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Q9CXV1

- DHSD_MOUSE

UniProt

Q9CXV1 - DHSD_MOUSE

Protein

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Gene

Sdhd

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 2 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Iron (heme axial ligand); shared with SDHCBy similarity
    Binding sitei114 – 1141Ubiquinone; shared with IP/SDHBBy similarity

    GO - Molecular functioni

    1. heme binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. ubiquinone binding Source: UniProtKB

    GO - Biological processi

    1. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Electron transport, Transport, Tricarboxylic acid cycle

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00223.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
    Short name:
    CybS
    Alternative name(s):
    CII-4
    QPs3
    Succinate dehydrogenase complex subunit D
    Succinate-ubiquinone oxidoreductase cytochrome b small subunit
    Succinate-ubiquinone reductase membrane anchor subunit
    Gene namesi
    Name:Sdhd
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1914175. Sdhd.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB
    3. mitochondrial respiratory chain complex II Source: UniProtKB
    4. mitochondrion Source: MGI

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5656MitochondrionSequence AnalysisAdd
    BLAST
    Chaini57 – 159103Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialPRO_0000006488Add
    BLAST

    Proteomic databases

    PaxDbiQ9CXV1.
    PRIDEiQ9CXV1.

    Expressioni

    Gene expression databases

    BgeeiQ9CXV1.
    GenevestigatoriQ9CXV1.

    Interactioni

    Subunit structurei

    Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CXV1.
    SMRiQ9CXV1. Positions 59-159.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini57 – 637Mitochondrial matrixBy similarity
    Topological domaini86 – 905Mitochondrial intermembraneBy similarity
    Topological domaini112 – 1209Mitochondrial matrixBy similarity
    Topological domaini143 – 15917Mitochondrial intermembraneBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei64 – 8522HelicalBy similarityAdd
    BLAST
    Transmembranei91 – 11121HelicalBy similarityAdd
    BLAST
    Transmembranei121 – 14222HelicalBy similarityAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CybS family.Curated

    Keywords - Domaini

    Transit peptide, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG264646.
    GeneTreeiENSGT00390000010003.
    HOGENOMiHOG000290645.
    HOVERGENiHBG003003.
    InParanoidiA6H629.
    KOiK00237.
    OMAiHTGFGNI.
    OrthoDBiEOG7M6D94.
    PhylomeDBiQ9CXV1.
    TreeFamiTF313310.

    Family and domain databases

    InterProiIPR007992. CybS.
    [Graphical view]
    PANTHERiPTHR13337. PTHR13337. 1 hit.
    PfamiPF05328. CybS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CXV1-1 [UniParc]FASTAAdd to Basket

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    MAVLLKLGVL CSGQGARALL LRSRVVRPAY VSAFLQDQPT QGRCGTQHIH    50
    LSPSHHSGSK AASLHWTSER VVSVLLLGLI PAGYLNPCSV VDYSLAAALT 100
    LHSHWGLGQV VTDYVHGDTL PKAARAGLLA LSALTFAGLC YFNYHDVGIC 150
    RAVAMLWKL 159
    Length:159
    Mass (Da):17,014
    Last modified:March 1, 2003 - v2
    Checksum:iCB3B3CB37E257A06
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013962 mRNA. Translation: BAB29086.2.
    AK135970 mRNA. Translation: BAE22752.1.
    BC145731 mRNA. Translation: AAI45732.1.
    BC145733 mRNA. Translation: AAI45734.1.
    CCDSiCCDS40623.1.
    RefSeqiNP_080124.1. NM_025848.3.
    UniGeneiMm.10406.

    Genome annotation databases

    EnsembliENSMUST00000000175; ENSMUSP00000000175; ENSMUSG00000000171.
    GeneIDi66925.
    KEGGimmu:66925.
    UCSCiuc009pjv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK013962 mRNA. Translation: BAB29086.2 .
    AK135970 mRNA. Translation: BAE22752.1 .
    BC145731 mRNA. Translation: AAI45732.1 .
    BC145733 mRNA. Translation: AAI45734.1 .
    CCDSi CCDS40623.1.
    RefSeqi NP_080124.1. NM_025848.3.
    UniGenei Mm.10406.

    3D structure databases

    ProteinModelPortali Q9CXV1.
    SMRi Q9CXV1. Positions 59-159.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9CXV1.
    PRIDEi Q9CXV1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000000175 ; ENSMUSP00000000175 ; ENSMUSG00000000171 .
    GeneIDi 66925.
    KEGGi mmu:66925.
    UCSCi uc009pjv.2. mouse.

    Organism-specific databases

    CTDi 6392.
    MGIi MGI:1914175. Sdhd.

    Phylogenomic databases

    eggNOGi NOG264646.
    GeneTreei ENSGT00390000010003.
    HOGENOMi HOG000290645.
    HOVERGENi HBG003003.
    InParanoidi A6H629.
    KOi K00237.
    OMAi HTGFGNI.
    OrthoDBi EOG7M6D94.
    PhylomeDBi Q9CXV1.
    TreeFami TF313310.

    Enzyme and pathway databases

    UniPathwayi UPA00223 .

    Miscellaneous databases

    ChiTaRSi SDHD. mouse.
    NextBioi 323033.
    PROi Q9CXV1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9CXV1.
    Genevestigatori Q9CXV1.

    Family and domain databases

    InterProi IPR007992. CybS.
    [Graphical view ]
    PANTHERi PTHR13337. PTHR13337. 1 hit.
    Pfami PF05328. CybS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Egg and Head.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiDHSD_MOUSE
    AccessioniPrimary (citable) accession number: Q9CXV1
    Secondary accession number(s): A6H629, Q3UX11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 31, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 89 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3