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Q9CXV1

- DHSD_MOUSE

UniProt

Q9CXV1 - DHSD_MOUSE

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Protein

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Gene

Sdhd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Iron (heme axial ligand); shared with SDHCBy similarity
Binding sitei114 – 1141Ubiquinone; shared with IP/SDHBBy similarity

GO - Molecular functioni

  1. heme binding Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW
  3. succinate dehydrogenase activity Source: MGI
  4. ubiquinone binding Source: UniProtKB

GO - Biological processi

  1. cellular response to hypoxia Source: MGI
  2. regulation of catecholamine secretion Source: MGI
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Short name:
CybS
Alternative name(s):
CII-4
QPs3
Succinate dehydrogenase complex subunit D
Succinate-ubiquinone oxidoreductase cytochrome b small subunit
Succinate-ubiquinone reductase membrane anchor subunit
Gene namesi
Name:Sdhd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1914175. Sdhd.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB
  3. mitochondrial respiratory chain complex II Source: UniProtKB
  4. mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 5656MitochondrionSequence AnalysisAdd
BLAST
Chaini57 – 159103Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialPRO_0000006488Add
BLAST

Proteomic databases

MaxQBiQ9CXV1.
PaxDbiQ9CXV1.
PRIDEiQ9CXV1.

Expressioni

Gene expression databases

BgeeiQ9CXV1.
GenevestigatoriQ9CXV1.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9CXV1.
SMRiQ9CXV1. Positions 59-159.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini57 – 637Mitochondrial matrixBy similarity
Topological domaini86 – 905Mitochondrial intermembraneBy similarity
Topological domaini112 – 1209Mitochondrial matrixBy similarity
Topological domaini143 – 15917Mitochondrial intermembraneBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei64 – 8522HelicalBy similarityAdd
BLAST
Transmembranei91 – 11121HelicalBy similarityAdd
BLAST
Transmembranei121 – 14222HelicalBy similarityAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the CybS family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG264646.
GeneTreeiENSGT00390000010003.
HOGENOMiHOG000290645.
HOVERGENiHBG003003.
InParanoidiQ9CXV1.
KOiK00237.
OMAiHTGFGNI.
OrthoDBiEOG7M6D94.
PhylomeDBiQ9CXV1.
TreeFamiTF313310.

Family and domain databases

InterProiIPR007992. CybS.
[Graphical view]
PANTHERiPTHR13337. PTHR13337. 1 hit.
PfamiPF05328. CybS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXV1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVLLKLGVL CSGQGARALL LRSRVVRPAY VSAFLQDQPT QGRCGTQHIH
60 70 80 90 100
LSPSHHSGSK AASLHWTSER VVSVLLLGLI PAGYLNPCSV VDYSLAAALT
110 120 130 140 150
LHSHWGLGQV VTDYVHGDTL PKAARAGLLA LSALTFAGLC YFNYHDVGIC

RAVAMLWKL
Length:159
Mass (Da):17,014
Last modified:March 1, 2003 - v2
Checksum:iCB3B3CB37E257A06
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013962 mRNA. Translation: BAB29086.2.
AK135970 mRNA. Translation: BAE22752.1.
BC145731 mRNA. Translation: AAI45732.1.
BC145733 mRNA. Translation: AAI45734.1.
CCDSiCCDS40623.1.
RefSeqiNP_080124.1. NM_025848.3.
UniGeneiMm.10406.

Genome annotation databases

EnsembliENSMUST00000000175; ENSMUSP00000000175; ENSMUSG00000000171.
GeneIDi66925.
KEGGimmu:66925.
UCSCiuc009pjv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK013962 mRNA. Translation: BAB29086.2 .
AK135970 mRNA. Translation: BAE22752.1 .
BC145731 mRNA. Translation: AAI45732.1 .
BC145733 mRNA. Translation: AAI45734.1 .
CCDSi CCDS40623.1.
RefSeqi NP_080124.1. NM_025848.3.
UniGenei Mm.10406.

3D structure databases

ProteinModelPortali Q9CXV1.
SMRi Q9CXV1. Positions 59-159.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q9CXV1.
PaxDbi Q9CXV1.
PRIDEi Q9CXV1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000000175 ; ENSMUSP00000000175 ; ENSMUSG00000000171 .
GeneIDi 66925.
KEGGi mmu:66925.
UCSCi uc009pjv.2. mouse.

Organism-specific databases

CTDi 6392.
MGIi MGI:1914175. Sdhd.

Phylogenomic databases

eggNOGi NOG264646.
GeneTreei ENSGT00390000010003.
HOGENOMi HOG000290645.
HOVERGENi HBG003003.
InParanoidi Q9CXV1.
KOi K00237.
OMAi HTGFGNI.
OrthoDBi EOG7M6D94.
PhylomeDBi Q9CXV1.
TreeFami TF313310.

Enzyme and pathway databases

UniPathwayi UPA00223 .

Miscellaneous databases

ChiTaRSi SDHD. mouse.
NextBioi 323033.
PROi Q9CXV1.
SOURCEi Search...

Gene expression databases

Bgeei Q9CXV1.
Genevestigatori Q9CXV1.

Family and domain databases

InterProi IPR007992. CybS.
[Graphical view ]
PANTHERi PTHR13337. PTHR13337. 1 hit.
Pfami PF05328. CybS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Egg and Head.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiDHSD_MOUSE
AccessioniPrimary (citable) accession number: Q9CXV1
Secondary accession number(s): A6H629, Q3UX11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3