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Protein

Hydrolethalus syndrome protein 1 homolog

Gene

Hyls1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in ciliogenesis.By similarity

GO - Biological processi

Keywordsi

Biological processCilium biogenesis/degradation

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrolethalus syndrome protein 1 homolog
Gene namesi
Name:Hyls1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1924082. Hyls1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002849271 – 307Hydrolethalus syndrome protein 1 homologAdd BLAST307

Proteomic databases

PaxDbiQ9CXX0.
PRIDEiQ9CXX0.

PTM databases

iPTMnetiQ9CXX0.
PhosphoSitePlusiQ9CXX0.

Expressioni

Tissue specificityi

Expressed in hippocampus and dentate gyrus of 3-month adult brain.1 Publication

Developmental stagei

Detected at each embryonic stage, the highest expression level observed at E11.1 Publication

Gene expression databases

CleanExiMM_HYLS1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000110762.

Structurei

3D structure databases

SMRiQ9CXX0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HYLS1 family.Curated

Phylogenomic databases

eggNOGiENOG410J0N2. Eukaryota.
ENOG4111UPE. LUCA.
HOGENOMiHOG000112979.
HOVERGENiHBG107985.
InParanoidiQ9CXX0.
KOiK16472.
TreeFamiTF336132.

Family and domain databases

InterProiView protein in InterPro
IPR026227. HYLS1.
IPR027918. HYLS1_C_dom.
PfamiView protein in Pfam
PF15311. HYLS1_C. 1 hit.
PRINTSiPR02098. HYLETHALUSS1.

Sequencei

Sequence statusi: Complete.

Q9CXX0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKRQAYSV PEAMKQLIGP GGQKWANMDP EERMLAAATA FTRICAGQGE
60 70 80 90 100
GDSRREAQAG QYDPYSKASV TPGKRPALPM HLHFPHTASR VTSSTVSETS
110 120 130 140 150
QKCRKPVMKR KVLRRKPDGE VLVTDESVIS ECESGTESDL GLWDLRHRFM
160 170 180 190 200
NLQFQEGTES PVVTSQKFNL PCEYQGISQE DQLICYLQRE EMDPPVYEQD
210 220 230 240 250
LIVASRPKSF ILPRLDQLSR NRGKIDRVAR YFEYKRDWDS MRFPGEDHRK
260 270 280 290 300
ELRWSVRGQM LSRTEPPSKP QHVYVPNNYL VPLRWGVRCD LANGVMPKKL

PFPLSPS
Length:307
Mass (Da):35,141
Last modified:May 1, 2007 - v2
Checksum:i1F7D5A46BA95B813
GO

Sequence cautioni

Q9CXX0: The sequence AAH35953 differs from that shown. Reason: Erroneous initiation.Curated
Q9CXX0: The sequence BAB29044 differs from that shown. Reason: Frameshift at position 289.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013896 mRNA. Translation: BAB29044.1. Frameshift.
AK131639 mRNA. Translation: BAE20733.1.
BC035953 mRNA. Translation: AAH35953.1. Different initiation.
RefSeqiNP_084038.1. NM_029762.1.
UniGeneiMm.482285.

Genome annotation databases

GeneIDi76832.
KEGGimmu:76832.
UCSCiuc009oti.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiHYLS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CXX0
Secondary accession number(s): Q3V2R4, Q8CI83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: October 25, 2017
This is version 88 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families