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Protein

CUE domain-containing protein 2

Gene

Cuedc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.By similarity

GO - Biological processi

  • negative regulation of cytokine production involved in inflammatory response Source: MGI
  • negative regulation of macrophage cytokine production Source: MGI
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
CUE domain-containing protein 2
Gene namesi
Name:Cuedc2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1914366. Cuedc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284CUE domain-containing protein 2PRO_0000282993Add
BLAST

Proteomic databases

EPDiQ9CXX9.
MaxQBiQ9CXX9.
PaxDbiQ9CXX9.
PeptideAtlasiQ9CXX9.
PRIDEiQ9CXX9.

PTM databases

iPTMnetiQ9CXX9.
PhosphoSiteiQ9CXX9.

Expressioni

Gene expression databases

BgeeiQ9CXX9.
CleanExiMM_CUEDC2.
GenevisibleiQ9CXX9. MM.

Interactioni

Subunit structurei

Interacts with PGR and ESR1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053469.

Structurei

3D structure databases

ProteinModelPortaliQ9CXX9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini141 – 18444CUEPROSITE-ProRule annotationAdd
BLAST

Domaini

The CUE domain mediates interaction with PGR and ESR1.By similarity

Sequence similaritiesi

Belongs to the CUEDC2 family.Curated
Contains 1 CUE domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IJTC. Eukaryota.
ENOG4111GK5. LUCA.
GeneTreeiENSGT00390000014513.
HOGENOMiHOG000044753.
HOVERGENiHBG106839.
InParanoidiQ9CXX9.
OMAiLEMFPAC.
OrthoDBiEOG73JKW7.
PhylomeDBiQ9CXX9.
TreeFamiTF324328.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CXX9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELERIVGSA LLTFVQAHLP EADLSGLDEV IFSYVLGVLE DLGPSGPSEE
60 70 80 90 100
NFDMEAFTEM MEAYVPGFAH IPRGIIGDMM QKLSVQLSDA RNKENLHPQS
110 120 130 140 150
SCVQGQVPIF PETPRQAEKL EEESRPPAAP GNTLDEAAAA EELPGVDVLL
160 170 180 190 200
EVFPTCSMEQ AQWVLAKARG DLEEAVHMLV EGKEEGPPGW DGPSQDLPRR
210 220 230 240 250
LRGPQKDDLK SFILQKYMMV DRAEDQKTHR PMAPKEAPKK LIRYIDNQVV
260 270 280
STKGERFKDV RNPEAEEMKA TYINLKPARK YRFH
Length:284
Mass (Da):31,852
Last modified:June 1, 2001 - v1
Checksum:iDFFAB8D0261F03C2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131T → A in AAH03442 (PubMed:15489334).Curated
Sequence conflicti186 – 1861G → R in AAH03442 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB232359 mRNA. Translation: BAE19943.1.
AK013884 mRNA. Translation: BAB29035.1.
BC003442 mRNA. Translation: AAH03442.1.
CCDSiCCDS29876.1.
RefSeqiNP_001157762.1. NM_001164290.1.
NP_001157763.1. NM_001164291.1.
NP_001157764.1. NM_001164292.1.
NP_001157765.1. NM_001164293.1.
NP_001157766.1. NM_001164294.1.
NP_001157767.1. NM_001164295.1.
NP_077154.2. NM_024192.2.
XP_006527338.1. XM_006527275.2.
XP_006527339.1. XM_006527276.2.
XP_006527340.1. XM_006527277.2.
XP_006527341.1. XM_006527278.2.
XP_011245619.1. XM_011247317.1.
XP_011245620.1. XM_011247318.1.
XP_011245621.1. XM_011247319.1.
UniGeneiMm.218848.

Genome annotation databases

EnsembliENSMUST00000051234; ENSMUSP00000053469; ENSMUSG00000036748.
ENSMUST00000167861; ENSMUSP00000129589; ENSMUSG00000036748.
GeneIDi67116.
KEGGimmu:67116.
UCSCiuc008htg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB232359 mRNA. Translation: BAE19943.1.
AK013884 mRNA. Translation: BAB29035.1.
BC003442 mRNA. Translation: AAH03442.1.
CCDSiCCDS29876.1.
RefSeqiNP_001157762.1. NM_001164290.1.
NP_001157763.1. NM_001164291.1.
NP_001157764.1. NM_001164292.1.
NP_001157765.1. NM_001164293.1.
NP_001157766.1. NM_001164294.1.
NP_001157767.1. NM_001164295.1.
NP_077154.2. NM_024192.2.
XP_006527338.1. XM_006527275.2.
XP_006527339.1. XM_006527276.2.
XP_006527340.1. XM_006527277.2.
XP_006527341.1. XM_006527278.2.
XP_011245619.1. XM_011247317.1.
XP_011245620.1. XM_011247318.1.
XP_011245621.1. XM_011247319.1.
UniGeneiMm.218848.

3D structure databases

ProteinModelPortaliQ9CXX9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053469.

PTM databases

iPTMnetiQ9CXX9.
PhosphoSiteiQ9CXX9.

Proteomic databases

EPDiQ9CXX9.
MaxQBiQ9CXX9.
PaxDbiQ9CXX9.
PeptideAtlasiQ9CXX9.
PRIDEiQ9CXX9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051234; ENSMUSP00000053469; ENSMUSG00000036748.
ENSMUST00000167861; ENSMUSP00000129589; ENSMUSG00000036748.
GeneIDi67116.
KEGGimmu:67116.
UCSCiuc008htg.2. mouse.

Organism-specific databases

CTDi79004.
MGIiMGI:1914366. Cuedc2.

Phylogenomic databases

eggNOGiENOG410IJTC. Eukaryota.
ENOG4111GK5. LUCA.
GeneTreeiENSGT00390000014513.
HOGENOMiHOG000044753.
HOVERGENiHBG106839.
InParanoidiQ9CXX9.
OMAiLEMFPAC.
OrthoDBiEOG73JKW7.
PhylomeDBiQ9CXX9.
TreeFamiTF324328.

Miscellaneous databases

ChiTaRSiCuedc2. mouse.
PROiQ9CXX9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXX9.
CleanExiMM_CUEDC2.
GenevisibleiQ9CXX9. MM.

Family and domain databases

InterProiIPR003892. CUE.
[Graphical view]
PROSITEiPS51140. CUE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of mouse CUEDC2 mRNA."
    Matsumoto K., Abiko S., Ariga H.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiCUED2_MOUSE
AccessioniPrimary (citable) accession number: Q9CXX9
Secondary accession number(s): Q99LC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: June 1, 2001
Last modified: July 6, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.