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Protein

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Gene

Sdhd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in the pathway tricarboxylic acid cycle, which is part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi102Iron (heme axial ligand); shared with SDHCBy similarity1
Binding sitei114Ubiquinone; shared with IP/SDHBBy similarity1

GO - Molecular functioni

  • heme binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • succinate dehydrogenase activity Source: MGI
  • ubiquinone binding Source: UniProtKB

GO - Biological processi

  • cellular response to hypoxia Source: MGI
  • mitochondrial electron transport, succinate to ubiquinone Source: GO_Central
  • regulation of catecholamine secretion Source: MGI
  • tricarboxylic acid cycle Source: MGI
Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Short name:
CybS
Alternative name(s):
CII-4
QPs3
Succinate dehydrogenase complex subunit D
Succinate-ubiquinone oxidoreductase cytochrome b small subunit
Succinate-ubiquinone reductase membrane anchor subunit
Gene namesi
Name:Sdhd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1914175. Sdhd.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini57 – 63Mitochondrial matrixBy similarity7
Transmembranei64 – 85HelicalBy similarityAdd BLAST22
Topological domaini86 – 90Mitochondrial intermembraneBy similarity5
Transmembranei91 – 111HelicalBy similarityAdd BLAST21
Topological domaini112 – 120Mitochondrial matrixBy similarity9
Transmembranei121 – 142HelicalBy similarityAdd BLAST22
Topological domaini143 – 159Mitochondrial intermembraneBy similarityAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 56MitochondrionSequence analysisAdd BLAST56
ChainiPRO_000000648857 – 159Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrialAdd BLAST103

Proteomic databases

MaxQBiQ9CXV1.
PaxDbiQ9CXV1.
PeptideAtlasiQ9CXV1.
PRIDEiQ9CXV1.
TopDownProteomicsiQ9CXV1.

PTM databases

SwissPalmiQ9CXV1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000000171.
GenevisibleiQ9CXV1. MM.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000175.

Structurei

3D structure databases

ProteinModelPortaliQ9CXV1.
SMRiQ9CXV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CybS family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4097. Eukaryota.
ENOG4111RTW. LUCA.
GeneTreeiENSGT00390000010003.
HOGENOMiHOG000290645.
HOVERGENiHBG003003.
InParanoidiQ9CXV1.
KOiK00237.
OMAiPCSAVDY.
OrthoDBiEOG091G0RHX.
PhylomeDBiQ9CXV1.
TreeFamiTF313310.

Family and domain databases

CDDicd03496. SQR_TypeC_CybS. 1 hit.
InterProiIPR007992. CybS.
[Graphical view]
PANTHERiPTHR13337. PTHR13337. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CXV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVLLKLGVL CSGQGARALL LRSRVVRPAY VSAFLQDQPT QGRCGTQHIH
60 70 80 90 100
LSPSHHSGSK AASLHWTSER VVSVLLLGLI PAGYLNPCSV VDYSLAAALT
110 120 130 140 150
LHSHWGLGQV VTDYVHGDTL PKAARAGLLA LSALTFAGLC YFNYHDVGIC

RAVAMLWKL
Length:159
Mass (Da):17,014
Last modified:March 1, 2003 - v2
Checksum:iCB3B3CB37E257A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013962 mRNA. Translation: BAB29086.2.
AK135970 mRNA. Translation: BAE22752.1.
BC145731 mRNA. Translation: AAI45732.1.
BC145733 mRNA. Translation: AAI45734.1.
CCDSiCCDS40623.1.
RefSeqiNP_080124.1. NM_025848.3.
UniGeneiMm.10406.

Genome annotation databases

EnsembliENSMUST00000000175; ENSMUSP00000000175; ENSMUSG00000000171.
GeneIDi66925.
KEGGimmu:66925.
UCSCiuc009pjv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013962 mRNA. Translation: BAB29086.2.
AK135970 mRNA. Translation: BAE22752.1.
BC145731 mRNA. Translation: AAI45732.1.
BC145733 mRNA. Translation: AAI45734.1.
CCDSiCCDS40623.1.
RefSeqiNP_080124.1. NM_025848.3.
UniGeneiMm.10406.

3D structure databases

ProteinModelPortaliQ9CXV1.
SMRiQ9CXV1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000175.

PTM databases

SwissPalmiQ9CXV1.

Proteomic databases

MaxQBiQ9CXV1.
PaxDbiQ9CXV1.
PeptideAtlasiQ9CXV1.
PRIDEiQ9CXV1.
TopDownProteomicsiQ9CXV1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000175; ENSMUSP00000000175; ENSMUSG00000000171.
GeneIDi66925.
KEGGimmu:66925.
UCSCiuc009pjv.2. mouse.

Organism-specific databases

CTDi6392.
MGIiMGI:1914175. Sdhd.

Phylogenomic databases

eggNOGiKOG4097. Eukaryota.
ENOG4111RTW. LUCA.
GeneTreeiENSGT00390000010003.
HOGENOMiHOG000290645.
HOVERGENiHBG003003.
InParanoidiQ9CXV1.
KOiK00237.
OMAiPCSAVDY.
OrthoDBiEOG091G0RHX.
PhylomeDBiQ9CXV1.
TreeFamiTF313310.

Enzyme and pathway databases

UniPathwayiUPA00223.

Miscellaneous databases

ChiTaRSiSdhd. mouse.
PROiQ9CXV1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000171.
GenevisibleiQ9CXV1. MM.

Family and domain databases

CDDicd03496. SQR_TypeC_CybS. 1 hit.
InterProiIPR007992. CybS.
[Graphical view]
PANTHERiPTHR13337. PTHR13337. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHSD_MOUSE
AccessioniPrimary (citable) accession number: Q9CXV1
Secondary accession number(s): A6H629, Q3UX11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: March 1, 2003
Last modified: November 30, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.