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Q9CXW4

- RL11_MOUSE

UniProt

Q9CXW4 - RL11_MOUSE

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Protein

60S ribosomal protein L11

Gene

Rpl11

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Binds to 5S ribosomal RNA (By similarity). Required for rRNA maturation and formation of the 60S ribosomal subunits (By similarity). Promotes nucleolar location of PML.By similarity1 Publication

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-KW
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. protein localization to nucleus Source: UniProtKB
  2. translation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiREACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_231519. Eukaryotic Translation Termination.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_253640. Peptide chain elongation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L11
Gene namesi
Name:Rpl11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1914275. Rpl11.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. ribosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 17817760S ribosomal protein L11PRO_0000125083Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei44 – 441PhosphothreonineBy similarity
Modified residuei52 – 521N6-acetyllysineBy similarity
Modified residuei85 – 851N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9CXW4.
PaxDbiQ9CXW4.
PRIDEiQ9CXW4.

PTM databases

PhosphoSiteiQ9CXW4.

Expressioni

Gene expression databases

BgeeiQ9CXW4.
CleanExiMM_RPL11.
ExpressionAtlasiQ9CXW4. baseline and differential.
GenevestigatoriQ9CXW4.

Interactioni

Subunit structurei

Interacts with PML and MDM2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Mdm2P238044EBI-1548890,EBI-641788

Protein-protein interaction databases

BioGridi211883. 13 interactions.
IntActiQ9CXW4. 6 interactions.
MINTiMINT-1859586.

Structurei

3D structure databases

ProteinModelPortaliQ9CXW4.
SMRiQ9CXW4. Positions 9-176.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L5P family.Curated

Phylogenomic databases

eggNOGiCOG0094.
GeneTreeiENSGT00390000013411.
HOGENOMiHOG000231312.
HOVERGENiHBG055214.
InParanoidiQ9CXW4.
KOiK02868.
OMAiEDTMAWF.
OrthoDBiEOG7ZPNMB.
PhylomeDBiQ9CXW4.
TreeFamiTF300017.

Family and domain databases

Gene3Di3.30.1440.10. 1 hit.
InterProiIPR002132. Ribosomal_L5.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
[Graphical view]
PANTHERiPTHR11994. PTHR11994. 1 hit.
PfamiPF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view]
PIRSFiPIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMiSSF55282. SSF55282. 1 hit.
PROSITEiPS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQDQGEKEN PMRELRIRKL CLNICVGESG DRLTRAAKVL EQLTGQTPVF
60 70 80 90 100
SKARYTVRSF GIRRNEKIAV HCTVRGAKAE EILEKGLKVR EYELRKNNFS
110 120 130 140 150
DTGNFGFGIQ EHIDLGIKYD PSIGIYGLDF YVVLGRPGFS IADKKRRTGC
160 170
IGAKHRISKE EAMRWFQQKY DGIILPGK
Length:178
Mass (Da):20,252
Last modified:January 23, 2007 - v4
Checksum:i26EC965C9239774E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481P → Q in BAB29059. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002998 mRNA. Translation: BAB22504.1.
AK008422 mRNA. Translation: BAB25660.1.
AK011211 mRNA. Translation: BAB27470.1.
AK011800 mRNA. Translation: BAB27850.1.
AK013923 mRNA. Translation: BAB29059.1.
AK088967 mRNA. Translation: BAC40676.1.
AK153486 mRNA. Translation: BAE32034.1.
AK164445 mRNA. Translation: BAE37793.1.
AK169053 mRNA. Translation: BAE40841.1.
BC025077 mRNA. Translation: AAH25077.1.
BC069896 mRNA. Translation: AAH69896.1.
CCDSiCCDS18799.1.
RefSeqiNP_080195.1. NM_025919.2.
UniGeneiMm.276856.

Genome annotation databases

EnsembliENSMUST00000102536; ENSMUSP00000099595; ENSMUSG00000059291.
GeneIDi67025.
KEGGimmu:67025.
UCSCiuc008vhr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002998 mRNA. Translation: BAB22504.1 .
AK008422 mRNA. Translation: BAB25660.1 .
AK011211 mRNA. Translation: BAB27470.1 .
AK011800 mRNA. Translation: BAB27850.1 .
AK013923 mRNA. Translation: BAB29059.1 .
AK088967 mRNA. Translation: BAC40676.1 .
AK153486 mRNA. Translation: BAE32034.1 .
AK164445 mRNA. Translation: BAE37793.1 .
AK169053 mRNA. Translation: BAE40841.1 .
BC025077 mRNA. Translation: AAH25077.1 .
BC069896 mRNA. Translation: AAH69896.1 .
CCDSi CCDS18799.1.
RefSeqi NP_080195.1. NM_025919.2.
UniGenei Mm.276856.

3D structure databases

ProteinModelPortali Q9CXW4.
SMRi Q9CXW4. Positions 9-176.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211883. 13 interactions.
IntActi Q9CXW4. 6 interactions.
MINTi MINT-1859586.

PTM databases

PhosphoSitei Q9CXW4.

Proteomic databases

MaxQBi Q9CXW4.
PaxDbi Q9CXW4.
PRIDEi Q9CXW4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102536 ; ENSMUSP00000099595 ; ENSMUSG00000059291 .
GeneIDi 67025.
KEGGi mmu:67025.
UCSCi uc008vhr.1. mouse.

Organism-specific databases

CTDi 6135.
MGIi MGI:1914275. Rpl11.

Phylogenomic databases

eggNOGi COG0094.
GeneTreei ENSGT00390000013411.
HOGENOMi HOG000231312.
HOVERGENi HBG055214.
InParanoidi Q9CXW4.
KOi K02868.
OMAi EDTMAWF.
OrthoDBi EOG7ZPNMB.
PhylomeDBi Q9CXW4.
TreeFami TF300017.

Enzyme and pathway databases

Reactomei REACT_196445. SRP-dependent cotranslational protein targeting to membrane.
REACT_198524. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
REACT_198528. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
REACT_231519. Eukaryotic Translation Termination.
REACT_249044. Formation of a pool of free 40S subunits.
REACT_253640. Peptide chain elongation.
REACT_259469. L13a-mediated translational silencing of Ceruloplasmin expression.
REACT_262078. GTP hydrolysis and joining of the 60S ribosomal subunit.

Miscellaneous databases

NextBioi 323340.
PROi Q9CXW4.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXW4.
CleanExi MM_RPL11.
ExpressionAtlasi Q9CXW4. baseline and differential.
Genevestigatori Q9CXW4.

Family and domain databases

Gene3Di 3.30.1440.10. 1 hit.
InterProi IPR002132. Ribosomal_L5.
IPR020929. Ribosomal_L5_CS.
IPR022803. Ribosomal_L5_domain.
[Graphical view ]
PANTHERi PTHR11994. PTHR11994. 1 hit.
Pfami PF00281. Ribosomal_L5. 1 hit.
PF00673. Ribosomal_L5_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF002161. Ribosomal_L5. 1 hit.
SUPFAMi SSF55282. SSF55282. 1 hit.
PROSITEi PS00358. RIBOSOMAL_L5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Bone marrow, Brain, Embryonic head, Eye, Small intestine and Thymus.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Mammary tumor.
  3. "PML regulates p53 stability by sequestering Mdm2 to the nucleolus."
    Bernardi R., Scaglioni P.P., Bergmann S., Horn H.F., Vousden K.H., Pandolfi P.P.
    Nat. Cell Biol. 6:665-672(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH PML AND MDM2, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiRL11_MOUSE
AccessioniPrimary (citable) accession number: Q9CXW4
Secondary accession number(s): Q3TPE3, Q6ZWY0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3