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Q9CXX0

- HYLS1_MOUSE

UniProt

Q9CXX0 - HYLS1_MOUSE

Protein

Hydrolethalus syndrome protein 1 homolog

Gene

Hyls1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydrolethalus syndrome protein 1 homolog
    Gene namesi
    Name:Hyls1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1924082. Hyls1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. centrosome Source: Ensembl
    2. cytoplasm Source: MGI
    3. nucleus Source: MGI
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Hydrolethalus syndrome protein 1 homologPRO_0000284927Add
    BLAST

    Proteomic databases

    PRIDEiQ9CXX0.

    PTM databases

    PhosphoSiteiQ9CXX0.

    Expressioni

    Tissue specificityi

    Expressed in hippocampus and dentate gyrus of 3-month adult brain.1 Publication

    Developmental stagei

    Detected at each embryonic stage, the highest expression level observed at E11.1 Publication

    Gene expression databases

    BgeeiQ9CXX0.
    CleanExiMM_HYLS1.
    GenevestigatoriQ9CXX0.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HYLS1 family.Curated

    Phylogenomic databases

    eggNOGiNOG76010.
    GeneTreeiENSGT00390000008848.
    HOGENOMiHOG000112979.
    HOVERGENiHBG107985.
    KOiK16472.
    OrthoDBiEOG72C51J.
    TreeFamiTF336132.

    Family and domain databases

    InterProiIPR026227. HYLS1.
    IPR027918. HYLS1_C_dom.
    [Graphical view]
    PfamiPF15311. HYLS1_C. 1 hit.
    [Graphical view]
    PRINTSiPR02098. HYLETHALUSS1.

    Sequencei

    Sequence statusi: Complete.

    Q9CXX0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAEKRQAYSV PEAMKQLIGP GGQKWANMDP EERMLAAATA FTRICAGQGE    50
    GDSRREAQAG QYDPYSKASV TPGKRPALPM HLHFPHTASR VTSSTVSETS 100
    QKCRKPVMKR KVLRRKPDGE VLVTDESVIS ECESGTESDL GLWDLRHRFM 150
    NLQFQEGTES PVVTSQKFNL PCEYQGISQE DQLICYLQRE EMDPPVYEQD 200
    LIVASRPKSF ILPRLDQLSR NRGKIDRVAR YFEYKRDWDS MRFPGEDHRK 250
    ELRWSVRGQM LSRTEPPSKP QHVYVPNNYL VPLRWGVRCD LANGVMPKKL 300
    PFPLSPS 307
    Length:307
    Mass (Da):35,141
    Last modified:May 1, 2007 - v2
    Checksum:i1F7D5A46BA95B813
    GO

    Sequence cautioni

    The sequence BAB29044.1 differs from that shown. Reason: Frameshift at position 289.
    The sequence AAH35953.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013896 mRNA. Translation: BAB29044.1. Frameshift.
    AK131639 mRNA. Translation: BAE20733.1.
    BC035953 mRNA. Translation: AAH35953.1. Different initiation.
    RefSeqiNP_084038.1. NM_029762.1.
    UniGeneiMm.482285.

    Genome annotation databases

    EnsembliENSMUST00000115110; ENSMUSP00000110762; ENSMUSG00000050555.
    GeneIDi76832.
    KEGGimmu:76832.
    UCSCiuc009oti.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013896 mRNA. Translation: BAB29044.1 . Frameshift.
    AK131639 mRNA. Translation: BAE20733.1 .
    BC035953 mRNA. Translation: AAH35953.1 . Different initiation.
    RefSeqi NP_084038.1. NM_029762.1.
    UniGenei Mm.482285.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9CXX0.

    Proteomic databases

    PRIDEi Q9CXX0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000115110 ; ENSMUSP00000110762 ; ENSMUSG00000050555 .
    GeneIDi 76832.
    KEGGi mmu:76832.
    UCSCi uc009oti.2. mouse.

    Organism-specific databases

    CTDi 219844.
    MGIi MGI:1924082. Hyls1.

    Phylogenomic databases

    eggNOGi NOG76010.
    GeneTreei ENSGT00390000008848.
    HOGENOMi HOG000112979.
    HOVERGENi HBG107985.
    KOi K16472.
    OrthoDBi EOG72C51J.
    TreeFami TF336132.

    Miscellaneous databases

    NextBioi 345911.
    PROi Q9CXX0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXX0.
    CleanExi MM_HYLS1.
    Genevestigatori Q9CXX0.

    Family and domain databases

    InterProi IPR026227. HYLS1.
    IPR027918. HYLS1_C_dom.
    [Graphical view ]
    Pfami PF15311. HYLS1_C. 1 hit.
    [Graphical view ]
    PRINTSi PR02098. HYLETHALUSS1.
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cerebellum and Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    3. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiHYLS1_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXX0
    Secondary accession number(s): Q3V2R4, Q8CI83
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 1, 2007
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 70 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3