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Protein

Hydrolethalus syndrome protein 1 homolog

Gene

Hyls1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Hydrolethalus syndrome protein 1 homolog
Gene namesi
Name:Hyls1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1924082. Hyls1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. centrosome Source: MGI
  2. cytoplasm Source: MGI
  3. nucleus Source: MGI
  4. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Hydrolethalus syndrome protein 1 homologPRO_0000284927Add
BLAST

Proteomic databases

PRIDEiQ9CXX0.

PTM databases

PhosphoSiteiQ9CXX0.

Expressioni

Tissue specificityi

Expressed in hippocampus and dentate gyrus of 3-month adult brain.1 Publication

Developmental stagei

Detected at each embryonic stage, the highest expression level observed at E11.1 Publication

Gene expression databases

BgeeiQ9CXX0.
CleanExiMM_HYLS1.
GenevestigatoriQ9CXX0.

Family & Domainsi

Sequence similaritiesi

Belongs to the HYLS1 family.Curated

Phylogenomic databases

eggNOGiNOG76010.
GeneTreeiENSGT00390000008848.
HOGENOMiHOG000112979.
HOVERGENiHBG107985.
InParanoidiQ9CXX0.
KOiK16472.
OrthoDBiEOG72C51J.
TreeFamiTF336132.

Family and domain databases

InterProiIPR026227. HYLS1.
IPR027918. HYLS1_C_dom.
[Graphical view]
PfamiPF15311. HYLS1_C. 1 hit.
[Graphical view]
PRINTSiPR02098. HYLETHALUSS1.

Sequencei

Sequence statusi: Complete.

Q9CXX0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAEKRQAYSV PEAMKQLIGP GGQKWANMDP EERMLAAATA FTRICAGQGE
60 70 80 90 100
GDSRREAQAG QYDPYSKASV TPGKRPALPM HLHFPHTASR VTSSTVSETS
110 120 130 140 150
QKCRKPVMKR KVLRRKPDGE VLVTDESVIS ECESGTESDL GLWDLRHRFM
160 170 180 190 200
NLQFQEGTES PVVTSQKFNL PCEYQGISQE DQLICYLQRE EMDPPVYEQD
210 220 230 240 250
LIVASRPKSF ILPRLDQLSR NRGKIDRVAR YFEYKRDWDS MRFPGEDHRK
260 270 280 290 300
ELRWSVRGQM LSRTEPPSKP QHVYVPNNYL VPLRWGVRCD LANGVMPKKL

PFPLSPS
Length:307
Mass (Da):35,141
Last modified:May 1, 2007 - v2
Checksum:i1F7D5A46BA95B813
GO

Sequence cautioni

The sequence AAH35953.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB29044.1 differs from that shown. Reason: Frameshift at position 289. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013896 mRNA. Translation: BAB29044.1. Frameshift.
AK131639 mRNA. Translation: BAE20733.1.
BC035953 mRNA. Translation: AAH35953.1. Different initiation.
RefSeqiNP_084038.1. NM_029762.1.
UniGeneiMm.482285.

Genome annotation databases

EnsembliENSMUST00000115110; ENSMUSP00000110762; ENSMUSG00000050555.
GeneIDi76832.
KEGGimmu:76832.
UCSCiuc009oti.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013896 mRNA. Translation: BAB29044.1. Frameshift.
AK131639 mRNA. Translation: BAE20733.1.
BC035953 mRNA. Translation: AAH35953.1. Different initiation.
RefSeqiNP_084038.1. NM_029762.1.
UniGeneiMm.482285.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9CXX0.

Proteomic databases

PRIDEiQ9CXX0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115110; ENSMUSP00000110762; ENSMUSG00000050555.
GeneIDi76832.
KEGGimmu:76832.
UCSCiuc009oti.2. mouse.

Organism-specific databases

CTDi219844.
MGIiMGI:1924082. Hyls1.

Phylogenomic databases

eggNOGiNOG76010.
GeneTreeiENSGT00390000008848.
HOGENOMiHOG000112979.
HOVERGENiHBG107985.
InParanoidiQ9CXX0.
KOiK16472.
OrthoDBiEOG72C51J.
TreeFamiTF336132.

Miscellaneous databases

NextBioi345911.
PROiQ9CXX0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9CXX0.
CleanExiMM_HYLS1.
GenevestigatoriQ9CXX0.

Family and domain databases

InterProiIPR026227. HYLS1.
IPR027918. HYLS1_C_dom.
[Graphical view]
PfamiPF15311. HYLS1_C. 1 hit.
[Graphical view]
PRINTSiPR02098. HYLETHALUSS1.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  3. Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiHYLS1_MOUSE
AccessioniPrimary (citable) accession number: Q9CXX0
Secondary accession number(s): Q3V2R4, Q8CI83
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: May 1, 2007
Last modified: February 4, 2015
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.