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Q9CXW4

- RL11_MOUSE

UniProt

Q9CXW4 - RL11_MOUSE

Protein

60S ribosomal protein L11

Gene

Rpl11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Binds to 5S ribosomal RNA By similarity. Required for rRNA maturation and formation of the 60S ribosomal subunits By similarity. Promotes nucleolar location of PML.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. rRNA binding Source: UniProtKB-KW
    3. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. protein localization to nucleus Source: UniProtKB
    2. translation Source: InterPro

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    60S ribosomal protein L11
    Gene namesi
    Name:Rpl11
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1914275. Rpl11.

    Subcellular locationi

    Nucleusnucleolus 1 Publication

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB
    2. ribosome Source: UniProtKB-KW

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 17817760S ribosomal protein L11PRO_0000125083Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei44 – 441PhosphothreonineBy similarity
    Modified residuei52 – 521N6-acetyllysineBy similarity
    Modified residuei85 – 851N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9CXW4.
    PaxDbiQ9CXW4.
    PRIDEiQ9CXW4.

    PTM databases

    PhosphoSiteiQ9CXW4.

    Expressioni

    Gene expression databases

    BgeeiQ9CXW4.
    CleanExiMM_RPL11.
    GenevestigatoriQ9CXW4.

    Interactioni

    Subunit structurei

    Interacts with PML and MDM2.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Mdm2P238044EBI-1548890,EBI-641788

    Protein-protein interaction databases

    BioGridi211883. 13 interactions.
    IntActiQ9CXW4. 6 interactions.
    MINTiMINT-1859586.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXW4.
    SMRiQ9CXW4. Positions 9-176.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L5P family.Curated

    Phylogenomic databases

    eggNOGiCOG0094.
    GeneTreeiENSGT00390000013411.
    HOGENOMiHOG000231312.
    HOVERGENiHBG055214.
    KOiK02868.
    OMAiEDTMAWF.
    OrthoDBiEOG7ZPNMB.
    PhylomeDBiQ9CXW4.
    TreeFamiTF300017.

    Family and domain databases

    Gene3Di3.30.1440.10. 1 hit.
    InterProiIPR002132. Ribosomal_L5.
    IPR020929. Ribosomal_L5_CS.
    IPR022803. Ribosomal_L5_domain.
    [Graphical view]
    PANTHERiPTHR11994. PTHR11994. 1 hit.
    PfamiPF00281. Ribosomal_L5. 1 hit.
    PF00673. Ribosomal_L5_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
    SUPFAMiSSF55282. SSF55282. 1 hit.
    PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CXW4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF    50
    SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS 100
    DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC 150
    IGAKHRISKE EAMRWFQQKY DGIILPGK 178
    Length:178
    Mass (Da):20,252
    Last modified:January 23, 2007 - v4
    Checksum:i26EC965C9239774E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481P → Q in BAB29059. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002998 mRNA. Translation: BAB22504.1.
    AK008422 mRNA. Translation: BAB25660.1.
    AK011211 mRNA. Translation: BAB27470.1.
    AK011800 mRNA. Translation: BAB27850.1.
    AK013923 mRNA. Translation: BAB29059.1.
    AK088967 mRNA. Translation: BAC40676.1.
    AK153486 mRNA. Translation: BAE32034.1.
    AK164445 mRNA. Translation: BAE37793.1.
    AK169053 mRNA. Translation: BAE40841.1.
    BC025077 mRNA. Translation: AAH25077.1.
    BC069896 mRNA. Translation: AAH69896.1.
    CCDSiCCDS18799.1.
    RefSeqiNP_080195.1. NM_025919.2.
    UniGeneiMm.276856.

    Genome annotation databases

    EnsembliENSMUST00000102536; ENSMUSP00000099595; ENSMUSG00000059291.
    GeneIDi67025.
    KEGGimmu:67025.
    UCSCiuc008vhr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK002998 mRNA. Translation: BAB22504.1 .
    AK008422 mRNA. Translation: BAB25660.1 .
    AK011211 mRNA. Translation: BAB27470.1 .
    AK011800 mRNA. Translation: BAB27850.1 .
    AK013923 mRNA. Translation: BAB29059.1 .
    AK088967 mRNA. Translation: BAC40676.1 .
    AK153486 mRNA. Translation: BAE32034.1 .
    AK164445 mRNA. Translation: BAE37793.1 .
    AK169053 mRNA. Translation: BAE40841.1 .
    BC025077 mRNA. Translation: AAH25077.1 .
    BC069896 mRNA. Translation: AAH69896.1 .
    CCDSi CCDS18799.1.
    RefSeqi NP_080195.1. NM_025919.2.
    UniGenei Mm.276856.

    3D structure databases

    ProteinModelPortali Q9CXW4.
    SMRi Q9CXW4. Positions 9-176.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211883. 13 interactions.
    IntActi Q9CXW4. 6 interactions.
    MINTi MINT-1859586.

    PTM databases

    PhosphoSitei Q9CXW4.

    Proteomic databases

    MaxQBi Q9CXW4.
    PaxDbi Q9CXW4.
    PRIDEi Q9CXW4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102536 ; ENSMUSP00000099595 ; ENSMUSG00000059291 .
    GeneIDi 67025.
    KEGGi mmu:67025.
    UCSCi uc008vhr.1. mouse.

    Organism-specific databases

    CTDi 6135.
    MGIi MGI:1914275. Rpl11.

    Phylogenomic databases

    eggNOGi COG0094.
    GeneTreei ENSGT00390000013411.
    HOGENOMi HOG000231312.
    HOVERGENi HBG055214.
    KOi K02868.
    OMAi EDTMAWF.
    OrthoDBi EOG7ZPNMB.
    PhylomeDBi Q9CXW4.
    TreeFami TF300017.

    Enzyme and pathway databases

    Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
    REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
    REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

    Miscellaneous databases

    NextBioi 323340.
    PROi Q9CXW4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXW4.
    CleanExi MM_RPL11.
    Genevestigatori Q9CXW4.

    Family and domain databases

    Gene3Di 3.30.1440.10. 1 hit.
    InterProi IPR002132. Ribosomal_L5.
    IPR020929. Ribosomal_L5_CS.
    IPR022803. Ribosomal_L5_domain.
    [Graphical view ]
    PANTHERi PTHR11994. PTHR11994. 1 hit.
    Pfami PF00281. Ribosomal_L5. 1 hit.
    PF00673. Ribosomal_L5_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002161. Ribosomal_L5. 1 hit.
    SUPFAMi SSF55282. SSF55282. 1 hit.
    PROSITEi PS00358. RIBOSOMAL_L5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Bone marrow, Brain, Embryonic head, Eye, Small intestine and Thymus.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Mammary tumor.
    3. "PML regulates p53 stability by sequestering Mdm2 to the nucleolus."
      Bernardi R., Scaglioni P.P., Bergmann S., Horn H.F., Vousden K.H., Pandolfi P.P.
      Nat. Cell Biol. 6:665-672(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH PML AND MDM2, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiRL11_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXW4
    Secondary accession number(s): Q3TPE3, Q6ZWY0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 107 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3