRCC5/KU80. Forms a complex with ILF3, YLPM1, KHDRBS1, RBMX, NCOA5 and PPP1CA. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with IGF2BP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi212438. 4 interactions.
    IntActiQ9CXY6. 4 interactions.
    MINTiMINT-4125797.

    Structurei

    Secondary structure

    1
    390
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi34 – 363
    Helixi38 – 403
    Helixi51 – 6414
    Helixi68 – 9023
    Turni94 – 985
    Beta strandi99 – 1057
    Helixi106 – 1105
    Beta strandi119 – 12810
    Helixi132 – 14918
    Beta strandi151 – 1533
    Beta strandi156 – 1605
    Beta strandi163 – 1675
    Beta strandi172 – 1798
    Helixi181 – 1855
    Turni189 – 1913
    Helixi195 – 21420
    Helixi218 – 23316
    Helixi235 – 2373
    Helixi242 – 25413
    Beta strandi256 – 2605
    Helixi264 – 27613
    Turni277 – 2804
    Beta strandi292 – 2943
    Helixi298 – 3014
    Helixi304 – 32219
    Helixi326 – 3294
    Beta strandi332 – 3343
    Helixi337 – 3404
    Beta strandi344 – 3463
    Beta strandi349 – 3513

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AT7X-ray1.90A29-390[»]
    4AT8X-ray2.69A/C29-390[»]
    4AT9X-ray2.80A29-390[»]
    4ATBX-ray3.10A/C29-390[»]
    ProteinModelPortaliQ9CXY6.
    SMRiQ9CXY6. Positions 29-361.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 371348DZFAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi366 – 3727Poly-Glu
    Compositional biasi381 – 3844Poly-Glu

    Sequence similaritiesi

    Contains 1 DZF domain.Curated

    Phylogenomic databases

    eggNOGiNOG247512.
    GeneTreeiENSGT00550000074528.
    HOGENOMiHOG000067801.
    HOVERGENiHBG052120.
    InParanoidiQ9CXY6.
    KOiK13089.
    OMAiFEENAHH.
    OrthoDBiEOG75XGM4.
    PhylomeDBiQ9CXY6.
    TreeFamiTF320194.

    Family and domain databases

    InterProiIPR006116. 2-5-oligoadenylate_synth_N.
    IPR006561. DZF.
    [Graphical view]
    PfamiPF07528. DZF. 1 hit.
    [Graphical view]
    SMARTiSM00572. DZF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CXY6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRGDRGRGRG GRFGSRGGPG GGFRPFVPHI PFDFYLCEMA FPRVKPAPDE    50
    TSFSEALLKR NQDLAPNSAE QASILSLVTK INNVIDNLIV APGTFEVQIE 100
    EVRQVGSYKK GTMTTGHNVA DLVVILKILP TLEAVAALGN KVVESLRAQD 150
    PSEVLTMLTN ETGFEISSSD ATVKILITTV PPNLRKLDPE LHLDIKVLQS 200
    ALAAIRHARW FEENASQSTV KVLIRLLKDL RIRFPGFEPL TPWILDLLGH 250
    YAVMNNPTRQ PLALNVAYRR CLQILAAGLF LPGSVGITDP CESGNFRVHT 300
    VMTLEQQDMV CYTAQTLVRI LSHGGFRKIL GQEGDASYLA SEISTWDGVI 350
    VTPSEKAYEK PPEKKEGEEE EENTEEPPQG EEEESMETQE 390
    Length:390
    Mass (Da):43,062
    Last modified:June 1, 2001 - v1
    Checksum:i75BAD022DCD4EE01
    GO

    Sequence cautioni

    The sequence BAC27594.1 differs from that shown. Reason: Intron retention.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458249 Genomic DNA. Translation: AAL59388.1.
    AK013858 mRNA. Translation: BAB29021.1.
    AK031892 mRNA. Translation: BAC27594.1. Sequence problems.
    AK078003 mRNA. Translation: BAC37097.1.
    AK157129 mRNA. Translation: BAE33972.1.
    BC004033 mRNA. Translation: AAH04033.1.
    BC024718 mRNA. Translation: AAH24718.1.
    CCDSiCCDS17530.1.
    RefSeqiNP_080650.1. NM_026374.3.
    UniGeneiMm.227258.

    Genome annotation databases

    EnsembliENSMUST00000001042; ENSMUSP00000001042; ENSMUSG00000001016.
    GeneIDi67781.
    KEGGimmu:67781.
    UCSCiuc008qcj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF458249 Genomic DNA. Translation: AAL59388.1 .
    AK013858 mRNA. Translation: BAB29021.1 .
    AK031892 mRNA. Translation: BAC27594.1 . Sequence problems.
    AK078003 mRNA. Translation: BAC37097.1 .
    AK157129 mRNA. Translation: BAE33972.1 .
    BC004033 mRNA. Translation: AAH04033.1 .
    BC024718 mRNA. Translation: AAH24718.1 .
    CCDSi CCDS17530.1.
    RefSeqi NP_080650.1. NM_026374.3.
    UniGenei Mm.227258.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AT7 X-ray 1.90 A 29-390 [» ]
    4AT8 X-ray 2.69 A/C 29-390 [» ]
    4AT9 X-ray 2.80 A 29-390 [» ]
    4ATB X-ray 3.10 A/C 29-390 [» ]
    ProteinModelPortali Q9CXY6.
    SMRi Q9CXY6. Positions 29-361.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 212438. 4 interactions.
    IntActi Q9CXY6. 4 interactions.
    MINTi MINT-4125797.

    PTM databases

    PhosphoSitei Q9CXY6.

    Proteomic databases

    MaxQBi Q9CXY6.
    PaxDbi Q9CXY6.
    PRIDEi Q9CXY6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001042 ; ENSMUSP00000001042 ; ENSMUSG00000001016 .
    GeneIDi 67781.
    KEGGi mmu:67781.
    UCSCi uc008qcj.1. mouse.

    Organism-specific databases

    CTDi 3608.
    MGIi MGI:1915031. Ilf2.

    Phylogenomic databases

    eggNOGi NOG247512.
    GeneTreei ENSGT00550000074528.
    HOGENOMi HOG000067801.
    HOVERGENi HBG052120.
    InParanoidi Q9CXY6.
    KOi K13089.
    OMAi FEENAHH.
    OrthoDBi EOG75XGM4.
    PhylomeDBi Q9CXY6.
    TreeFami TF320194.

    Miscellaneous databases

    ChiTaRSi ILF2. mouse.
    NextBioi 325549.
    PROi Q9CXY6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXY6.
    CleanExi MM_ILF2.
    Genevestigatori Q9CXY6.

    Family and domain databases

    InterProi IPR006116. 2-5-oligoadenylate_synth_N.
    IPR006561. DZF.
    [Graphical view ]
    Pfami PF07528. DZF. 1 hit.
    [Graphical view ]
    SMARTi SM00572. DZF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of cyclosporin A- and FK506-sensitive nuclear factor of activated T-cells: NF45 and NF90."
      Kao P.N., Chen L., Brock G., Ng J., Kenny J., Smith A.J., Corthesy B.
      J. Biol. Chem. 269:20691-20699(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Head, Medulla oblongata and Spleen.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.
    4. "Autoantibodies define a family of proteins with conserved double-stranded RNA-binding domains as well as DNA binding activity."
      Satoh M., Shaheen V.M., Kao P.N., Okano T., Shaw M., Yoshida H., Richards H.B., Reeves W.H.
      J. Biol. Chem. 274:34598-34604(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ILF3.
    5. "Ilf2 is regulated during meiosis and associated to transcriptionally active chromatin."
      Lopez-Fernandez L.A., Parraga M., del Mazo J.
      Mech. Dev. 111:153-157(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiILF2_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXY6
    Secondary accession number(s): Q3U083
    , Q5RKG0, Q8CCY9, Q99KS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3