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Q9CXX0 (HYLS1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hydrolethalus syndrome protein 1 homolog
Gene names
Name:Hyls1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in hippocampus and dentate gyrus of 3-month adult brain. Ref.3

Developmental stage

Detected at each embryonic stage, the highest expression level observed at E11. Ref.3

Sequence similarities

Belongs to the HYLS1 family.

Sequence caution

The sequence AAH35953.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAB29044.1 differs from that shown. Reason: Frameshift at position 289.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Hydrolethalus syndrome protein 1 homolog
PRO_0000284927

Sequences

Sequence LengthMass (Da)Tools
Q9CXX0 [UniParc].

Last modified May 1, 2007. Version 2.
Checksum: 1F7D5A46BA95B813

FASTA30735,141
        10         20         30         40         50         60 
MAEKRQAYSV PEAMKQLIGP GGQKWANMDP EERMLAAATA FTRICAGQGE GDSRREAQAG 

        70         80         90        100        110        120 
QYDPYSKASV TPGKRPALPM HLHFPHTASR VTSSTVSETS QKCRKPVMKR KVLRRKPDGE 

       130        140        150        160        170        180 
VLVTDESVIS ECESGTESDL GLWDLRHRFM NLQFQEGTES PVVTSQKFNL PCEYQGISQE 

       190        200        210        220        230        240 
DQLICYLQRE EMDPPVYEQD LIVASRPKSF ILPRLDQLSR NRGKIDRVAR YFEYKRDWDS 

       250        260        270        280        290        300 
MRFPGEDHRK ELRWSVRGQM LSRTEPPSKP QHVYVPNNYL VPLRWGVRCD LANGVMPKKL 


PFPLSPS 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Cerebellum and Head.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Salivary gland.
[3]"Hydrolethalus syndrome is caused by a missense mutation in a novel gene HYLS1."
Mee L., Honkala H., Kopra O., Vesa J., Finnilae S., Visapaeae I., Sang T.-K., Jackson G.R., Salonen R., Kestilae M., Peltonen L.
Hum. Mol. Genet. 14:1475-1488(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK013896 mRNA. Translation: BAB29044.1. Frameshift.
AK131639 mRNA. Translation: BAE20733.1.
BC035953 mRNA. Translation: AAH35953.1. Different initiation.
RefSeqNP_084038.1. NM_029762.1.
UniGeneMm.482285.

3D structure databases

ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9CXX0.

Proteomic databases

PRIDEQ9CXX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000115110; ENSMUSP00000110762; ENSMUSG00000050555.
GeneID76832.
KEGGmmu:76832.
UCSCuc009oti.2. mouse.

Organism-specific databases

CTD219844.
MGIMGI:1924082. Hyls1.

Phylogenomic databases

eggNOGNOG76010.
GeneTreeENSGT00390000008848.
HOGENOMHOG000112979.
HOVERGENHBG107985.
KOK16472.
OrthoDBEOG72C51J.
TreeFamTF336132.

Gene expression databases

BgeeQ9CXX0.
CleanExMM_HYLS1.
GenevestigatorQ9CXX0.

Family and domain databases

InterProIPR026227. HYLS1.
IPR027918. HYLS1_C_dom.
[Graphical view]
PfamPF15311. HYLS1_C. 1 hit.
[Graphical view]
PRINTSPR02098. HYLETHALUSS1.
ProtoNetSearch...

Other

NextBio345911.
PROQ9CXX0.
SOURCESearch...

Entry information

Entry nameHYLS1_MOUSE
AccessionPrimary (citable) accession number: Q9CXX0
Secondary accession number(s): Q3V2R4, Q8CI83
Entry history
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 19, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot